관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이

한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.

경제환경 변화와 금융산업의 구조조정 방향

김병주 명지대학교 금융지식연구소 1998 보험과 금융연구 Vol.2 No.-

韓國의 인플레이션과 總需要管理政策

金秉柱 서울大學校 經濟硏究所 1979 經濟論集 Vol.18 No.4

부실기업문제를 보는 하나의 관점 : A Game on the Brink

김병주 西江大學校 經商大學 1989 經商評論 Vol.- No.11

水稻作 主要 省力栽培技術別 經濟的效果 比較硏究 : 어린모, 直播栽培의 經營成果를 중심으로

朴坪湜,趙誠柱 韓國農業政策學會 1996 농업경영정책연구 Vol.23 No.1

정신분열증 환자의 혈청 총 CPK 활성치 및 동위효소의 분획상

金平周,金明正,延炳吉 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.4

The purpose of this study was to determine the total serum CPK activity and the fractions of the isoenzymes in the schizophrenic patients and to investigate the correlation between the CPK activity and several clinical variables such as symptoms, course, subtype of schizophrenia. 18 hospitalized schizophrenic patients and 9 healthy adult controls were subjects of this study. The results were as follows ; 1) total serum CPK activity of all the normal controls fell in the normal range but that of 3 schizophrenic patients exceeded the normal range. Means of total serum CPK of both groups were in the normal range, but that of the schizophrenic group was significantly higher than that of the control group by 59.1±23.2 I.U./ℓvs. 45.0±9.1 I.U./ℓ. 2) Mean value of the MB type isoenzyme of the schizophrenic group was 6.1±3.9 I.U./ℓ, a significantly higher level than that of the control group in which the value was 1.4±1.1 I.U./ℓ. Mean of MM type isoenzyme of the schizophrenic group was 49.7±20.7 I.U./ℓ and that of control group was 43.6±8.6 I.U./ℓ, showing no significant difference. The BB type was detected in 3 schizophrenics and in none of the control group. 3) The correlation coefficients calculated between the total serum CPK activity and 16 symptom categories of the Psychiatric Evaluation Form of Spitzer et al excluding 3 symptom categories of Narcotics-Drugs, Antisocial Attitudes-Acts, and Alcohol Abuse revealed significantly high correlation in the symptoms of Social Isolation, Belligerence-Negativism and Disorientation-Memory. The remaining items of Agitation-Excitation, Suicide-Self Mutilation, Grandiosity, Somatic Concern, Speech Disorganization, Hallucination, Anxiety, Inappropriateness, Suspicion-Persecution, Denial of Illness, Depression, Daily Routine-Leisure Time and Retardation-Lack of Emotion did not correlate with the CPK activity. No significant difference was noted between paranoid and non-paranoid schizophrenics and between the groups of long and short durations of the active symptoms. From the above results, the authors could confirm the elevation of the total serum CPK activity in the schizophrenics as compared to the normal controls. They also suggest further probing into the alterations of the isoenzymes with sufficient number of the subjects and with more refined procedures.

고주파 가열에 따른 반응고 알루미늄합금의 미세조직 특성

신평우,이정환,이상용,노진호,이영선 國立 昌原大學校 産業技術硏究所 1997 産技硏論文集 Vol.11 No.-

Semi-solid forming is relatively new process for forming alloys in the semi-solid condition into near net produce. It relies on the behaviour of semi-solid slurrys in which the solid exists in the form of non-dendritic, spheroidal particles in a liquid matrix. Powder of the Al-20Si-5Fe-2Ni alloy was manufactured by spray forming and powder metallurgy, one of the rapid cooling method, and its microstructure became fine with several ㎛ size through the extrusion process. Spray forming and powder metallurgy are a rapid solidification process in which capable of producing materials consisted of very fine, uniform particles. Spray forming can be described as incorperating the advantages of powder metallurgy without disadvantages of degassing and consolidation. In this paper, the microstructural evolution of the P/M, S/F Al-20Si-5Fe-2Ni alloys and wrought Al 2024 alloys were investigated various heating conditions by high frequency induction heating system.

교육공학의 연구에 대한 고찰 및 분석 : 1960년~1983년

김인경,신은주,이평희,정인영 이화여자대학교 사범대학 시청각교육과 1983 시청각 교육 Vol.- No.13

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

Nitrostyrylphenylsulfone에 대한 Hydrogen Cyanide의 친핵성 첨가반응 메카니즘 연구

鄭昌雄,朴茂淳,明平根,孟柱煬 순천향대학교 1982 논문집 Vol.5 No.2

The rate constant of the nucleophilic addition reaction of hydrogen cyanide to p-Nitrostyrylphenylsulfone were determined at various pH and a rate equation which can be applied over wide pH range was obtained. Analysis of the equation suggest that below pH11, the nucleophilic addition reaction of hydrogen cyanide to p-Nitrostyrylphenylsulfone is initiated by the attack of hydrogen cyanaide molecule on the activated carbon double bond, and above PH 13 cyanide ion is the only nucleophile to p-Nitrostyrylphenylsulfone.