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( Ja Kyung Koo ),( Jeong Han Kim ),( Yun Jung Choi ),( Cho I Lee ),( Jae Hoon Yang ),( Hyeon Young Yoon ),( Hye Jin Choi ),( Soon Young Ko ),( Won Hyeok Choe ),( So Young Kwon ),( Chang Hong Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: The Model for end-stage liver disease (MELD) has been widely used for predicting short term mortality in cirrhotic patients and employed for deceased donor liver allocation in the U.S. In year 2011, modification of MELD score was published (Gastroenterology 2011;140:1952-1960). We aimed to validate this for Korean cirrhotic patients. Methods: We retrospectively reviewed medical records of cirrhotic patients who admitted at konkuk university hospital from 2006 to 2010. Predictive value for 3 months mortality was compared between Refit MELD, Refit MELD-Na, current MELD, current MELD-Na, Child-Pugh score. Comparison was done by calculating area under receiver operating curve (AUROC). Results: Total 882 patients were enrolled and there were 77 deaths (8.7%) within 3 month. The most common etiology was alcohol (n=400, 45.4%) and the next was hepatitis B (n=302, 34.2%). 666 patients were male (75.5%), and Child-Pugh class A, B and C were 256 (29.0%), 379 (43.0%) and 247 (28.0%). AUROC of Refit MELD, Refit MELD-Na, MELD, MELD-Na and Child-Pugh score were 0.842, 0.817, 0.844, 0.848 and 0.831 respectively. There was no significant difference between scores except between Refit MELD-Na and MELD (p=0.0447), andu between Refit MELD-Na and MELD-Na (p=0.0008). After exclude Child-Pugh class A patients, AUROC of Refit MELD, Refit MELD-Na, MELD, MELD-Na and Child-Pugh score were 0.793, 0.751, 0.795, 0.798 and 0.765 respectively. The Refit MELD-Na showed lower value than MELD-Na (p=0.0005), MELD (p=0.0190) and Refit MELD (p=0.0174). Conclusions: Improvement of predictive value for 3 months mortality was not definite. Especially Refit MELD-Na showed the lowest value. This result may be due to difference of underlying etiology of cirrhosis between Korea and U.S. More large prospective study is warranted.
The study on the participation of Korean dentists in public posts
( Ja-won Cho ),( Su-hyun Shim ) 조선대학교 구강생물학연구소 2017 Oral Biology Research (Oral Biol Res) Vol.41 No.3
There have been few reports about the manpower planning of dentists in the public sector in Korea. The purpose of this study was to research dentists` opinions about the public posts, and to suggest public health policies for the new dental manpower position. A total of 536 dentists were asked to fill out questionnaires inquiring about their opinions of public posts. We used an online survey methodology to involve 500 participants. The chi-square tests and frequency distributions were implemented to analyze the dentists` opinions about the public posts. The significance level of 0.05 was applied. A statistical package SPSS 21.0 was used for the analysis. An overwhelming majority of dentists (95.6%) answered that it is necessary to set up public posts for dentists. Respondents pointed out that the Korean Dental Association (35.5%) and the Ministry of Health and Welfare (33.2%) were the main institutes that should carry out this process. Especially, 47.4% of dentists answered they would quit their job if they had opportunities to fill public posts. Most dentists wanted to work as administrative officials (36.3%) in the public sector. Many dentists (62.4%) wanted to contribute to public welfare as health care professionals in public posts. Most of all, respondents (95.6%) answered that it is imperative to improve the manpower system of dentists in public posts.
( Ja Young Moon ),( Won Il Kim ),( Jin Hur ),( Won Kyung Kim ),( Min Su Choi ),( Jae Sam Lim ),( Sung Bok Kim ),( Jeong Sang Cho ),( Yeong Hwan Choi ),( Byoung Joo Seo ) 한국동물위생학회(구 한국가축위생학회) 2017 韓國家畜衛生學會誌 Vol.40 No.4
Enterotoxigenic Escherichia coli (ETEC) strains producing each F4, F5, F6 and F41 fimbriae were lysed by GI24 peptide. The lysate cells were used as ETEC vaccine candidate. This study was carried out to examine whether intramuscular (im) immunization of pregnant sows with the novel vaccine candidate could effectively protect their neonatal piglets against ETEC colibacillosis. All pregnant sows were primed at 11 weeks and were boosted at 14 weeks of pregnancy. Group A sows were im inoculated with PBS. Group B sows were im immunized with 2×10<sup>9</sup> the mixture. Seral IgG, colostral IgA and IgG titers from group B sows, and seral IgG and IgA levels in group B piglets were significantly higher than those of group A sows and piglets, respectively. After challenge with wild-type ETEC, diarrhea and mortality was not observed in group B piglets. However, diarrhea was observed in 66.7% of group A piglets, and 33.3% mortality was observed. These findings indicate that im immunization of sows with the mixture of the novel vaccine candidate can effectively protect their offspring from ETEC colibacillosis.
Ja Kyung Lee,Eu Jeong Ku,Su-jin Kim,Woochul Kim,Jae Won Cho,Kyong Yeun Jung,Hyeong Won Yu,Yea Eun Kang,Mijin Kim,Hee Kyung Kim,Junsun Ryu,June Young Choi 대한외과학회 2024 Annals of Surgical Treatment and Research(ASRT) Vol.106 No.1
Purpose: Current clinical practices favor less or no thyroid-stimulating hormone (TSH) suppression for low- to intermediate-risk thyroid cancer patients who receive thyroid lobectomy. The association of TSH suppression on healthrelated quality of life (HR-QoL) in patients after thyroid lobectomy is not well studied. This study aimed to evaluate the effect of TSH suppression on patient HR-QoL after thyroid lobectomy. Methods: This study included patients enrolled in an ongoing, multicenter, randomized controlled study investigating the effects of TSH suppression. Patients were randomized to either the low-TSH group (TSH target range, 0.3–1.99 μIU/mL) or the high-TSH group (TSH target range, 2.0–7.99 μIU/mL). The HR-QoL, hyperthyroidism symptom, and depression symptom questionnaires performed preoperatively and 2 weeks and 3 months postoperatively were evaluated. Results: Total of 669 patients (low-TSH group, 340; high-TSH group, 329) were included. Although total HR-QoL score changes were not different between the 2 groups, the high-TSH group had a significantly higher score in the physical domain at postoperative 3 months (P = 0.046). The 2 groups did not have significant differences in hyperthyroidism and depression scores. Conclusion: In the short-term postoperative period, the physical HR-QoL scores in thyroid lobectomy patients were better when they did not receive TSH suppression. This study suggests the importance of considering HR-QoL when setting TSH suppression targets in thyroid lobectomy patients.
The Effect of Attachment-Improvement Activities for Korean Children Ages 12 to 35 Months
Won Young Rhee,Young Ja Lee,Chan Ok Park,Hyung Sook Cho 한국유아교육학회 2000 INTERNATIONAL JOURNAL OF EARLY CHILDHOOD EDUCATION Vol.5 No.-
The purpose of the study was to find out whether the attachment-improving activities for working mothers of young children and their teachers at childcare centers could increase the attachment level when Q-set was given. Activities, which were developmentally appropriate and easy to perform at home and centers were selected. Mothers and teachers were expected to do at least two activities a week at home and centers with children for 10 weeks. Sixty three young children, their mothers and 19 teachers participated in the study. The results of the study indicated that the attachment level of the teachers of the experimental group improved significantly compared to that of the comparative group. But mothers‘ attachment level with children for both groups shows no significant difference. For a long time it has been believed that attachment is the emotional quality, which should be formed at home between mothers and their children. However, this research showed that the attachment level can be improved by teachers. It is important to improve the attachment quality in social contexts such as centers.
Cho, Chi‐,Hyun,Nam, Myoung Hyun,Kim, Jang Su,Han, Eun Taek,Lee, Won Ja,Oh, Jun Seo,An, Seong Soo A.,Lim, Chae Seung Blackwell Publishing Ltd 2011 Tropical medicine & international health Vol.16 No.2
<P><B>Summary</B></P><P>Introduction of rapid malaria diagnostic tests (RDT) initiated numerous field evaluations in various epidemiologic settings. But the efficiency of some RTD kits based on aldolase raised reservations for direct implementation of RDT into clinical settings. We performed Binax Now malaria test in 84 Korean <I>Plasmodium vivax</I> isolates and compared it with the traditional Giemsa stain microscopy test as the reference standard. The sensitivity of Binax Now was 62.0% for <I>P.?vivax</I> cases (52/84, 95% CI 51.2–71.6%) with 100.0% specificity (50/50, 95% confidence interval 92.9–100%). After the aldolase gene sequence analysis of 84 isolates, two synonymous mutations in aldolase gene were identified in both Binax Now positive and negative samples. No significant association between the mutations and Binax Now malaria tests was found. Thus, the genetic variability would not explain the poor performance of <I>P.?vivax</I> RDTs by detecting aldolase in ROK isolates.</P>