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Antibacterial Butenolides from the Korean Tunicate <i>Pseudodistoma antinboja</i>
Wang, Weihong,Kim, Hiyoung,Nam, Sang-Jip,Rho, Boon Jo,Kang, Heonjoong American Chemical Society and American Society of 2012 Journal of natural products Vol.75 No.12
<P>Six new (<B>1</B>, <B>2</B>, and <B>5</B>–<B>8</B>) and three known (<B>3</B>, <B>4</B>, and <B>9</B>) butenolide metabolites were isolated from the tunicate <I>Pseudodistoma antinboja</I> by activity-guided fractionations. The structures were elucidated by combined NMR and MS spectroscopic methods. These compounds were evaluated for their antibacterial activity, and most of them exhibited moderate to significant activity that selectively targeted Gram-positive strains and did not exhibit cytotoxicity in the MTT assay at 100 μM. Cadiolides <B>5</B>–<B>9</B> in particular exhibited significant antibacterial activity that was comparable to or even better than those of marketed drugs such as vancomycin and linezolid against all of the drug-resistant strains tested.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2012/jnprdf.2012.75.issue-12/np300544a/production/images/medium/np-2012-00544a_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np300544a'>ACS Electronic Supporting Info</A></P>
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Bioactive Sesterterpenoids from a Korean Sponge <i>Monanchora</i> sp.
Wang, Weihong,Mun, Bora,Lee, Yehee,Venkat Reddy, Mallepally,Park, Youngmin,Lee, Jihye,Kim, Hiyoung,Hahn, Dongyup,Chin, Jungwook,Ekins, Merrick,Nam, Sang-Jip,Kang, Heonjoong American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.2
<P>Chemical investigation of a Korean marine sponge, <I>Monanchora</I> sp., yielded nine new sesterterpenoids (<B>1</B>–<B>9</B>) along with phorbaketals A–C (<B>10</B>–<B>12</B>). The planar structures were established on the basis of NMR and MS analysis, and the absolute configurations of <B>1</B>–<B>9</B> were defined using the modified Mosher’s method and CD spectroscopic data analysis. Compounds <B>1</B>–<B>8</B>, designated as phorbaketals D–K, possess a spiroketal-modified benzopyran moiety such as phorbaketal A, and their structural variations are due to oxidation and/or reduction of the tricyclic core or the side chain. Compound <B>9</B>, designated as phorbin A, has a monocyclic structure and is proposed to be a possible biogenetic precursor of the phorbaketals. Compounds <B>1</B>–<B>9</B> were evaluated for cytotoxicity against four human cancer cell lines (A498, ACHN, MIA-paca, and PANC-1), and a few of them were found to exhibit cytotoxic activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-2/np300573m/production/images/medium/np-2012-00573m_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np300573m'>ACS Electronic Supporting Info</A></P>
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Weihong Wu,Jingjing Leng,Zheng Wang,Hongqiang Qu,Jungang Gao 한국고분자학회 2016 Macromolecular Research Vol.24 No.3
Boron-containing bisphenol-S formaldehyde resin (BBPSFR) with different amounts of nano-SiO2 by in situ formation was used to cure o-cresol formaldehyde epoxy resin (o-CFER). The curing kinetics, dynamic mechanical properties, and thermal stability of BBPSFR/o-CFER/nano-SiO2 composites (BCS) were investigated by differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), thermogravimetry (TG), and thermogravimetrymass spectrometry (TGMS). Morphology of nano-SiO2-containing BBPSFR and glass fiber laminates of the BCS were characterized by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The mechanical properties and electrical properties were also determined. The results showed that nano-SiO2 accelerated the curing process and decreased the curing temperature; the non-isothermal curing kinetics of the BCS can be described by the two-parameter (m, n) Šesták-Berggren kinetic model, and the average value of m was 0.32 and n was 1.00. The thermal stability was enhanced by the addition of nano-SiO2, especially at higher temperatures, and the residual weight increased with increasing nano-SiO2 content. Incorporation of 6 wt% of nano-SiO2 increased the impact strength from 105 to 149 kJ/m2 and storage modulus at ambient from 6.85 to 12.7 GPa, and the TEM photograph of which showed that nano-SiO2 particles (about 50 nm) were dispersed in the matrix more uniformly. The volume resistance, Rv, and dielectric constant, ε, slightly increased when the nano-SiO2 content was 3 wt%.
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Weihong Qin,Wang Song,Peng Feng,Zhuo Xi,Tongqing Zhang 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.85 No.1
To explore the effect of Engineered Cementitious Composite (ECC) on improving the progressive collapse resistance of reinforced concrete frames under a middle column removal scenario, six beam-column substructures were tested by quasistatic vertical loading. Among the six specimens, four were ECC-concrete composite specimens consisting of different depth of ECC at the bottom or top of the beam and concrete in the rest of the beam, while the other two are ordinary reinforced concrete specimens with different concrete strength grades for comparison. The experimental results demonstrated that ECC-concrete composite specimens can improve the bearing capacity of a beam-column substructure at the stages of compressive arch action (CAA) and catenary action in comparison with ordinary concrete specimen. Under the same depth of ECC, the progressive collapse resistance of a specimen with ECC at the beam bottom was superior to that at the beam top. With the increase of the proportion of ECC arranged at the beam bottom, the bearing capacity of a composite substructure was increased, but the increase rate slows down with the proportion. Meanwhile, the nonlinear numerical analysis software MSC Marc was used to simulate the whole loading process of the six specimens. Theoretical formulas to calculate the capacities of ECC-concrete composite specimens at the stages of flexural action, CAA and catenary action are proposed. Based on the research results, this study suggests that ECC should be laid out at the beam bottom and the layout depth should be within 25% of the total beam depth.
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Cytotoxic 5a,8a-epidioxy sterols from the marine sponge Monanchora sp.
문보라,Weihong Wang,김희영,한동엽,양인호,원동환,김은희,이지혜,한철경,김현지,Merrick Ekins,남상집,최혁재,강헌중 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.1
Three new sterols, 5a,8a-epidioxy-24-norcholesta-6,9(11),22-trien-3b-ol (1), 5a,8a-epidioxy-cholesta-6,9(11),24-trien-3b-ol (2), and 5a,8a-epidioxy-cholesta-6,23-dien-3b,25-diol (3), with four known sterols (4–7)were isolated from a marine sponge Monanchora sp. Theirchemical structures were elucidated by extensive spectroscopicanalysis. Compounds 1 and 3–7 showed moderatecytotoxicity against several human carcinoma cell linesincluding renal (A-498), pancreatic (PANC-1 and MIAPaCa-2), and colorectal (HCT 116) cancer cell lines.
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Jing Wang,Wenying Zhang,Weixing Li,Weihong Xing 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.7
A new hollow fiber composite membrane of chitosan-poly (vinyl alcohol)/polyvinylidene fluoride (CSPVA/ PVDF) was prepared by casting the solution of CS and PVA on PVDF hollow fiber support for pervaporation dehydration of isopropanol. The composite membranes were crosslinked with glutaraldehyde (GA) and sulfuric acid. The microstructure and physicochemical properties of the membranes were characterized by scanning electron microscope (SEM), attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), thermogravimetry (TG) and contact angle measurements. Results from SEM images showed that dense separation layers were successfully coated onto the supports, and the ATR-FTIR results showed that GA had crosslinked the composite membranes. Results of TG and contact angle showed the thermostability of membranes increased and the hydrophilicity decreased after blending CS and PVA. The swelling degree of composite membranes increased with increasing CS content and water content. Effects of the content of CS and GA in solution on membrane separation performance were investigated. The pervaporation experiments for dehydration of isopropanol showed that the membrane with 60 wt% CS and 0.1 wt% GA had a good separation performance. The permeate flux was 306 g/(m2·h) and the separation factor was 2140 for the feed solution containing 90% isopropanol at 60 oC. When the water content increased from 3 wt% to 15 wt%, the permeate flux increased from 207 g/(m2·h) to 346 g/(m2·h) while the separation factor decreased from 2406 to 1876. The separation factor and permeation flux increased with feed temperature.
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A New 2,3-Dimethyl Butenolide from the Brittle Star <i>Ophiomastix mixta</i>
Lee, Jinsoo,Wang, Weihong,Hong, Jongki,Lee, Chong-Ok,Shin, Sook,Im, Kwang Sik,Jung, Jee Hyung Pharmaceutical Society of Japan 2007 Chemical & pharmaceutical bulletin Vol.55 No.3
<P>A new butenolide (1) was isolated, along with a known acyclic polyhalogenated monoterpene (2), from the brittle star <I>Ophiomastix mixta</I>. The structures were defined by analysis and comparision of the spectral data with those in the literature. The 2,3-dimethyl butenolide (1) is uncommon and first encountered in a marine organism. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and displayed mild to significant activity.</P>
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Bionic natural small molecule co-assemblies towards targeted and synergistic Chemo/PDT/CDT
Shiyao Fu,Mingao Wang,Bin Li,Xu Li,Jianjun Cheng,Haitian Zhao,Hua Zhang,Aijun Dong,Weihong Lu,Xin Yang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Multi-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained increased attention as a promising strategy to improve clinical outcomes in cancer treatment. However, there remains a challenge in developing biodegradable, biocompatible, less toxic, yet highly efficient multicomponent nanobased drug delivery systems (DDS). Here, our study presents the screening and development of a novel DDS based on co-assemblies natural small molecule (NSMs). These molecules (oleanolic acid, and betulinic acid) are combined with photosensitizers Chlorine6 (Ce6) and Cu2+ that are encapsulated by tumor cell membranes. This nanocarrier encapsulated in tumor cell membranes achieved good tumor targeting and a significant improvement in tumor accumulation. Methods A reprecipitation method was used to prepare the co-assembled nanocarrier, followed by the introduction of Cu2 + into the DDS (OABACe6 NPs). Then, by wrapping the surface of NPs with the cell membranes of 4T1 which is a kind of mouse breast cancer cells (CM@OABACe6/Cu NPs). and analysis of its structure and size distribution with UV– Vis, XPS, FT-IR, SEM, TEM, and DLS. The synergistic effects of in vitro chemotherapy, CDT and PDT and targeting were also validated by cellular and animal studies. Results It was shown that CM@OABACe6/Cu NPs achieved good tumor targeting and a significant improvement in tumor accumulation. In the composite nano-assembly, the NSMs work together with the Ce6 to provide effective and safe chemo and PDT. Moreover, the effect of reduced PDT due to the depletion of reactive oxygen species (ROS) by excess glutathione (GSH) in the tumor can be counteracted when Cu2 + is introduced. More importantly, it also confers CDT through a Fenton-like catalytic reaction with H2O overexpressed at the tumor site. Conclusions By constructing CM@OABACe6/Cu NPs with homologous targeting, we create a triple synergistic platform for cancer therapy using PDT, chemo, and CDT. We propose here a novel combinatorial strategy for designing more naturally co-assembled small molecules, especially for the development of multifunctional synergistic therapies that utilize NSMs.
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