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Xpert MTB/RIF Assay as a Substitute for Smear Microscopy in an Intermediate-Burden Setting
Lee, Hyun-Seung,Kee, Seung-Jung,Shin, Ju-Hyeon,Kwon, Yong-Soo,Chun, Sejong,Lee, Jun Hyung,Won, Eun Jeong,Choi, Hyun-Jung,Kim, Soo Hyun,Shin, Myung-Geun,Shin, Jong-Hee,Suh, Soon-Pal American Thoracic Society 2019 American journal of respiratory and critical care Vol.199 No.6
Lee, Ji-Yeon,Park, Sung-Woo,Chang, Hee Kyoung,Kim, Ho Young,Rhim, TaiYoun,Lee, June-Hyuk,Jang, An-Soo,Koh, Eun-Suk,Park, Choon-Sik American Thoracic Society 2006 American journal of respiratory and critical care Vol.173 No.7
<P>BACKGROUND: ADAM33 has been identified as a novel asthma susceptibility gene in genomewide screening and association studies. High-level expression in smooth muscles and fibroblasts suggests that ADAM33 plays a role in airway remodeling in patients with asthma. METHODS: The ADAM33 protein was identified in the bronchoalveolar lavage (BAL) fluids of patients with asthma and normal control subjects using Western blotting antibody against the catalytic domain. ADAM33 expression was analyzed using immunohistochemical staining of mucosal biopsy specimens. The levels of ADAM33 protein in the BAL fluids were measured by dot blotting, and were correlated with the FEV1 values of the patients with asthma. RESULTS: Western blot analysis revealed the presence of the ADAM33 protein, with a molecular mass of approximately 55 kD in the BAL fluids. ADAM33 was expressed in the smooth muscles and basement membranes of almost all the patients with asthma, but was absent in the normal control subjects. The ADAM33 levels were increased significantly in patients with moderate to severe asthma and in patients with mild asthma, as compared with normal control subjects (p = 0.001 and p = 0.016, respectively). The ADAM33 protein levels correlated inversely with the FEV(1)% predicted in the patients with asthma (r = -0.486, p = 0.018). CONCLUSIONS: ADAM33 is associated with asthma development, and the levels of ADAM protein are related to asthma severity.</P>
Association Analysis of CD40 Polymorphisms with Asthma and the Level of Serum Total IgE
Park, Ju Hyun,Chang, Hun Soo,Park, Choon-Sik,Jang, An-Soo,Park, Byung Lae,Rhim, Tai Youn,Uh, Soo-Taek,Kim, Yong Hoon,Chung, Il Yup,Shin, Hyung Doo American Thoracic Society 2007 American journal of respiratory and critical care Vol.175 No.8
Complement C3a and C4a Increased in Plasma of Patients with Aspirin-induced Asthma
Lee, Seung-Ha,Rhim, TaiYoun,Choi, Yun-Sung,Min, Ji-Won,Kim, Sung-Ho,Cho, Sun-Young,Paik, Young-Ki,Park, Choon-Sik American Thoracic Society 2006 American journal of respiratory and critical care Vol.173 No.4
<P>RATIONALE: Aspirin-induced asthma (AIA) is a distinct clinical syndrome that affects up to 10% of adults with asthma. Although eicosanoid metabolites appear to play an important role in AIA, the exact pathogenic mechanism for the syndrome remains obscure. In addition, the proposed mechanism fails to explain why aspirin does not cause bronchoconstriction in all individuals. OBJECTIVES: We aimed to identify proteins that were differentially expressed in between AIA and aspirin-tolerant asthma (ATA) plasma. Methods and Main Results: By using a proteomics approach, six proteins were found to be differentially expressed in plasma between patients with AIA and patients with ATA at baseline, and eight proteins were significantly up- or down-regulated after aspirin challenge in patients with AIA. These proteins, which were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry, can be classified into four groups: complement components, apolipoproteins, modified albumin, and unknown proteins. Among them, the complement component levels in plasma were validated by using ELISA. Plasma concentrations of C3a and C4a were higher in patients with AIA (n = 30) than in patients with ATA (n = 24). After the aspirin challenge, C3 decreased in both patients with AIA and those with ATA, but the C3a concentration increased in the AIA patient group (p = 0.019). Moreover, C3a and C4a levels and the ratios of C3a/C3 and C4a/C4 were correlated with the changes of FEV(1) values after aspirin challenge. CONCLUSIONS: Aspirin intolerance may be related to alterations in the levels of complements, as well as those of lipoprotein and other proteins.</P>
Early-Stage Lung Cancer Mimicking Pulmonary Arteriovenous Malformation
Choi, Kyoung Hwa,Park, Seoung Ju,Min, Kyung Hoon,Kim, So Ri,Lee, Min Hee,Chung, Chi Ryang,Han, Hyo Jin,Han, Young Min,Chung, Myung Ja,Lee, Yong Chul American Thoracic Society 2011 American journal of respiratory and critical care Vol.183 No.11
Clinical Significance of Differentiation of Mycobacterium massiliense from Mycobacterium abscessus
Koh, W.-J.,Jeon, K.,Lee, N.Y.,Kim, B.-J.,Kook, Y.-H.,Lee, S.-H.,Park, Y.K.,Kim, C.K.,Shin, S.J.,Huitt, G.A. American Thoracic Society 2011 American journal of respiratory and critical care Vol.183 No.3