진행성 위장관 암에 대한 5-Fluorouracil, Leucovorin 및 Mitomycin-C 복합 화학요법

김성록 인제대학교 1990 仁濟醫學 Vol.11 No.4

진행성 위장관의 악성종양에 대한 약물 치료는 아직도 만족스럽지 못하며, 유효한 경우에도 약물 치료에 따른 독성 등으로 계속 치료하기가 곤란한 경우가 많았다. 이에 저자는 아직도 위장관암의 주된 치료제인 5-Fluorouracil과 Mitomycin-C에 5-FU의 효력 증강제인 Leucovorin을 첨가하여 제2위상 시험을 한 후 그 효과와 독성을 관찰하였다. A phase II study was conducted to determine the efficacy and toxicity of 5-fluorouracil (5-FU), low dose leucovorin (LV) and mitomycin-C (MMC) in patients (pts) with advanced gastrointestinal tract cancer. The treatment regimen consisted of 5-FU 375 mg/m2 IV over 15 minutes daily for 5 days, just after IV bolus of LV 20 mg/m2 each, and MMC IV bolus 9 mg/m2 which was reduced to 7 mg/m2 from the second cycle. The treatment was repeated every 3-4 weeks, 21 eligible pts have been entered on study. 18 pts are presently evaluable for response and toxicity ; 3 pts were lost to follow up after chemotherapy. Among 18 evaluable pts, there were 111 pts with stomach cancer, pancreas 2, bile duct 1, gall bladder 1, and colon 3. 17 patients had adenocarcinoma ; 1 bile duct cancer was not confirmed pathologically. The median alee was 57 (Range 37-84) years. 3 pts had 5-FU containing chemotherapy previously. The pts on this trial received a median of 2 cycles (range 1-7). 1pt (bile duct) had radiotherapy of 800 cGy after chemotherapy. There were partial reponses (stomach 7, pancreas 1) tasting 1-7+months and 3 objective responses (for "evaluable disease". stomach 2, bile duct 1) lasting 1-4+months. 2 pts with stable disease or progressive disease on prior 5-FU containing chemotherapy had partial responses. 5 pts were in stable disease and 2 in progressive desease. 2 pts died so far ; one in one month with progressive disease and the other in 6 months after treatment, with the remission duration of 4 months. Toxicities were tolerable ; no one was hospitalized due to toxicity. Grade (G) 1 nausea / emesis was observed in 4 pts and G 2 in 1 pt. G 2 mucositis in 3 pts, diarrhea G 1 in 2 pts and G 2 in 1 pt were noted. Granulocytopenia G 1 in 4 pts, G 3 in 2 pts and G 4 in 1 pt (who had radiotherapy), and G 1 thrombocytopenia in 2 pts were observed. This appears to be a well tolerated regimen having comparable effects. The study continues to accrue pts to better define the response rates and effects on survival.

지역산업연관 투입계수 추계기법의 적합성 비교

김성록,윤준상,이종상 한국비교정부학회 2011 한국비교정부학보 Vol.15 No.2

정보속으로 : 정보화정책 ; 공공정보 민간활용 촉진 종합게획

김성록 한국지역정보개발원 (구 자치정보화조합) 2010 지역정보화 Vol.63 No.-

원발성 간세포암 환자에 있어서 간염 바이러스이 혈청학적 표식자 및 혈청 α-Fetoprotein에 관한 연구

김성록,외1인 大韓消化器病學會 1984 大韓消化器病學會誌 Vol.16 No.1

중국의 지역간 경제지표를 이용한 지역개발정책의 효과분석 -10․5계획 전후를 중심으로-

김성록,이병주,조원향,윤준상 한국비교정부학회 2010 한국비교정부학보 Vol.14 No.1

Since the 1978 economic reform, China has been one of the fastest growing countries in the world. However, the benefits from the growth have not been distributed equally across China, and the regional disparity has become a burning issue of the governmental policy. The Chinese government has implemented policies to cope with the regional disparity effectively as of the 10․5Plan in 2001. Therefore, the study was conducted with the statistics of the year in 2001 and 2006, which are the periods of before and after the 10.5plan. Through the study would look into the variation of the regional disparity and find out which factors contribute to the regional growth. The results of the analysis, Balancing Development Policy of the 10․5plan was effective in the regional disparity problems, and factors affecting regional growth were changed.

농촌중심지활성화사업의 변화와 실무적 개선방안

김성록,김지석 한국법정책학회 2017 법과 정책연구 Vol.17 No.4

As the phenomena of the decline of rural areas and the degradation of their functions due to the centralization of the metropolis, the phenomenon of aging and low fertility rates emerge as realistic problems, for the improvement of the conditions of residents’ settlement in rural areas, the necessity of life service functions increases. In rural areas, such as the eup and myeon areas, since most areas, excluding the central areas, are spread spatially wide, the level of benefits from life service differs depending on the area. In terms of the fairness of the policy, an equal level of facilities and programs should be provided for each village, but it is hard to consider this a reasonable alternative due to the budget problem. Thus, it is necessary to concentrate life service function facilities in the rural center and to build up an efficient service delivery system in the surrounding areas, rather than small-scale diversified investment. A rural center revitalization project is a policy to enhance the quality of life in the center and the surrounding areas together, by building up a system that can expand the central functions such as education, welfare and culture to the eup and myeon areas, which are the rural centers and to deliver the services of the center to the surrounding areas, responding to the increase of underpopulated villages. This study discussed changes and problems of the rural center revitalization project and drew plans for improvement as follows: First, it would be necessary to strengthen the connection system with city/county master plans and to stipulate the time of consultation among the related departments of the local government in the planning process. Second, it would be necessary to clarify the roles and authority of PM group and stake holders. Third, it would be necessary to improve the system to increase the participation rate of residents in the surrounding areas and to improve the accessibility between the center and its surrounding areas. Lastly, it would be necessary to concretize measures for the practical support after the completion of the project. 대도시 집중화・고령화・저출산 등으로 인한 농촌지역의 공동화와 기능저하가 현실적인 문제로 부각되고 있어, 농촌지역 주민의 정주여건 개선을 위하여 생활서비스 기능에 대한 필요성이 증대되고 있다. 농촌지역은 읍・면소재지와 같은 중심지를 제외한 대부분의 지역들이 공간적으로 넓게 분포되어 있어 생활서비스에 대한 수혜수준이 지역마다 상이하다. 정책의 형평성 측면에서는 각 마을마다 동등한 수준의 시설과 프로그램을 제공해야 하겠지만, 이는 예산상의 문제 등으로 인하여 합리적인 대안으로 보기에는 어렵다. 그러므로 소규모 분산 투자보다 생활서비스 기능시설 등을 농촌중심지에 집중하고, 배후지역에 대해 효율적인 서비스 전달 체계를 구축할 필요가 있다. 농촌중심지활성화사업은 인구 과소마을의 증가에 대응하여, 농촌중심지인 읍・면소재지에 교육・복지・문화 등 중심기능을 확충하고, 배후마을로 중심지서비스를 전달할 수 있는 체계를 구축함으로써 중심지와 배후지의 삶의 질을 함께 향상시키기 위한 정책이다. 이 연구는 농촌중심지활성화사업의 변화와 문제점에 대해 고찰하였고, 다음과 같은 개선방안을 도출하였다. 첫째, 도시・군기본계획과의 연계체계 강화 및 계획수립과정에 있어서 지자체 관련 부처간 협의시기를 명문화 할 필요가 있다. 둘째, PM단 및 참여주체의 역할과 권한에 관한 명확화가 필요하다. 셋째, 배후지역주민의 참여율을 높이기 위한 제도개선 및 중심지와 배후지간의 접근성을 강화해야 하며, 마지막으로 사업완료 이후 운영지원 방안을 구체화할 필요가 있다.

말기 신부전 환자의 미각 감소에 대한 혈액투석의 효과

김성록,윤종보,조용호 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.2

In patients with end-stage renal disease, depressed taste acuity may often affect their food intake and causes malnutrition. We measured mean recognition thresholds for the four primary tastes before and after hemodialysis to evaluate the efficacy of hemodialysis on taste acuity and measured serum zinc concentrations to determine the relationship between taste acuity and zinc status in 21 patients undergoing hemodialysis. The results were as follows : 1) Mean taste recognition thresholds of sour(0.0034±0.0021 N), sweet(0.027±0.012 M), and salty(0.027±0.014 M) were significantly higher than those of controls(0.0012±0.0007 N, 0.016±0.008 M, and 0.015±0.008 M, respectively)(P$lt;0.05). 2)After hemodialysis, mean taste recognition thresholds of sour(0.0014±0.0011 N), sweet(0.015±0.011 M), and salty(0.020±0.011 M) were significantly decreased(P$lt;0.05) but were not different from those of controls. 3) The mean recognition threshold for bitter was not improved after hemodialysis and was not different fromcontrols. 4) The serum zinc concentration of patients with chronic renal failure was not different from that of controls. Finally, the mean taste recognition thresholds for sour, sweet, and salty were decreased in patients with end-stage renal disease and were improved after hemodialysis. The mean taste recognition threshold for bitter was not improved after hemodialysis and was not different from that of controls.

수도권 공간구조 변화에 관한 연구: 1995년∼2010년

김성록 국토지리학회 2014 국토지리학회지 Vol.48 No.1

There have been numerous changes since the mid-1990s in the spatial structure in the metropolitan area due to the development of new towns, progress in traffic systems and sophistication of industries. This study analyzed changes in spatial structure of metropolitan area using prestige centrality and connection structure of 66 cities, districts and towns in metropolitan area in 1995 and 2010. The results are as follows: During the period analyzed, while northern Seoul including Jung-gu and Chongno-gu maintains its status in the usual manner, the area south of Han river has raised its status. In addition, there has been a gradual decrease in eigenvector centrality index of Incheon area whereas the status of southern region of Gyeonggi Province has ascended steadily. Changes in linkage structure of Seoul metropolitan area can be explained by a decline of linkage between central and northern region, and an intensified linkage structure between midwest and southern region of metropolitan area, which is considered to be a result from increased mutual interchange between major community in Seoul and southern metropolitan area in particular. 1990년대 중반이후 신도시의 개발과 교통체계의 발달 및 산업의 고도화 등의 요인으로 인하여 수도권의 공간구조는 많은 변화가 있었다. 이 연구는 수도권 66개 시군구를 대상으로 1995년과 2010년의 위세중심성과 연계 구조를 파악하여 수도권 공간구조 변화를 분석하였다. 그 결과는 다음과 같다. 분석기간 동안 중구-종로구를 포함한 서울강북지역의 위상은 여전히 유지가 되고 있는 모습을 보였으나, 서울강남지역의 위상이 점점 높아졌다. 또한 인천지역들의 위세중심성 순위가 점차 낮아지는데에 반하여 경기도 남부지역의 위상이 점점 상승한 것으로 나타났다. 수도권 연계구조의 변화는 중북부의 연계성 하락, 수도권 중서부·수도권 남부의 연계구조의 강화로 설명될 수 있는데, 특히 서울지역 대군집과 수도권 남부의 상호교류의 증가에 따른 결과라 판단된다.

소도시의 도시계획에 관한 연구

김성록 대한지방행정공제회 1974 도시문제 Vol.9 No.11

만성 활동성 간염에 있어서 Ursodeoxycholic acid의 치료효과

김성록,안병철,윤영미,탁원영,곽규식,최용환,정준모 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.4

The purpose of this study is to evaluate the clinical and biochemical effects of SGD-F^(R)(UDCA, Vitamin B_1, Vitamin B_2 complex) in chronic active hepatitis. Observed cases were given orally after each meal(three times a day) for 4 weeks. The results were as follows: 1. Among subjective symptoms, improvement rate showed in easy fatigability 86.7%, anorexia 68.0%, indigestion 80.0%, nausea and vomiting 72.7%, RUQ pain 83.3%. 2. Biochemical parameters such as SGOT, SGPT, showed to be improved significantly after the 4 weeks treatment.(p<0.01) 3. There was no specific side effect during the study period in all cases. In conclusion, SGD-F^(R) capsule may be safe and effective for chronic active hepatitis.