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Jeong, Lak Shin,Moon, Hyung Ryong,Park, Jae Gyu,Shin, Dae Hong,Choi, Won Jun,Lee, Kang Man,Kim, Hea Ok,Chun, Moon Woo,Kim, Hee-Doo,Kim, Joong Hyup 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
Jeong, Lak Shin,Park, Jae Gyu,Choi, Won Jun,Moon, Hyung Ryong,Lee, Kang Man,Kim, Hea Ok,Kim, Hee-Doo,Chun, Moon Woo,Park, Hea-Young,Kim, Kilhyoun,Sheen, Yhun Y. 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Novel halovinyl analogues of neplanocin A without 4'-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.
Design and Synthesis of A₃ Adenosine Receptor Ligands, 2´-Fluoro Analogues of Cl-IB-MECA
Kim, Hea Ok,Park, Jae Gyu,Moon, Hyung Ryong,Gunaga, Prashantha,Lim, Moo Hong,Chun, Moon Woo,Jacobson, Kenneth A.,Kim, Hee-Doo,Jeong, Lak Shin 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Synthesis of 2'-deoxy-2'-fluoro-N^(6) -substituted adenosines as bioisosteres of Cl-IB-MECA and their binding affinities to A₃ adenosine receptor are described.
Kim, Hea-Ji,Yun, Sin Weon,Yu, Jeong Jin,Yoon, Kyung Lim,Lee, Kyung-Yil,Kil, Hong-Ryang,Kim, Gi Beom,Han, Myung-Ki,Song, Min Seob,Lee, Hyoung Doo,Ha, Kee Soo,Sohn, Sejung,Ebata, Ryota,Hamada, Hiromichi Korea Genome Organization 2018 Genomics & informatics Vol.16 No.2
<P>Kawasaki disease (KD) is an acute febrile vasculitis predominately affecting infants and children. The dominant incidence age of KD is from 6 months to 5 years of age, and the incidence is unusual in those younger than 6 months and older than 5 years of age. We tried to identify genetic variants specifically associated with KD in patients younger than 6 months or older than 5 years of age. We performed an age-stratified genome-wide association study using the Illumina HumanOmni1-Quad BeadChip data (296 cases vs. 1,000 controls) and a replication study (1,360 cases vs. 3,553 controls) in the Korean population. Among 26 candidate single nucleotide polymorphisms (SNPs) tested in replication study, only a rare nonsynonymous SNP (rs4365796: c.1106C>T, p.Thr369Met) in the lymphoid enhancer binding factor 1 (<I>LEF1</I>) gene was very significantly associated with KD in patients younger than 6 months of age (odds ratio [OR], 3.07; p<SUB>combined</SUB> = 1.10 × 10<SUP>-5</SUP>), whereas no association of the same SNP was observed in any other age group of KD patients. The same SNP (rs4365796) in the <I>LEF1</I> gene showed the same direction of risk effect in Japanese KD patients younger than 6 months of age, although the effect was not statistically significant (OR, 1.42; p = 0.397). This result indicates that the <I>LEF1</I> gene may play an important role as a susceptibility gene specifically affecting KD patients younger than 6 months of age.</P>
Lim, Kyu,Song, Hea-Jeong,Byun, Sang-Hyun,Yun, Kyung-Ah,Son, Mee-Young,Park, Jong-Il,Kweon, Gi-Ryang,Yoon, Wan-Hee,Hwang, Byung-Doo 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-
Epidermal growth factor (EGF) is a potent mitogen for rat hepatocytes and mammalian histone synthesis is functionally and temporally coupled to DNA replication. To gain an insight on the role of EGF in the regulation of H2B histone gene expression in primary hepatocyte cultures, the binding patterns of nuclear proteins to various elements in the H2B histone gene upstream region have been investigated. EGF induced H2B histone mRNA with maximal stimulation reached at 36 hours. The induction of H2B histone mRNA was dependent on the concentration of EGF and almost reduced by actinomycin-D pretreatment. In DNaseⅠ footprinting analysis, one nuclear factor (TATA element-binding protein, TBP) bound at -20 bp (TATA element) in either the absence or presence of EGF. One DNA-protein complex was formed by DNA mobility shift assay when TATA element was incubated with nuclear extract prepared from EGF-free hepatocytes, and the amount of TBP was increased after EGF treatment. These results suggest that TBP may be correlated with with transcriptional regulation of H2B histone gene by EGF in primary hepatocytes.
Lee Hyeon-Soo,Jeong Ui-Chan,Seo Kang-Yu,Lee Sin-Doo,Park Hea-Lim 한국물리학회 2024 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.84 No.4
Solution-processed organic photosynaptic transistors (S-OPTs), inspired by the way biological nervous systems process visual information, ofer several advantages such as large bandwidth, low latency, low energy consumption, tunable optoelectronic properties via molecular design, and applicability for simple and low-cost solution process at low temperatures. However, S-OPTs sufer high leakage current with undesirable current pathways, which is unavoidably a result of flm formation over the entire substrate during solution processes. Herein, we propose a strategy of improving the photosensitivity of S-OPTs by patterning the organic semiconductor (OSC) flm for application in smart and accurate optoelectronic systems. The OSC flm of the device is simply patterned through selective evaporation contact printing. The OSC patterns with micrometer scale efectively contribute to reduction in the undesirable current paths and the resultant leakage current. Compared with conventional devices with nonpatterned OSC, our patterned S-OPT exhibits highly improved photosensitivity. Furthermore, our device demonstrates various types of synaptic characteristics, ranging from short- to long-term plasticity. By reducing the of-current level of the OSTs, hardware neural networks built using our patterned cells can successfully achieve recognition accuracy exceeding 90% for recognition of handwritten numerical images, which is comparable to those of ideal software systems. Thus, we believe that this study will introduce new avenues for fabrication of high-photoresponse S-OPTs and their utilization as essential building blocks for construction of neuromorphic systems.
Lim, Kyu,Song, Hea-Jeong,Byun, Sang-Hyun,Yun, Kyung-Ah,Son, Mee-Young,Park, Jong-Il,Kweon, Gi-Ryang,Yoon, Wan-Hee,Hwang, Byung-Doo 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1
Epidermal growth factor (EGF) is a potent mitogen for rat hepatocytes and mammalian histone synthesis is functionally and temporally coupled to DNA replication. To gain an insight on the role of EGF in the regulation of H2B histone gene expression in primary hepatocyte cultures, the binding patterns of nuclear proteins to various elements in the FOB histone gene upstream region have been investigated. EGF induced H2B histone mRNA with maximal stimulation reached at 36 hours. The induction of H2B histone mRNA was dependent on the concentration of EGF and almost reduced by actinomycin-D pretreatment. In DNase I footprinting analysis, one nuclear factor (TATA element-binding protein, TBP) bound at -20 bp (TATA element) in either the absence or presence of EGF. One DNA-protein complex was formed by DNA mobility shift assay when TATA element was incubated with nuclear extract prepared from EGF-free hepatocytes, and the amount of TBP was increased after EGF treatment. These results suggest that TBP may be correlated with transcriptional regulation of H2B histone gene by EGF in primary hepatocytes.