기관지천식 환자에서 Furosemide, Disodium cromoglycate 및 Heparin 흡입이 고장액 식염수 기관지유발검사에 미치는 영향

강천일,현상훈,남언정,김건우,윤종수,서영익,이종명,김능수 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 기관지천식 환자에서 고장액 식염수의 흡입은 기도수축을 유발할 수 있으며 이는 운동유발성 천식반응과 밀접한 관계가 있는 것으로 알려져 있다. 저자들은 알레르겐 흡입이나 운동에 의해 유발되는 천식에 예방효과가 있는 것으로 알려진 disodium cromoglycate(DSCG), furosemide 및 heparin 흡입이 4.5% NaCl 기관지유발검사(BPT)에 미치는 영향을 조사하였다. 대상 및 방법 : 4.5% NaCl BPT에서 양성반응을 보이는 기관지천식 환자 13명을 대상으로 하였으며 사용된 약물은 furosemide 40㎎, DSCG 40㎎ 및 heparin 1,000μ/㎏이었다. 먼저baseline 4.5% NaCl BPT를 시행한 다음 이들 약물로 전처치후 다시 4.5% NaCl BPT를 시행하여 약물의 효과를 관찰하였다. 결과 : Furosemide 40㎎, DSCG 40㎎및 heparin 1,000μ/㎏의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였다. Furosemide와 DSCG로 전처치한 군(n=6)에서 이들의 기도수축 방어율은 각각 100.6±6.6%, 91.1±17.2%였으며 furosemide와 heparin으로 전처치한 군(n=7)에서는 각각 58.7±29.2%, 59.0±51.1%로서 각 군에서 이들 약제간의 방어율에는 유의한 차이가 없었다. 결론 : Furosemide(40㎎), DSCG(40㎎) 및 heparin(1000μ/㎏)의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였으며, 적어도 이 용량에서 기도수축 예방 정도에는 유의한 차이가 없음을 알 수 있었다. Background: Hypertonic saline (4.5% NaCl) inhalation is known to induce broncho-constriction by affecting mast cell, epithelial cell and vagal afferent pathway in some asthmatics. Disodium cromoglycate (DSCG) is known to have a preventive effect on allergic asthma and exercise induced asthma, and recently it was reported that furosemide and heparin had similar effect. The purpose of this study was to evaluate the effects of furosemide, DSCG and heparin on hypertonic saline provocation test in asthmatics. Methods: Thirteen asthmatics with a positive response to hypertonic saline challenge were enrolled. Hypertonic saline and test drugs were generated by ultrasonic nebulizer. After taking baseline 4.5% NaCl challenge, subjects were rechallenged with 4.5% NaCl after inhalation of furosemide 40㎎, DSCG 40㎎ or heparin 1,000μ/㎏. Results: 1. There was a significant positive relationship between PC_20-methacholine and PTM-4.5% NaCl(r=0.5575, p = 0.024). 2. Furosemide, DSCG and heparin had no direct bronchodilating effects. 3. Premedication of furosemide and DSCG(n=6) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 100.6±6.6% and 91.1±17.2%, respectively. 4. Premedication of furosemide and heparin(n=7) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 58.7±29.2% and 59.0±51.1%. respectively. Conclusions: Furosemide(40㎎), DSCG(40㎎) and heparin(1.000μ/㎏) had significant protective effects on hypertonic saline induced broncho-constriction in asthmatics, and there were no significant differences in their potency of protection rate.

비소세포폐암에서 동시화학방사선요법을 받는 중 생긴 기관폐루1례

강건희,조성우,김성록,유영진,이효락 인제대학교 2008 仁濟醫學 Vol.29 No.-

최근 근치적 절제가 불가능한 국소진행성 비소세포 폐암에서 화학요법을 방사선요법과 동시에 투여하는 치료방법에 대한 연구가 활발이 이루어지고 있으며 이러한 치료과정 중 생긴 여러 부작용에 대한 연구도 이루어지고 있지만 아직까지 기관폐루가 생겼다고 보고는 없다. 따라서 치료과정 중 기관폐루가 의심되는 소견이 있을 경우 이에 대한 조기 진단과 치료를 통하여 부작용에 따른 사망률을 최소화하여야 하겠다. The incidence of lung cancer is increasing steadily and various methods have been attempted to enhance the cure rate of locally advanced non small cell lung cancer, which is hardly removable surgically, but the results are not satisfactory yet. Recently, research is being made actively on the simultaneous application of chemotherapy and radiotherapy for locally advanced non small cell lung cancer that cannot be radically resected and the we experienced a case of patient diagnosed with bronchopulmonary fistula during the treatment process, and therefore report it here.

감사(Gratitude)의 선행변수와 결과변수에 대한 질적연구

조상리,강명주,김상조,김영근 동의대학교 경제경영전략연구소 2011 經濟經營硏究 Vol.6 No.2

Effects of Gratitude on Social Relationship have been argued in many psychology literature. And although the marketing practical and academic evidence is currently limited, we thinks, customer's gratitudes from salesperson may directly influence marketing performance. Our study has two goals. The first is to test the mediator of gratitude and the other is to find the causes and effects of gratitude between consumers and employees. To do that, this study practiced focus group interview, in-depth and expert interviews. The results are like these; Consumers feel gratitude toward employees when they try to understand customer's need and wants, manage their affect, and provide additional information, trust, humanism, surprising service and sympathy. These can summarise sincerity, emotional sympathy, trust and surprising service. Consumers who feel gratitude show brand loyalty, such as repurchase and positive mouth, provide feedback, allow employee' mistakes, and act prosocial.

3차원 물체 복원과 자료 압축을 위한 적응 Simplex-Mesh 기술의 응용

문성환,조용군,강훈 중앙대학교 정보통신연구소 1999 정보통신연구소논문집 Vol.1 No.1

대부분의 3차원 물체 복원 기술은 물체를 다수의 평면으로 나누어 물체의 표면을 근사시켜 표현한다. 주어진 분류치를 사용하여 mesh를 초기화시키는 Marching Cubes 알고리듬과 Delaunay Tetrahedrisation이 널리 사용되고 있다. 이와 더불어 deformable 모델은 적은 수의 가정만으로도 다양한 종류의 데이터들에 대한 복원 및 재구성을 할 수 있기 때문에 일반적인 물체 복원에 적합하다. 현재 deformable 모델이 기반이 된 복원 시스템에 대한 연구가 활발히 진행중이다. 본 논문에서는 곡면으로 이루어진 물체에 대해서 적응 simplex mesh 기술을 바탕으로 3차원 물체를 압축, 복원하는 방법을 제시한다. 이 방법은 미리 정해진 mesh 구조를 변형시키고 곡률과 같은 기하학적인 특성들을 다시 설정하면서 본래의 3차원 물체로 접근시킨다. 시뮬레이션을 통해서 높은 압축률로 물체롤 복원하고, 물체의 모양을 최적으로 기술하기 위해 정점들이 곡률이 높은 곳으로 집중되는 것을 보인다. Most of the 3D object reconstruction techniques divide the object into multiplane and approximate the surfaces of the object. The Marching Cubes Algorithm which initializes the mesh structure using a given isovalue, and Delaunay Tetrahedrisation are widely used. Deformable models are well-suited for general object reconstruction because they make little assumptions about the shape to recover and they can reconstruct objects from various types of datasets. Now, many researchers are studying the reconstruction systems based on a deformable model. In this paper, we propose a novel method for reconstruction of 3D objects. This method, for a 3D object composed of curved planes, compresses the 3D object based on the adaptive simplex-mesh technique. It changes the pre-defined mesh structure, so that it may approach to the original object. Also, we redefine the geometric characteristics such as curvatures. As results of simulations, we show reconstruction of the original object with high compression and concentration of vertices towards parts of high curvature in order to optimize the shape description.

후두 편평세포암종에서 Galectin-1 및 -7의 발현 의의

김건형,강차영,윤혁수,도남용,조성일,임성철 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background and Objectives: The role of different Galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of Galectin-1 and -7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Methods: Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007, were immunohistochemically stained for Galectin-1 and -7. Results: Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion: Expression of Galectin-1 and -7 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.

Sol-Gel방법에 의해서 성장시킨PbTiO₃박막의 결정화와 물리적 성질

구영진,강민진,정원태,김태현,김상수 昌原大學校 基礎科學硏究所 2000 基礎科學硏究所論文集 Vol.12 No.-

Ferroelectric PbTiO3 thin films coated on SiO2/Si(100) and ITO glass substrates were prepared by sol-gel processing of metal alkoxide solutions and solvents. The use of sol-gel method for preparing various functional films makes it possible for the homogeneous distribution of elements at the molecular level, precise composition control, lower temperature synthesis, large surface coating and high optical quality. First of all, the XRD investigation shows that perovskite phase of polycrystalline PbTiO3 was formed by four times coating of the concentrated solution and by the heat treatment over 500, 600℃(O2 gas and air) and over 10, 20, 30 min. Surfaces of thin films were crack-free and uniform and the average grain size investigated by SEM was 0.25∼1.00 ㎛. Dielectric constant of PbTiO3/ITO glass thin film were 380 ∼ 5.25 in the region of 1 kHz∼ 10 MHz at room temperature(30℃), respectively. From the hysteresis loop of PbTiO3/ITO glass thin film, a remnant polarization of 0.382 μC/cm2 and a coercive filed of 23.85 kV/cm were obtained. At the frequency(5 kHz), C-V measurements of films in MFIS and MFM configurations showed well-behaved C-V characteristics and an injection type hysteresis. The capacitance of flat band(CFB) was 60 pF. The band gap energies of the thin films depend on the assumption of direct or indirect transition. Using one layer structure model, we calculated refractive index, extinction coefficient, absorption coefficient and band gap energy of thin film in the wavelength range of 300 to 800 nm. The band gap energy, refractive index and extinction coefficient at λ = 6325 Å of the PbTiO3 thin film were 3.7 eV, 1.96 and 0.1 respectively.

위 장관 상피암에서 에스트로젠 수용체 표출에 대한 면역 조직학적 연구

김인건,김창진,강상균 순천향대학교 1992 논문집 Vol.14 No.4

The presence of Estrogen Receptor(ER) has been reported in various tumors, as orain tumor, lung cancer, gastrointestinal carcinomas and others, which have been believed to be non targer organs for the estrogen. The gastrointestinal carcinoma is one of the most frequent malignancy in Korea and several therapeutic modalities such as surgery, chemotherapy, radiotherapy and immunotherapy. are tried Hormone therapy had been applied selected cases with ER positive cancers and the results were good. To observe the presence of ER in gastrointestinal carcinomas We studied 20 cases of gastric carcinoma and 20 cases of colorectal carcinomas by immunohistochemical method. The results were as follows: 1. The ER was present in 35% (n=7) of 20 cases of gastric adenocarcinoma. Carcinomas in male showed ER positivity in 20% while in 40% in female. 2. Histologically, expanding type(n=4) showed 75% positivity of ER while infiltrative type)n=16) showed 13% of positivity. 3. The ER was present in 45%(n=9) of 20 cases of colorectal carcinomas. The male to female ratio of ER positivity was 57%(n=7) to 38%(n=5). 4. All the mucinous carcinomas(n=4) showed ER negativity, but poorly differentiated adenocarcinoma(n=1) and squamous cell carcinoma((n=1) showed ER positivity. 5. Well differentiated adenocarcinoma of the colorectum showed 50%(n=7) positivity of ER. Above results suggest that carcinomas in gastrointestinal tract, which was not considered as estrogen target organ, can express estrogen recetor and the trial of hormone therapy might be highly encouraged.

Panipenem을 포함한 Carbapenem 계열 항생제의 몇 가지 임상균주에 대한 시험관내 항균력

이동건,김명신,강진한,전혜선,최수미,위성헌,김상일,최정현,유진홍,신완식,강문원 대한감염학회 2003 감염과 화학요법 Vol.35 No.2

목적 : Panipenem은 일본에서 개발된 카바페넴계 항생제로 그람양성균, 그람음성균, 혐기균에 이르기까지 광범위한 항균력을 나타낸다고 보고되고 있지만 국내에서 분리되는 균주에 대한 감수성 검사결과는 아직 없다. 본 연구에서는 임상에서 분리된 E. coli, K. pneumoniae, P. aeruginosa, S. pneumoniae 균주를 대상으로 carbapenem 계열 및 몇 가지 항생제와 감수성을 비교하고, 특히 P. aeruginosa의 경우 carbapenem의 효과를 Muller-Hinton agar (MHA)가 반감시킬 수 있는 특성을 고려하여 감수성에 변화가 있는지 확인하고자 하였다. 방법 : 2002년 3월부터 6월까지 가톨릭대학교 성모병원, 강남성모병원, 성가병원, 성모자애병원, 성빈센트병원에서 분리된 임상균주 E. coli, K. pneumoniae, P. aeruginosa, S. pneumoniae를 대상으로 하였다. 항생제 감수성 검사는 NCCLS 기준에 따랐고 P. aeruginosa의 경우 MHA 이외에 minimal agar Davis (MAD)를 추가로 사용하였다. 감수성 결과 해석시 panipenem은 imipenem과 같은 기준을 적용하였다. 결과 : E. coli, K. pneumoniae, P. aeruginosa는 각각 100균주였고, S. penumoniae는 134균주였다(PSSP 41, PNSP 93균주). E. coli, K. pneumoniae는 모든 균주가 imipenem, meropenem, panipenem에 대해 감수성을 보였다. P. aeruginosa의 경우 imipenem, meropenem, panipenem, ceftazidime의 MIC_(90)은 각각 16, 8, 32, 64㎍/mL이었다. MHA와 MAD 배지를 이용하여 P. aeruginosa에 대한 항생제 감수성을 비교해 본 결과 imipenem, panipenem의 MIC_(90)가 각각 16, 32㎍/mL에서 8㎍/mL로 감소하였고, imipenem에 비해 panipenem이 더 많이 감소하였다. S. pneumoniae의 경우 PSSP는 imipenem, meropenem, panipenem에 대해 모두 내성이 없었고 PNSP는 imipenem, meropenem, panipenem에 대한 MIC_(90)가 각각 1, 2, 0.25㎍/mL이었다. 결론 : 결론적으로 panipenem은 E. coli, K. pneumoniae에 대해 기존의 카바페넴계 항생제와 유사한 우수한 항균력을 보였다. P. aeruginosa의 경우 ceftazidime, imipenem과 비슷한 항균력을 보였고 아미노산 함량이 적은 배지를 사용함에 따라 MIC가 낮아졌으며 imipenem보다 더 많은 영향을 받았다. S. pneumoniae의 경우 특히 PNSP에서 기존의 카바페넴계 항생제보다 우수한 항균력을 보였다. Panipenem은 주요 그람음성균 및 폐렴연쇄구균 감염에 유용할 것으로 기대된다. Background : Panipenern (PAPM) is a new carbapenern which has an enhanced broad spectrum against both gram-positive and negative organisms. The aim of study was to compare the activities of PAPM with those of imipenern (IMPM), meropenern (MRPM) against several clinical isolates in Korea. Methods : We tested the in vitro antimicrobial activities of PAPM, IMPM, and MRPM against total 300 clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa and 134 Streptococcus pneumoniae collected from 5 different university hospitals. Using NCCLS guidelines, MICs of PAPM, IMPM, MRPM, and/or ceftazidime were determined. Results : All isolates of E. coli and K. pneumoniae were susceptible to PAPM, IMPM and MRPM. MIG_(90) of PAPM, IMPM, and MRPM against P. aeruginosa were 32, 16, and 8 ㎍/mL, respectively. Comparing Mueller-Hinton agar (MHA) and minimal agar Davis (MAD), the MIG_(go) of PAPM and IMPM were reduced from 16 and 32 ㎍/mL to 8 and 8 ㎍/mL, respectively. PAPM was more influenced by MAD than IMPM. All isolates of penicillin susceptible S. pneumoniae showed 0% of resistance to the carbapenems tested. MIC_(90) of PAPM, IMPM and PRPM against penicillin non-susceptible S. pneumoniae were 0.25, 1 and 2 ㎍/mL, respectively. Conclusion : Panipenern could be one of the potentially useful drugs for the treatment of infections caused by E. coli, K. pneumoniae, and S. pneumoniae. We also showed that PAPM had good anti-pseudomonal activity when examined in MAD, the amino acid-limited media. Therefore, it could be useful for the treatment of infections caused by P. aeruginosa.

原因不明熱의 臨床的 考察

박석건,최성재,최강원 대한감염학회 1984 감염 Vol.16 No.1

Etiology of Fever of Unknown Origin and contribution of diagnostic tests as bone marrow biopsy, liver biopsy, radionuclide liver scan, and anti-ds DNA antibody test to the final diagnosis of F.U.O. was studied in 41 patients who were admitted to the Seoul National University Hospital from December '80 to January '84. We used Petersdorf's criteria for patient selection. 1) According to the final diagnosis, patients were grouped into 6 diagnostic categories; Infectious disease was 29%, Malignancy 17%, Connective tissue disease 24%, granulomatous disease 3%, others 3%, and unknown 22%. 2) Contribution of diagnostic tests to the final diagnosis was tested by positive diagnostic rates of the each tests; 17% in bone marrow biopsy, 29% in liver biospy. 3) Liver scan and anti-dsDNA antibody test seemed to be good screening to tests, although positive diagnostic rate were low.

段 가공을 한 SM20C 異徑材 摩擦熔接部의 機械的 性質에 關한 硏究

김진건,강성보,민택기 충남대학교 공업교육연구소 1998 論文集 Vol.21 No.1

This study deals with mechanical properties in friction welding of SM20C steel bars and pipes which have different overhang lengths(0mm∼5mm). The experimental results m summarized as follows; In case of pipe, we can conclude that 1mm overhang is optimal condition for the products which needs the tensile and bending strength. But in case of bar, we can conclude that 0mm overhang is optimal condition for the Products which needs the tensile and bending strength.