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Yan-Fu Lin,Jiann-Rong Chen,Jo-Ming Tseng,Shu-Yu S. Wang,Chi-Min Shu 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.3
Methyl ethyl ketone peroxide (MEKPO) is an unstable material that is classified as an explosive substance. We evaluated MEKPO 10 mass% under mixing with three inorganic acids (6 N HNO3, 6 N H3PO4, and 6 N H2SO4) by adiabatic system of vent sizing package 2 (VSP2). Results from evaluation and testing indicated that these three inorganic acids could increase the degree of hazard while combined with pure MEKPO. Therefore, information on the hazards and phenomena of runaway reaction should be provided in order to lessen the degree of hazard.
Yan-Bin Zhang,Fu-Quan Chen,Yu-Jian Lin,Hao-Biao Chen 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.4
Inverted T-type retaining walls are commonly used in subgrade or slope support engineering, which inevitably satisfies a narrow backfill. Using the classical earth pressure calculation method in a narrow-backfill case causes an inevitable error. The current narrow-backfill earth pressure theory does not apply to inverted T-type retaining walls. In this study, the failure mechanism in a narrow backfill when the inverted T-type retaining wall rotates about the heel is investigated using adaptive finite element analysis method. Numerical analysis reveals multiple sliding surfaces. A theoretical model for calculating earth pressure using difference and limit equilibrium methods is proposed. The proposed model is suitable for more complex conditions, including narrow backfill, irregular ground, and non-uniform overload, than previous models. Parameter analysis reveals that the cross-sectional area of the plastic zone and active earth pressure have a positive correlation. Further, the interface friction influences the decrease in active earth pressure. Fitting formulas for assessing the cases of long and short heel and the critical size of backfill width are presented to facilitate practitioners to evaluate the backfill.
Fu-Chao Yu,Xiao-Pan Hao,Xiu-Yang Jiang,Sheng-jiao Yan,Jun Lin 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
A concise and efficient one-pot synthesis of chroman-2,4-dione-based HKA derivatives by three component reaction of HKAs, triethoxymethane and 4-hydroxycoumarin derivatives under solvent-free and catalyst-free conditions is described. This protocol has many advantages, in that the GAP (Group-Assistant-Purification) chemistry process is involved in this method. As a result, the experimenter can avoid cumbersome process steps such as traditional chromatography and recrystallization purifications. The desired products can be easily obtained by washing the crude products with 95% EtOH.
Pei Lin,Fu-Qing Wang,Chang-Tian Li,Zheng-Fei Yan 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.3
In this study, biosynthesis of silver nanoparticles (AgNPs) by using Eurotium cristatum, isolated from Fuzhuan brick-tea and its antibacterial activity has been demonstrated. AgNPs were characterized at 425 nm as maximum absorbance peak by ultraviolet-visible spectrophotometry. The images of transmission electron microscopy revealed that AgNPs are spherical shape with at 15-20 nm in size. The X-ray diffraction pattern corresponding to planes (111), (200), (220), (311), and (222) demonstrated the crystalline nature of AgNPs. Fourier transform infrared spectrum showed that functional groups involved in reduction of silver ions to metal nanoparticles. For antibacterial application, AgNPs showed antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Candida albicans, and Bacillus subtilis. It also acted synergistically with various antibiotics to inhibit growth of pathogenic strains, which produced an effect greater than the sum of their individual effects. For neomycin with no resistance to C. albicans, it combined with AgNPs, which had significant synergistic effect against C. albicans, with maximum inhibitory zone at 20.9 mm, which was 2.5-fold greater than that of AgNPs alone (8.2 mm). Other antibiotics combined with AgNPs also existed similar synergistic effect. Therefore, AgNPssynthesized by E. cristatum could enhance antibacterial activity in combination with antibiotics against pathogenic strains through synergistic effects. It might provide a new strategy for treatment of resistant bacteria.
Li, Fu-Rong,Yu, Feng-Xiu,Yao, Shu-Tong,Si, Yan-Hong,Zhang, Wei,Gao, Lin-Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Background: A number of effective prevention measures have been introduced in attempts to substantially reduce both the incidence and mortality due to many kinds of cancer. The search for new anti-cancer compounds in foods or in plant medicines is one realistic and promising approach to prevention. Chinese medicines provide a rich pool of novel and efficacious agents for cancer prevention and treatment. Previously it was demonstratrated that hyperin extracted from the Manchurian rhododendron leaf reduces the proliferation of many cancer cells. The present study was carried out to evaluate its effects on human endometrial cancer cell viability and apoptosis and to investigate its mechanisms of action in RL952 cells. Methods: Cell viability was measured using the MTT assay. Intracellular calcium ions were detected using laser-scanning confocal microscopy. The effects of hyperin on apoptosis related proteins in RL952 cells were examined using Western blot analysis. Results: The growth of RL952 cells was inhibited by treatment with hyperin. OD values of caspase-3 and caspase-9 were increased and expression of bcl-2 was increased and bax was decreased in protein levels in RL952 cells after 24 h of hyperin treatment, Moreover, intracellular calcium accumulation occurred in hyperin-treated cells. Conclusion: These results suggest that hyperin may play an important role in tumor growth suppression by inducing apoptosis in human endometrial cells via a $Ca^{2+}$-related mitochondrion apoptotic pathway in RL952 cells.
Yu, Fu-Chao,Hao, Xiao-Pan,Jiang, Xiu-Yang,Yan, Sheng-Jiao,Lin, Jun Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
A concise and efficient one-pot synthesis of chroman-2,4-dione-based HKA derivatives by three component reaction of HKAs, triethoxymethane and 4-hydroxycoumarin derivatives under solvent-free and catalyst-free conditions is described. This protocol has many advantages, in that the GAP (Group-Assistant-Purification) chemistry process is involved in this method. As a result, the experimenter can avoid cumbersome process steps such as traditional chromatography and recrystallization purifications. The desired products can be easily obtained by washing the crude products with 95% EtOH.
Quality of Life of Male Spouse Caregivers for Breast Cancer Patients in China
Zhu, Ping,Fu, Ju-Fang,Wang, Bo,Lin, Jing,Wang, Yan,Fang, Ning-Ning,Wang, Dan-Dan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10
Background: The aim of this study was to describe the characteristics of male spouse caregivers of breast cancer patients in China, assess their quality of life (QOL), and investigate the influencing factors. Materials and Methods: A total of 243 breast cancer patient-spouse caregiver dyads were recruited from four hospitals in Shanxi and Anhui province of China. A cross-sectional design was applied to collect data and the Chinese version of the Medical Outcomes Study 36-item Short Form (SF-36) was used to measure caregivers' QOL, and the Chinese version of M.D. Anderson Symptom Inventory (MDASI-C) was applied to measure patient symptom severity and interference. Pearson's correlation was used to examine the correlations between caregiver burden and QOL. The multiple regression analysis was used to determine the most predictive factors influencing QOL. Results: The scores of all SF-36 scales were above 50.0, which were much lower than that of general mainland Chinese males. Mental QOL was significantly worse than physical QOL. Spouses demographic characteristics, caregiving-related variables and patient symptoms were related to spouse QOL. Caregiver burden has a negative relationship with QOL. Conclusions: A decrease in life events and patient symptoms, as well as increase in spouse sleeping time and family income, ought to improve QOL.
Yu-Chih Lin,Chung-Liang Chang,Tser-Sheng Lin,Hsunling Bai,Ming-Gu Yan,Fu-Hsiang Ko,Chia-Tien Wu,Cheng-Hsiung Huang 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.3
This study utilized the activated carbon fiber (ACF) modified with metal catalyst via physical vapor deposition (PVD) process (ACF/PVD) to diminish ozone. Furthermore, the ozone removal efficiency of ACF/PVD was compared with that of original ACF and ACF modified with metal catalyst via impregnation process (ACF/impregnation). In addition to the kinds of coated metal and the inlet ozone concentrations, the effects of the coating thickness and the reaction temperature on ACF/PVD for ozone removal were also examined. The results indicate that the ozone removal efficiency of ACF/PVD is better than that of original ACF and ACF/impregnation. The ozone removal efficiency of different metal-coated ACF/PVD in the superior order is gold (Au), and manganese (Mn). The increase of Au-coated thickness (3 nm to 80 nm) on ACF/PVD will enhance the ozone removal. However, when the Mn-coated thickness on ACF/PVD is larger than 15 nm, the ozone removal efficiency displays a declining trend. Furthermore, a higher reaction temperature will result in a better ozone removal of ACF/PVD and the original ACF.
Lei Zhou,Lin Fu,Na Lv,Jing Liu,Yan Li,Xiaosu Chen,Qingyu Xu,Guofeng Chen,Baoxu Pang,Lili Wang,Yonghui Li,Xiaodong Zhang,Li Yu 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
The AML1-ETO fusion protein (A/E), which results from the t(8;21) translocation, is considered to be a leukemiainitiating event. Identifying the mechanisms underlying the oncogenic activity of A/E remains a major challenge. In this study, we identified a specific down-regulation of brain acid-soluble protein 1 (BASP1) in t(8;21) acute myeloid leukemia (AML). A/E recognized AML1-binding sites and recruited DNA methyltransferase 3a (DNMT3a) to the BASP1 promoter sequence, which triggered DNA methylation-mediated silencing of BASP1. Ectopic expression of BASP1 inhibited proliferation and the colony-forming ability of A/E-positive AML cell lines and led to apoptosis and cell cycle arrest. The DNMT inhibitor decitabine up-regulated the expression of BASP1 in A/E-positive AML cell lines. In conclusion, our data suggest that BASP1 silencing via promoter methylation may be involved in A/E-mediated leukemogenesis and that BASP1 targeting may be an actionable therapeutic strategy in t(8;21) AML.