감염된 가축과의 직접 접촉 없이 발생한 브루셀라증 환자1례와 축산 부산물 시장에서의 역학조사 : Sero-epidemiology Study on Market, by-product, Stock-raising

정성주,김성범,박대원,정혜원,기세윤,권정아,박만석,박미연,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

브루셀라증은 전 세계적으로 발생하는 인수공통 전염병중에 하나로서, 본 증례는 국내에서 감염된 가축에 대한 노출력이 없는 집단에서 현증 브루셀라증이 발생한 첫 증례이기에 문헌 고찰과 함께 보고한다. 또한 환자가 근무하였던 축산물 부산물 시장에서 역학 조사를 실시하여, 현증환자 및 기감염자를 발견하여 축산물 부산물 시장 근무자에서 현증 브루셀라증이 발생할 위험성을 평가하였다. 역학 조사 결과 축산물 부산물을 다루는 일을 하는 사람들에서 감염된 가축과의 직접 접촉이 없이도 브루셀라증이 발생할 수 있음을 알 수 있었다. Brucellosis is a world-wide zoonotic disease. We report the first case of brucellosis in South Korea that is not related to direct contract with intected cattles. The patient had been working in the market of by-product, stock raising for twenty years and complained of 1-month history of fever, chill, and intermittent epistaxis. We confirmed brucellosis by anti-brucella antibody test and PCR. After 6 weeks' treatment with rifampicin and doxycycline, fever and chilling subsided, and, generalized weakness and oral intake improved. We performed seroepidemiology study against workers who were working in the same market as the patient. However, we couldn't find out other cases with seropositivity. We concluded that although the workers of by-product market have a risk of getting brucellosis, the risk is low.

우리나라 입학사정관제 도입의 사회적 논의 과정 분석 : 일간지 보도기사를 중심으로

안정희,배성아 이화여자대학교 교육과학연구소 2009 교육과학연구 Vol.40 No.3

본 연구는 입학사정관제를 둘러싼 사회적 논의의 전개과정을 분석함으로써 입학사정관제의 개념을 보다 정확히 이해하고 우리나라 입시문제를 개선하기 위한 제도로서 정착되기 위하여 어떠한 노력이 필요한지를 모색하는데 목적이 있다. 일간지 분석을 통해 얻은 연구결과, 2004년 도입된 입학사정관제가 2008년, 주요대학을 중심으로 급격히 확산국면으로 접어들었고 2009년도에는 정부가 주축이 되어 입시제도 개선의 주요 해법으로 강조하면서 시행대학 및 선발인원이 급증하는 한편, 제도시행과 관련한 제반 여건이 미흡한 상황에서 학교 현장에 미칠 혼란을 우려하는 목소리가 동시에 높아지게 되었다. 현재 제도의 장점과 단점을 공론화하는 과정을 거쳐 우리나라 교육현실을 고려한 제도로서 새롭게 조정되어야 함이 강조되고 있는 단계이다. 이에 본 연구에서는 입학사정관제가 성공적으로 정착 및 발전하기 위한 방안을 제시하였다. 입학사정관제는 우리나라의 대학입시 문제를 개선해 나가기 위한 여러 가지 방안 중의 하나이며 선진국의 사례를 그대로 이식하기보다는 우리 교육현실에 맞게 재구조화할 필요가 있음을 강조하였다. 또한 입학사정관제 도입을 계기로 고교-대학 간 교육과정 및 학생평가의 과정이 연계될 수 있으며 고등학교 교육에 대한 신뢰를 바탕으로 공교육정상화를 이루어 낼 수 있을 것이라고 기대한다 This study analyzes the Korean AO (admissions officer) system by reviewing issues highlighted in newspapers and further providing some suggestions for its successive establishment in Korea. The AO system was first introduced to Korea in 2004 and spread nationwide in 2008. It is currently viewed as a promising solution for improving our college admissions system. At the same time, however, a sudden increase in social awareness has caused people to be concerned about its negative effects on school education. Accordingly, we should critically consider both the system's strengths and weaknesses from a realistic perspective. In this regard, the study suggested multidisciplinary views of the system. We also emphasized that the AO system could be one option to improve our college entrance system. Furthermore, abruptly implementing a foreign system into the Korean educational situation without considering local factors should be avoided. Through the AO system, the connection between high school and colleges could be stronger in terms of curriculum and student evaluation. This would contribute to strengthening the Korean public education system.

Colwyn, Age 5 1/2, “Protecting Mom and Dad”

Klaus G. Witz,Sung Ah Bae,Hyunju Lee,Youngcook Jun,Yongsock Chang 아시아질적탐구학회 2022 아시아질적탐구 Vol.1 No.1

The present paper is part of a larger case study of a 5 1/2 year old Korean boy, Colwyn, with his mother, Dr. Bae. Dr. Bae interviewed Colwyn twice, about 2 months apart; the first interview was audiotaped, the second videotaped. The present paper is based primarily on the second interview where Colwyn tells several wildly imaginative stories of himself like a superhero “protecting mom and dad.” Our aim is to communicate a sense of Colwyn’s “feeling, consciousness, state” when he is telling these “stories”, using the portraiture philosophy of Lawrence-Lightfoot and Davis and the “Participant-as-ally - Essentialist portraiture” approach of Witz and his students. The paper suggests that Colwyn’s “telling stories” in that Interview involves a highly self-actualized way of “being involved with his ‘I’”, which was apparently prompted by Interview 1 and is expressed in the drawing in Fig. 1. (In Interview 2 he constantly comes back to this drawing and uses it as a jumping off point for ideas in the stories). In addition, when he is telling a story, his whole being (feeling and mind) is “as if flowing in a direct channel,” manifesting as a constant stream of inspiration (creativity), ideas and diverse kinds of energy which is coming from within him, and that is carried on a powerful undercurrent of moral feeling of “being good.” At the same time telling the story represents a state of “subjectively being in a unity with” his mother’s feelings of appreciation and love. These things represent intense genuine spiritual engagement that at the same time manifests itself as creative expression in painting and in verbal interaction, already at this young age. This conclusion is supported by various additional data available.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

비글개에서 인체 재조합 적혈구 조혈인자, rHuEPO의 아만성 정맥독성에 관한 연구

조명행,성하정,김형식,곽승준,천선아,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

The subchronic toxicity study of rHuEPO, a newly developed recombinant erythropoietin, was investigated for 13 weeks in Beagle dogs intravenously treated with doses of 100,500 and 2,500 IU/㎏/day. There were no significant changes in body weight, food intake, physical and opthalmic examination, urine analysis, etc. Any toxic response was not observed except for enlarged spleen and extramedullary hematopoiesis. These results indicate that the no-observed adverse effect level (NOAEL) of rHuEPO is 100 IU/㎏ in Beagle dogs.

S-352 : Glycaemic and Haemoglobin A1c Thresholds for Detecting Diabetic Retinopathy

( Sung Bae Cho ),( Yong Moon Park ),( Seung Hyun Ko ),( Yu Bae Ah ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Objective: We investigated the association between diabetic retinopathy (DR) and fasting plasma glucose (FPG) and A1C levels among Korean adults. Method: Using data from the Korea National Health and Nutrition Examination Survey (2011), a total of 5,212 adults (≥ 19 years old) were analysed. When participants had diabetes mellitus and/or a suspicion of DR in two-field nonmydriatic fundus photography, 7 standard photographs were obtained after pupil dilatation. DR was defined as the presence of ≥ 1 retinal microaneurysms or blot haemorrhages with or without more severe lesions. Result: The overall appropriate glycaemic thresholds for diabetes-specific retinopathy were 6.3 mmol/l for FPG and 6.2% for A1C. The diagnostic accuracy was better for DR than for FPG (area under curve: 0.908 for FPG and 0.953 for A1C, p=0.007). After being controlled for other covariates, the odds ratio for the risk of DR increased significantly in the category of 6.2-6.6% for A1C and 6.3-7.0 mmol/l for FPG (Reference; <5.7% of A1C, <5.5 mmol/l of FPG). Conclusion: According to this nationally representative data, the current diagnostic value of FPG and A1C based on DR may be lowered for the Korean population.

Clinical outcomes of three- or five-day treatment with clomiphene citrate combined with gonadotropins and a timed intercourse cycle in polycystic ovary syndrome patients

Bae, Sung-Ah,Joo, Jong-Kil,Choi, Jong-Ryeol,Kim, Sun-Suk,Lee, Kyu-Sup The Korean Society for Reproductive Medicine 2015 Clinical and Experimental Reproductive Medicine Vol.42 No.3

Objective: This study aimed to investigate the effect of a new clomiphene citrate (CC) regimen on preventing thin endometrial lining in polycystic ovary syndrome (PCOS) patients receiving CC plus gonadotropin treatment with a timed intercourse cycle. Methods: A total of 114 women with PCOS were included in this trial. Patients were divided into two groups and treated in accordance with the controlled ovarian stimulation (COS) protocol. In group A, 104 COS cycles in 67 patients were included, and in each cycle 150 mg CC was given for three days, starting from day 3. In group B, 69 COS cycles in 47 patients were included, in which 100 mg CC was given for five days, starting from day 3. The thickness of the endometrium was measured on the day of human chorionic gonadotropin (hCG) injection. Timed intercourse was recommended at 24 and 48 hours after the hCG injection. Results: Additional doses of human menopausal gonadotropin and the number of days of hCG administration were not significantly different between the two groups. Endometrial thickness on the day of hCG administration was significantly larger in group A than group B (4$9.4{\pm}2.1mm$ vs. $8.5{\pm}1.7mm$, p=0.004). The pregnancy rate was significantly higher in group A than in group B (38.4% vs. 21.7%, p=0.030). Conclusion: Three-day CC treatment resulted in a significantly higher pregnancy rate than the standard five-day CC treatment in a timed intercourse cycle in PCOS patients. Facilitating adequate endometrial growth via the early discontinuation of CC might be a crucial factor in achieving a higher pregnancy rate.

초상화법 기반의 고등학교 중도탈락에 관한 인물 사례 연구

배성아(Bae Sung ah),전영국(Jun Young cook),이현주(Lee Hyun ju) 학습자중심교과교육학회 2015 학습자중심교과교육연구 Vol.15 No.1

본 논문의 목적은 초상화법을 적용하여 고등학교 중도탈락 경험이 있는 학생들의 사례를 소개함으로써 자료 해석과 글쓰기에 관련된 초상화법의 특징을 탐구하는 것 이다. 초상화법은 화가가 초상화를 그리듯이 연구자가 연구 참여자에 대해 글로써 심층 묘사하여 제시하는 방법으로, Lawrence-Lightfoot에 의해 처음 소개된 사례연 구의 한 방법이다. 초상화법의 특징은 연구 참여자의 ‘나’를 연구의 중심에 두고 깊 이 있게 묘사하여 연구 참여자 개인에게서 지속적이고 만연하게 부각되는 개인의 고유한 측면을 통합적으로 묘사하는데 있다. 우리는 초상화법의 특징을 보여주는 구 체적인 사례로서 고등학교 중도탈락 후 복귀한 경험을 가진 미국 고등학생 2명(매 기와 오스틴)에 대한 초상 글쓰기를 제시하였다. 매기의 초상화는 그녀의 내면에서 주요하게 관찰되는 “자아의 발견(self-awakening)”이라는 흐름이 삼촌의 죽음을 계 기로 발현된 후, 학교 복귀로 이어지는 과정과 그 의미에 대해 보여주었다. 또한 오 스틴의 초상화는 “학교가 너무 싫었던” 소녀가 중도탈락 후에 “변화에 대한 갈증”을 느끼고 다시 학교로 복귀하게 되는 계기와 여정에 대해 조망하였다. 끝으로, 두 사 례 간 해석적 논의와 기존 연구와의 비교를 통하여 초상화법에 대한 특징을 고찰하 였다. This review study deals with major features of essentialist portraiture using two cases of high school dropouts. The methodology projects major aspects of participants regarding research theme in terms of describing a unified image of the each participant. The researcher usually articulates the meanings of the participant s experiences based on grasping major strands of his/her experiences and mapping them onto a timeline. In the course of work, the whole aspects of a person can be emerged as a unity which enables the researcher to write up the essence of the participant s experiences of dropping out and returning to school in terms of portrait. We presented two cases of high school drop-outs where the readers can appreciate the major features of portrait writing based on the essentialist portraiture. Maggie s portrait illustrates how her self-awakening evoked by her cousin s death gradually helped her inner goodness and finally come back to school. Austin s case depicts a girl who really hated school life and returned to school feeling inner thirst for her own change. At the end this paper, we presented several features of identifying unity of a person via cross-case discussion and future research issues related to other qualitative methods.

제조물책임(PL)법 시행에 따른 품질경영시스템 개선방안

배성아(Sung Ah Bae),김복만(Bok Man Kim) 한국산업경영시스템학회 2002 한국산업경영시스템학회 학술대회 Vol.2002 No.추계

In this research, we investigate the countermeasure of Product Liability through existing research or books for reference about PL and ISO 9000:2000 quality management system. And we analyze relation between PL system and ISO 9000:2000 Quality Management System after compare ISO 9000:2000 and ISO 9000:1994. base on this analysis, we integrate the Quality Management System of company and an important factor of PL system in accordance with the product liability law. So we present a general improvable scheme of ISO 9000:2000 quality management system that reduces overlap of quality business and utilize efficiently.