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오병훈,권준수,남궁기,김승현,지익성,김창윤,하규섭,박원명,김성곤,오강섭,김정범,이수정,정한용,이창욱,박용천,이영문,김세주,이병욱 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5
Four Years Reports of "Journal of Korean Neuropsychiatric Association" during 2001 to 2005 were evaluated by 18 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation Processes, "Journal of Korean Neuropsychiatric Association" will develop a good journal.
복압성요실금(Stress urinary incontinence)과 절박성요실금(Urge incontinence)환자에서 TVT 수술 결과의 비교
이경구,이준호,권용욱,정태융,심희영,이상익 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1
Tension-free vaginal tape(TVT) has been widely used in the management of stress urinary incontinence(SUI), and has been applied to urge incontinence (UI). We evaluated and compared the outcomes between SUI and UI for patients who had undergone TVT. Patients were categorized into SUI(33 patients) and UI(26 patients). Before treatment, we asked about LUTSs using female bladder questionnaire. And we asked about sexual function. After treatment, the same questionnaires were repeated. During the postperative period, the objective and subjective success rate were evaluated. For operation outcome results, in SUI group there were 29 cases of cure (87.9%)and 2 of improvement(6.1%), and in UI group there were 20 cases of cure(76.9%)and 3 of improvement(11.5%) (p>0.05). The operation satisfaction rate of patients was 90.9% in SUI group and 84.6% in UI group(p>0.05). Improvement of sexual satisfaction occurred in 6(20.0%) of SUI group, and 3 (18.8%) of UI group, respectively(p>0.05). The objective success rate, satisfaction rate and sexual satisfaction of SUI patients did not significantly differ from the women with UI. Also, these results shows that TVT procedure improves some LUTSs in both groups. We consider the TVT procedure to be an effective treatment not for stress urinary incontinence but also urge incontinenece.
Femur Neck Fracture in a Young Marfan Syndrome Patient
( Yong-uk Kwon ),( Gyu-min Kong ),( Jun-ho Park ) 대한고관절학회 2016 Hip and Pelvis Vol.28 No.4
Marfan syndrome is an autosomal dominant and could decrease bone mineral density. So patients with Marfan syndrome could vulnerable to trauma in old ages. We present the first report, to the best of our knowledge, of a rare fracture of the femoral neck with a minor traumatic history in a juvenile Marfan syndrome patient whose physis is still open. Although the patient is young, her bone mineral density was low and the geometry of femur is changed like old ages. The femur neck fracture in children is very rare and only caused by high energy trauma, we concluded that the Marfan syndrome makes the bone weaker in young age and preventative medications to avoid fractures in younger Marfan syndrome patients are necessary in early ages.
Chemical Tools for Glycomics : GPI-based Malaria Vaccines and Glycan Microarray
Yong-Uk Kwon 한국당과학회 2008 한국당과학회 학술대회 Vol.2008 No.1
Malaria continues to claim over 2 million people annually and is considered a reemerging fatal disease due to the spread of drug-resistant parasites and insecticide-resistant mosquitoes. Though vaccines have been one of the most cost- effective and easily administered means of controlling infectious diseases, no viable vaccine candidate has been developed for malaria. Glycosylphosphatidylinositol (GPI) anchors are a class of naturally occurring glycolipids that link proteins and glycoproteins via C-terminus to cell membranes. GPI originating from the malarial parasite Plasmodium falciparum has the properties predicted of a toxin, indicating that it is involved in the malarial pathogenesis. The initial efforts demonstrated that anti-GPI antibodies produced against the synthetic GPI glycan, might recognize the native GPI -containing toxin and neutralize proinflammatory activity by P. falciparum, revealing that the synthetic GPI is a prototype carbohydrate anti-toxin vaccine against malaria. In this presentation, a convergent synthesis of a series of oligosaccharides comprised of the malaria GPI glycan, a promising antitoxin malaria vaccine candidate currently in preclinical trials and related deletion sequences as well as a serological study using a GPI glycan microarray will be described.
흉, 요추부 다발성 경막외 지주막낭종: 자기공명 척수조영술을 이용한 경막 결손부의 확인 후 시행한 최소 침습적 수술
권용욱(Yong-Uk Kwon),박대현(Dae-Hyun Park),김동석(Dong-Seok Kim) 대한정형외과학회 2022 대한정형외과학회지 Vol.57 No.5
척추 경막외 지주막낭종(spinal extradural arachnoid cyst, SEAC)은 희귀한 질환으로, 다발성 SEAC는 전 세계적으로 매우 드문 질환이며, 국내에서는 극히 드물게 보고되었다. 저자는 흉부 유형 I 및 요추 유형 II로 진단된 성인에서의 다발성 SEAC 환자에서 수술 전 자기공명 척수조영술(magnetic resonance myelogram)을 사용한 경막 결손 위치의 확인 후 최소 침습적 추궁절제술과 낭종 창냄술을 통해 수술을 시행하였다. 추적 관찰 시 자기공명영상에서 낭종의 크기가 현저하게 감소함이 확인되어 자기공명 척수조영술을 통한 최소 침습적 수술로 광범위 수술 없이 효율적 감압이 이루어짐을 보고하고자 한다. A spinal extradural arachnoid cyst (SEAC) is a rare disease. Multiple SEAC is a very rare disease that has been reported worldwide, mainly in children, but there are few case reports in Korea. The authors report a marked reduction in cyst size on magnetic resonance (MR) imaging at the follow-up after surgery in surgically treated case of a patient diagnosed with thoracic type I and lumbar type II SEAC. After localization of the dural defect using preoperative MR myelograms, a minimally invasive laminectomy and cyst fenestration could prevent many surgical-related complications.
청피(靑皮)가 강제수영부하에 따른 우울행동에 미치는 영향
권용욱 ( Yong Uk Kwon ),이태희 ( Tae Hee Lee ) 대한본초학회 2008 大韓本草學會誌 Vol.23 No.4
Objectives: Investigation of the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR) Methods: In order to investigate the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR), we performed the forced swimming test. Also the expression of CRF, HSP70 and c-fos was measured with immunohistochemical method at PVN. Results: 1. The duration of immobility in the forced swimming test was significantly decreased in the CR 100mg/kg, 400mg/kg groups. 2. In the Control group, CRF expression was significantly increased in the PVN. Also, these CRF increase were significantly reduced in the CR 100mg/kg and 400mg/kg treated group. 3. HSP70 expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group. 4. C-fos expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group. Conclusions: According to the results, it can be considered that Citri Reticulatae Viride Pericarpium has antidepressant effect.
권용욱(Yong-Uk Kwon),박대현(Dae-Hyun Park),이선주(Sun-Joo Lee),박하영(Ha-Young Park) 대한정형외과학회 2022 대한정형외과학회지 Vol.57 No.6
동면종은 연부조직에서 흔히 발견되는 양성종양으로 척추의 골내 동면종은 드물어 2008년부터 2019년까지 13예밖에 보고되지 않았다. 본 증례에서는 대장암 환자의 전이 병변 여부를 확인하다가 우연히 발견된 척추 골내 동면종에 대하여 생검 및 추시 자기공명영상 검사를 시행하였다. 본 저자들은 척추에 발생한 골내 동면종으로 진단된 증례를 문헌 고찰과 함께 보고하고자 한다. Although hibernomas are commonly found in soft tissues, spinal intraosseous hibernomas are extremely rare and 13 cases have been published from 2008 to 2019. While checking for metastatic lesions in a colorectal cancer patient, a spinal lesion found accidentally, thereafter biopsy and follow-up magnetic resonance imaging were performed. The authors present an intraosseous hibernoma of the spine, which is very rare.