神經精神科에 入院한 精神分裂症 患者의 幻覺에 關한 硏究

延炳吉 대한신경정신의학회 1979 신경정신의학 Vol.18 No.3

Author studied the incidence, sort, subjects, and contents hallucinations manifested in 148 schizophrenic patients among 342 neuropsychiatric patients who had been hospitalized in the neuropsychiatric department of Seoul National University Hospital during the period of Jan. 1977 to Dec. 1978 and compare the demographic data, body type and premorbid personality between schizophrenic patients with hallucination and schizophrenic patients without hallucination. The result were as follows : 1. The incidence of hallucinations in the whole neuropsychiatric in-patiens was 15. 2% while the these in schizophrenic in-patients was 30. 4%. 2. In schizophrenia, auditary hallucinations were most frequently seen, visual hallucinations the next, and olfactory hallucinations were rare. 3. The frequency of hallucinations among the subtypes of schizophrenia was high in acute schizophrenic episode, chronic undifferentiated type, paranoid type, simple type in decreasing order. 4. No statistical difference was not noted about the age, sex’ education, marrital status, ecconomic state, occupation, place of growth, religion, body type and premorbid personality between schizpphrenic patients with hallucination and schizophrenic patients without hallucination. 5. As the subjects of auditary hallucination, people without acquaintance appeared more frequently than the acquaintances or family members. The contents were more frequently persecutary and instructive than daily routine or sexual. The objects of visual hallucinations were frequently the related persons, religious objects, demons, on nonspecified individuals. 6. The auditary hallucinations were of positive in nature in 17. 9 % , negative in 64.1%, neutral in 10.3%, mixed in 7 .7%. 7. The therapeutic outcome of schizophrenic patients with hallucination was not significantly different from that of schizophrenic patients without hallucination.

정신의학적 역학의 현황

延炳吉 漢陽大學校 精神健康硏究 1987 精神健康硏究 Vol.5 No.-

정신분열증 환자의 혈청내 Haloperidol과 Prolactin 함량에 관한 연구

연병길,한규희,양병환,김철규,전남호 漢陽大學校 精神健康硏究 1985 精神健康硏究 Vol.3 No.-

입원된 주정의존증 환자와 그 부인의 정신증상

정기일,연병길 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.3

Psychopathology of 20 male, hospitalized alcoholics and their wives were measured by Symptom Checklist-90(SCL-90). Twenty wives of schizophrenic husbands and twenty normal couples, matched for age and education, were used for controls. Correlation was looked for between the degree of alcohol dependence of the alcoholic husbands as assessed by Alcohol Screeing Test(AST) and the psychopathology of their wives as measured by SCL-90. The results were as follows. 1) The alcoholics, as compared with the normal males, showed significantly higher scores on depression, interpersonal sensitivity, anxiety, obsession, paranoia and psychoticism, in that order. 2) The wives of the alcoholics, as compared to the wives of the normal couples, showed significantly higher scores on anxiety depression, obsession, hostility, and somatization, in that order However, the wives of the schizophrenics showed no higher scores than the wives of the normal couples. The wives of the alcoholics, when compared to the wives of the schizophrenics, showed higher scores on somatization and anxiety. 3) The AST scores of the alcoholics did not correlate with the wives' psychopathology as assessed by SCL-90 in all scales except phobic anxiety, the significance of which was doubted since their scores of phobic anxiety was not higher. than that of the wives of the normal couples.

치매의 약물요법

延炳吉 대한의사협회 1999 대한의사협회지 Vol.42 No.10

한국의 정신보건에 관한 역학적 조사 : 정신질환의 5년 추적조사(Ⅰ) 광역조사 A 5-Year Follow-up Study of Mental Disorders(Ⅰ) Extensive Study

연병길,박문희 서울대학교 의과대학 정신과학교실 1983 精神醫學報 Vol.7 No.7

치매란 무엇인가?

연병길 주식회사 녹십자 1999 녹십자의보 Vol.27 No.6

정신분열증 남자환자의 혈청 Prolactin함량의 변화와 임상적 호전과의 연관성에 관한 연구

김명숙,연병길 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.1

Thirty male schizophrenics admitted to the Seoul National Mental Hospital between March 20, and July 11,1985, were studied for 4 weeks on the correlation between serum prolactin levels and clinical improvement. On admission, the baseline serum prolaction levels were determined by double antibody radioimmunoassay method, the baseline rating of Psyshopathology were done by two raters using BPRS. According to the severity of clinical symptoms, all the patients were administered haloperidol of variable dosage. Follow-up serum prolactin levels and BPRS rating were done at 1st, 2nd, 4th week, the results are as follows. 1)Serum prolactin levels and BPRS total scores showed statistically significant changes proportional to daily haloperidol dosage in the 1st, 2nd, 4th week(1st week:P<0.05, 2nd & 4th week:p<0.01). Significant improvement were observed in BPRS subscales, thought disturbance and paranord disturbance in the 2nd & 4th week and in withdrawal retardation in the 4th week. 2)The correlation between daily haloperidol dosage and serum prolactin levels was not significant. The correlation between serum prolactin levels and BPRS total scores was significant in the 1st week(P<0.05). There were statistically significant correlations between a BPRS subscale, paranid disturbance and serum prolaction levels in the 2nd & 4th week(P<0.05) 3)Mean changes of daily haloperidol dosage, serum prolactin levels and BPRS total scores showed statistically significant difference in the 4th week(P<0.01). Significant changes were observed in two BPRS subscales, thought disturbance and paranoid disturbance in the 2nd & 4th week(thought disturbance in the 2nd & 4th week, paranoid disturbance in the 4th week, paranoid disturbance in the 4th week: P<0.01, Paranoid disturbance in the 2nd week:P<0.05) 4)The correlation between changes of serum prolactin levels and a BPRS subscale, withdrawal retardation was significant(r=-0.404, P<0.05). 5)The Serum Prolactin levels & the changes of them between improvement group in BPRS(above 20 Points, N=8) and non-improvement group in BPRS(below 10 Points, N=9) were not significant. 6)The serum Prolactin levels and the changes of them between the drug free group(N=9) and the antipsychotics treated group for over 2 years(N=8) were not significant.

자살 기도자에 있어 유발요인, 위험도-구조가능도 접수와 생활의 스트레스에 관한 임상적 연구

안석철,기평석,연병길 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.3

The authors have studied the relationships between precipitating factors evaluated by the social readjustment rating scales, and risk scores, rescue scores, risk rescue scores of 295 suicide attempters who admitted to Han Gang Sacred Heart Hospital from Mar. 1981 to Jul. 1984. The results are as follows; 1) The most frequent precipiting factor of suicidal attempts classified by the social readjustment rating spouse(16.8) and next one was difficulty is friendship with opposite sex(12.7%) 2) There were no significant differences in risk scores, rescue scores, and risk-rescue scores between large life stress group and small stress group which were divided at the score of 300 in the social readiustment rating scale. 3) There were no significant differences in risk scores, recue scores, and risk-rescue scores among the categories of social readjustment rating scale. 4) The social readjustment rating scale was significantly correlated with rescue scores(p=0.045, Y=0.00198X+7.436) but not with risk and risk and risk-rescue scores.

정신분열증 환자의 혈청 총 CPK 활성치 및 동위효소의 분획상

金平周,金明正,延炳吉 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.4

The purpose of this study was to determine the total serum CPK activity and the fractions of the isoenzymes in the schizophrenic patients and to investigate the correlation between the CPK activity and several clinical variables such as symptoms, course, subtype of schizophrenia. 18 hospitalized schizophrenic patients and 9 healthy adult controls were subjects of this study. The results were as follows ; 1) total serum CPK activity of all the normal controls fell in the normal range but that of 3 schizophrenic patients exceeded the normal range. Means of total serum CPK of both groups were in the normal range, but that of the schizophrenic group was significantly higher than that of the control group by 59.1±23.2 I.U./ℓvs. 45.0±9.1 I.U./ℓ. 2) Mean value of the MB type isoenzyme of the schizophrenic group was 6.1±3.9 I.U./ℓ, a significantly higher level than that of the control group in which the value was 1.4±1.1 I.U./ℓ. Mean of MM type isoenzyme of the schizophrenic group was 49.7±20.7 I.U./ℓ and that of control group was 43.6±8.6 I.U./ℓ, showing no significant difference. The BB type was detected in 3 schizophrenics and in none of the control group. 3) The correlation coefficients calculated between the total serum CPK activity and 16 symptom categories of the Psychiatric Evaluation Form of Spitzer et al excluding 3 symptom categories of Narcotics-Drugs, Antisocial Attitudes-Acts, and Alcohol Abuse revealed significantly high correlation in the symptoms of Social Isolation, Belligerence-Negativism and Disorientation-Memory. The remaining items of Agitation-Excitation, Suicide-Self Mutilation, Grandiosity, Somatic Concern, Speech Disorganization, Hallucination, Anxiety, Inappropriateness, Suspicion-Persecution, Denial of Illness, Depression, Daily Routine-Leisure Time and Retardation-Lack of Emotion did not correlate with the CPK activity. No significant difference was noted between paranoid and non-paranoid schizophrenics and between the groups of long and short durations of the active symptoms. From the above results, the authors could confirm the elevation of the total serum CPK activity in the schizophrenics as compared to the normal controls. They also suggest further probing into the alterations of the isoenzymes with sufficient number of the subjects and with more refined procedures.