해마 theta리듬과 pyramidal neuron의 세포내 특성과의 상관관계

권오흥,조진화,남순현,김현정,최병주,김영진,이만기 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.4

Eledctrophysiological phenomena of pyramidal cells in the CAI area of the dorsal hippocampus were recorded from and filled with neurobiotin in anesthetized rats. The electropharmacological properties of membrane as well as the cellular-synaptic generation of rhythmic slow activity (theta)were examined. The intracellular response characteristics of these pyramidal cells were distinctly different from responses of inteneurons. Pyramidal cells had a high resting membrane potential, a low input resistance, and a large amplitude action potential. A afterhyperpolarization was followed a single action potential. Most of pyramidal cells did not display a spontaneous firing. Pyramidal cells displayed weak inward rectification and anodal break excitation. The slope of the frequency-current relation was 53.4 Hz/nA for the first interspike interval and 15.9 Hz/nA for the last intervals, suggesting the presence of spike frequency adaptation. Neurobiotin-filled neurons showed pyramidal morphology. Cells were generally bipolar dendritc processes ramifying in stratum lacunosum-moleculare, radiatum, and oriens. Commissural stimulation discharged pyramidal cells, followed by excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs). The frequency of theat-related membrane potential oscillation was voltage-independent in pyramidal neurons. At strong depolarization levels (less than 30 mV) pyramidal cells emitted sodium spike oscillation, phase-locked to theta. The observations provide direct evidence that theta-related rhythmic hyperpolarization of principal cells is brought by the rhythmically discharging interneurons. Furthermore, the findings in which interneurons were also paced by rhythmic inhibitory postsynaptic potentials during theta suggest that they were periodically hyperpolarized by their GABAergic septal afferents.

생물학 탐구에서 학생들이 생성한 가설검증방법의 유형

박순화,고경태,정진수,권용주 한국과학교육학회 2005 한국과학교육학회지 Vol.25 No.2

이 연구의 목적은 학생들의 생물학 가설검증방법의 유형을 분류 데 있다. 이를 위해 고등학생 35명과 대학생 40명을 표집 하여 수국, 제비 나비, 감자즙, 펭귄 등 4개의 가설검증 과제를 투입하였다. 각 과제에서 연구대상 학생들은 현상을 관찰하여 인과적 의문을 생성하고, 집단토의를 통해서 하나의 가설을 생성하였다. 그런 후 스스로 생성한 가설을 검증할 수 있는 방법을 고안하였다. 연구자들은 이렇게 고안된 학생들의 가설검증방법을 분석하여 몇 가지로 유형화하였다 그 결과에 의하면 먼저, 하나의 원인으로 된 가설의 검증유형은 직접 관찰법, 유사현상 비교법, 긍정 비교법, 긍정-부정 비교법, 비례 비교법 등으로 분류되었다 그리고 여러 개의 원인으로 된 가설은 크게 부분 검증법과 전체 검증법으로 구분되었고, 부분 검증법은 다시 단일 유형과 다수 유형의 하위 유형으로 구분되었으며, 전체 검증법은 유기적 유형, 기계적 유형, 혼합 유형 등의 하위 유형으로 구분되었다. The purpose of this study was to analyze the college students' and high school students' testing methods for biological hypotheses. Subjects were 35 11th grade students and 40 college students. Four hypothesis-testing tasks were developed and administered to the subjects: hydrangea, swallow butterfly, juiced potato, and penguin tasks. After being presented with the phenomena of the tasks, students were asked to generate questions and hypotheses and then to write a hypothesis-testing method on a questionnaire. Students' hypothesis-testing methods were classified into 5 types for mono-cause hypotheses; direct observation, similar phenomenon comparison, positive comparison, positive-negative comparison, and proportion comparison. In addition, students' hypothesis-testing methods were classified into 5 types for multi-cause hypotheses; mono type, poly type, organic type, mechanic type, and mixed type. This study also discussed the implications of these findings for teaching and learning in science education.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351)

호소수를 이용한 용존공기부상법(DAF)의 효율에 관한 연구

이선주,권순범 대한상하수도학회 2002 상하수도학회지 Vol.16 No.3

The purpose of testing the efficiency of the DAF process, we operated a pilot plant scaled to about 60㎥/day. We tested a sedimentation basin in comparison to DAF, changed the G values in the coagulation and flocculation process and the removal efficiency of the turbidity. As well, we investigated the efficiency of the DAF process. Variables such as low temperature water, coagulation and flocculation type and remove of algae ability were examined. Testing results showed that DAF is superior than a sedimentation basin in turbidity and UV-254 removal efficiency. A combination of the G values in the flocculation process yields the best results at 70/50 and alum of 83%, PACS is 87% marked removal efficiency. An in line static mixer and back mix coagulation type is better than a back mixed coagulation type in turbidity removal efficiency, and algae was almost removed after 1 hours,

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.

老人女性의 운동에 대한 認識 및 與件과 實態에 관한 調査硏究

梁順子,權永玉,元周淵 忠南大學校體育科學硏究所 1988 體育科學硏究誌 Vol.6 No.1

The purpose of this study was to provide a fundamental information for plan for positive and active participation or execution of exercise in Female elderly. Questionaire about the Leisure activities, the understanding for exercise and health, the actual and given condition of exercise participation and facilities was used for this study. 330 Aged women (over 60 year-old) who live in Seoul city were answered the Questionaire. Following conclusions were obtained were obtained : 1. Aged women's main daily works are managing house hold duties, attending a lecture in College for elderly, Seeing and Hearing of T. V. or Radio. And their Leisure activities are very simple (not various) and Static, for example seeing and Hearing of T. V. or Radio, gardening, reading, chess and Korean playing cards etc. 2. Aged women are very interested in Health and they point out illness and lack of exercise as a factor of weakness. Furthermore they understand the necessity of exercise for health and their daily life in old age, and also have a lot of intention to do exercise. 3. Exercises that aged women are enjoying or want to enjoy are taking a walk, mountain climbing, physical exercises, Aerobic dance, Badminton, and Jogging. 4. Almost aged women are doing exercise sometimes or usually, and also are seeing and hearing a T. V. or Radio for sports game. 5. Places that aged women are doing excercise are generally not well equipped place (e. g. medicinal water fountain, low hill, and around their house). Besides almost doing exercise alone or just with intimate friends and family. Club sports activities are not general. 6. As inconvinient factor for exercise, a lot of aged women pointed out the not specially equipped or established sports facilities for elderly, lack of number of equipment, and the long distance from home to facilities.

성폭력 피해여성의 경험에 관한 연구

정연강,권혜진,지순주,남선영,김경희 韓國學校保健學會 1996 韓國學校保健學會誌 Vol.9 No.1

This studies designed to work out a theoretical framework on the experience of sexual abuse from the perspective of grounded theory in an effort to provide more practical and efficient nursing intervention for female victims. The subcategories identified were "sexual abuse", "threatening", "absent mindness", "embarrassment", "horripilation", "dizziness", "wondrousness", "filthiness", "sexual curiousity", "violence level", "victim's age", "neighbors response", "victims personality", "common experience", "sexual abuse information", "family relations", "level of familiarity", "hiding", "suppression", "self-torture", "self-protection", 'avoidance", "asking aid", "withdrawal", "hatred", "confusion", "dodging", "remmant", and "pursuing". The 29 subcategories given above were further integrated into 16 categories such as "victimizedness", "being astounded", "filthiness", "degree", "developmental stage", "response pattern", "personality", "rarity", "infromation availability", "family support", "cover-up", "escaping", "informing", "negative internalization", and "positive pursuit of change". The core categories linked to all the other categories turned out to be "being taken aback" and "filthiness" incorporation the relevant subcategories. A total of 23 theoretical hypothesis emerged in the process of analyzing data. 1. the grater sexual curiosity, the weaker the senses of being taken aback and filthiness. 2. The weaker sexual curiosity, the stronger the senses of being taken aback and filthness. 3. The stronger the level of violence, The more violent the senses of being taken aback and filthiness. 4. The lower the level of violence, the weaker the senses of being taken aback and filthiness. 5. The younger the victims, the stronger the senses of being taken aback and filthness. 6. The older the victims, The weaker the senses of being taken aback and filthness. 7. 'Escaping' will transpire regardless of the given circumstances. 8. The weaker the senses of being taken aback and filthness, the more probable 'informing' and 'escaping' transpire. 9. The stronger the senses of being taken aback and filthness, the more probable 'informing' and 'escaping' transpire. 10. The more protective the response from 'informing' and 'escaping' transpire around, the more likely the response to 'being taken aback' and 'filthiness' will be 'informing' and 'escaping'. 11. The more repelling the response from around, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 12. The more open minded the personality of subject, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 13. The more closed the personality of subject, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 14. The more frequent the experience of sexual abuse, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 15. The less frequent the experience of sexual abuse, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 16. The more available information concerning sexual abuse, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 17. The less available information concerning sexual abuse, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 18. The more cohesive the family of the subject, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 19. The less cohesive the family of the subject, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 20. The more familiar the subject is with the abuser, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 21.The less familiar the subjec is with the abuser, the more likely the response to 'being taken aback' and 'filthiness' will be 'covering-up' and 'escaping'. 22. The more likely the response to 'being taken aback' and 'filthines' is 'informing' and 'escaping', the more positive changes the subject will pursue. 23. The more likely the response to 'being taken aback' and 'filthiness' is 'covering-up' and 'escaping', the more negative changes the subject will pursue. The following four hypothneses were conformed in the process of data analysis. 1) In case the level of violence is strong but 'being taken aback' and 'filthiness' in weak because of strong sexual curiosity and also if information concerning sexual abuse is not readily available and the frequency is low, negative internationalization marked by 'covering-up' and 'escaping' will take place despite the fact the subject is open-minded, the family is cohesive and the abuser is unfamiliar. 2) In case the level of violence is weak but 'being taken aback' and 'filthiness' is weak combined wit weak sexual curiosty and also if information concerning sexual abuse is readily available and the response from around is protective and the frequency is high, the subject will pursue positive changes to 'being taken aback' and 'filthiness' , further aided by the fact that the subject is open-minded, the family is cohesive and the abuser is unfamilar. 3) In case the level of violence is strong but 'being taken aback' and 'filthiness' is strong because of weak sexual curiosity and also if information concerning sexual abuse is reading available and the response from around is readily available and the response from around is protecvice and the frequency is low, the subject will persue positive changes marked by 'informing' and 'escaping' despit the fact that the family cohesion is weak and the abuser is familiar. 4) In case the level of violence is strong but 'being taken aback' and 'filthiness' is strong because of weak sexual curiosity and also if information concerning sexual abuse is not readily available and the response from around is respelling and the frequnecy is low negative internalization like 'covering-up' and 'escaping' will take place, further aggravated by the fact that the subject's personality is closed, family cohension is weak, and subject is familiar. On the basis of the above finding, it is recommended that nursing intervention should focus on promoting the milieu conductive to the victims pursuing positive changes along with the adequate aids from protection facilities as well as from the people around them.

Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예

남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.

세포성 면역 알고리즘을 이용한 AGV의 주행제어

이영진,손주한,조현철,이권순 동아대학교 정보기술연구소 2000 情報通信硏究所論文誌 Vol.8 No.1

In this paper, cell-mediated immune algorithm(CMIA) controller was proposed and applied for the autonomous guided vehicle(AGV) driving. It was based on specific immune response of the biological immune system which is the cell-mediated immunity. To verify the performance of the designed CMIA controller, some experiments were performed for the control of steering and speed of AGV. And then the displacement and speed tracking error of the AGV was mainly investigated. As a result, the capability of realization and reliableness were proved by comparing the response characteristics of the classical controller with the proposed CMIA controller

화학기상응축법으로 제조한 Fe-Co 나노입자의 구조 및 자기적 상태에 관한 뫼스바우어 분석

오세진,최철진,권순주,진상호,김병기 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.7

Nine nano-sized Fe-Co particle samples synthesized by Chemical Vapor Condensation(CVC) were analyzed using Mo¨ssbauer spectroscopy, XRD, BET and HRTEM. The synthesized nanoparticles consisted of metallic core and oxide shell structures, and their surfaces were covered with a-FeOOH, γ-FeOOH and Fe_(3)O_(4). The increase of cobalt content enhanced magnetic field. However, when the decomposition temperature and the oxygen content in the carrier gas (Ar) increased, the magnetic field of nanoparticles reduced with decreasing the average particle size. with increasing the vacuum pressure, the average particle size and the magnetic field increased.