기관지내 전이암

김현수,이상수,오미희,이재갑,원구태,홍희승,용석중,신계철 대한내과학회 1991 대한내과학회지 Vol.40 No.4

The lung is the most common site of metastasis of extrapulmonary malignant tumor. According to past reports, metastatic cancer of the lung has been found in about 2% of all patients at autopsy. But these days, a diagnosis of endobronchial metastatic cancer utilizing bronchoscopy only is not easy. Thus we need other means of gathering more informaction, such as past history, discovery of other metastatic sites, and pathologic findings with special staining and electronmicroscope, especially in cases of poorly differentiated adenocarcinoma and epidermoid cancer, which are common types of primary lung cancer. We present 5 cases of endobronchial metastatic cancer. We found endobronchial metastatic cancer 2 cases of cervix cancer (epidermoid, adenocarcinoma), 1 case of colon cancer (adenocarcinoma), hypernephroma (renal cell carcinoma), and bladder cancer (transitional cell carcinoma). Since it was impossiole to diagnose the metastatic adenocarcinoma from the cervix only with lightmicroscopic findings, we could use past history and unusual radiologic and bronchoscopic findings which was thought to be the specific endoscopic finding of metastic endobronchial cancer. The interval between the diagnosis of the primary cancer and endobronchial metastatic cancer was 25.7 months. In the future, development of immunohistochemistry, monoclonal antibody, and molecular biologic techniques will give us diagnostic clue for differential diagnosis of metastatic endobronchial cancer from primary bronchogenic lung cancer.

배양된 혈관내피세포에서 uncoupling protein 2 유전자 과발현이 세포내 산화스트레스 및 endothelin - 1 mRNA 발현에 미치는 영향

강효경,한정희,홍성관,김하영,남궁일성,박기영,박혜선,이재담,박중열,이인규,이기업 한국지질학회 2001 韓國脂質學會誌 Vol.11 No.2

당뇨병유발백서에서 급성패혈증 병발시 적혈구막지질과산화의 변화

박성우,홍성관,유형준,장대영,강승식,유재명,임성희,최문기,노정우,이규만 대한당뇨병학회 1994 Diabetes and Metabolism Journal Vol.18 No.3

늑막조직생검으로 진단한 Pleural Paragonimiasis 1 예

김기영,이승환,박진현,이재갑,용석중,신계철,홍욱균,김향인,진춘조 대한내과학회 1991 대한내과학회지 Vol.40 No.5

We report a 28-year old female patient with pleural paragonimiasis who did not have the usual diagnostic triad for this parasitic disease. She did not have chronic hemoptysis, there were no pulmonary infiltrations, and stool, sputum and pleural fluid examinations did not yield paragonimus ova. The diagnosis was made on the basis of ova found in the pleural biopsy. Paragonimus pleural effusion was resolved with frequent thoracentesis and oral praziquantel therapy.

Mycobacterium Avium - in tracellulare Complex 와 M . Fortuitum 에 의한 폐항산균증(肺抗酸菌症) 3예

김상재,홍수표,배길한,김성진,진병환,정충모 대한미생물학회 1982 大韓微生物學會誌 Vol.17 No.1

Two cases of pulmonary disease in a 54 year-old female and a 70 year-old male patient due to Mycobacterium avium-intracellulare complex (MAIC) and a case of pulmonary infection in a 69 year-old male patient due to M fortuitum (MF) were found recently in this institute. All three patients bad a long history of anti-tuberculous chemotherapy because they were initially diagnosed as pulmonary tuberculosis. A 70 year-old male patient infected with MAIC had an unsuccessful chemotherapy history of isoniazid (INH), para-aminosalicylic acid (PAS) and streptomycin (SM) with an incomplete, temporary, symptomatic improvement, for three years since 1964 when he was first diagnosed as pulmonary tuberculosis on physical examination. A 54 year-old female patient infected with MAIC also had an unsuccessful chemotherapy history with the various anti-tuberculous drugs since 1958. Both patients discharged large number of MAIC in their sputum specimens for at least more than one year, but no M tuberculosis at all. A 69 year-old male patient infected with MF was diagnosed as moderately advanced pulmonary tuberculsis in 1977. Combined chemotherapy with INH+PAS+pyrazinamide (PZA) improved his clinical symptoms, however, his chest radiograph was deteriorated again in 1980 one year after he stopped therapy. Therefore he started chemotherapy again with INH+ethionamide (TH)+cycloserine(CS) but no improvement was noticed. MF was cultured from his sputum in August 1983 and he continuously discharged the same baeilli until last examination of January l982. Whether all three patients were initially infected with nontuberculous mycobacteria or complicated with predisposing tuberculosis was not clear because there were no reliable bacteriological Examination records.

반추위 미생물의 질산염 환원 조절물질에 관한 연구

손용석,홍성호,이성호 한국영양사료학회 1999 韓國營養飼料學會誌 Vol.23 No.5

반추위내 미생물들의 질산염(NO₃^-) 환원능력에 관여할 수 있는 물질로 잠재성이 있다고 판단되는 Yeast culture(YC), L-cysteine(CSH) 및 Sodium tungstate(W)의 첨가효과를 관찰하고자, in vivo 및 in vitro 실험을 실시하였다. In vitro 실험에서는 미생물 공여축으로 반추위 누관이 장착된 55㎏ 숫면양에 체중 ㎏당 400 ㎎의 NaNO₃를 2주간 급여 적응시킨 후, 반추위액을 채취하여 첨가물질(YC, CSH. W)들과 함께 배양하면서 pH, 질산염, 아질산염 및 암모니아의 농도변화를 시간별로 관찰하였다. 배양액 내 NO₃^-농도는 대조구에 비해 CSH구와 W구에서는 높게, 그리고 YC구에서는 낮게 나타났다(P<0.05). 배양액 내 NO₂^- 농도는 대조구에 비해 YC, CSH, W구에서 유의적으로 감소하였고(P<0.05), 암모니아 농도는 CSH구에서 가장 낮게 나타났다(P<0.05). In vivo 시험에서는 질산염 중독반응에 대한 Yeast culture의 첨가효과를 관찰하기 위하여, 1차 시험에서는 숫면양 4두를 Switch-over design으로 배치하여 2%의 YC를 2주간 첨가급여하였다. 2차 시험에서는 L-cysteine (CSH)의 첨가효과를 관찰하고자 3두의 숫면양을 3×3 Latin Square 방법으로 배치하여 2주간 NaNO₃(0.5g NO₃^-/BW ㎏^(0.75))와 L-cysteine(0.115g S/W ㎏^(0.75))을 누관을 통해 주입한 후 혈중 NO₂^-와 MHb의 농도 변화를 시간별로 관찰하였다. 혈액 내 NO₂^- 농도는 NaNO₃ 투여 후 2시간때에 대조구에 비해 YC 첨가구에서 유의적으로 낮게 나타났으며, 혈액 내 MHb 농도는 NaNO₃ 투여 후 3시간과 4시간때에 YC 첨가구에서 유의적으로(P<0.05) 감소하였다. 또한, L-Cysteine의 경우에도 NaNO₃에서 유래한 혈중 NO₂^- 농도를 유의적으로(P<0.05) 감소시켰으며, NaNO₃ 투여 후 6시간 때에 혈중 MHb 형성을 유의적으로(P<0.05) 억제시켰다. 따라서, 본 시험에 공시한 3가지 물질들은 모두가 반추위 내 질산염 대사 속도를 조절함으로써 대사산물에서 유래하는 독성을 예방 또는 억제하는데 기여할 수 있음이 확인되었다. This study was conducted to examine the activities of some materials which could affect nitrate and nitrite reduction in the rumen and eventually their toxicity in ruminant animals. Rumen fluid (RF) taken from a fistulated ram was used as inoculum for an in vitro study, where 400 ㎎ NO₃^- ㎏^(-1) BW was added to RF donor rams for 14 days for adaptation. RF was incubated with 20 mM NaNO₃ in the presence of 0.25% Yeast culture (YC), 10 mM L-cysteine (CSH) or 1 mM sodium tungstate (W) for 24 hrs, and time changes of NO₃^-, NO₂^- and NH₃ concentrations in the medium were observed. NO₃^- concentration showed higher values in the medium with CSH and W group than that without addition (P<0.05). As compared with control, significantly lower NO₂^- concentrations were observed in the medium incubated with YC, CSH and W (P<0.05). The addition of CSH caused lower NH₃ concentration than control (P<0.05). Prophylactic effects of yeast culture and L-cysteine on the intensity of nitrate poisoning were also observed in vivo. Four rams were assigned to two group (Control, 2% YC) in a Switch-over design, and three rams were allotted to three treatments (CSH, NO₃^-, CSH + NO₃^- supplement) in a 3 × 3 Latin square design. The sheep fed Yeast culture had lower NO₂^- and MHb concentrations of blood than those fed without Yeast culture (P<0.05). A supplementation of L-cysteine to the diet decreased the level of blood NO₂^- as well as concentration of MHb (P<0.05) caused by NaNO₃ feeding. Consequently, continuous feeding either Yeast culture or L-cysteine could help prevent nitrate toxicity.

제 2 형 당뇨병에서 미세혈관 합병증과 대혈관 합병증의 대비

강문호,이기영,정연실,김홍규,서찬종,송광식,박혜영,이원기 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.2

Background: Type 2 diabetes is a heterogeneous disease. As to its complications, microangiopathy predominantly develop in some patients while macroangiopathy is more predominant in others. Therefore, this study was performed to identify the factors associated with such dissociation. Methods: Type 2 diabetic patients were classified into the macro and microangiopathy groups by carotid intima-medial thickness (IMT) and the presence of severe diabetic retinopathy. Patients with IMT ≤ 0.83 mm and severe NPDR or PDR were assigned to microangiopathy group; those with IMT 0.84 mm and no diabetic retinopathy were assigned to macroangiopathy group. Of 95 patients studied, 14 were classified as microangiopathy group and 20 as macroangiopathy group. Results: When the microangiopathy and macroangiopathy groups were compared, the microangiopathy group were significantly younger at the time of examination and at the onset of diabetes, and had longer duration of diabetes. Percentage of patients receiving insulin treatment was significantly higher and plasma C-peptide significantly lower in the microangiopathy group. However, HDL-cholesterol levels were significantly lower in the macroangiopathy group. Furthermore, the multiple logistic regression analyses revealed that younger onset of type 2 diabetes was an independent factor that was associated with the acceleration of microangiopathy. Conclusion: This study suggests that the age at onset of diabetes is an important independent risk factor that is associated with predominant development of microangiopathy in type 2 diabetic patients.

매설 천연가스배관의 지반침하에 의한 응력 분석

홍성호,김우식,김형식,방인완,오규환 한국산업안전학회 1998 한국안전학회지 Vol.13 No.2

This study was initiated to examine the stress and deformation characteristics of the pipelines which were subjected to various environmental conditions in order to confirm their integrity. As the part of them, this paper presents the analysis results for the effect of ground subsidence combined with main loads on buried natural gas pipelines. The ground subsidence which can occur for buried gas pipeline has been classified to the three cases. Finite element method was used to analyze the effect of ground subsidences on pipeline of 26 inch(0.660 m) and 30 inch(0.762 m) diameter used as high pressure (70㎏_f/㎠(6.86 ㎫)) main pipelines of KOGAS. This paper shows the result of stress analysis for the pipelines subjected to those three case ground subsidence. Comparing these results with safety criterion of KOGAS(0.9 σ_y), maximum allowable settlement and loads have been calculated.

RF Plasma 법으로 증착된 TiCN 박막의 구조 및 기계적 거동에 관한 연구

위명용,백창현,박상렬,홍주화,강희재 한국열처리공학회 2000 熱處理工學會誌 Vol.13 No.2

The structure and mechanical properties of TiN and TiCN thin films deposited on STD61 steel substrates by the RF-sputtering methods has been studied by using XPS, XRD, micro-hardness tester, scratch tester, and wear-resistance tester. XPS results showed that the TiCN thin film formed with chemical bonding state. The TiN thin films grew with (111) orientation having the lowest strain energy by compressive stress, whereas the TiCN thin films grew with both (111) and (200) orientation, but (200) orientation having the lowest surface energy becomes dominant as carbon contents increase. The pre-etching treatment of substrate did not affect on the preferred orientation of thin films, but it played an important role in improving mechanical properties of thin films such as the hardness, adhesion and wear-resistance. Especially, the TiCN thin films showed the superior wear resistances due to high hardness and low friction coefficient compared with TiN thin films.

후판 표면 산화층 색상에 미치는 산화층의 표면 현상 및 상분율의 영향

박신화,유경종,이중주,홍순태,손병준 대한금속재료학회(대한금속학회) 2001 대한금속·재료학회지 Vol.39 No.10

It was known that the color of Hematite(Fe₂O₃) is red, while Magnetite(Fe₃O₄) is dark blue. To clarify the origin of red color on the steel plate, the relationship between the volume fraction of oxide phases and the color of steel plate was investigated in this study. The volume fraction of Wu¨stite, Magnetite, and Hematite was quantitatively evaluated by a direct comparison X-ray method using crystal structure informations. Furthermore, the effect of volume fraction and the manufacturing process on the surface color of steel plate was investigated. It was found that FRT(final rolling temperature) played an important role on the plate color.