http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
나노구조형 Carbon/TiO_2 광촉매의 제조 및 특성
박수진,김병주,이종문 한국공업화학회 2003 공업화학 Vol.14 No.3
본 연구에서는 나노구조형 cellulose/TiO_2를 탄화시켜 나노구조형 carbon/TiO_2 광촉매를 제조하였으며, 이때 담지체인 carbon과 촉매인 TiO_2의 미세구조가 carbon/TiO_2 광촉매의 광활성에 미치는 영향에 대하여 고찰하였다. Carbon/TiO_2의 제조 과정에 따른 화학적 조성의 변화는 EDS를 통해 알아보았으며, 표면 관능기는 FT-IR을 통하여 분석하였다. 또한 시료의 미세구조와 비표면적은 XRD와 BET를 통해 각각 알아보았으며, 제조한 광촉매의 광활성은 UV하에서 전분 분해실험을 통해 알아보았다. 실험 결과, 탄화과정 후에도 TiO_2상은 anatase형을 취하고 있으며, 제조된 carbon/TiO_2 광촉매는 순수한 TiO_2보다 다소 높은 광활성을 나타내는 것을 알 수 있었다. 이는 탄화과정이 진행됨에 따라 초기 담지체인 cellulose의 질량손실에서 기인된 carbon표면의 TiO_2양의 상대적인 증가와, TiO_2의 결정 크기의 증가로 인한 결정의 광흡수가 증가 때문인 것으로 사료되며, carbon/ TiO_2가 담지체의 특성 때문에 순수한 TiO_2보다 상대적으로 큰 비표면적을 가지기 때문인 것으로 사료되어진다. In this work, nanostructured carbon/ TiO_2 photocatalysts were made by the carbonization of cellulose/ TiO_2 which was prepared by anchoring the TiO_2 on the surfaces of cellulose particles in order to improve the photoactivity of pure TiO_2. The surface properties of the photocatalysts were studied in the context of FT-IR and XRD measurements. The specific surface areas and elemental compositions of the photocatalysts were studied in volumetric N_2/77 K measurement and EDS, respectively. The photoactivities of the photocatalysts were evaluated using a photo-decomposition method under UV light. The experimental results showed that the TiO_2 crystal phases of the carbon/ TiO_2 had an anatase-from revealed by WAXRD. The carbon/ TiO_2 was observed to have a better photoactivity than that of pure TiO_2. This result was probably due to the relatively increased specific surface areas of the carbon/ TiO_2, compared to pure TiO_2 and to the growth TiO_2 crystals that caused increased light absorption of TiO_2 in carbon/ TiO_2.
가황형태 및 온도가 천연고무 컴파운드의 물리적 특성에 미치는 영향
허양일,윤찬호,나창운,한승철,이종문 한국고무학회 2000 엘라스토머 및 콤포지트 Vol.35 No.3
Cure characteristics, tensile properties, and dynamic properties were investigated on the carbon black-filled natural rubber compounds, in which three typical vucanization types: conventional vulcanization(Conv), semi-efficient(Semi-EV), and efficient(EV) vulcanizations were used. The effects of vulcanization temperature on both the mechanical property and aging resistance of rubber compounds were also investigated. The Conv cure system showed a slightly slower rate of vulcanization than those of Semi-EV and EV ones. On the other hand, it showed a higher value in the maximum torque of cure curve. Higher tensile moduli were observed in Conv system than those in Semi-EV and EV ones, while lower elongation at break were obtained in Conv one. The tensile strength at break were found to be about the same for three cure systems. Hardness, modulus, and tensile strength decreased with increasing the vulcanization temperature, and the degree of changes in the properties was found to be smaller for EV and Semi-EV systems than that in Conv one. The EV system was found to be superior m thermal-aging resistance to Conv one.
자가미세유화를 이용한 이부프로펜 액상제제의 제조와 특성
안용산,송지희,강복기,김문석,조선행,이종문,이해방,강길선 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1
Ibuprofen (IBU), is a non-steroidal anti-inflammatory drug, used to treat rheumatoid arthritis, removal of fever and mild to moderate pain. Because of small dosage and very low accumulation in the body, IBU has been used to heal children's fever. However, IBU was very low solubility in a low pH and water (in water 0.03∼2.5 ㎎/ml). A nanoemulsion containing IBU by means of self-micromulsion drug delivery system (SMEDDS) was prepared in order to enhance the solubility of IBU. The SMEDDS was composed of cosurfactant, oil and surfactant. The solubility of IBU in various components such as cosurfactant, oil and surfactant was examined. Carbitol^(??) (389.99±20.5 ㎎/ml) as a cosurfctant, Labrafil^(??) M1944CS (90.16±1.60 ㎎/ml) as an oil and Cremopher^(??) RH-40(239.01±2.8 ㎎/ml) as a surfactant were used in this study for preparing SMEDDS. Optimized formulation of SMEDDS was obtained by phase diagram which express the section of nanoemulsion formation. The SMEDDS containing IBU had higher dissolution rate than conventional IBU sirups. Thus the SMEDDS was a potential candidate of stable conventional and effective oral dosage form for IBU.
아시클로비어 고체분산체의 용해도에 대한 수용성 고분자의 종류 및 배합 비율에 따른 효과
안용산,이하영,홍금덕,정성범,조선행,이종문,이해방,강길선 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4
Acyclovir (ACV) is one of the most effective and selective agents against viruses of the herpes group. Because of low solubility, bioavailability of ACV has shown below 30% with oral dosage form. In our previous study, we reported that the fabrication of solid dispersion of ACV was possible and the solid dispersion of ACV and PVP was the most useful in all samples. In this study, we examined the effect of mixture ratio of polymers (PEG and PVP) to ACV. Solubility of ACV was dramatically increased up to 25 mg/ml in 80°C distilled water. So water was used as a solvent to eliminate problem of residual solvent. Spray drying method was used for the solid dispersion of ACV as solvent extraction. Different scanning calorimeter was used to check degradation of drug. Polymer carriers were PEG 6,000 and PVP. In summary, ACV-PVP (1:3) showed the best solubility in distilled water.
뷰틸레이트하이드록시애니솔이 서방화된 PLGA 필름을 이용한 골수간엽줄기세포의 신경세포화
장우영 ( Woo Young Jang ),김선화 ( Seon Hwa Kim ),이일우 ( Il Woo Lee ),김문석 ( Moon Suk Kim ),이종문 ( John M. Rhee ),강길선 ( Gil Son Khang ),이해방 ( Hai Bang Lee ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.2
It has been widely recognized that bone marrow stromal cells (BMSCs) can be differentiated into osteoblasts, chondrocytes, and neuronal cells under the controlling of culture condition. In the present study, poly(L-lactide- co-glycolide) (PLGA) film was fabricated to release butylated hydroxyanisole (BHA) for the purpose of neurogenesis of BMSCs. PLGA films loaded BHA were manufactured as the concentrations of 200, 400, and 600 ? M/0.2 g PLGA and characterized by scanning electron microscope (SEM). The inverted microscope was used for the observation of the morphology of BMSCs cultivated on BHA/PLGA film during 5 days. MTT assay used for the measurement of the viability of the cells and cytotoxicity. After 5 days, differentiation of neuronal cells were confirmed by means of staining such as neurofilament (NF) and neuron-specific enolase (NSE). The changes of BMSCs to neuronal cell observed onto the fabricated PLGA film from after 1 day by the stimulation of BHA. The more the concentration of BHA increased, the less the viability of the cells, however, the cytotoxicity of the cells showed little effect until up to 600 ?M/0.2 g PLGA of concentration from the result of immunohistochemistry. It can be concluded that the controlled release of BHA from BHA loaded PLGA film might be differentiated BMSCs to neuronal cells due to the diffusion of BHA and biodegradation of PLGA. This study suggested that BHA/PLGA film is released the desired period in delivery system and useful neuronal growth culture of BMSCs for the application of neuronal regenerative medicine.
함량별 DBP 스폰지에서 골수간엽줄기세포를 이용한 조직공학적 골분화 유도
홍희경 ( Hee Kyung Hong ),김순희 ( Soon Hee Kim ),이선경 ( Seon Kyoung Lee ),김대성 ( Dae Sung Kim ),최진희 ( Jin Hee Choi ),이동원 ( Dong Won Lee ),이종문 ( John M Rhee ),손영숙 ( Young Sook Son ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Demineralized bone particle(DBP) that affects to cell proliferation and differentiation has been used as biomaterials. Bone marrow stromal cells(BMSCs) exhibit multiple traits of a stem cell population, and they can expand many times in vitro and be induced to differentiate into multiple cell types. In this study, we evaluated the effect of type of medium and contents DBP sponge on bone differentiation of rat BMSCs. Growth medium was consisted of DMEM, 10% FBS, 1% antibiotic antinycotics and Osteogenesis medium added to β-glycerophosphate 10 mM, L-ascorbic acid, dexamethasone 10-8 M, vitamin D3 10-8 M. DBP sponge were prepared by freeze-drying method from 1, 2 and 3 wt% DBP solution. BMSCs were harvested from the femurs of adult female Fischer rat. The effect of DBP sponge on the proliferation and ostegenesis of rat BMSCs were assessed in culture using the MTT assay, SEM, ALP assay, and RT-PCR was conducted to confirm mRNA expression of ALP and osteocalcin for osteogenic marker. According to our results, the cell viability and the quantity of ALP in 3 wt% DBP sponge were superior to other sponges. The osteogenesis medium provided the better osteogenesis effect than the growth medium. We concluded that osteogenesis medium and 3 wt% DBP sponge will be useful to bone differentiation using 3 wt% DBP sponge.