유제놀에 의한 즉시형 알레르기 반응의 억제

김상현,신태용,김형룡,이영미,이은희,신보경,김윤철,안년형,김형민 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The current study evaluates the capacity of eugenol to regulate immediate allergic reaction by control of histamine release. Administrations of eugenol (1 M/kg. i.p.) at 60 min before and 5.10 min after the compound 48/80 treatment (8 mg/kg.i.p.) were shown the mortality rates as 0.44.4. and 77.8%. respectively. A 60 min before administered group revealed a singificant inhibition of serum his-tamine release compared with those of 5 and 10 min after the compound 48/80 injection. Eugenol (6-48mM) was also showed a dose-dependent activity on the compound 48/80-induced histamine release from the highly purified population of Alcian Blue-positive peritoneal mast cells. These results indicate that in vitro treatment with exogenous eugenol inhibited the active response of mast cell populations and modulated its characteristics.

곰쓸개 복용 후 발생한 육안적 혈뇨와 신유두부 괴사증 1예

김우진,한민석,김수항,박인형,박진석,선제형,홍세인,박옥영,신정현,이숭,신병철 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Renal papillary necrosis occurs most commonly in association with urinary tract infection, diabetes mellitus, sickle cell disease, vascular disease, and analgesic nephropathy. Clinical presentation may be related to symptoms of pyelonephritis such as flank pain, renal colic, hematuria, Proteinuria, recurrent fever. The necrotic tissue may be sloughed off, and the diagnosis can sometimes be made by finding piece of renal medullary tissue in the urine. Pyelography may demonstrate cavities and sinuses in the resion of papillae. Anuria & oliguria can lead to the acute renal failure, and especially prognosis and progress may be affect influenced by urinary infection. We report a case of renal papillary necrosis with ingestion of bear gallbladder. On pyelography, Persistent contrast is diagnostic clue of renal papillary necrosis. This case is not be related to urinary tract infection, but occurred acute renal failure. Expectant treatment was gone.

北韓의 軍事政策과 軍事戰略

申亨澈 부산정치학회 1994 부산정치학회보 Vol.1994 No.4

광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교

신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.

苛性소다 處理에 依한 農産副産物의 飼料價値 增進硏究

辛炯泰,韓泳根,李光淳 成均館大學校 1982 論文集 Vol.31 No.-

A factorial experiment (6x5) involving 6 kinds of crop residues (barley straw, corn stover, rice straw, rye straw, soybean straw, wheat straw), 5 levels of sodium hydroxide (0,3,6,9,12%) was conducted with four Korean native male goats using a practical dairy cattle ration. Crop residues digestion was measured in situ with nylon bags containing test material in the rumen of the fistulated goats. Bags of 9×15㎠ made of 100-mesh nylon cloth were filled with one of ground crop residues to give 3-5g dry matter. These bags were put into the ventral sac of the rumen and taken out at the end of 72 hours. They were washed in cold water, dried at 105℃ for 8 hours and weighed. The straw dry matter remaining was calculated by difference and analyzed for organic matter. The results which were obtained with this experiment were as follows: 1. The nylon bag dry matter digestibility (NBDMD, %) and nylon bag organic matter digestibility (MBOMD, %) of NaOH-treated crop residues were highly significant different (P<0.01) in different levels of NaOH and kinds of crop residues. 2. The relationship between cell-wall constituents (Y, %) of crop residues and level of NaOH (X, %) was: Y=-1.63X+77.06 (r=0.99^**) 3. The optimum level of NaOH for improving NBDMD (%) from crop residues, on the basis of Shin et al (1981), was 0% NaOH for soybean straw, 3% NaOH for barley straw and wheat straw, 6% NaOH for corn stover and rice straw, and 12% NaOH for rye straw.

간질환에서의 Cellulose acetate 전기 영동 분획변화에 대한 연구

신태호,이형동,김창세 朝鮮大學校 醫學硏究所 1979 The Medical Journal of Chosun University Vol.- No.-

Cellulose acetate electrophoretic fractions of serum proteins were performed and the following results were obtained: 1) The mean values for the electrophoretic fraction of serum proteins in control groups (normal) were 3.29±0.6gm/100㎖ (48.36±6.65%), 0.22±0.09gm/100㎖ (3.49±1.32%), 0.76±0.23gm/100㎖(10.58±2.87%), 0.99±0.20gm/100㎖ (14.38±3.27%), and 1.50= 0.34gm/100㎖ (21.28±4.64%), respectively, for the albumin, α_1-, α_2-,β-, and γ-glo-bulin fractions. 2) The mean values for the electrophoretic fractions of serum proteins in liver cirrhosis group were 2.41±0.46gm/100㎖ (34.11±8.27%) 0.28±0.15gm/100㎖ (4.06±2.19%), 0.64±0.24gm/100㎖ (9.08± 3.67%), 1.00±0.34gm/100㎖ (14.08±4. 23%), and 2.74±0.99gm/100㎖(38.78±9.91%), respectively, for the albumin, α_1-, α_2-,β-, and γ-globulin fractions. It was also found that the changes observed in liver cirrhosis were more marked than in control group particularly other forms of liver disease-the most charac-teristic abnormalities being decreased concentrations of albumin and increased concentra- tions of γ-aglobulin. 3) The mean values for the electrophoretic fractions of serum proteins in heptitis group were 2.67±0.76gm/100㎖ (41.95±10.43%), 0.30±0.15.gm/100㎖ (4.60±2.62%), 0.73±0.28gm/100㎖ (11.19±4.35%), 0.88±0.36gm/100㎖(14.03±4.33%), and 1.74±0.55gm/100㎖ (27.51±6.11%), respectively, for the albumin, α_1-, α_2-,β-, and γ-globulin fractions. It was found that the decreased concentration of albumin observed in hepatitis was more marked than in control group. 4) The mean values for the electrophoretic fractions of serum proteins in hepatoma group were 2.66±0.58gm/100㎖(38.04±8.92%), 0.31±0.13gm/100㎖(4.53±2.39%), 0.75±0.31gm/100㎖(10.79±3.68%), 1.11±0.46gm/100㎖(16.00±5.43%), and 1.96±0.63gm/100㎖ (28.73±8.13%), respectively, for the albumin α_1-, α_2-,β-, and γ-globulin fractions. It was found that decreased concention of albumin and increased concentration of γ-globulin fractions in hepatoma were more marked than in control group. 5) The mean values for the electrophoretic fractions of serum proteins in cholecystopa- thy group were 2.55±0.65gm/100㎖(40.63±11.56%), 0.25±0.14gm/100㎖(4.13±2.03%), 0.82±0.25gm/100㎖(12.69±3.49%), 0.97±0.31gm/100㎖(14.75±3.21%), and 1.77±0.75gm/100㎖(27.25±9.51%), respectively, for the albumin, α_1-, α_2-,β-, and γ-globulin fractions. It was found that the decreased concentration of albumin in cholecystopathy was more marked than in control group. 6) The mean values for the electrophoretic fractions of serum protins in liver abscess group were 2.36±0.43gm/100㎖(35.27±5.06%), 0.58±0.28gm/100㎖(8.38±3.43%), 0.98±0.36gm/100㎖(l4.38±4.89%), 0.95±0.29gm/100㎖(13.69±3.12%), and 1.83±0.71gm/100㎖ (27.15±8.40%), respectvely, for the albumin, α_1-, α_2-,β-, and γ-globulin fractions. It was found that decreased concentration of albumin and increased concentration of α_1-globulin fractions were marked than in control group. 7) All of the clinical chemistry data, so-called liver function tests, were shown the increased concentrations except cholesterol. Most chracteristic findings were the increased concentration of serum potassium observed in liver cirrhosis and hapatoma groups.

뇌간 경색증 후 핵간 안근마비를 동반한 수구증후군

정두신,이보람,조상걸,박형국,신현길,성기범 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

정향 수침액에 의한 아나필락시의 억제 효과

신태용,김상현,이석봉,엄동옥,임종필,이은희,김형민 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The current study evaluates the capacity of Caryophylli Flos water extract(CFWE) to regulate immediate allergic reaction by control of histamine release. CFWE was found to exhibit a ingibitory activity on the compound 48/80-induced anaphylaxis. CFWE inhibited the serum histamine release induced in anaphylaxis by compound 48/80. CFWE was also showed a dose-depent activity on the conpound 40/80-induced histamine release from the highly purified population of Alcian Blue-positive peritoneal mast cells. This result suggest that CFWE may be useful for the prevention and treatment of allergy related disease.

실험적 부자 시신경병증에서 Methylprednisolone의 효능

신재필,이상희,서형덕,김인택 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

동물실험에서 aconite 또는 aconitine은 신경계통에 독성을 나타낸다고 이미 알려져 있다. 그러한 독성은 시유발전위와 병리조직에서 탈수초증으로 나타난다. 저자들은 실험적으로 aconite을 주입하여 탈수초신경증을 일으킨 후 고용량이 methylprednisolone(MP)투여가 효능이 있는지를 알아보고자 하였다. Aconite를 복강내 주입하고 곧 이어 가토의 이연정맥으로 MP를 주입한 군과 aconite만을 주입한 군으로 나누었고 이들을 서로 비교하였다. 그리고 이 두 군을 정상군과도 비교하였다. 시유발전위에서 aconite를 주입후 MP를 투여한 군에서 aconite만을 주입한 군에 비하여 onset latency와 peak latency 그리고 진폭 모두에서 2주째에 통계학적으로 의미있게 회복되었으나 (p<0.05) 정상군과 비교하여 의미있는 차이를 나타내지 아니하였다. 그러나 정상군과 비교하여 1개월과 2개월에서 onset latency은 의미있게 지연되었고 (p<0.05) peak latency와 진폭은 다소 회복되었으나 정상군의 평균값에는 미치지 못하였다. 병리조직에서 MP으로 치료한 군과 aconite만을 주입한 군 모두에서 수초의 탈수초변화가 관찰되었으나 MP으로 치료한 군은 상대적으로 탈수초변화가 현저하지 아니하였다. 본 연구에서 실험적으로 가토에 aconite를 전신에 투여하여 시신경병증을 일으킨 후 고용량의 MP를 즉시 투여한 경우에 시신경의 기능을 정상상태까지 회복시키는데는 한계가 있으나 부분적으로 시신경의 기능을 회복시키는데 도움이 될 것으로 생각된다(한안지 37:1730~1740, 1996). Studies in animals indicate that aconitine or aconite has toxic effects in the visual system of a rabbit model. Such a toxic effects causes myelo-optic neuropathy in the visually evoked cortical potential(VECP) and histopathologic studies. Whether the administration of intravenous high-does of methyprednisolone(MP) in the myelo-optic neuropathy caused by aconitine(1.5㎖/㎏, equivalent to 0.7㎎/㎏ of aconitine) is experimentally effective remains uncertain. The group treated with MP(daily 30㎎/㎏×2 for 3 days followed by 15㎎/㎏ for 3 days) in addition to aconite was compared with the aconite alone group and the normal control group. In the MP treated group, increased recovery of onset latency, peak latency, and amplitude in VECP in comparision with the aconite alone group was recorded at 2 weeks(p<0.05). The MP treated group in comparision with the normal control group showed a significant delay in onset latency at 1 month and 2 months(p<0.05). But, the amplitude in both the MP treated group and the aconite alone group increased at 2 months and did not show a significant difference in comparision with the normal group(p<0.05). In histopathologic study, pathologic findings of myelin sheath in the MP treated group were less severe than in the aconite alone group generally. The true benefit of high-does MP was at least clear within 2 weeks. The authors conclude that treatment with intravenous high-does MP immediate after aconite injection may have some beneficial effects in recovery of neurologic function although such a treatment do no have the definite recovery in aconite induced myelo-optic neuropathy(J Korean Ophthalmol Soc 37:1730~1740, 1996).

韓國統一政策의 變遷過程에 관한 硏究

신형철,정경환 慶星大學校 1992 論文集 Vol.13 No.3