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      • 소아에서 발생한 일광 두드러기 1례

        강훈,조상현,김의한,강훈 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.3

        Solar urticaria is a rare disorder in which immediate erythema and wheals are induced by ultraviolet or visible irradiation. This condition usually occurs in the third and fifth decades of life and is very rare in childhood. A 3-year-old girl presented with a history of an erythematous rash which had occurred on the face and neck, immediately after exposure to sunlight for one month. A diagnosis of solar urtiacria was made on the clinical reviews and phototest. Other photosensitive disorders could be excluded by the clinical and laboratory findings. She was treated with ketotifen and sun protection showing good early results.

      • SCOPUSKCI등재

        모낭성 점액증 1예

        강훈,손숙자,김삼형 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.5

        We report a case of follicular mucinosis which oecurred in a 28-year old female. She had an adult fist-sized erythemlatous indurated infiltrative plaque with an ill-defined border on the left cheek area. Histopatholcigical findings, including mucin stains, showed characteristic reticular degeneration and cystic spece formation in hair follicles and sebaceous glands with mucinous degeneration and infiltration of abundant eosinophiles. The present case should be differentiated from plaque type eosinophilic pustular folliculitis clinically and histologically. (Korean J Dermatol 1997;35(5): 1022-1026)

      • SCOPUSKCI등재

        비특이적 임상 소견을 보인 Gianotti - Crosti 증후군 1예

        강훈,손숙자,홍석진,김삼형 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.4

        We report herein a case of Gianotti-Crosti syndrome showing unusual features. A 12-month-old male patient presented with papular skin lesions on his face and papulovesicular skin lesions on the trunk, upper and lower extremities, which were distributed symmetrically. Three days before the skin eruptions, he had been immunized with a measles vaccination. Serologically, antigens of the type B hepatitis virus and antibodies to coxsackie virus B-4, Epstein-Barr virus, and varicella-zoster virus were all negative and antibodies to the measles virus (IgG, IgM) and the type B hepatitis virus were positive. After conservative treatment the skin lesions subsided with exfoliation within 4 weeks. An association with the measles vaccination and the initial papulovesicular skin lesions are considered as peculiar features of this case. (Kor J Dermatol 1997;35(4): 830-834)

      • KCI등재

        Projection Spectral Analysis

        강훈,하준수 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.6

        This study investigates ‘Projection Spectral Analysis’, which generalizes ‘Principal or Independent Component Analysis’ by dealing with a non-symmetric square correlation or covariance matrix with multiplicities or singularities. This type of covariance matrix is decomposed into projections and nilpotents according to the spectral theorem. Projection spectral analysis solves a learning problem by reducing the dimension for multiple zero eigenvalues, and may be applied to a non-symmetric co-variance with distinct eigenvalues. This method involves a sum-product of orthogonal projection operators and real distinct eigenvalues for a symmetric covariance, which makes it equivalent to principal component analysis. However, it becomes independent component analysis if the covariance is not symmetric. This study investigates ‘Projection Spectral Analysis’, which generalizes ‘Principal or Independent Component Analysis’ by dealing with a non-symmetric square correlation or covariance matrix with multiplicities or singularities. This type of covariance matrix is decomposed into projections and nilpotents according to the spectral theorem. Projection spectral analysis solves a learning problem by reducing the dimension for multiple zero eigenvalues, and may be applied to a non-symmetric covariance with distinct eigenvalues. This method involves a sum-product of orthogonal projection operators and real distinct eigenvalues for a symmetric covariance, which makes it equivalent to principal component analysis. However, it becomes independent component analysis if the covariance is not symmetric.

      • The Effect of Epidural Ketamine used with Patient-Controlled Analgesia on Postoperative Pain

        강훈,박상희,이동훈 충북대학교 의과대학 충북대학교 의학연구소 2008 忠北醫大學術誌 Vol.18 No.1

        Purpose: Acute pain can be abolished by intravenous administration of ketamine in doses insufficient to induce anesthesia. Therefore we designed this study to see if this subanesthetic dosage of ketamine administered epidurally with patient-controlled analgesia (PCA) after abdominal surgery can also provide sufficient analgesic effect on postoperative pain. Materials and Methods: 20 consecutive patients were allocated randomly to receive either ketamine (n=10) or placebo (n=10) for pain relief after surgery. At 30 minutes before the end of surgery patients were attached to an PCA infusor programmed to epidurally deliver same amount of placebo or ketamine 3-5 mg/h (72-120 mg/day) in combination with background PCA regimen composed of bupivacaine, morphine, fentanyl etc for 48 hours postoperatively. Patients were evaluated for pain on ten-point Verbal Analogue Scale (VAS) and nausea on a four-point scale at 30 minutes, and 1, 6, 12, 24 hours after surgery. Results: The pain score in the placebo group is not significantly higher than in ketamine group postoperatively. While the pain scores in the two groups were very similar, throughout the 24 hours period, the incidence of nausea/emesis was also similarly low in both groups. Conclusion: It was found that a fixed rate epidural infusions of ketamine (3-5 mg/h) are ineffective in controlling pain after surgery. 연구목적: 강력한 진통작용를 나타내는 케타민은 마취농도 이하의 용량을 정맥투여함으로써 수술 후 통증같은 급성 통증을 치료할 수 있다. 저자들은 이와 같은 마취농도 이하의 저용량을 경막외에 투여하는 경우도 급성통증에 비슷한 효과가 있는지 알아보고자 본 연구를 시행하였다. 대상 및 방법: 연구 대상 환자는 충북대학교병원 수술실에서 복부에 정규 외과 수술을 받은 후 48시간 이상 자가통증조절(Patient-Controlled Analgesia)을 이용하여 통증치료를 받은 성인 남녀 환자들이며 환자들은 무작위로 ketamine군(n=10)과 위약 대조군(placebo, n=10)의 두 군으로 나누고 수술 종료 30분 전에 미리 준비한 patient-controlled analgesia에 ketamine (3-5 mg/h) 혹은 placebo를 섞어서 투여하기 시작하였다. 수술 후 회복실 또는 병실에서 필요한 경우 급성통증을 예방하기 위하여 ketorolac 30 mg을 정맥 투여하였다. 환자의 통증과 부작용에 대한 평가는 회복실에서 그리고 수술 후 1, 6, 12, 24 시간에 시행하였다. 결과: 두 군 간에 인구학적 차이는 없었으며 수술 직 후 회복실에서 통증의 정도는 두 군 간에 유의한 차이가 없었으며 오심 및 구토 등의 부작용도 의미 있는 차이를 보여주지 않았다. 결론: 마취농도 이하의 저용량의 ketamine (3-5 mg/h)을 경막외에 투여하는 경우 의미있는 진통효과를 보여주지 못하였다.

      • SCOPUSKCI등재

        비전형적인 임상 양상을 보인 호산구성 농포성 모낭염 4예

        강훈,손숙자,홍석진,김삼형 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.6

        We report three cases of u.iiusual eosinophilic pustular folliculit is whose initial manifestation is indurated plaque rather than papule and pustule and one case of eosinophilic pustular folliculitis was found in an infant. None of the adult patients in these cases complained of any suhjective syrnptoms other t.han the skin lesion, but an itching sensation might be present in the case of the infant. In laborat ory test, eos nophilia was observed in only one case and any other abnormal results were not observed. In all cases, histopathologic study revealed numerous eosinophilic infil tration around the follicles ext.i nding to the periappendageal and perivacscular area, that is consistent with the finfings of eosinophilic pustuar folliculitis. All adult patients relatively responded well to dapsone and topical stroid and the infant patient-resporided well to topical steroids, But they had a chronic course with remission and exacerhation (Korean J Dermatol 1997;35(6): 1244-1249)

      • SCOPUSKCI등재

        단애양 피낭성 신경종 ( Palisaded , Encapsulated neuroma ) 1예

        강훈,장희진,손숙자,홍석진,김삼형 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.1

        Palisaded, encapsulated neuroma is characterized clinically by a solitary, slowly-growing and dome-shaped papule or nodule, usually accompanied by telangiectasia on the surface, and histopathologically by an encapsulated nodule in the dermis and the palisading arrangement of nuclei. A 57-year-old female patient presented with a 1cm-sized, solitary nodule on the right ala nasi which had been present for about 5 years. The nodule had a tendency to slow growth and it became a polypoid nodule. Telangiectasia was shown on the surface of the lesion. Histopathlogical findings showed a well-defined and encapsulated nodule in the dermis, composed of spindle cells with basophilic and plump nuclei in a palisading fashion. On immunohistochemical staining, the tumor cells of the nodule were positive for S-100 protein, while the capsule of the nodule was negative for S-100 protein. Epithelial membrane antigens were focally positive only on the capsule of the nodule. We report herein a case of palisaded, encapsulated neuroma, one case of which has been reported in Korea. (Korean J Dermatol 1998;36(1): 173-176)

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