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H. pylori 제균으로 완전 관해된 위의 고도 MALT 림프종 1예 : a case report
황창연,류민희,강윤구,김태원,장흥문,엄대운,허주령 대한내과학회 2004 대한내과학회지 Vol.66 No.1
위의 저도 MALT 림프종은 H. pylori 제균 후에 60∼90%가 관해를 보이는 것으로 알려져 있으나 고도 MALT 림프종은 H. pylori 제균 만으로는 치료가 부족한 것으로 알려져 있다. 그러나 최근에 위의 고도 MALT 림프종에서도 H. pylori 제균 치료를 통해 관해에 이른 사례들이 보고 되었고, 저자들도 고도 MALT 림프종 환자에서 H. pylori 제균 치료를 통하여 내시경적 및 조직학적 완전 관해에 도달한 증례를 경험하여 이를 보고하는 바이다. Low grade MALT lymphoma of stomach is associated with H. pylori infection in more than 90% of cases, and eradication of H. pylori leads to regression of the low grade MALT lymphoma in 60∼90% of cases. On the contrary, high grade MALT lymphoma is thought to be independent from H. pylori for growth and usually is thought to require antitumor chemotherapy. However, there have been recent reports of high grade MALT lymphoma regressing after H. pylori eradication. We experienced and are reporting a case of high grade MALT lymphoma arising in the background of low grade MALT lymphoma that showed complete regression after H. pylori eradication.
Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma
Yoon, Seon-Jin,Shim, Jin-Kyoung,Chang, Jong Hee,Moon, Ju Hyung,Roh, Tae-Hoon,Sung, Kyoung Su,Lee, Ji-Hyun,Kim, Eui-Hyun,Kim, Sun Ho,Hong, Yong-Kil,Lee, Su-Jae,Huh, Yong-Min,Kang, Seok-Gu Hindawi Publishing Corporation 2016 Stem cells international Vol.2016 No.-
<P>The isolation from brain tumors of tumor mesenchymal stem-like cells (tMSLCs) suggests that these cells play a role in creating a microenvironment for tumor initiation and progression. The clinical characteristics of patients with primary glioblastoma (pGBM) positive for tMSLCs have not been determined. This study analyzed samples from 82 patients with pGBM who had undergone tumor removal, pathological diagnosis, and isolation of tMSLC from April 2009 to October 2014. Survival, extent of resection, molecular markers, and tMSLC culture results were statistically evaluated. Median overall survival was 18.6 months, 15.0 months in tMSLC-positive patients and 29.5 months in tMSLC-negative patients (<I>P</I> = 0.014). Multivariate cox regression model showed isolation of tMSLC (OR = 2.5, 95% CI = 1.1~5.6, <I>P</I> = 0.021) showed poor outcome while larger extent of resection (OR = 0.5, 95% CI = 0.2~0.8, <I>P</I> = 0.011) has association with better outcome. The presence of tMSLCs isolated from the specimen of pGBM is associated with the survival of patient.</P>
강준기,김문찬,조태훈,백민우,강세기,윤석훈,허춘웅,송진언 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.3
Cerebral somatosensory evoked potentials(SEPs) produced by stimulation of peripheral nerves provide a useful diagnostic index of conduction in somatosensory pathways to the cortex. Thus the integrity of both dorsal column-medial lemniscus pathway and primary sensorimotor area has been considered an essential requirement to record a nomal SEP. There are suggestions that SEPs contain several components arising from different neuronal sources, the early short latency potentials corresponding to the lemniscus-mediated responses and the late waves to the diffuse spino-thalamic projections. The present work analyses the influence on SEPs of focal brain lesions, using the computerized tomography in detecting and localizing brain lesion. Somatosensroy evoked potentials were recorded in 20 patients with focal brain lesions recognized by computerized tomography. 1) Patients with primary sensorimotor area (PSMA) damages (group Ⅰ) had a very abnormal of the early component (No, Po, N1, Pl) in 100% on the lesion side. 2) Patients presented supratentorial lesions, sparing PSMA (group Ⅱ), 87.5% showing abnormal SEPs in early components and characterized by increment of amplitude in late components. 3) Brainstem damage (group Ⅲ) produced a distortion of the early components especially N11, N20 msec latency. 4) In incomplete spinal cord injuries, the SEPs is indeed signal of functional recovery, of posterior column and incorrespondance with clinical improvement.
Clinical Characteristics of Post-COVID-19 Persistent Cough in the Omicron Era
Kang Yu Ri,Huh Jin-Young,Oh Ji-Yoon,Lee Ji-Hyang,Lee Daegeun,Kwon Hyouk-Soo,Kim Tae-Bum,Choi Jae Chol,Cho You Sook,Chung Kian Fan,Park So-Young,Song Woo-Jung 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.3
Cough is one of the most common symptoms of acute coronavirus disease 2019, but cough may persist for weeks or months. This study aimed to examine the clinical characteristics of patients with post-coronavirus disease (COVID) persistent cough in the Omicron era. We conducted a pooled analysis comparing 3 different groups: 1) a prospective cohort of post-COVID cough (> 3 weeks; n = 55), 2) a retrospective cohort of post-COVID cough (> 3 weeks; n = 66), and 3) a prospective cohort of non-COVID chronic cough (CC) (> 8 weeks; n = 100). Cough and health status was assessed using patient-reported outcomes (PROs). Outcomes, including PROs and systemic symptoms, were longitudinally evaluated in the prospective post-COVID cough registry participants receiving usual care. A total of 121 patients with post-COVID cough and 100 with non-COVID CC were studied. Baseline cough-specific PRO scores did not significantly differ between post-COVID cough and non-COVID CC groups. There were no significant differences in chest imaging abnormality or lung function between groups. However, the proportions of patients with fractional exhaled nitric oxide (FeNO) ≥ 25 ppb were 44.7% in those with post-COVID cough and 22.7% in those with non-COVID CC, which were significantly different. In longitudinal assessment of the post-COVID registry (n = 43), cough-specific PROs, such as cough severity or Leicester Cough Questionnaire (LCQ) scores, significantly improved between visits 1 and 2 (visit interval: median 35 [interquartile range, IQR: 23–58] days). In the LCQ score, 83.3% of the patients showed improvement (change ≥ +1.3), but 7.1% had worsened (≤ −1.3). The number of systemic symptoms was median 4 (IQR: 2–7) at visit 1 but decreased to median 2 (IQR: 0–4) at visit 2. In summary, post-COVID persistent cough was similar in overall clinical characteristics to CC. Current cough guideline-based approaches may be effective in most patients with post-COVID cough. Measurement of FeNO levels may also be useful for cough management.
Kang, Jengmin,Shin, Seung-Hyun,Yoon, Haejin,Huh, June,Shin, Hyun-Woo,Chun, Yang-Sook,Park, Jong-Wan American Association for Cancer Research 2018 Cancer Research Vol.78 No.5
<P>These findings deepen understanding of oxygen-dependent gene regulation and cancer metastasis in response to hypoxia.</P><P>The prolyl hydroxylase domain-containing proteins (PHD1-3) and the asparaginyl hydroxlyase factor inhibiting HIF (FIH) are oxygen sensors for hypoxia-inducible factor-driven transcription of hypoxia-induced genes, but whether these sensors affect oxygen-dependent epigenetic regulation more broadly is not known. Here, we show that FIH exerts an additional role as an oxygen sensor in epigenetic control by the histone lysine methyltransferases G9a and GLP. FIH hydroxylated and inhibited G9a and GLP under normoxia. When the FIH reaction was limited under hypoxia, G9a and GLP were activated and repressed metastasis suppressor genes, thereby triggering cancer cell migration and peritoneal dissemination of ovarian cancer xenografts. In clinical specimens of ovarian cancer, expression of FIH and G9a were reciprocally associated with patient outcomes. We also identified mutations of FIH target motifs in G9a and GLP, which exhibited excessive H3K9 methylation and facilitated cell invasion. This study provides insight into a new function of FIH as an upstream regulator of oxygen-dependent chromatin remodeling. It also implies that the FIH-G9a/GLP pathway could be a potential target for inhibiting hypoxia-induced cancer metastasis.</P><P><B>Significance:</B> These findings deepen understanding of oxygen-dependent gene regulation and cancer metastasis in response to hypoxia. <I>Cancer Res; 78(5); 1184–99. ©2017 AACR</I>.</P>