혈전성 혈소판감소성 자반증으로 발현된 전신홍반루푸스 1예

오명근,유미라,변유미,윤찬영,권세훈,박치영,김상현 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.3

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening syndrome characterized by the classic pentad of clinical features that includes microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever, and renal dysfunction. Early diagnosis and utilization of plasmapheresis can improve the survival rates of patients with TTP. TTP rarely may be seen in association with autoimmune disease such as systemic lupus erythematous (SLE). We report here a 42-year-old female who was presented with severe digital gangrenes, microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever, and renal dysfunction. Her condition responded to combined therapy with high dose steroid, immunosuppressants, and plasmapheresis therapy.

폐쇄성 수면 무호흡 환자의 측모 두부방사선계측사진 및 치아모형 연구

정미라,황상희,남기영,김종배,권오원 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.3

폐쇄성 수면 무호흡증이란 수면도중 주기적으로 호흡이 멈추는 증상을 말한다. 상악과 하악이 후퇴되어 있거나 하악이 작으며 수평적으로 기도 폭경이 좁고 혀가 후방에 위치하는 등 폐쇄성 수면 무호흡 환자의 전후방적인 악골 및 연조직 특성에 대한 평가는 많았으나 치열 및 악궁에 대한 평가가 부족하여 폐쇄성 수면 무호흡증 환자의 골격적 특징과 악궁의 폭경과 구개깊이와 수면무호흡지수와의 상관관계를 알아보고자 하였다. 계명대학교 의과대학 동산의료원 수면클리닉에 수면장애를 주소로 내원한 환자 중 수면다원검사와 측모 두부방사선계측사진과 치아모형이 갖추어진 38명의 남자를 대상으로 하여 치아모형과 측모 두부방사선계측사진, 수면무호흡지수와 체질량지수를 비교하였다. 수면무호흡지수와 악궁의 횡폭경, 구개깊이, 수직피개량 및 수평피개량과는 상관관계가 없었으며 수면무호흡군에서 상기도 폭경은 좁고, 하기도 폭경은 넓은 경향이 있었다. 수면무호흡지수와 상기도 폭경은 미약한 음의 상관관계를 가졌으나 하기도 폭경은 미약한 양의 상관관계를 가졌고, 수면무호흡지수가 클수록 하악 하연으로터 설골까지의 거리도 멀었다. To evaluate the cephalometric and dental characteristics of obstructive sleep apnea (OSA) patients, 23 OSA patients and 15 control, non-OSA, patients who visited the Sleep Disorder Clinic Center, Keimyung University were investigated. Patients who suffered from apnea-hypopnea episodes over 10 times per hour were diagnosed as having OSA after polysomnograph testing. Impressions were taken with alginate. Cephalometric radiographs were taken at maximum intercuspation. The dental cast measurements, including transpalatal width, intercanine width, intermolar width and palatal depth did not differ between the control and OAS groups and did not have a positive correlation with the apnea-hypopnea index (AHI). Upper airway width was statistically narrower than the control group. Upper airway width had a low negative correlation with AHI, but, lower airway width had a low positive correlation, and, the higher the AHI score, the longer the mandibular border to hyoid distance.

국내의 치매관련 간호연구논문 분석

김혜영,홍춘실,오경옥,이선영,정현숙,이지혜,남미라 충남대학교 간호과학연구소 2002 충남대 간호학술지 Vol.5 No.1

The purpose of this study was to analyze the trends of korean nursing research on dementia and to suggest the direction of future research. A total of 52 nursing research articles published from 1992 to 2001 were selected for this study. These articles were analyzed in a systematic way including time and source of publication, design of research, type of subjects, variable and tool of measurement, intervention outcome of experimental research, and theme of qualitative research. The results were as follows : 1. The nursing research about dementia has appeared since 1992 and increased rapidly since 1998. 2. Eighteen of 52 studies were composed of dissertation of graduate school, and the research designs were mostly quantitative. There were 36 nonexperimental research, 11 experimental research, and 5 qualitative research designs. 3. The subjects of studies were mostly the caregivers of dementia patients as 33 of 52 studies. 4. Most measurement instruments used for research were developed by researcher him/herself, or redesigned and translated into korean as the original foreign version was used. 5. In correlational research, the trend was to study physical conditions in relation to activities of daily living and functional status in dementia patients and psychological conditions in relation to burden, quality of life, depression, and stress in their families. 6. 2 methodological research were development of assessment tool of dementia patients in community, and assessment of burden of caregiver. 7. In experimental research, subjects were all dementia patients, and interventions were music therapy(5), light therapy(2), education program, cognitive stimulation training, validation therapy, hand massage, reminiscence, horticultural therapy, and art therapy. 8. Theme of qualitative research was all caring experience of family. There were 3 phenomenologic methodology, l ethnography and l case study. Based on these findings, the following recommendations were made: 1. It' s necessary to develop a reliable and valid instrument to measure the characteristics of dementia patients and family caregivers of dementia patients. 2. Experimental study should be repeated to prove the effect of intervention for dementia patients and their family.

광중합기를 이용한 광학적 치아우식활성도 검사법

이난영,김미라,오유향,이창섭,이상호 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

레이저와 플라스마 광, 할로겐 광 중합기를 이용하여 각 개인의 우식 활성도를 측정할 수 있는지를 규명하기 위해 7-8세 아동 45명을 대상으로 치아의 순면과 협면에 각 광원을 조사하고 특수 필터를 사용하여 초기 치아우식증으로 판별된 치아의 개수를 측정하여 기존의 우식활성도 측정방법인 dDfFtT rate와 mutans streptococci 측정법 Lactobacilli 측정법과 비교, 평가하고 그 특이도, 민감도, 예측력을 평가하였다. 1. 아르곤 레이저, 플라스마 광, 할로겐 광 조사시 육안검사시 보다 유의하게 많은 초기우식 병소가 관찰되었다(p<0.05). 2. 아르곤 레이저, 플라스마 광, 할로겐 광을 이용한 우식활성도 측정법은 dDfFtT rate와 양의 상관관계(γ= 0.42, 0.41, 0.39)를 보였다(p<0.01). 3. 기존의 우식활성도 측정방법을 기준으로 하여 평가한 결과 특이도와 민감도, 예측력은 모두 레이저가 가장 높았으며 플라스마 광, 할로겐 광 순으로 나타났다. 이상의 결과를 종합하여 볼 때 아르곤 레이저와 플라스마 광, 할로겐 광을 이용한 형광법은 모두 양호한 진단학적 지표를 보여줌으로써 향후 광학적 우식활성검사법으로 활용 가능성이 높을 것으로 사료된다. The purpose of this study was to develop a practical caries activity test by fluorescence using laser, plasma light and halogen light. The subjects of study were 45 children of 7-8 years old. Argon laser, plasma light and halogen light were irradiated to buccal or labial surface of all teeth. Fluorescence of initial carious lesion from teeth was observed through barrier filter and the number of teeth showing lesion was counted. Visual examination for the dDfFtT, mutans streptococci screening test and Lactobacilli colony counting were also done. Data analysis was accomplished by Axelsson's method. The result from the present study can be summarized as follows. 1. Laser, plasma light and halogen light could detect the initial carious lesions better than visual examination(p<0.05). 2. There was positive correlation between laser(r=0.42), plasma light(r=0.41), halogen light(r=0.39) and dDfFtT rate(p<0.01). 3. The specificity, sensitivity and predictive value was showed highest value in laser. but was showed favorable value in plasma light and halogen light. In regard to above results, laser, plasma light and halogen light all considered to be reliable method for determining individual caries activity. And they were also considered to be practical method because it would be simple, inexpensive, and time saving method.

Alprazolam함유 poly(D,L-lactic acid) microsphere의 제조 및 평가

용철순,오두만,권미라,박새해 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-

Poly(D.L-lactic acid)(PLA) microspheres containing alprazolam(APZ) were prepared by a solvent-emulsion evaporation method and their release patterns were invostigated in vitro. Various batches of microspherss with different size and drug content were obtained by changing the ration of APZ to PLA, PLA concentration in the dispersed phase and stirring rate. Rod-like APZ crystals on microsphere surface, which were released rapidly and could act as a loading dose, were observed with increasing drug content. The release rate was increased with increase in drug contents and decresase in the molecular weight of PLA. The release rate of APZ for long-acting injectable delivery system in vitro, which would aid in predicting in vivo release profile, could be controlled by properly optimizing various factors affecting characteristics of microspheres.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

Word-Initial Stops in Korean and English Monolinguals and Bilinguals

( Mi Ra Oh ),( Robert Daland ) 경희대학교 언어정보연구소 2011 언어연구 Vol.28 No.3

The theoretical status of early bilinguals is an area of some controversy. This study investigates subphonemic variation in Korean and English by monolinguals, and bilinguals who were born in the US (simultaneous), moved to the US as young children (early), or moved to the US during late adolescence (late). Speakers were recorded producing word-initial stops in a phrase-medial context. Measurements included stop VOT, H1-H2 and initial pitch on the following vowel. Bilingual productions were generally similar to monolinguals`. However, early and simultaneous bilinguals exhibited a 3-way VOT contrast for Korean stops that was recently neutralized to a 2-way contrast in Korea (Silva 2006). These findings are discussed with respect to transfer/convergence effects and phonetic change in Korea.

Morphological Effects in Loanword Adaptation: Adaptation of the English Plural Suffix into Korean

( Mi Ra Oh ),( Sye Jeong Kim ) 경희대학교 언어연구소 2012 언어연구 Vol.29 No.2

Oh, Mira & Kim, Syejeong. 2012. Morphological Effects in Loanword Adaptation: Adaptation of the English Plural Suffix indo Korean. Linguistic Research 29(2), 299-314. Most previous studies related to the input to loanword adaptation have centered on the division between phonological mapping LaCharite & Paradis, 2005) and perceptual mapping (Silverman 1992). However, few have considered morphological information in loan adaptation. Investigating adaptation of the English plural suffix into Korean by analyzing the corpus data from N1KL (1991), Bae (2002) and Google searches (2010), the present study makes four claims, First. (he morphology of a borrowed word should be referred to in calculating sound mappings in loanword adaptation since the same consonant can be adapted differently depending on whether it is morphemic by itself or morpheme-internal. Second, phonetic information of the incoming new word still influences loan adaptation. Different phonetic realization of allomorphs between voiced and voiceless allomorphs determine different rates of vowel epenthesis. Further, adaptation of the allomorphs /ts, dz/ into a single sound in Korean supports this perceptual account. Third, comparison of sound mappings over two decades suggests that sound mappings move toward uniform mappings (Kang 2010).

[P6-17] Hypoglycemic Effects of Fermented Red Ginseng in Subjects with Impaired Fasting Glucose

Mi-Ra Oh,Hyang-Im Back,Sun-Young Kim,Min-Gul Kim,Ji-Young Jeon,Won-Taek Na,Soo-Wan Chae,Tae-Sun Park 한국식품영양과학회 2010 한국식품영양과학회 학술대회발표집 Vol.2010 No.10

Bayesian Estimation of the Two-Parameter Kappa Distribution

Oh, Mi-Ra,Kim, Sun-Worl,Park, Jeong-Soo,Son, Young-Sook 한국통계학회 2007 Communications for statistical applications and me Vol.14 No.2

In this paper a Bayesian estimation of the two-parameter kappa distribution was discussed under the noninformative prior. The Bayesian estimators are obtained by the Gibbs sampling. The generation of the shape parameter and scale parameter in the Gibbs sampler is implemented using the adaptive rejection Metropolis sampling algorithm of Gilks et al. (1995). A Monte Carlo study showed that the Bayesian estimators proposed outperform other estimators in the sense of mean squared error.