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노동현,김도형,김나래,박종선,이창헌,김미경,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2
전격성 제1형 당뇨병은 특발성 당뇨병환자에서 임상 경과가 짧고 진단 당시 심각한 대사 합병증을 동반하면서 췌장 효소 수치가 높고 췌도 특이 자가항체가 음성인 새로운 아형으로 알려져 있으며, 일본과 일본 외에서의 유병률에는 차이가 있는 것으로 보인다. 아직 전격성 제1형 당뇨병의 발생 기전은 명확하지 않으며 유전적 감수성이 있는 개체에서 바이러스 감염 등의 환경적인 인자와의 연관성이 가능한 병태생리로 제시되고 있으며 이에 대한 추가적인 연구가 요구된다. 저자들은 케톤산증으로 내원하여 전격성 제1형 당뇨병을 진단받은 증례를 경험하였기에 문헌고찰과 함께 보고 하는 바이다. Some patients with idiopathic type 1 diabetes have a fulminant disorder characterized by the absence of insulitis and of diabetes-related antibodies, a remarkably abrupt onset and high serum pancreatic enzyme concentrations. This is referred to as fulminant type 1 diabetes. A 29-year-old man suffering from abdominal pain, nausea and vomiting consulted to our hospital. Laboratory findings revealed high blood glucose level and the evidence of diabetic ketoacidosis, but the serum HbA1c was normal nevertheless. The low level of plasma C-peptide indicated the loss of endogenous insulin secretion. The patient satisfied the criteria for the diagnosis of fulminant type 1 diabetes. After the patient has been treated with insulin, his symptoms were improved and abnormal laboratory data were normalized. We report this case with a review of the literature
장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4
Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.
Na Gyeong Geum(Na Gyeong Geum),Ju Hyeong Yu(Ju Hyeong Yu),So Jung Park(So Jung Park),Min Yeong Choi(Min Yeong Choi),Jae Won Lee(Jae Won Lee),Gwang Hun Park(Gwang Hun Park),Hae-Yun Kwon(Hae-Yun Kwon),J 한국자원식물학회 2022 한국자원식물학회지 Vol.35 No.6
Under the COVID-19 pandemic, interest in immune enhancement is increasing. Although the immune-enhancing activity of plants of the genus Hibiscus has been reported, there is no study on the immune-enhancing activity of H. syriacus. Thus, in this study, we investigated the immune-enhancing activity of Hibiscus syriacus leaves (HSL) in mouse macrophages, RAW264.7 cells, and immunosuppressed mice. HSL increased the production of immunostimulatory factors such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) and activated the phagocytosis in RAW264.7 cells. The HSL-mediated production of immunostimulatory factors was dependent on toll-like receptor 4 (TLR4), p38, and c-Jun N-terminal kinase (JNK) in RAW264.7 cells. In the immunosuppressed mouse model, HSL increased the spleen index, the levels of the cytokines, and the numbers of lymphocytes, neutrophils, and monocytes. Taken together, HSL may be considered to have immune-enhancing activity and be expected to be used as a potential immune-enhancing agent.
Magnetic Resonance Imaging of Ferumoxytol-Labeled Human Mesenchymal Stem Cells in the Mouse Brain
Lee, Na Kyung,Kim, Hyeong Seop,Yoo, Dongkyeom,Hwang, Jung Won,Choi, Soo Jin,Oh, Wonil,Chang, Jong Wook,Na, Duk L. Springer US 2017 Stem cell reviews and reports Vol.13 No.1
<P>The success of stem cell therapy is highly dependent on accurate delivery of stem cells to the target site of interest. Possible ways to track the distribution of MSCs in vivo include the use of reporter genes or nanoparticles. The U.S. Food and Drug Administration (FDA) has approved ferumoxytol (Feraheme® [USA], Rienso® [UK]) as a treatment for iron deficiency anemia. Ferumoxytol is an ultrasmall superparamagnetic iron oxide nanoparticle (USPIO) that has recently been used to track the fate of transplanted cells using magnetic resonance imaging (MRI). The major objectives of this study were to demonstrate the feasibility of labeling hUCB-MSCs with ferumoxytol and to observe, through MRI, the engraftment of ferumoxytol-labeled human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) delivered via stereotactic injection into the hippocampi of a transgenic mouse model of familial Alzheimer’s disease (5XFAD). Ferumoxytol had no toxic effects on the viability or stemness of hUCB-MSCs when assessed <I>in vitro</I>. Through MRI, hypointense signals were discernible at the site where ferumoxytol-labeled human MSCs were injected. Iron-positive areas were also observed in the engrafted hippocampi. The results from this study support the use of nanoparticle labeling to monitor transplanted MSCs in real time as a follow-up for AD stem cell therapy in the clinical field.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s12015-016-9694-0) contains supplementary material, which is available to authorized users.</P>
Lee Yun Gyu,Lee Hyeong Uk,Lee Jae Min,Kim Na Young,Jeong Dong Hwi 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.1
To successfully attain the objective of carbon neutrality, the active incorporation of carbon capture utilization (CCU) technology becomes imperative within the engineering framework. This technology facilitates the generation of high value-added materials by harnessing carbon dioxide, sourced from either the atmosphere or industrial processes, as a fundamental raw material. Dimethyl carbonate (DMC) is an environmentally friendly chemical that can be produced using CCU technology. This study fi rst models the base process of the ethylene carbonate (EC) transesterifi cation method that produces DMC based on carbon dioxide, ethylene oxide (EO), and methanol (MeOH). Based on this, three processes for recycling by-products, ethylene glycol (EG) and EC, are proposed, and economic analysis and overall environmental impact evaluation are conducted. Each process is modeled through Aspen Plus V12.1, economic feasibility is evaluated through Aspen Process Economic Analyzer (APEA), and environmental impact is evaluated through OpenLCA. As a result, the fi nal DMC production is increased by 0.644–18.9% compared to the base process in the process of recycling by-products. In the base process, the net present value (NPV) and payback period (PBP) were 46 M$ and 8.3 years, respectively, and in the proposed 1 (recycling EG) and proposed 3 (recycling EG and EC) processes, the NPV was 231 M$ and 73 M$, respectively, and the PBP was 3.8 and 7.4 years, respectively. In the proposed 2 process (with EC recycling), a substantial negative net present value (NPV) of − 135 M$ was observed, indicating that recovering the investment cost was unfeasible within this scenario. Through sensitivity analysis, it was shown that the parameters with high volatility of NPV are DMC price and raw material cost. Finally, the result for climate change among the environmental impact categories is 3.85 kgCO2−eq in the base process, 3.47 kgCO2−eq in the proposed 1 process, 3.57 kgCO2−eq in the proposed 2 process, and 3.33 kgCO2−eq in the proposed 3 process, respectively.