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Na, Jung-Hyun,Joo, Man-Seok,Lee, Won-Kyu,Shim, Hyunbo,Lim, Si-Hyung,Jung, Sang Taek,Yu, Yeon Gyu Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
Single-chain variable fragments of antibodies (scFv) specific to 2,4-dinitrotoluene (DNT) were isolated from a phage library displaying synthetic human scFv fragments with 6 diversified complementary determining regions (CDRs). A DNT derivative that contained an extended amine group was synthesized and conjugated to the NHS-group that was linked to magnetic beads. Phages specific to the immobilized DNT derivatives were isolated from the library after 4 rounds of sequential binding and elution processes. The displayed scFv fragments from the isolated phages showed consensus CDR sequences. One DNT-specific scFv was expressed in E. coli and purified using Ni-affinity chromatography. The purified DNT-specific scFv binds specifically to the immobilized DNT-derivative with $K_D$ value of $6.0{\times}10^{-7}$ M. The scFv and DNT interaction was not disrupted by the addition of 4-nitrotoluene or benzoic acid. These data demonstrate that the screened scFv from the phage displayed library could be used for selective and sensitive detection of explosives such as TNT.
The prognosis of patients less than 40 years with bladder cancer.
Na, Seong Woong,Yu, Seong Hyeon,Kim, Kwang Ho,Hwang, Eu Chang,Jung, Seung Il,Kwon, Dong Deuk,Kang, Taek Won Medknow Publications 2014 Journal of cancer research and therapeutics Vol.10 No.3
<P>Natural history of young patients with bladder cancer has not yet been known. So this study aimed to understand characteristics and prognosis of patients less than 40 years with bladder cancer.</P>
Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma.
Shin, Won-Sik,Kwon, Junhye,Lee, Hae Won,Kang, Moon Chul,Na, Hye-Won,Lee, Seung-Taek,Park, Jong Ho Japanese Cancer Association 2013 CANCER SCIENCE Vol.104 No.8
<P>Esophageal squamous cell carcinoma (ESCC) is a common subtype of esophageal cancer that is particularly prevalent in East Asian countries. Our previous expression profile analysis showed that the gene encoding protein tyrosine kinase 7 (PTK7) is upregulated in ESCC tissues. Here, we aimed to validate PTK7 as a prognostic factor and a candidate target for molecular treatment of ESCC. Both RT-PCR and Western blot analysis of tissues from ESCC patients revealed that PTK7 was significantly upregulated in tumor tissue samples of ESCC. Immunohistochemical staining of PTK7 showed that increased expression of PTK7 was inversely correlated with overall survival (P = 0.021). In vitro knockdown of PTK7 inhibited proliferation, survival, wound healing, and invasion of ESCC cells. In addition, PTK7 knockdown decreased phosphorylation of Akt, Erk, and focal adhesion kinase (FAK), important determinants of cell proliferation, survival, and migration. Therefore, our findings suggest that PTK7 has potential as a prognostic marker for ESCC and might also be a candidate for targeted therapy in the treatment of ESCC.</P>
Olanzapine과 Lithisum 복용 후 나타난 Neuroleptic Malignant Syndrome에 동반된 급성신부전과 Lithium 중독
오원택 ( Won Taek Oh ),맹치훈 ( Chi Hoon Maeng ),박미나 ( Mi Na Park ),최선영 ( Sun Young Choi ),정경환 ( Kyung Hwan Jeong ),문주영 ( Ju Young Moon ),이태원 ( Tae Won Lee ),임천규 ( Cheon Gyu Ihm ),이상호 ( Sang Ho Lee ) 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.5
We report a patient developed neuroleptic malignant syndrome (NMS) with myoglobulinemic acute renal failure and lithium intoxication due to lithium-olanzapine combination, who was successfully treated by hemodiafiltration. A 34-year-old woman with a 14-year history of bipolar disorder had been treated with lithium-olanzapine during last four days. She was admitted to our hospital for muscular rigidity, hyperthermia and altered consciousness. On admission, rhabdomyolsis was demonstratd by biochemical methods and serum level of lithium was 3.78 mEq/L which was far above toxic level. After the diagnosis of NMS with acute renal failure and lithium intoxication, olanzapine and lithium were discontinued and conservative measures and continuous venovenous hemodiafiltration were instituted. She recovered without any neurologic sequelae. (Korean J Nephrol 2006;25(5):835-839)
손택준(Taek-Joon Son),나경수(Kyung-Su Na),임재혁(Jae Hyuk Lim),김경원(Kyung-Won Kim),황도순(Do-Soon Hwang) 한국항공우주연구원 2013 항공우주기술 Vol.12 No.1
국가우주개발계획에 따라 2020년 이후 한국형 달탐사선이 발사될 예정이다. 달탐사선은 무인 경량화모델로 달궤도선과 달착륙선 2종을 개발할 계획이다. 달탐사선의 구조체는 발사 및 궤도하중, 착륙하중을 견딜 수 있는 구조적 안정성과 탑재장비의 장착공간을 제공할 뿐만 아니라 발사체의 탑재능력을 고려하여 가볍게 설계되어야 한다. 이를 위해 달탐사선 구조체의 개발과 관련된 핵심기술의 선행개발이 요구된다. 특히, 달착륙선의 경우 착륙선이 달 지면에 안전하게 착륙할 수 있게 해주는 착륙장치의 개발기술이 필수적이다. 본 논문에서는 달착륙선 지상시험모델 구조체의 설계, 제작, 시험을 포함한 개발내용을 다룬다. Korean Lunar Explorer is planned to be launched in the 2020s according to national space development strategy. The Lunar Explorer will be developed as two unmanned light weight models: a lunar orbiter and a lunar lander. The Lunar Explorer"s structure should be designed to have light weight due to constraints from launcher as well as to provide structural safety against launch load, in-orbit condition and landing condition and to serve accommodation space for mission equipment. Core technology related to structural development of lunar explorer should be developed in advance. Especially, for lunar lander, technology for developing landing gear which enables lander to land safely on lunar surface is required essentially. This paper deals with structural development of lunar lander ground test model including design, manufacturing and test.
동반자가 중, 고등학교 골프선수에게 미치는 영향에 관한 연구
박나미 ( Na Mi Park ),육동원 ( Dong Won Yook ),김지수 ( Ji Soo Kim ),신정택 ( Jung Taek Shin ) 연세대학교 체육연구소 2005 체육연구논문집 Vol.12 No.1
The purpose of this study was to explore companying type and examine player satisfaction of middle and high school by companying type. Also, this study was to present useful data for performance improvement of golf player in middle and high school by exploring the effects of companying type on them through qualitative method. The subjects were made up of 214 golf players in middle school and 216 golf players in high school. This study explored companying type and examined the effects of companying type on their human relationships and satisfaction through these subjects. To deeply explore the effects of companying type on golf players of middle and high school, this study selected 5 golf players companying parent, 5 golf players companying coach, and 5 golf players companying parent and coach. Quantitative data were analyzed by SPSS Package 12. 0 and qualitative data were analyzed by qualitative research procedures. This results were as follows. Firstly, type companying parent and coach had the highest level and type companying coach had the lowest level in golf player of middle and high school. Secondly, type companying parent was significantly different with other types in the truth and sympathetic understanding and type companying coach was significantly different with other types in positively respect on the effects of companying type on human relationships of golf player in middle school. Also, type companying parent and coach was significantly different with other types in the truth, sympathetic understanding, and positively respect in high school. Thirdly, type companying parent was significantly different with other types in task performance satisfaction and social interaction satisfaction on the effects of companying type on satisfaction of golf player in middle school. Also, type companying parent and coach was significantly different with other types in task performance satisfaction, social interaction satisfaction, and coaching behavior satisfaction in high school. Fourths, positive effects(175 raw data, 4 dimensions) and negative effects(63 raw data, 4 dimensions) were categorized by exploring the effects of companying type on golf players through qualitative method. Positive effects were categorized in psychological aspect, technical aspect, life aspect, and monetary aspect. Negative effects were categorized in role aspect, psychological aspect, technical aspect, and monetary aspect. Lastly, type companying parent and coach had the highest level and type companying coach had the lowest level in companying type which players prefer. Also, all subjects responded that companying type had effect on player psychology and score.