위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

T 세포활성항원 CTLA-4의 기능에 관한 연구 : T 세포에서 표적세포 살해능과 CTLA-4 발현과의 연관성 Target Cytotoxicity of T Cell Correlates with CTLA-4 Production

노만택,조양자,김용식,최용,조보현,최장원,정용훈 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.4

CTLA-4, a T cell activation antigen and a homologue of CD28, was originally identified as a gene by a series of reverse genetic approaches. While CD28 molecule has been characterized well as a stimulator of T-cell function via enhanced lymphokines production and stablilization of those mRNA, most of the functions of CTLA-4 remain unknown. It has been widely accepted that CTLA-4 functions as an immune suppressor which is down-regualting the function of CD28. We previously showed that 34 KD form of this antigen mainly expressed CD8+ subset, a cytotoxic or suppressor, of activated peripheral blood lymphocyte. Based on our previous finding this study was conducted to further characterize immunological function of CTLA-4 especially in terms of involvement of this molecule in T-cell effector function mediating target cell cytotoxicity. 4 human T cell clones with different target cytotoxicities were employed in this study. NBL46 (CD4+) and NBL77 (CD8+) were cytotoxic and NBL32 (CD4+) and NBL58 (CD 8+) were non-cytotoxic to target LBF cell in target cell chromium release assay. And in Western blot assay 34 kD antigen was detected in NBL46 (CD4+) and NBL77 (CD8+) clones but not in NBL32 (CD4+) and NBL58 (CD8+) clones. It was summarized that expression of the CTLA-4 antigen was associated with cytotoxicity but not with subset phenotypes of T cells. In conclusion CD8+ T subset of PHA-stimulated PBL was major and only CTLA-4 producer and this molecule was induced during mid to late stage of T cell activation. The cytotoxicity of T cell clones to its target cell was directly correlated with its CTLA-4 production and vice versa. And it was highly suggested that primary function of CTLA-4 may involved in T cell effector function which mediates target cell killing.

Hybrid Light‐Emitting Diodes: Electrically Driven Quantum Dot/Wire/Well Hybrid Light‐Emitting Diodes (Adv. Mater. 45/2011)

Ko, Young‐,Ho,Kim, Je‐,Hyung,Jin, Li‐,Hua,Ko, Suk‐,Min,Kwon, Bong‐,Joon,Kim, Joosung,Kim, Taek,Cho, Yong‐,Hoon WILEY‐VCH Verlag 2011 ADVANCED MATERIALS Vol.23 No.45

<P>Electrically driven hybrid light‐emitting diodes (LEDs) consisting of quantum dots, wires, and wells based on the nanometer‐sized pyramid GaN structure are reported by Taek Kim, Yong‐Hoon Cho, and co‐workers on page 5364. The LEDs exhibit mixed emissions from InGaN quantum dots, wires, and wells formed at the tops, edges, and sidewalls of the pyramids, respectively. The hybrid LEDs containing low‐dimensional quantum structures provide a broad‐band, highly efficient visible lighting source. </P>

그림책의 패러디 전략과 구성원리 : ｢아기 돼지 삼형제｣를 중심으로

조용훈 한국초등국어교육학회 2009 한국초등국어교육 Vol.41 No.-

이 연구는 그림책 ｢아기 돼지 3형제｣의 패러디 전략을, 그림과 글과의 미적 관계를 고찰하여 구명한 논문이다. ｢아기 돼지 3형제｣는 도덕적·윤리적 가치를 교육하거나, 새로운 텍스트의 생산, 이밖에도 읽기와 쓰기의 통합교육을 위해 연구돼 왔다. 그런데 패러디 대상으로서의 원전에 대한 논의 없이 연구가 진행돼 왔고 더구나 그림책임에도 불구하고 글과 그림의 미적 관계를 동시에 고려하지 않았다. 이에 주목하여 이 글은 모본으로 알려진 제이콥스의 텍스트와 최근 국내외에서 출간되는 텍스트들을 우선 비교 검토했다. 그리고 3편을 선정해서 글과 그림의 관계가 패러디 전략에 어떻게 작용하고 있는지 상세하게 고찰했다. 3편은 글과 그림이 설명과 보완의 관계가 아니라 괴리와 이화, 즉 아이러니관계에 있는 텍스트이다. 글과 그림의 충돌을 통해 주제를 참신하게 전달하는데 주력한다. 그 결과 ｢늑대가 들려주는 아기돼지 삼형제 이야기｣는 글의 내용만으로는 기존의 통념을 깨는 텍스트처럼 읽히나 실은 그것이 왜곡됐다는 것을 글과 그림의 아이러니칼한 관계로 제시한다. 이 텍스트는 패러디를 재차 패러디한 중층 구조로 구성됐다. ｢아기늑대 세 마리와 못된 돼지｣는 두 동물의 역할을 전도시켜 관습적 생각을 새삼 재고하게 만든다. 요컨대 이웃이나 타자에 대한 배타적 태도는 실은 타자의 실제적 위협에서가 아니라 자기 안위라는 이기적 태도에서 기인한다고 주장한다. 공동체는 서로를 이해하고 함께 할 때 공존가능하다는 것을 새삼 일깨운다. 끝으로 ｢아기돼지 세 마리｣는 계승돼 온 텍스트를 새로운 방식으로 재생산한다는 것은 어떤 시의성을 갖고 있으며 그것은 어떻게 가능한가 등의 질문을 통해 글쓰기의 본질을 새삼 고민케 한다. 특히 텍스트의 교차와 공존을 다양한 그래픽과 연계시켜 그림책이 갖는 그림과 글의 중요성을 끊임없이 환기시켜 주목된다. 패러디는 전통적 유산을 새롭고 비판적으로 통찰하되 예술성을 잃지 않아야 하며 항상 새로운 해석의 가능성을 제공해야 한다. 이런 점에서 그림책은 글과 그림의 미학적 관계가 패러디 전략에 어떻게 기능하는지 검토하는 것은 당연하다 할 것이다. This study has considered the parody technique of the illustrated book [Three Little Pig Brothers] by examining the aesthetic relation of writing and painting. This book has been studied in light of the education of its moral or ethical value, or production of a new text, or integral education of writing and reading. However, there has been no study on the original text as the object for parody;moreover, despite the fact that it is an illustrated book, the previous studies have not concerned themselves with the aesthetic relation of writing and painting. Shedding light upon these aspects, this study has compared and examined the text by Jacobs known as the original text, and other texts recently published inside and outside the nation. After that, it has examined in detail the impact of the relation of writing and painting on the parody technique by selecting three particular texts. The three texts are the texts in which writing and painting are in ironical relation, namely the relation of alienation and differentiation not the relation of explanation and supplementation. They focus on conveying the theme in a fresh way by making writing being in conflict with painting. As a result, while the content of ｢The true story of the 3 little pigs by a wolf｣ reads like a text that subverts the normal conception, the text shows that in fact it is distorted by with the ironical relation of writing and painting. This text consists of multiple structures in which a parody is parodied. The text ｢The three little wolves and the big bad pig｣ makes the reader to rethink the conventional thought by reversing the role of two animals. In short, it argues that the unfriendly attitude on neighbours and others in fact stems from the egoistic attitude with concern for self-safety rather than real antagonism towards them. This reawakens the truth that a community can exist when the members of the community understand each other cooperating with each other. Lastly, the text ｢The 3 little pigs｣ allows the reader to reconsider the nature of writing by presenting such questions as what kind of implications does it have to re-produce a text inherited in a new way, and how it is possible. In particular, it is worth attention as it continuously reminds the reader of the importance of the mixture of writing and painting in an illustrated book by combining variety of graphics with the texts. The parody work should not lose its value as an artwork always providing the reader with the possibility to be newly interpreted while it should reconsider the tradition from a new and critical perspective. In this regard, it would be worthwhile to examine how the aesthetic relation of writing and painting has an effect upon the parody technique in the illustrated book.

위상배열 초음파를 이용한 터빈 블레이드 루트부내 결함평가 기법 연구

조용상,정계조,박상기,김재훈 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.2

초음파검사는 재료의 표면 또는 내부에 존재하는 불 연속부를 검출하기 위해, 초음파를 재료에 전달시켜 검사하는 비파괴검사법의 일종이다. 이러한 일반 초음파검사 방법 및 일반 결함평가 방법은 복잡한 현상에서 반사되는 신호로부터 결함을 구분하기가 어려워 결함의 평가 및 검사결과에 신뢰성이 떨어지고 있는 실정이다. 따라서 이러한 crack성 결함의 발생 가능성이 높으나 기존의 초음파검사 방법으로는 결함 판별에 어려움이 있는 설비에서의 검사방법 및 결함평가 방법의 제고가 필수 불가결한 실정이다. 본 연구에서는 위상배열 초음파를 사용하여 크랙 검출능력이 높고 길이 평가가 가장 정확한 방사각도를 규명하고, 주요발전설비중 하나인 터빈에 적용하였다. 기존의 초음파 검사 방식이 아닌 위상배열 초음파를 이용하여 결함의 크기를 평가할 수 있는 신 기법 및 이를 이용하여 터빈 블레이드 루트부 내에 존재하는 미세 결함에 대하여 크기평가 방법 및 결함탐지 방법에 대하여 고찰하였다. Ultrasonic testing is a kind of nondestructive test to detect a crack or discontinuity in materials or on material surfaces by sending ultrasound to it. This conventional ultrasonic technique has some limitations in reliably detecting crack or accurately assessing materials in the case of complex-shaped power plant components such as a turbine blade root. An alternative method for such a difficult inspection is highly needed. In this study, application of a phased array ultrasonic testing (UT) system to a turbine blade, one of the critical power plant components, has been considered, and the particular incident angle has been determined so that the greatest crack detectability and the most accurate crack length evaluation may be achieved. The response of ultrasonic phased array was also analyzed to establish a special method to determine the crack length without moving the transducer. The result showed that the developed method for crack length assessment is a more accurate and effective method, compared with the conventional method.

대학교 신입생의 특성에 관한 실태조사(Ⅱ) : 1995학년도 조선대학교 신입생을 대상으로 1995 chosun University Entrants

조용래,박상학,김상훈,표경식,김학렬,김양옥,김기순,박종 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

레니텍^(�) 정(말레인산 에날라프릴, 10mg)에 대한 에나레이스 정의 생물학적 동등성

조성희,하용화,홍성제,서성훈,류재환,김동현,이경태 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

The purpose of present study was to evaluate the bioequivalence of two enalapril maleate tablets, Renitec^(™) (MSD Korea Ltd.) and Enalace ^(™) (Welfide Korea Ltd.), according to the guidelines of Korea Food Drug Administration (KFDA). Twenty-four normal male volunteers, 22.33±2.55 year in age and 66.54±8.30 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containint 10 ㎎ of enal-april maleate per tablet wre orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as AUC_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transfored data were acceptance range of log0.8 to log1.25(e.g., log1.02∼log1.14 and log1.03∼log1.19 for AUC_(t) and C_(max), respectively). The major parameters, AUC_(t) and C_(max), met the criteria of KDFA for bioequivalence indicating that Enalace^(™) tablet is bioequivalent to Renitec^(™) tablet.

폐결핵의 조기진단에 있어서 이중중합효소연쇄반응법의 유용성

조성란,최영진,김용훈,이철세,김영창,김휘준 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Background: Pulmonary tuberculosis is a great public health problem in Korea. Early detection of Mycobacterium tuberculosis (M. tuberculosis) in clinical samples becomes more and more important in the control of tuberculosis. Recently, molecular methods have been applied to early detection of M. tuberculosis. Methods: To elucidate the effectiveness of nested polymerase chain reaction (PCR) in early diagnosis of pulmonary tuberculosis, we peformed Acid-fast bacilli (AFB) stain, AFB culture, and nested PCR on 84 sputa. Results: 8 (9.5%) specimens were positive by AFB stain, 17 (20.2%) by AFB culture, and 15 (17.9%) by nested PCR. Using AFB culture as standard method, the sensitivity of AFB stain and nested PCR was 47.1% and 82.4%, respectively. The specificity of AFB stain and nested PCR was 100% and 98.5%, respectively. Conclusions: Nested PCR was more sensitive than AFB stain and had shorter processing time(24-48hrs) than AFB culture. So it may be effective to use nested PCR in order to detect M. tuberculosis when AFB smear Is negative.

安城市 都市·建築 保全方案

趙庸薰,金大翼 안성산업대학교 1998 論文集 Vol.30 No.2

During high speed economic growth period, our society has focused it's energy on the demolition and destruction of all our natural and man-made environment. In progress with that trend, our small cities a1so have just followed the metropolitan physical change and considered that imitation be the same meaning as "modernization". Therefore, our valuable urban and architectural heritages have been constantly destructed and that situation has been same in this small city, ANSUNG. But in spite of many environmental destruction and new development, ANSUNG has still more historic architectures and urban districts than other cities, i.e. PYONGTAEK or CHEONAN, because of comparatively low speed growth. By using this comparatively good condition, the execution of gradual development strategy with conservation method of urbanity and architecture should be carried immediately, and that strategy should be accompanied with the participation of citizens, local authority, and expert groups.

운율, 미적 구조의 원리

조용훈 청주교육대학교 2001 論文集 Vol.38 No.-