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요통(腰痛) 환자에 대한 침치료(針治療)와 직접구(直接灸) 병행치료(竝行治療)에 대한 비교(比較) 연구(硏究)
위종성,원승환,황정수,선승호,안영민,손승현,박기철,박희수,We, Jong-sung,Won, Seung-hwan,Hwang, Jung-soo,Sun, Seung-ho,Ahn, Young-min,Sohn, Seung-hyun,Park, Ki-chul,Park, Hee-soo 대한침구의학회 2004 대한침구의학회지 Vol.21 No.6
Objective : The purpose of this report is to examine the effects of direct moxibustion in the Low back pain patient. Methods : Clinical studies were done 30 patients who were treated with low back pain to Dept. of Acupuncture & Moxibustion, of Oriental Medical Sang-Ji University from September 1, 2003 to August 31, 2004. We treated them by Oriental medical therapy(including direct moxibustion)for 10 days. The evaluation was performed five times(admission day, before and after each twice). Results : 1. VAS was decreased after direct moxibustion for 10 days significantly(p<0.01). 2. After direct moxibustion, S.L.R. T angle of patients were increased. ConclUsions : We brought to the conclusion that direct moxibustion has possibility to the efficient to cure the Low back pain. So we suggest the possibility to use this treatment for Low back pain.
Sang-Ho Lee,Ki-Seok Oh,Yong-Min Kim,이진아,Seong-Won Sohn,손창호 한국임상수의학회 2016 한국임상수의학회지 Vol.33 No.5
Cell-free fetal RNA is useful to determine fetal sex and detect other inherent genetic disorders. However,non-invasive fetal sex determination methods using fetal RNA from maternal plasma is not yet well established instudies pertaining to bovine animals. Thus, the aim of this study was to systematically evaluate the presence of themale-specific ZRSR2Y gene transcript in maternal plasma using Reverse Transcriptase-Polymerase Chain Reaction (RTPCR)assays, and to verify its accuracy, sensitivity, and specificity in determining fetal sex between 30 and 100 daysof gestation. Overall accuracy, sensitivity, and specificity of the ZRSR2Y gene transcripts in determining fetal sexwere 89.1%, 86.3%, and 100%, respectively. The 30 to 100 days of gestation were further classified into five stagesof gestation, and each stage had relatively high accurate, sensitive, and specific results. Overall, these results indicatethat the expression of the ZRSR2Y gene can be used for fetal sex determination in bovine animals using circulatingcell-free RNA in maternal plasma during early pregnancy
Protective Effects of Natrii Sulfas on Cerebral Focal Ischemia Induced by MCAO in Rats.
Sohn, Youngjoo,Kang, Ho Chang,Kim, Kon Sik,Park, Sun-Min,Sohn, Nak-Won,Jung, Hyuk-Sang,Kim, Sung-Hoon Institute for Advanced Research in Asian Science a 2009 The American journal of Chinese medicine Vol.37 No.2
<P>This study examined the effect of Natrii sulfas, a treatment for stroke patients suffering constipation in Oriental medicine, on the physiological indices and brain edema of rats. Brain edema was induced by a middle cerebral artery occlusion (MCAO), Natrii sulfas was administered after the MCAO. At 3, 6, 15, 24, and 48 hours after reperfusion, the physiological indices such as the fecal weight, urine volume and water content in the stools were assessed. The edema index was measured 48 hours after reperfusion. At 48 hours, the expressions of iNOS, MMP9, VEGF, GFAP, Bax, Bcl-2, c-Fos, and HSP72 positive astrocytes were observed on the brain tissues by immunohistochemistry. Natrii sulfas significantly improved the decrease in fecal weight, urine volume and water content in the stool caused by the ischemic insult (p < 0.05) and attenuated the brain edema caused by the ischemia insult (p < 0.05). Natrii sulfas significantly down-regulated iNOS and MMP9 expressions and attenuated the astrocyte swelling due to brain edema in the penumbra of the cerebral cortex of MCAO rats. Natrii sulfas reduced the excess Bax and HSP72 expressions in ischemic brain, which was statistically significant in the penumbra of the cerebral cortex but not in the caudate putamen. These results suggest Natrii sulfas has a protective effect on ischemia-induced brain edema and improves the physiological symptoms.</P>
Genetic Variation in the Promoter Region of<i>Chitinase 3-Like 1</i>Is Associated with Atopy
Sohn, Myung Hyun,Lee, Ji Hyun,Kim, Kyung Won,Kim, So Won,Lee, Sung Hee,Kim, Kyu-Earn,Kim, Kyung Hwan,Lee, Chun Geun,Elias, Jack A.,Lee, Min Goo American Thoracic Society 2009 American journal of respiratory and critical care Vol.179 No.6
<P>RATIONALE: Atopy or atopic syndrome is an allergic hypersensitivity subject to hereditary influences. Aberrant expression of chitinase 3-like 1 (CHI3L1), also known as YKL-40 or HC gp-39, is involved in the pathogenesis of inflammatory and allergic diseases. OBJECTIVES: The genetic contribution of CHI3L1 gene to atopic susceptibility was investigated using an integrated population genetic and molecular analysis. METHODS: Genetic variations in CHI3L1 were identified and genotyped in 295 unrelated patients with atopy and 180 control subjects. Serum YKL-40 and IgE levels were analyzed according to genotype. The effects of a promoter polymorphism (g.-247C/T) on promoter activity were examined in reporter and protein binding assays. MEASUREMENTS AND MAIN RESULTS: In the case-control association analysis, the g.-247C/T polymorphism at the promoter region (rs10399805; P = 0.0062) and the IVS7+82C/T polymorphism at intron 7 (rs2275353; P = 0.0056) of CHI3L1 showed a significant association with atopy. Subjects with the g.-247T risk allele had significantly higher serum YKL-40 (P < 0.0001) and IgE (P = 0.012) levels. An in vitro promoter assay using THP-1 human monocyte cells revealed that the C to T conversion at g.-247 induced a more than twofold increase of reporter gene expression. Moreover, the g.-247T allele showed an increased affinity for CCAAT enhancer-binding protein, a well known transcriptional activator, by electrophoretic mobility shift assay. Accordingly, subjects with the g.-247TT genotype showed a 2.5-fold increase in CHI3L1 mRNA expression in peripheral blood cells compared with those with the g.-247CC genotype. CONCLUSIONS: These results strongly suggest that the g.-247C/T polymorphism in the CHI3L1 promoter region is associated with the risk of atopy.</P>
Sohn, Young Bae,Kim, Su Jin,Park, Sung Won,Park, Hyung‐,Doo,Ki, Chang‐,Seok,Kim, Chi Hwa,Huh, Seung Won,Yeau, Sunghee,Paik, Kyung‐,Hoon,Jin, Dong‐,Kyu Wiley Subscription Services, Inc., A Wiley Company 2010 AMERICAN JOURNAL OF MEDICAL GENETICS PART A Vol.a152 No.12
<P><B>Abstract</B></P><P>Mucopolysaccharidosis type II (Hunter syndrome) is a lysosomal storage disease caused by a deficiency of iduronate‐2‐sulfatase. Most reported patients are males because of X‐linked recessive inheritance pattern. Only a few female patients with Hunter syndrome have been reported, and there is no prior report of offspring from a patient with Hunter syndrome. In this report, we describe a woman with mild manifestations of Hunter syndrome who gave birth to a daughter. Both the mother and daughter carried the p.R443X mutation in exon 9 of the <I>ID2S</I> gene. Iduronate‐2‐sulfatase activity in the mother was as low as that found in male Hunter syndrome patients, but it was in the low‐normal range in her daughter. Unlike her mother, the daughter did not show any physical signs of Hunter syndrome, and urinary excretion of glycosaminoglycan was within normal range. However, she had severe pulmonary vein stenosis with pulmonary hypertension and a large atrial septal defect and died at 11 months of age. © 2010 Wiley‐Liss, Inc.</P>
( Sung Heon Song ),( Young Jin Jun ),( Seung Sam Paik ),( Hyun Jung Kwak,),( Sang Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Dong Ho Shin ),( Sung Soo Park ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.6
Non small cell lung cancer (NSCLC) frequently metastasizes to brain, bone, liver, and adrenal glands. While an autopsy of NSCLC reveals some cases of metastasis to the kidney, clinical detection of renal metastases is extremely rare. Furthermore, metastases to the kidney usually present as multifocal or bilateral lesions and solitary renal metastases are usually suspected to be renal cell carcinoma. We now report a case of asymptomatic solitary renal metastasis from a primary squamous cell carcinoma, which was detected by routine surveillance with abdominal CT after curative surgery.
A Survey of Dental Caries in Mongolia in 2014
Sung-Wook Yun,Seung-Chul Shin,Yeon-Soo Chang,Ho-Kil Kim,Sun-Joo Sohn,Jung-Kyu Kim,Soo-Jung Park,Hyun-Jun Yoo,Ja-Won Cho 대한예방치과학회 2014 International Journal of Clinical Preventive Denti Vol.10 No.3
Objective: The authors had conducted the oral health survey of Mongolian people with dual methods as direct oral examination by trained dentists and indirect method through taking the intra oral photos of the subjects by use of Nikon digital camera, in order to interpretate the image for finding the caries states of the subject people. Methods: One thousand three hundred seven persons of subject were examined in this dental survey, and classified with age distribution as 5, 9, 12, 15, 20s, 40s, and 60s years old at urban area of Ulaanbaatar area and the others at the rural areas at Bornuur as steppe area and at Mandalgovi as desert area. Results: Primary decayed tooth (dt), primary filled tooth (ft), and primary decayed, filled tooth (dft) index of Mongolian 5 years old were calculated as 6.25±4.56, 1.09±2.17, and 7.34±4.69 as high in caries incidence without treatment. Permanent decayed tooth (DT), permanent filled tooth (FT), permanent decayed, missing, filled tooth (DMFT) index of Mongolian 12 years old were as 2.37±2.76, 0.29±0.93 and 2.93±3.11, as high caries incidence without early treatment, and 12.1% of DMFT rate, 77.7% of DMF rate as the most children have been caries experienced. Conclusion: Oral health promotion and early treatment of caries in public oral health plan were recommended to promote the oral health level of Mongolian people.