혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

후열처리에 따른 Cu-NiCrBSi 이종 레이저 클래드부의 미세조직 및 기계적 성질 변화

김경민,정예선,심아진,박원아,박창규,천은준,Kim, Kyeong-Min,Jeong, Ye-Seon,Sim, Ahjin,Park, Wonah,Park, Changkyoo,Chun, Eun-Joon 한국재료학회 2020 한국재료학회지 Vol.30 No.9

For surface hardening of a continuous casting mold component, a fundamental metallurgical investigation on dissimilar laser clads (Cu-NiCrBSi) is performed. In particular, variation behavior of microstructures and mechanical properties (hardness and wear resistance) of dissimilar clads during long-term service is clarified by performing high-temperature post-clad heat treatment (temperature range: 500 ~ 1,000 ℃ and isothermal holding time: 20 ~ 500 min). The microstructures of clad metals (as-clads) consist of fine dendrite morphologies and severe microsegregations of the alloying elements (Cr and Si); substrate material (Cu) is clearly confirmed. During the post-clad heat treatment, the microsegregations are totally homogenized, and secondary phases (Cr-based borides and carbides) precipitated during the short-term heat treatment are also almost dissolved, especially at the heat treatment conditions of 950 ℃ for 500 min. Owing to these microstructural homogenization behaviors, an opposite tendency of the surface mechanical properties can be confirmed. In other words, the wear resistance (wear rate) improves from 4.1 × 10^-2 ㎣/Nm (as-clad condition) to 1.4 × 10^-2 ㎣/Nm (heat-treated at 950 ℃ for 500 min), whereas the hardness decreases from 453 HV (as-clad condition) to 142 HV (heat-treated at 950 ℃ for 500 min).

검은 비늘버섯 Pholiota adiposa로부터 항치매성 Butyrylcholinesterase 저해물질의 생산

한상민, 박선정, 문정수, 이종수 배재대학교 자연과학연구소 2021 自然科學論文集 Vol.32 No.1

본 연구에서는 식용버섯 유래의 새로운 항치매성 butyrylcholinesterase(BChE) 저해물질을 생산할 목적으로 식용버섯 추출물들의 BChE 저해활성을 측정하였다. 식용버섯들 중에서는 검은비늘버섯의 물 추출물이 42.7 %의 BChE 저해활성을 보여 최종 선발하였다. 또한 검은비늘버섯 자실체를 30 ℃에서 24시간 물 추출하였을 때 BChE 저해활성이 가장 높았다. n this paper, screening potent edible mushroom with high anti-dementia butyrylcholinesterase(BChE) inhibitory activity and optimal extraction condition of BChE inhibitors were described. Among various edible mushroom, the water extract from Pholiota adiposa fruiting body had high BChE inhibitory activity of 42.7 %. BChE inhibitor from P.adiposa fruiting body was maximally extracted when its fruiting body was trated with distilled water for 24 hr at 30 ℃.

하수에서 분리한 합성세제 분해균의 특성

정민선,전진경,정영건,이해경,권오진,지원대,김관배 嶺南大學校 環境問題硏究所 1993 環境硏究 Vol.13 No.1

대구시와 경산시의 하수에서 음이온계 합성세제인 sodium dodecyl sulfate(SDS)와 sodium dodecylbenzene sulfonate(SDBS)를 유일한 탄소원으로 이용하는 균주 289종을 분리하고 이중 합성세제 분해력이 강한, 그람음성 간균으로 운동성인 8균주를 선정하여 그 선정균들의 특성을 조사하였다. 선정균은 40℃ 이상에서는 생육하지 못하였으며 생육 최적 pH는 균주간에 다소 차이가 있었으며 pH 4.0 이하에서는 선정균 모두 생육치 못하였다. 질소원으로는 SDS분해균의 생육에는 potassium nitrate가, SDBS 분해균의 생육에는 soytone이 좋았다. SDS 분해균인 DS-3, 6, 8, 24 및 SDBS 분해균인 BS-7, 8은 세제농도가 5.0% 이상에서도 생육이 가능하였다. 선정균들은 tetracycline에 감수성이 강한 것으로 나타났지만 penicillin에는 강한 내성을 띠는 것으로 나타났고, ??와 ??금속이온은 모든 선정균들의 생육을 억제하는 것으로 나타났다. On purpose to isolate the organisms, which would utilize detergents(sodium dodecyl sulfate, SDS and sodium dodecylbenzene sulfonate, SDBS) as a sole carbon source, from the waste water of Kyungsan and Taegu city 289 strains were isolated. Among them 8 strains, which are gram negative rods with motility and produce strong enzyme to biodegrade the synthetic detergents, were selected. The characteristics of them were investigated as follows, 8 strains were failed to grow above the temperature of 40℃ and below the pH 4.0 even though they have variable optimum pH. Potassium nitrate was very effective for the growth of SDS-biodegradable strains and soytone was effective for the growth of SDBS-biodegradable strains as a sole nitrogen source. Among 8 strains especially DS-3, DS-6, DS-8 and DS-24(SDS-biodegradation strains) and BS-7 and BS-8(SDBS-biodegradation strains) could grow above 5.0% of detergent concentration. All of 8 strains were very sensitive to tetracycline but resistant to penicillin. Selected 8 strains were inhibited by metal ions of ??(0.156mg/㎖) and ??(0.156mg/㎖).

상아질 접착제의 미세누출에 관한 연구

손정민,최남기,김선미,양규호,박지일 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

본 연구는 여러가지 상아질 접착제들의 법랑질 변연과 상아질 변연에서의 미세누출을 비교 평가하기 위해 이루어졌다. 발거된 건전한 영구치의 협면과 설명에 5급 와동을 형성하고 형성된 50개의 와동을 무작위로 5개의 군으로 나누어 각군에 Adper™ Scotchbond™ Multi-purpose Plus Adhesive (SM; 3M ESPE. USA), Adper™ Single bond 2 (SB; 3M ESPE, USA), Clearfil™ SE Bond (SE; Kuraray Medical Inc., Japan), Adper™ Prompt™ L-Pop™ (PL; 3M ESPE, USA), G-Bond™ (GB; GC Co., Japan)를 적용하고 Filtec™ Z350 A3 (3M ESPE. USA)로 충전하였다. 시편을 37℃ 증류수에 24시간 보관한 후 5℃와 55℃에서 10초씩 1000회 열순환하고 2% methylene blue 용액을 24시간 넣어 염색한 뒤, 주수 하에 치아를 협설로 절단하여 색소의 침투 정도를 화상분석현미경을 이용하여 침투깊이를 측정한 뒤 각 군간의 미세누출 정도를 비교하여 침투깊이에 따라 0~3점으로 분류하여 다음과 같은 결과를 얻었다. 1. 범랑질 변연에서의 미세누출은 PL(0.85), SB(0.55), GB(0.50), SM(0.35), SE(0.25) 순이었으며 PL은 SM 및 SE와 통계학적으로 유의한 차이를 나타냈다(p<0.05). 2. 상아질 변연에서의 미세누출은 GB(2.10), SE(1.45), PL(1.40), SB(1.05), SM(0.70) 순이었으며 GB는 SB 및 SM과 통계학적으로 유의한 차이를 나타냈다(p<0.05). 3. 각 실험재료 군내에서 법랑질 변연에 비해 상아질 변연에서 미세누출이 더 크게 나타났으며, SE, PL, GB에서 통계학적으로 유의한 차이를 나타냈다(p<0.05). The objective of this study was to compare the microleakage of five adhesive systems in the enamel and dentin of permanent teeth. Class V cavity preparations with occlusal margins in enamel and gingival margins in dentin were prepared on both buccal and lingual surfaces of 25 extracted human molar teeth. The tested adhesives were: Adper Scotchbond Multi-purpose Plus Adhesive (SM), Adper Single bond 2 (SB), Clearfil SE Bond (SE), Adper Prompt L-Pop (pL) and G-Bond (GB). The results were as follows: 1. At the enamel margins, PL showed the highest leakage value(0.85), and others showed values of SB(0.55), GB(O.50), SM(O.35) and SE(0.25) in decreasing order. There were statistically significant differences in PL vs. SM and PL vs. SE(p<O.05). 2. At the dentin margins, GB showed the highest leakage value(2.10), and others showed values of SE(1.45), PL(1.40), SB(1.05), SM(0.70) in decreasing order. There were statistically significant differences in GB vs. SB and GB vs. SM(p<O.05). 3. Dentin margins showed high dye penetration rate than enamel margins in all material tested groups and there were statistically significant differences for SE, PL and GB.

뼈흡수유도호르몬이 ROS17/2.8세포로부터 Nitric Oxide 형성에 미치는 영향

고선일,김민성,한원정,김세원,김정근 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.3

Purpose : We performed the present study to investigate whether osteotropic hormomes play roles on the nitric oxide (NO) production in culture of ROS17/2.8 osteoblastic cells. Materials and Methods : The osteoblastic cell line ROS17/2.8 cells were cultured in F12 medium supplemented with 5% fetal bovine serum (FBS) at 37?C in a humidified atmosphere of 5% CO₂ in air. ROS17/2.8 cells were plated in 96-well plates at a density of 2-3×10³ cells/well and grown to confluence. Then the cells were pretreated with osteotropic hormones (parathyroid hormone (PTH) 20-500 ng/mL, 1,25 dihydroxycholecalciferol (1,25[OH]₂D₃) 1-100 nM; prostaglandin E₂ (PGE₂) 20-500 ng/mL) in the medium supplemented with 0.4% FBS for 72 hours and the cells were treated with cytokines (TNFα and IFNγ) in phenol red-free F12 medium for an additional 48 hours. NO synthesis was assessed by measuring the nitrite anion concentration, the reaction product of NO, in the cell culture medium using Griess reagent. Results : PTH and 1, 25[OH]₂D₃ pretreatment induced a significant increase in NO production in the presence of TNFα and IFNγ. PGE₂ slightly induced NO production compared to the control group. But, PGE2 pretreatment did not affect in NO production in the presence of TNFα and IFNγ. Conclusions : These results suggest that the actions of osteotropic hormones in bone metabolism may be partiallymediated by NO in the presence of cytokines.

부분 무치증 환아의 증례보고

손정민,최남기,김선미,양규호 大韓小兒齒科學會 2007 大韓小兒齒科學會誌 Vol.34 No.4

부분 무치증은 제 3대구치를 제외한 6개 이상의 선천적 치아 결손으로 정의된다. 제3대구치를 제외한 선천적 치아 결손의 유병율은 1.6∼9.6%이며 부분 무치증의 유병율은 O.08∼1.1%이다. 가장 많이 이환되는 치아는 하악 제 2소구치이며 그 다음은 상악 측절치,상악 제2소구치 순으로 호발하며 영구치에 비해 유치에서는 드물고 여성에게 호발하는 경향이 있다. 부분 무치증은 외배엽 이형성증과 같은 특정 증후군과 연관되거나 치판의 생리적인 장애나 파열,공간적 제한,치성 상피의 기능적인 비정상,기저 간엽세포의 유도 실패나 유전적 영향 등의 원인에서 유래된다고 알려져 있다. 부분 무치증은 안모의 심미적 문제와 함께 치아의 교합 이상 등 기능적인 장애가 야기될 수 있으므로 임상 검사와 방사선 검사를 통한 조기 진단이 필요하며,이에 따른 적절한 치료계획이 요구된다. 이에 본 증례에서는 특별한 전신질환이 없는 부분 무치증 환아의 구강내 소견 및치료경과에 대해 보고하고자 한다. Oligodontia is defined as the congenital absence of six or more teeth in dentition, excluding the third molars. The prevalence of congenital missing teeth is about 1.6 to 9.6% of population and the prevalence of oligidontia is about 0.08 to 1.1%. The mandibular second premolar is the most frequently absent after the third molar, followed by the maxillary lateral incisor and upper second premolar. Females seem to be affected slightly more than males. Oligodontia may occur either in isolation, or as a part of a syndrome such as ectodermal dysplasia. Different causes are possible for oligodontia: physical obstruction or distruction of the dental lamina, space limitation, functional abnormalities of the dental epithelium, failure of induction of the underlying mesenchyme, chemotherapy, radiotherapy or genetic factor. Because oligodontia would result in esthetic and functional problems, such as facial asymmetry or occlusal disharmony, early diagnosis from clinical and radiographic examination was necessary. And appropriate treatment plan should be followed. This case report was about oral conditions and treatment of the oligodontia patients who have no specific systemic disease.

단클론성 IgG 침착을 동반한 증식성 사구체 신염 1예

차정민,정덕은,송주흥,안선호 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

Proliferative glomerulonephritis with monoclonal IgG deposits is a novel phenotype of glomerular injury with the diagnostic criteria of (1) the presence of glomerular monoclonal IgG deposits restricted to a single IgG subclass and a single light chain isotype, associated with endocapillary proliferative, membranoproliferative, or membranous features; (2) the presence of granular("immune complex type") deposits by electron microscopy; and (3) the absence of clinical and laboratory evidence of cryoglobulinemia. We report a case of 65-year-old man with generalized edema who was diagnosed as proliferative glomerulonephritis with monoclonal IgG deposits by renal biopsy.

MMSE를 이용한 도시지역 노인들의 인지기능검사 성적

오민아,신윤오,이태용,김정선 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was performed to assess the degree of cognitive function impairment by MMSE performances and the effects. Data was collected by interviewers from 1,325 elderly people in Seogu, Daejeon city from June to July, 2002 and the collected data were analysed by SPSSWIN(ver 10.0). The results of analysis were as follows. The mean score of MMSE was 24.16±4.36 and significantly lower in female, in the older group and in the non-educated group. The subset score of MMSE were significantly lower in female group about each items: orientation in time and place, registration, attention/calculation, language except recall. And the scores were significantly lower in the older group and non-educated group about the all items of MMSE. In conclusion, sex, age and education showed significant effects on total and subset MMSE score. Cognitive function decline were higher in female sex, older age group and non-educated group. Therefore, those three factor are thought to be one of important risk factors for development of dementia because MMSE examination is useful instrument for evaluation of elderly dementia.

3차 병원의 병동에서 시행된 심폐소생술의 분석

류진호,정경운,위준선,문정미,전병조,문원식,김용권,소정일,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Although cardiopulmonary resuscitation(CPR) is a very effective therapy in cardiac arrest, it is hard to prove the true effectiveness of CPR. Several studies about out-of-hospital and emergency department CPR exist, but only a few reports about in-hospital CPR are available. This study was designed to investigate in-hospital cardiac arrest, to analyze the result of CPR, and to evaluate the problems associated with in-hospital CPR. Methods: A clinical analysis of 71 cases of in-hospital CPR announcement from January 2000 to August 2000 was performed. The initial rhythm on cardiac arrest, return of spontaneous circulation(ROSC), and the survivals were analyzed in the case of the 46 true cardiac arrest patients. Results: During 8 months, there were 71 cases of in-hospital CPR announcement. Among them, there were 46 cases of true cardiac arrest and 25 cases of non-cardiac arrest. Of the 46 true cardiac-arrest cases, 27(58.7%) experienced ROSC, 15(32.6) survived for over 24 hours, and 7(15.2%) survived to be discharged. The initial rhythms on cardiac arrest were 30 cases(65.2%) of asystole, 14(30.4%) of PEA(pulseless electrical activity), and 2(4.3%) of ventricular fibrillation, with ROSC being 17 cases(56.7%), 9(64.3%) and 1(50.0%) cases and discharged survivors being 4 cases(13.3%), 3(21.4%) and 0(0.0%) cases, respectively. Conclusion: Extraordinarily high proportions of asystole and PEA were seen in the initial rhythm of cardiac arrest, and those were associated with high survival rates. Although further study is needed to evaluate the course leading to this high proportion of asystole and PEA, this result suggests that if the EMS system in the hospital is activated promptly and systematically, a better outcome will be achieved in case of cardiac arrest with asystole and PEA.