원위부 신세뇨관성 산증에서 산-염기 운반체의 결손

김혜영,한진석,이정상,김현리,김진,이중건,이서진,김근호,진호준,전은실,주권욱,나기영,정우경,오지은,엄재호,궁성수 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5

The purpose of this study was to elucidate whether the molecular defect of acid-base transporters in renal tubules is related to the functional defect of urinary acidification in distal renal tubular acidosis(RTA). We performed NH₄Cl, furosemide, or bicarbonate loading test to evaluate renal acidification function, and immunohistochemistry using antibodies to H^+ -ATPase, Cl^-/HCO₃^- exchanger(band-3 protein), and Na^+/K^+ -ATPase in kidney tissue in 6 patients with RTA and renal cell carcinoma patients as normal controls. Kidney tissue was obtained either by percutaneous needle biopsy(RTA) or nephrectomy(NC). The results were as follows; 1) In all six RTA patients, proton secretory defect of distal acidification was shown by a failure to lower the urine pH after NHC1 loading or furosemide test or abnormally low urine-blood pCO₂ difference during bicarbonate loading. In two patients with RTA, proximal acidification defect was combined, which was demonstrated by increased fractional excretion of bicarbonate. 2) In mal control, intense H^+ -ATPase and band-3 protein staining was observed in collecting ducts. 3) In distal RTA patients, H6+ -ATPase and band-3 protein staining was not demonstrable or markedly decreased in the intercalated cells of distal nephron. 4) In two patients who had both proximal and distal RTA, H^+ -ATPase staining was markedly decreased in the brush border of proximal tubules as well as the distal nephron. In conclusion, the defect of acid-base transporters in renal tubule was related with the functional defect of urinary acidification in distal RTA.

고속 주행 모드에서 자동차 디퓨저의 스트레이크 개수와 배치에 따른 공기저항 유동해석

이진호,박성하,최동석,한영진,곽나영,이상욱 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

This study proposes an optimized diffuser strake design that can improve driving performance for cars in high-speed driving mode. The speed of the vehicle is set to 160km/h, and the number of strake is set to 4, 6 and 8, and the angle of the diffuser is set to 4, 5 and 6 degrees. The arrangement of the strake is centered, edged and equally arranged. The optimized diffuser design induced with the Ansys Fluent analysis shows a drag coefficient of 16% less than the basic diffuser-free model at a diffuser angle of 6 degree, 8 strakes, and equal arrangement.

결장직장암 환자의 임상적 고찰 : 조선대학교 부속병원의 10년 간의 결과

나은종,문성표,장정환,김권천,민영돈,김성환,조현진,김정용,김경종 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: The colorectal cancer rates 4th in the total cancer prevalence in Korea. The clinical patient demographics were considered with the incidence rate of the colon and rectal cancer. The clinicopathological factors were analyzed for the 5 year survival rate. Materials Methods: Of the 282 patients who were operated from Jan. 1, 1992 to Dec. 31, 2001 and diagnosed by pathological biopsy as colo-rectal cancer, 234 patients were followed up. The age, sex, location of the cancer, TNM stage, operation method, histopathological classification, metastatic region, complications after operation and the survival rate were investigated. Results: Of the 234 patients, male and female consisted of 120 cases (51.3%) and 114 cases (46.7%), with an average age of 61.6 years. The average follow up period was 52.3 months and the peri operative mortality was 5.6%. The site of the cancer was most frequent at the rectum with 127 cases (54.3%). The patients were classified according to the TNM stages with 38 cases of stage 1 (16.2%), 98 cases of II (41.9%), 72 cases of III (30.8%) and 26 cases of IV (11.1%). The 5 year survival rate in the age group older than 50 was 63.3 % and 73.5% in the group younger than 50. In regard to the operation type, the 5 year survival rate was 65.4% for elective operation and 65.8% for emergency operation. The 5 year survival rate for well differentiated, moderately differentiated, poorly differentiated cancer, and mucinous adenocarcinoma was 73.7%, 60.2%, 58.3%, and 92.6%, respectively. The 5 year survival rate of each of the TNM stage is 81.1%, 74.8%, 57.0%, and 11.5% for Classes I, II, III, and IV, respectively. Conclusion: The clinical factors were analyzed for the 5 year survival rate with no statistical significance for the age, sex, and location of the cancer. The TNM stage and histopathological differentiation were statistically significant. The colon cancer showed better prognosis compared to the rectal cancer.

도농간 교육격차 해소를 위한 농촌지역 유형별 교육혁신 추진과제 탐색

나승일,정철영,구자억,박행모,장호순,김진구,마상진,조단비,문세연 한국농업교육학회 2007 농업교육과 인적자원개발 Vol.39 No.1

이 연구는 교육혁신에 대한 이론적 고찰을 토대로 농촌지역 교육혁신 성공요소를 도출하고, 농촌의 지역특성을 고려하여 도농간 교육격차 해소를 위한 농촌지역 유형별 추진과제를 제시하는 데 목적이 있었다. 연구목적 달성을 위해 문헌고찰 및 사례연구를 실시하였고, 연구결과의 타당성 확보를 위해 전문가협의회를 실시하였다. 농촌지역 교육혁신 성공요소는 마을공부방 운영 등 26개가 최종적으로 도출되었다. 또한 농촌지역 교육혁신모형을 개발하여 목표와 전략을 수립하고, 이를 기초로 농촌지역 유형별 추진과제를 제시하였다. 농촌지역 교육혁신의 비전은 "도농간 교육격차 해소를 위한 교육혁신 실현으로 살고 싶은 농촌지역 구현" 으로 설정하고, 이를 달성하기 위한 목표는 도시수준의 교육기회 제공, 농촌형 수월성 교육 추구, 지역 인적자원개발로 설정하였다. 농촌지역 유형별 중점적으로 추진해야 할 과제는 발전 농촌지역은 마을 공부방 운영 및 학습도우미 지원, 중간수준 농촌지역은 교육환경 개선, 장학금 지원 및 다양한 교육기회 제공, 저개발 농촌지역은 기존 지원 유지, 적극적 학습 지원 및 교원의 근무여건 개선, 도농복합 농촌지역에서는 교통편의 제공, 학습기회 개선 및 학부모의 교육참여 유도 등이 선정되었다. 그리고 농촌지역 유형별 중점 추진과제에 대한 단계별 로드맵과 이를 적용하기 위한 정책적 제언을 제시하였다. The purpose of this research was to derive success factors and explore actions plan for the education innovation of rural areas for releasing education gaps between urban and rural areas. For the purpose, the researcher carried out literature reviews and case analysis were conducted, and experts council were executed. As a result, 26 success factors for the education innovation of rural area were derived. And, this study suggested the education innovation model of rural area including goals and strategies to identify action plan for the education innovation by types of rural areas. The vision of the education innovation model was making the place pleasant to live in by doing education innovation for releasing education gaps between urban and rural areas. The goals of the education innovation model were to provide urban-level educational opportunities, to pursue rural-customized education for excellency and to develope local human resources. This study identified several core tasks corresponding to each rural area: additional establishment and operation of village study-rooms and support for learning assistant system for highly-developed rural areas; improvement of educational condition and provision of scholarship and various educational opportunities for middle-developed rural areas; maintenance of existing support, active learning-support and improvement of teachers' working conditions for lowly-developed rural areas; provision of traffic convenience, improvement of learning opportunities and promotion of parents' educational participation for urban-rural complex areas. Moreover, this study suggested roadmap according to action plan divided by types of rural areas, and political proposal for effective actualization of that.

광주광역시 전문계 고등학교 특성화 및 종합발전방안

나승일,정철영,김진모,안강현,한홍진,김기용,민상기,장현진 한국농업교육학회 2008 농업교육과 인적자원개발 Vol.40 No.1

이 연구의 목적은 광주광역시 전문계 고등학교의 특성화 및 종합발전방안을 수립하는데 있다. 이 연구는 ① 전문계 고등학교 관련 선행연구 분석,② 인력육성 및 특성화 방향을 설정하기 위하여 광주광역시,전라남도,우리나라의 산업여건 분석,③ 광주광역시 전문계 고등학교에 대해 Malcolm Baldrige 평가모형에 의한 진단평가와 SWOT 및 활용전략 분석, ④ 광주광역시 전문계 고등학교의 개편 요구 분석,⑤ 광주광역시 전문계 고등학교의 특성화 및 종합발전방안 설정 등의 과정을 통해 수행되었다. 이 연구의 결과는 다음과 같다. 첫째,비전은 광주광역시 전문계고 특성화와 발전 역량 구축을 통한 산업체 요구에 부합하는 우수 인력 양성이며,이를 위한 전략은 특성화 체제구축,학교교육 혁신,인적 자원 혁신,학교경영 혁신,인프라 구축으로 설정하는 것이 필요하다. 둘째, 특성화 체제 구축은 특성화 체제 개편,교육과정 중심 특성화,학과 재배치 통합형 고교 도입,특성화고 신설을 통해 추진할 수 있 는데 특히,교육과정 중심 특성화가 적극 도입되어야 한다. 셋째,학교교육 혁신은 교육과정 개편,교수 학습 개선,진로지도 개선,시설 및 기자재 개선을 통해 추진할 수 있다. 넷째,인적자원 혁신은 학교 관리자 역량 강화,교원 역량 강화,학생 역량 강화를 통해 추진할 수 있다. 다섯째,학교경영 혁신은 경영 리더십 제고,경영 성과관리 강화,학교 재정 혁신을 통해 추진할 수 있다. 여섯째,인프라 구축을 위해 지자체,대학,산업체,지역주민과 연계 강화를 통해 추진할 수 있다. 일곱째,13개 전문계 고둥학교의 여건 및 특성에 적합한 단위학교별 특성화 및 종합발전방안을 수립하였다. The purpose of this study was to suggest strategies to specialize and develop vocational high schools in Gwangju Metropolitan City. The study was orderly performed as follows: (1) reviewing literature about vocational high school, (2) analyzing the condition of industries, (3) diagnosing the vocational high school through Malcolm Baldrige model, (4) analyzing the SWOT and application strategies, (5) analyzing the needs of reform, and (6) establishing the strategies for the specialization and development of Vocational High Schools in Gwangju Metropolitan City. The major findings of this study were as the following: First, the vision was to bring up excellent human resources to corresponds industrial needs through specialization and development of vocational high schools in Gwangju Metropolitan City. Five strategies to achieve it were creating the specialization system, innovating the school education, human resources, and the school management, and building the infrastructure. Second, creating the specialization system can be performed through five tasks which were restructuring the specialization system, creating curriculum-based specialization, trading departments in inter-schools, introducing an integrated high school, and building a new specialized high school. Especially curriculum based specialization needs to be accepted. Third, innovating the school education can be performed through four tasks which were reorganizing the curriculum, improving the teaching and learning, improving the career guidance, and improving the facilities and equipments. Fourth, innovating human resources can be performed through three tasks which were enhancing each competencies of a school manager, a teacher, and a student. Fifth, innovating the school management can be performed through three tasks which were improving the management leadership, developing the performance management, and innovating the school finance. Sixth, building the infrastructure can be performed through four tasks which were enhancing the relationships with a local government, colleges, industries, and local residents. Seventh, individual strategies for the specialization and development of thirteen vocational high schools were also developed by corresponding to their conditions and characteristics.

농업교육훈련 프로그램 평가

나승일,김강호,민상기,이민욱,장현진 한국농업교육학회 2007 농업교육과 인적자원개발 Vol.39 No.3

이 연구의 목적은 2006년 농림부의 국고지원을 통해 77개 기관에서 운영된 총 157개 농엽교육훈련 프로그램의 효율성 및 성과에 대한 평가와 개선방안을 수립하는데 있었다. 이를 위해 프로그램별 모니터링,프로그램별 자체보고서,농업교육훈련 담당자 질의응답을 설시하였으며,평가위원회를 구성하여 최종 평가결과를 도출하였다. 그리고 평가에 활용된 평가기준은 4개 평가영역,16개 평가항목,26개 평가지표로 구성하였다. 평정을 위한 체크리스트에서 각 평가지표를 2∼4단계의 실행수준을 설정하였으며,이를 바탕으로 지표별 점수가 산출되었다. 평가등급은 A등급(90점 이상),B등급(80점 이상), C등급(70점 이상),D등급(70점 미만)과 평가유보로 부여하였다. 농업교육훈련 프로그램의 전체적인 평가결과는 A등급 43개(27.4%),B등급 70개(44.6%),C등급 33개 (21.0%),평가유보 11개(7.0%)로 나타났다. 그리고 농업교육훈련 프로그램 유형별 평가영역과 항목에 대한 평점을 도출하였다. 이러한 농업교육훈련 프로그램의 평가를 바탕으로 한 농업교육훈련의 종합적인 개선방안을 기관별 중장기 교육프로그램 체계 구축,교육대상자 확대 및 이력관리,예산지원 체계 개편,교육기관별 프로그램 특성화,교육기관 및 프로그램 인증제 도입,교육대상의 특성에 맞는 프로그램 다양화,농업교육훈련 담당자 역량 개발 지원,비농업관련 강사진의 농업소양교육 지원,우수 사례 벤치마킹 및 활용 지원 등을 제시하였다. The purpose of this study was to set up evaluation about efficiency and performance in total of 157 agricultural education & training program operated by 77 institutions through the support from the ministry of agriculture in 2006. Monitoring, in-house report in each program, and survey of HRD practitioner in the field of agricultural education & training was performed and result of evaluation was finalized through committee of evaluation, In addition, evaluation standard was composed of 4 domains, 16 sub-domains, and 26 indicators. The score for each indicator was decided based on a checklist, which has 2 to 4 levels for each indicator. And evaluation grade was consisted of As(over 90), Bs(over 80), Cs(over 70), Ds(under 70) and Undecided. The overall result of evaluation agricultural education & training program was rated as 43 As(27,4%), 70 Bs (44.6%) 33 Cs (21.0%), 11 of undecided (7.0%). Grade point indicating domains and sub-domains of evaluation according to program type was driven. Based on this direction of improvement regarding agricultural education & training program was suggested as follow: ① Set up middle- and long-term system of education program in every institution, ② expand learning opportunities to farmers and resume management ③ improve budget supporting system ④ customize program according to institutions ⑤ introduce certification of education institution and program ⑥ diverse program according to farmers' characteristics ⑦ support competency development of HRD practitioner in the field of agricultural education & training ⑧ support agriculture-related education for non-agricultural instructors. ⑨ support the utilization of best practices.

Glass-ionomer cement 이장재의 세포독성에 관한 연구

나영민,민병순,최호영,박상진,최기운 慶熙大學校 齒科大學 1993 慶熙齒大論文集 Vol.15 No.1

양식넙치, Paralichthys olivaceus 치어의 스쿠티카충 감염경로

진창남,이창훈,오상필,나오수,허문수 한국어병학회 2003 한국어병학회지 Vol.16 No.1

넙치양식시 피해가 많은 스쿠티카충의 치어기 감염경로를 규명하기 위하여 2001년도에 제주도지역 넙치양식장과 종묘배양장을 대상으로 조사를 실시하였다. 종묘생산 과정에서의 감염경로 조사를 위해 먹이생물인 클로렐라, 알테미아, 로티퍼 배양수조를 조사한 결과 로티퍼 배양수조에서 밑바닥 찌꺼기와 로티퍼 사체 및 생체에서 스쿠티카충 감염이 확인되었다. 스쿠티카충이 감염된 로티퍼를 주어에 투여한 후 자어 사육수조 바닥에는 스쿠티카충이 다량 번식하였다. 넙치 치어에 최초 감염은 부화자어가 착저 완료후 10일경 (부화후 40일경)에 사육수조 바닥에 서식하고 있던 스쿠티카충이 치어에 감염되었다. 스쿠티카충에 감염된 넙치 치어를 조직학적 방법으로 조사하여 감염경로를 확인한 결과, 안구나 뇌에 감염되는 경로는 주둥치 부분이나 등지느러미 앞부분의 표피에 감염된 후 상피조직과 근조직과 신경조직에 따라 뇌로 이행되었다. 그리고 내부장기에 감염되는 경로는 배지느러미나 뒷지느러미 연조막에 침투하여 상피조직과 근조직를 따라 항문과 직장으로 이행되었으며 비뇨생식공을 통해서 요도와 방광, 직장상피세포, 복강, 췌장, 신장외막, 신장 등으로 침투하였다. 스쿠티카충이 감염되지 않은 로티퍼를 이용하는 종묘배양장에서는 먹이생물 배양수조, 자어사육수조, 자어 및 치어 (전장 7㎝ 전후)에서 스쿠티카충이 감염되지 않았다. The infection characteristics with scuticociliates at on-land rearing farms and hatcheries of flounder, Paralithys olivaceus was investigated during they year of 2001 by juvenile infection routes. When culture tanks for living food organisms such as chlorella, rotifer, and Artemia were searched, scuticocilates were detected both in live and dead rotifer, and at the dregs of culture tank bottoms at almost hatcheries. When rotifer infected with scuticocilates fed on fish larvae, lots of scuticocilate were inhabited at the bottom of fry rearing tanks. After feeding on scuticocilates-infected rotifer on fish larvae, first infection was detected at 10 days after bottom dwelling or 40 days old after hatching. By histopathological examination we confirmed the infection route of eyeball of brain contamination was that the ciliate worms digged through mouth and front part of the dosal fin cuticle, transferred into eyeball along the epithelium and muscle tissue, and reached finally into brain by the muscle and nerve tissue. The infection of internal organs was clarified into two routes. The first route was started form the infection at ventral and anal fin rays by the worms, and reached at the anus and rectum through the epithelium and muscle tissue. The second route was initiated from the infection at urinary organ and reached into the rectum epithelium cells, inner wall of intestine, abdominal cavity, pancreas, kidney, and pancreas. At seed production farms where fish larvae fed on scuticocilate-free rotifer, the worms were not detected not only at the food organisms culture tanks and juvenile rearing tanks but also larval flounder less than 7㎝ in total length.

국산·수입산 동부를 이용한 모시잎송편의 영양성분비교

김영섭,김소민,오지연,황진봉,이기택,신정아,김상천,김세나,김행란,황영,최용민 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

유해화학물질의 계통분석

박성우,박유신,이진훈,유재훈,김유나,오세진,이진숙,김남이,박종신,남금문,노동석 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-