A novel design method for improving collapse resistances of multi-story steel frames with unequal spans using steel braces

Zheng Tan,Wei-hui Zhong,Bao Meng,Shi-chao Duan,Hong-chen Wang3,Xing-You Yao,Yu-hui Zheng 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.47 No.2

The bearing capacities resisted by the two-bay beams of multi-story planar frames with unequal spans under column removal scenarios differ considerably owing to the asymmetric stress on the left and right beams connected to the failed column and cause the potential for beams with larger span-to-depth ratios to be unable to exert effectively, which is disadvantageous for resisting the vertical load in unequal-span frame structures. To address this problem, the structural measure of adding braces to the weak bays of multi-story unequal-span frames was proposed, with the objective of achieving a coordinated stress state in two-bay beams with unequal spans, thereby improving the collapse resistance of unequal-span frame structures. Before conducting the numerical simulation, the modeling methods were verified by previous experimental results of two multi-story planar frames with and without steel braces. Thereafter, the effects of the tensile and compressive braces on the collapse behavior of the frame structures were elucidated. Then, based on the mechanical action laws of the braces throughout the collapse process, a detailed design method for improving the collapse resistance of unequal-span frame structures was proposed. Finally, the proposed design method was verified by using sufficient example models, and the results demonstrated that the design method has good application prospects and high practical value.

Novel Water-Air Circulation Quenching Process for AISI 4140 Steel

Liyun Zheng,Dawei Zheng1,Lixin Zhao,Lihui Wang,Kai Zhang 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.6

AISI 4140 steel is usually used after quenching and tempering. During the heat treatment process in industry production, there are some problems, such as quenching cracks, related to water-cooling and low hardness due to oil quenching. A water-air circulation quenching process can solve the problems of quenching cracks with water and the high cost quenching with oil, which is flammable, unsafe and not enough to obtain the required hardness. The control of the water-cooling and air-cooling time is a key factor in the process. This paper focuses on the quenching temperature, water-air cycle time and cycle index to prevent cracking for AISI 4140 steel. The optimum heat treatment parameters to achieve a good match of the strength and toughness of AISI 4140 steel were obtained by repeated adjustment of the water-air circulation quenching process parameters. The tensile strength, Charpy impact energy at -10 °C and hardness of the heat treated AISI 4140 steel after quenching and tempering were approximately 1098 MPa, 67.5 J and 316 HB, respectively.

Status, Trend and Strategy on Municipal Wastewater Management in China

Wang Baozhen,Wang Lin,Liu Shuo,Wang Li,Wang Zheng 대전대학교 환경문제연구소 2007 환경문제연구소 논문집 Vol.11 No.-

Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study

Wang Qi,Dai Huajie,Hou Tianzhichao,Hou Yanan,Wang Tiange,Lin Hong,Zhao Zhiyun,Li Mian,Zheng Ruizhi,Wang Shuangyuan,Lu Jieli,Xu Yu,Liu Ruixin,Ning Guang,Wang Weiqing,Bi Yufang,Zheng Jie,Xu Min 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3

Background and Purpose We investigated the causal relationships between the gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR). Methods We leveraged the summary statistics of GM (n=18,340 in the MiBioGen consortium), blood metabolites (n=115,078 in the UK Biobank), and stroke (cases n=60,176 and controls n=1,310,725 in the Global Biobank Meta-Analysis Initiative) from the largest genome-wide association studies to date. We performed bidirectional MR analyses to explore the causal relationships between the GM and stroke, and two mediation analyses, two-step MR and multivariable MR, to discover potential mediating metabolites. Results Ten taxa were causally associated with stroke, and stroke led to changes in 27 taxa. In the two-step MR, <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family, <i>Desulfovibrio</i> genus, apolipoprotein A1 (ApoA1), phospholipids in high-density lipoprotein (HDL_PL), and the ratio of apolipoprotein B to ApoA1 (ApoB/ApoA1) were causally associated with stroke (all <i>P</i><0.044). The causal associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were validated using the weighted median method in an independent cohort. The three GM taxa were all positively associated with ApoA1 and HDL_PL, whereas <i>Desulfovibrio</i> genus was negatively associated with ApoB/ApoA1 (all <i>P</i><0.010). Additionally, the causal associations between the three GM taxa and ApoA1 remained significant after correcting for the false discovery rate (all q-values <0.027). Multivariable MR showed that the associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were mediated by ApoA1 and HDL_PL, each accounting for 6.5% (<i>P</i>=0.028) and 4.6% (<i>P</i>=0.033); the association between <i>Desulfovibrio</i> genus and stroke was mediated by ApoA1, HDL_PL, and ApoB/ApoA1, with mediated proportions of 7.6% (<i>P</i>=0.019), 4.2% (<i>P</i>=0.035), and 9.1% (<i>P</i>=0.013), respectively. Conclusion The current MR study provides evidence supporting the causal relationships between several specific GM taxa and stroke and potential mediating metabolites.

Nature-based Tourism in Small Islands Adjacent to Jakarta City, Indonesia:A case study from Seribu Islands

Wang Baozhen,Wang Lin,Liu Shuo,Wang Li,Wang Zheng 한국습지학회 2007 한국습지학회지 Vol.9 No.1

Status, Trend and Strategy on Municipal Wastewater Management in China

Wang Baozhen,Wang Lin,Liu Shuo,Wang Li,Wang Zheng 대전대학교 환경문제연구소 2007 환경문제연구소 논문집 Vol.11 No.-

Direct Interaction between Ras Homolog Enriched in Brain and FK506 Binding Protein 38 in Cashmere Goat Fetal Fibroblast Cells

Wang, Xiaojing,Wang, Yanfeng,Zheng, Xu,Hao, Xiyan,Liang, Yan,Wu, Manlin,Wang, Xiao,Wang, Zhigang Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.12

Ras homolog enriched in brain (Rheb) and FK506 binding protein 38 (FKBP38) are two important regulatory proteins in the mammalian target of rapamycin (mTOR) pathway. There are contradictory data on the interaction between Rheb and FKBP38 in human cells, but this association has not been examined in cashmere goat cells. To investigate the interaction between Rheb and FKBP38, we overexpressed goat Rheb and FKBP38 in goat fetal fibroblasts, extracted whole proteins, and performed coimmunoprecipitation to detect them by western blot. We found Rheb binds directly to FKBP38. Then, we constructed bait vectors (pGBKT7-Rheb/FKBP38) and prey vectors (pGADT7-Rheb/FKBP38), and examined their interaction by yeast two-hybrid assay. Their direct interaction was observed, regardless of which plasmid served as the prey or bait vector. These results indicate that the 2 proteins interact directly in vivo. Novel evidence is presented on the mTOR signal pathway in Cashmere goat cells.

Status, Trend and Strategy on Municipal Wastewater Management in China

Wang Baozhen,Wang Lin,Liu Shuo,Wang Li,Wang Zheng 한국습지학회 2007 한국습지학회지 Vol.9 No.1

The rapid development of economy in China at the expense of consuming huge amount of energy and resources, water resource in particular, which has resulted in the production and discharge of increasing amount of wastewater to the water environment. In order to effectively control the increasing water pollution trend, the State Council has stipulated that all the cities with population over 500,000 should reach wastewater treatment rate of 60% by 2005, and all the cities should reach the rate of 60% by 2010, of which Capital Beijing and all the province capital cities and important tourism cities should reach 70% then. By the end of 2005, of the 661 cities in China, 393 have built and operated municipal wastewater treatments with a total number of 790 sets, total treatment capacity of 80.91×106 m3/d and total treatment rate of > 48%. Other 73 cities have started the construction of municipal wastewater treatment plants, and other 168 cities have started to prepare, planning and design of wastewater treatment plants. Most of municipal wastewater treatment plants in big cities in China operate normally and perform well with good quality of effluent in terms of wastewater treatment train, but the sewage sludge treatment is usually poor with big problems. It has been found that the small scale WWTPs using activated sludge process in the towns are usually operated and maintained abnormally because of lack of fund, skilled operators and energy. It is therefore suggested that the small scale MWWTPs in small cities and towns adopt appropriate technologies, of which the most available ones are multi-stage ponds, constructed wetlands and the combination of them for further purification and reuse of treated wastewater.

Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration

Peihe Zheng,Yinbin Chen,Yangyang Fu,Hecheng Wang,Jia Wang,Siwen Zheng,Shengyuan Xiao,Yingping Wang 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.11

After cultivation of ginseng, ginsenosides, which are the major active ingredients of gingeng, were approved for use by the food industry, and began to be used as added functional ingredients to try to improve the quality and price of functional foods. However, the interaction between different types of ginsenosides and nutrients needs further study. We investigated the effect of B-complex vitamins (which are essential nutrients) on the pharmacokinetics of the ginsenosides protopanaxatriol-type saponin Rg1, protopanaxadiol-type saponin Rb1, and oleanolic acid-type saponin Ro after oral administration. Ginsenosides Rg1, Rb1, and Ro, with or without B-complex vitamins, respectively, were administered orally to rats to evaluate their pharmacokinetics. The concentration of ginsenosides in plasma was determined by liquid chromatography/tandem mass spectrometry. Pharmacokinetic parameters were fitted using WinNonlin v6.2. After oral coadministration with B-complex vitamins, the area under the concentration–time curve from zero to infinity (AUC0–∞) of ginsenoside Rg1 was reduced by 70%, that of ginsenoside Rb1 was reduced by 43%, and that of ginsenoside Ro was reduced by 34%. The AUC0–∞ of ginsenosides Rg1 and Rb1 showed significant differences between different treatments, but the AUC0–∞ of ginsenoside Ro did not. These results suggest significant ginsenoside-nutrient interactions between ginsenosides Rg1, Rb1, and B-complex vitamins.

Radiotherapy combined with immunotherapy could improve the immune infiltration of melanoma in mice and enhance the abscopal effect

Yufeng Zheng(Yufeng Zheng),Xue Liu(Xue Liu),Na Li(Na Li),Aimei Zhao(Aimei Zhao),Zhiqiang Sun(Zhiqiang Sun),Meihua Wang(Meihua Wang),Judong Luo(Judong Luo) 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2

Purpose: To analyze the gene mutation, immune infiltration and tumor growth of primary tumor and distant tumor under different treatment modes. Materials and Methods: Twenty B16 murine melanoma cells were injected subcutaneously into the of both sides of the thigh, simulating a primary tumor and a secondary tumor impacted by the abscopal effect, respectively. They were divided into blank control group, immunotherapy group, radiotherapy group, and radiotherapy combined immunotherapy group. During this period, tumor volume was measured, and RNA sequencing was performed on tumor samples after the test. R software was used to analyze differentially expressed genes, functional enrichment, and immune infiltration. Results: We found that any treatment mode could cause changes in differentially expressed genes, especially the combination treatment. The different therapeutic effects might be caused by gene expression. In addition, the proportions of infiltrating immune cells in the irradiated and abscopal tumors were different. In the combination treatment group, T-cell infiltration in the irradiated site was the most obvious. In the immunotherapy group, CD8+ T-cell infiltration in the abscopal tumor site was obvious, but immunotherapy alone might have a poor prognosis. Whether the irradiated or abscopal tumor was evaluated, radiotherapy combined with anti-programmed cell death protein 1 (anti-PD-1) therapy produced the most obvious tumor control and might have a positive impact on prognosis. Conclusion: Combination therapy not only improves the immune microenvironment but may also have a positive impact on prognosis.