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Cytotoxic 5a,8a-epidioxy sterols from the marine sponge Monanchora sp.
문보라,Weihong Wang,김희영,한동엽,양인호,원동환,김은희,이지혜,한철경,김현지,Merrick Ekins,남상집,최혁재,강헌중 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.1
Three new sterols, 5a,8a-epidioxy-24-norcholesta-6,9(11),22-trien-3b-ol (1), 5a,8a-epidioxy-cholesta-6,9(11),24-trien-3b-ol (2), and 5a,8a-epidioxy-cholesta-6,23-dien-3b,25-diol (3), with four known sterols (4–7)were isolated from a marine sponge Monanchora sp. Theirchemical structures were elucidated by extensive spectroscopicanalysis. Compounds 1 and 3–7 showed moderatecytotoxicity against several human carcinoma cell linesincluding renal (A-498), pancreatic (PANC-1 and MIAPaCa-2), and colorectal (HCT 116) cancer cell lines.