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Venu M. Nemani,Philip K. Louie,Caroline E. Drolet,John M. Rhee 대한척추신경외과학회 2022 Neurospine Vol.19 No.4
Objective: It remains unclear whether cervical sagittal deformity (CSD) should be defined by radiographic parameters alone versus both clinical and radiographic factors, and whether radiographic malalignment by itself warrants a CSD corrective surgery in patients who present primarily with neurologic symptoms. Methods: We administered a survey to a group of expert surgeons to evaluate whether radiographic parameters alone were sufficient to diagnose CSD, and in which scenarios surgeons recommend a CSD realignment procedure versus addressing the neurologic symptoms alone. Results: No single radiographic criteria reached a 50% threshold as being sufficient to establish the diagnosis of CSD. When asymptomatic radiographic malalignment was present, a sagittal deformity correction was more likely to be recommended in patients with myelopathy versus those with radiculopathy alone. The majority of surgeons recommended deformity correction when symptoms of cervical deformity were present in addition to radiographic malalignment (85% with deformity symptoms and radiculopathy, 93% with deformity symptoms and myelopathy). Conclusion: There is no consensus on which radiographic and/or clinical criteria are necessary to define the presence of CSD. We recommend that symptoms of cervical deformity, in addition to radiographic parameters, be considered when deciding whether to perform deformity correction in patients who present primarily with myelopathy or radiculopathy.
Venu Reddy,K.K.C. Satish Babu,Sri Ramulu Torati,엄윤지,TranQuangTrung,이내응,김철기 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.63 No.-
The development of environmentally benign, low-processing and low-cost approaches to the large-scale preparation of advanced nanomaterials based on the use of biological materials is currently attracting great interest. Here, we report the discovery that aqueous honey solutions reduce graphene oxide in a low-cost and an eco-friendly manner, yielding highly water dispersive functionalized reduced graphene sheets. The roles of honey in the reduction of graphene oxide of as-prepared graphene are demonstrated. The possible mechanism for the de-epoxidation of graphene oxide is elucidated. The fabricated a honey-reduced graphene oxide-based field-effect transistor exhibited ambipolar transfer characteristics, thereby demonstrating that the developed material may therefore have applications in electronic devices and sensors.
Hepatic Fibrosis and Steatosis in Metabolic Syndrome
Venu Gopala Reddy Gangireddy,Courtney Pilkerton,Jun Xiang,Ruben Tinajero,Amie M. Ashcraft 대한비만학회 2022 The Korean journal of obesity Vol.31 No.1
Background: Metabolic syndrome (MetS) is a group of factors associated with increased risks of cardiovascular disease and overall mortality. Nonalcoholic fatty liver disease (NAFLD) is a common disorder that has been shown to cause hepatic steatosis and fibrosis. The relationship between NAFLD and MetS appears to be bidirectional, but very few studies have examined the role of MetS in hepatic steatosis and fibrosis. The present study investigated the relationships between MetS and its components and the severity of hepatic fibrosis and steatosis, and fibrosis independent of steatosis. Methods: The study was a cross-sectional population-based survey of 4,678 National Health and Nutrition Examination Survey participants from 2017 to 2018 in the United States. Hepatic fibrosis and steatosis were measured using liver elastography. The MetS components were assessed using demographic, examination, laboratory, and self-reported data. Results: Using survey-weighted population estimates, 26% of the population had steatosis, 7.5% had fibrosis, and 3.3% had fibrosis without steatosis. The adjusted odds ratio for any level of steatosis was 4.12 times higher (95% confidence interval [CI], 3.16–5.37) and any level of fibrosis was 3.34 times higher (95% CI, 2.26–4.94) among participants with MetS than those without. The adjusted odds ratio for fibrosis without steatosis is 2.67 times higher (95% CI, 1.47–4.87) among participants with MetS than those without. Conclusion: The presence of MetS significantly increases the risk of hepatic fibrosis and steatosis, providing evidence for MetS to be considered an additional independent risk factor for hepatic fibrosis together with other known etiologies.
Osteotomies in the Cervical Spine
Venu M. Nemani,Peter B. Derman,Han Jo Kim 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.1
Rigid cervical deformities are difficult problems to treat. The goals of surgical treatment include deformity correction, achieving a rigid fusion, and performing a thorough neural decompression. In stiff and ankylosed cervical spines, osteotomies are required to restore sagittal and coronal balance. In this chapter, we describe the clinical and radiographic workup for patients with cervical deformities, and delineate the various factors that must be considered when planning surgical treatment. We also describe in detail the various types of cervical osteotomies, along with their surgical technique, advantages, and potential complications.
Flavonoids: A new generation molecule to stimulate programmed cell deaths in cancer cells.
Venu Venkatarame Gowda Saralamma,Eun Hee Kim,Ho Jeong Lee,Suchismita Raha,Won Sup Lee,Jeong Doo Heo,Sang Joon Lee,Chun-Kil Won,Gon-Sup Kim 충북대학교 동물의학연구소 2017 Journal of Biomedical and Translational Research Vol.18 No.1
Programmed cell death (PCD) is decisive in eliminating affected cells in human cancers, whereas there are increasing cases of cancer-related death due to side effects of modern treatment methods. There is an urge for new methods of growth inhibition and elimination of cancer cells with a lower cytotoxicity to normal cells. Irregularity along PCD pathways plays a crucial role in cancer cell carcinogenesis. Apoptosis is a distinct cell death mechanism occurring in multicellular organisms and also called type one programmed cell death. Autophagy and paraptosis are non-apoptotic PCD occurring in multicellular organisms. Natural compounds are the fundament of pharmacological treatments, and flavonoids are natural polyphenolic compounds which are unique due to their diverse chemical structures and various biological active mechanisms like anticancer, anti-inflammatory, antioxidative and much more. This gives an increasing number of studies indicating that some flavonoids from medicinal plants could be promising candidates for new natural anticancer drugs, which attract high interests of academic researchers and advanced users. An understanding of the underlying mechanism of PCD induced by flavonoids in cancer cells is important as it plays a pivotal role in the pathogenesis of many diseases. This systematic review is to report flavonoids and their derivatives as new anticancer candidates to stimulate PCD with a different mechanism based on the pharmacological evidence.