마이크로 로봇을 위한 비젼 시스템 개발

石尙祐,林廣洙,李炅武 弘益大學校 科學技術硏究所 2001 科學技術硏究論文集 Vol.12 No.-

In this research, we have developed a new navigation scheme using computer vision technology. A line feature tacking-based scheme is developed in which the orientation of the line features on the ceiling are detected in the input image, and used for guiding the direction of motion of a robot. In order to detect line information robustly, preprocessing steps such as lens calibration, noise cancelling, feature enhancement are employed. An also, to enhance the accuracy and the speed, we employed Intel IPL(Image Processing Library) for the implementation. The developed vision-based navigation system is quite reliable so that it can be used in a variety of natural circumstances, for example, home, office, factory, and so on. The performance of the developed system has been tested in many real environments, and shows excellent results in both accuracy and speed.

인체 간 Microsome에서의 우슬 추출물의 Cytochrome P450 약물 대사효소에 대한 억제작용

김경아,이지숙,박히준,김진우,김창주,심인섭,한승무,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : Achyranthes bidentata radix (Usul) has been used as anti-arthritic, antiallergic, antidiuretic and so on Recently extracts of Achyranthes bidentata radix have shown anti-inflammatory and cancer preventive effects in vitro and in vivo. Methods : We therefore evaluated the inhibitory potential of ehtanol extracts of Achyranthes bidentata radix on cytochrome P450(CYP) isoforms-catalyzecd reactions, which relate to causes of cancer and inflammation, including CYP1A2, CYP2C9, CYP2C19, CYP2E1, CYP2D6, CYP2C8, and CYP3A4, using human liver microsomal preparations. Results : The extracts showed weak or negligible inhibitory effects on CYP2C9-catalyzed (S)-warfarin 7-hydroxylation, CYP2C19-catalyzed S-mephenytoin 4-hydroxylation, and CYP2D6-catalyzed dextromethorphan O-demethylation with each IC50 over 1750 g/㎖, respectively. However, it showed relatively significant inhibitory effect on CYP1A2-catalyzed phenacetin O-deethylation and CYP2E1-catalyzed chloizoxazone 6-hydroxylation with IC50s of 970.5 g/㎖ and 821.4 g/㎖, respectively. Conclusions : These results suggest that extracts of Achyranthes bidentata radix have inhibitory effects on CYP-catalyzed reactions, expeciallyCYP1A2 and CYP2E1, in human liver microsomes. These effects appear to relate to anti-inflammatory and cancer prevention following decrease of reactive oxygen species formed by CYP, especially CYP1A2 and CYP2E1, by Achyranthes bidentata radix. However, further evaluation is necessary to demonstrate and to confirm its effects in human.

건설공사의 재해예방에 관한 연구

연길환,조희제,임경택,윤석천 忠南大學校 産業技術硏究所 1994 산업기술연구논문집 Vol.9 No.2

This study aims to review the problems and status of accident and construction projects also to find out the ways of preventing the works from accident. It can let them understand the reasons for the accidents and the way of promoting the awareness of safety. For the study the literature and previous studies are reviewed and then the field managers and safety management members were interviewed intent of status of field safety management and accidents data occurred at domestic construction fields.

복수과 진료 환자의 중복 처방에 대한 분석 및 평가

이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1

In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.

반건식-백필터에 의한 소각배가스 중의 HCI, SOx 제거 (Ⅰ)

배병훈,신남철,고경숙,김춘희,문종익,임경택 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

This study has been carried out to investigate the removal efficiencies of HCl/SOx in a Spray-Dryer/Fabric-Filter system. In HCl/SOx removal, we could identify the key factors such as spray dryer outlet temperature, molar equivalence ratio(MER) and fabric filter velocity, but we couldn't find out the correlation of HCl and SOx. The removals of HCl/SOx were inversely proportional to spray dryer outlet temperature(l30~170℃) and filter velocity(l.0~1.5 m/min), at the MER, HCl removal efficiency was strongly proportional to MER, but SOx, removal efficiency was not particularly increased by MER over 1.5. The removal efficiencies of HCl/SOx were improved over 10% at the fabric filter. In this Spray-Dryer/Fabric-Filter system, HCl/SOx removal efficiencies were about 99%, 96% respectively.

RAW264.7 세포에서 interferon-r 및 LPS에 의해 유도되는 NO생성에 미치는 TALT-35의 영향

박종일,박경석,김종석,박지훈,윤은진,송경섭,서강식,김훈,윤완희,박승길,임규,황병두 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

TALP-35 purified from human term placenta is known to increase microtubule polymerization and stabilize the polymerized microtubule. To examine the effect of TALP-35 on immune system this study was performed. MTT assay was performed to investigate the effect of TALP-35 on the proliferation of RAW264.7 cells. TALP-35 dose dependently suppress the proliferation of RAW264.7 cells at high concentration (above 1 μM) in unstimulated cells, in case of 10 μM TALP-35 treated cells the suppression was 25% but in stimulated cells it was only 15%. Cosedimentation assay was carried out to investigate whether TALP-35 can bind to tubulin of RAW264.7, monocyte/macrophage lineage of mouse, and polymerize it. TALP-35 polymerize the tubulin of RAW264.7 cells and sedimented in dose-dependent manner. To investigate the effect of TALP-35 on the expression of iNOS protein western blotting was performed. The expression level of iNOS was decreased dose dependently in high concentration of TALP-35 treatment. To examine the activity of iNOS, secreted NO was determined by method based on Griess reaction. Interferon-γ and LPS-stimulated production of NO from RAW264.7 cells was decreased dose dependently above 0.1 μM concentration of TALP-35 and 50% is decreased at 10μM of it. This study shows TALP-35 can control cytokine induced-iNOS expression therefore it might control inflammatory diseases.

고지혈증 흰쥐에서 비배당체 이소플라본 고함유 대두분말의 혈청 지질 대사 영향과 항산화효과

임애경(Ae Kyoung Lim),정희경(Hee Kyoung Jung),홍주현(Joo Heon Hong),오정석(Jung-Suk Oh),곽정훈(Jung Hoon Kwak),김용해(Yong Hae Kim),김대익(Dae Ik Kim) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.3

비배당체 이소플라본 고함유 대두분말이 고지방식이를 섭취한 흰쥐의 지질대사와 항산화 효과에 미치는 영향을 조사하고자 식이성 고지혈 흰쥐를 정상군(NO), 고지방식이군(CO), 고지방식이에 비배당체 이소플라본 고함유 대두분말 10%, 20%(w/w) 첨가군(BFF10, BFF20)으로 나누어 7주간 사육한 결과는 다음과 같다. 비배당체 이소플라본 고함유 대두분말 섭취는 체중과 간 무게를 유의적으로 감소시켰으며, CO군에 비해 혈청의 총 콜레스테롤, LDL-콜레스테롤, 중성지질 농도가 유의적으로 감소하였다. 간조직 손상시 활성증가가 우려되는 alanine amino transferase와 aspartate amino transferase 수준도 유의적으로 감소하였다. Thiobarbituric acid reactive substance의 생성량은 비배당체 이소플라본 고함유 대두분말의 첨가량이 높을수록 현저하게 감소되었으며 superoxide dismutase 활성은 농도 의존적으로 증가시키는 것으로 나타났다. This study was performed to evaluate the effects of soybean powder with rich aglycone isoflavone through bio-transformation on lipid metabolism and antioxidative activites in diet induced hyperlipidemic rats. The rats were randomly divided into four groups: NO (basal diet normal group), CO (high fat diet control group), BFF10 (soybean powder with rich aglycone isoflavone 10% group), and BFF20 (soybean powder with rich aglycone isoflavone 20% group). After 7 weeks of BFF10 or BFF20 diets consumption, the concentrations in serum triglyceride, total cholesterol, LDL-cholesterol, and atherogenic index ratios were significantly decreased in the BFF10 and BFF20 diets groups compared with those in the CO group. The activities of alanine amino transferase and aspartate amino transferase were significantly decreased in the BFF10 and BFF20 than those in the CO group. Thiobarbituric acid reactive substance levels of serum were decreased in BFF10 and BFF20 groups compared to that of the CO group. The super oxide dismutase activites were increased in BFF10 and BFF20 groups compared to that of the CO group.

중학교 특수학급 교과 수업에 만화그림중재 전략을 적용한 수업실행 과정에서 얻게 된 특수교사의 실천적 지식

임현숙(Hyeon Suk Lim),임경원(Kyoung-won Lim) 한국특수교육교과교육학회 2022 특수교육교과교육연구 Vol.15 No.3

이 연구의 목적은 중학교 특수학급 교과 수업에 만화그림중재(Comic Strip Conversations) 전략을 적용한 수업실행의 과정을 살펴보고, 그 과정에서 얻게 된 특수교사의 실천적 지식을 알아보는 데 있다. 연구자가 연구도구로 참여하는 실천적 실행연구 방법에 근거하여 수행하였으며, 순환 반복 주기는 연구 초기, 중기, 후기이다. 연구 기간은 2020년 3월부터 10월까지 8개월이며, 참여자는 연구자가 담임하고 있는 발달장애 6명 학생이다. 수업의 형태는 온라인 수업과 교실수업을 병행한 블렌디드 러닝(Blended Learning)으로 이루어졌다. 수집한 질적자료(성찰일지, 수업일지, 학생 면담전사 자료와 수업 결과물 등)를 분석한 결과 2개의 범주와 9개의 주제를 찾을 수 있었다. 연구결과; 첫째, 만화그림중재전략을 교과 수업에 적용하기 위해서 장애 유형과 시지각 처리 능력, 시각적 지원 요구 정도에 따른 적용단계를 개발하여 지도하는 것이 효과적이었다. 또한, 특수교육대상학생에게 어렵고 복잡한 내용을 쉽게 전달하고 이해를 도울 수 있으며, 학교생활이나 일상에서 마주하는 상황 속에서 대처해야 하는 사회적 행동을 습득에 유용하였다. 둘째, 특수교사의 촘촘한 원격수업 설계는 자기 장학의 기회가 될 수 있었다. 특수교육에서 원격수업은 학생 상황과 특성에 맞게 수업 방법을 다양하게 적용해야 하며, 온라인 공간에서 협업이 가능한 수업 도구를 활용하여 또래 학습과 활동 중심의 수업 설계가 필요하였다. 특수교사와 일반교사와의 수업나눔 활동은 일반교사가 특수교육대상학생을 이해하는 수단이 될 수 있으므로, 교원학습공동체를 적극적으로 활용하는 것이 중요하다. 이러한 결과를 바탕으로 한계점과 후속연구를 제언하였다. The purpose of this study is to investigate the practical knowledge acquired by a special education teacher by applying Comic Strip Conversations to special classes in middle school. This study was conducted based on the action research method, and the cycle consisted of three stages (initial, mid, and late). A 8-month study period was from March to October in 2020. The participants are six students with developmental disabilities who the researcher was in charge of. The form of the class consisted of blended learning. As a result of analyzing the collected qualitative data 2 categories and 9 topics were found. Result; First, it was effective to develop and guide the application steps according to the type of disability, visual perception processing ability, and the request for visual perception support degree in order to apply the comic conversation strategy to the subject classes. In addition, the students with special education needs could easily communicate and understand difficult and complex contents. It was useful in acquiring social behaviors that should be dealt with in school life or daily life. Second, the distance learnig carefully designed by special education teachers can be an opportunity for self-scholarship. In special education, online classes must applied to various teaching methods according to the student's circumstances and characteristics. It was necessary to design classes centered on peer learning and activities by using teaching tools that can collaborate in online spaces. In addition, sharing class activities between special teacher and general teachers could make the teachers understand the students with special needs. Therefore, it is important to actively utilize the teacher learning community. Based on the research results, limitations and follow-up studies were presented.

Stimulation of keratinocyte differentiation by extract of combined medicinal plant

Xue Mei Li,Dae-Kyoung Choi,Seul Ki Lim,In Suk Ahn,Dong-Il Kim,Yong Jun Piao,Chang Deok Kim,Jeung-Hoon Lee 충북대학교 동물의학연구소 2014 Journal of Biomedical and Translational Research Vol.15 No.4

Skin is the outermost organ and acts as a barrier between the organism and environment. Skin protects the organism from environmental insults, such as chemicals, pathogens, and UV light. Much of the protective function of skin is dependent on the epidermis, a multi-layered epithelium that is composed of various cell types such as keratinocytes and melanocytes. Keratinocytes produce protective components through a sophisticated differentiation process. Disturbance of keratinocyte differentiation is related to several skin diseases such as psoriasis and atopic dermatitis. In this study, we prepared extract of combined medicinal plants (ECMP) consisting of Taraxacum platycarpum H. Dahlstedt, Heartleaf Houttuynia, Glycyrrhiza uralensis Fischer, and root bark of Ulmus davidiana. We demonstrated that ECMP enhanced keratinocyte differentiation and barrier functionality using an in vitro cell culture system and in vivo animal test. Treatment of cultured keratinocytes with ECMP resulted in induction of keratinocyte differentiation, as evidenced by increased differentiation markers such as involucrin, loricrin, and filaggrin. In line with these results, ECMP decreased proliferation of keratinocytes cultured in vitro. ECMP applied topically to tape-stripped mouse skins accelerated reduction of transepidermal water loss (TEWL), indicating fast recovery of barrier function. Immunohistochemistry showed that ECMP increased the filaggrin level in tape-stripped mouse skins. These results suggest that ECMP may be applicable for keratinocyte differentiation-related skin diseases.

Urinary Levels of phthalate metabolites in Korean population: KorSEP data, 2009

( Kyoung Mu Lee ),( Young Lim Kho ),( Jae Buhm Chun ),( Pan Gyi Kim ),( Suk Hwan Park ),( Jin Heon Lee ) 대한보건협회 2011 대한보건협회 보건종합학술대회 Vol.2011 No.-

[Background] Phthalates are ubiquitous industrial chemicals used as plasticizers, solvents, lubricants, and stabilizers in the manufacture of consumer products such as children`s toys, medical equipment and medications, cosmetics, and food packaging. Assessing human exposure to phthalates is of interest because of their potential adverse health effects, particularly among the young. [Objective] The national survey for environmental exposure monitoring in 2009 were funded by Korea Food of Drug Administration (KFDA) with a view to assessing human exposure to selected chemicals including phthalates and identifying major sources of them. [Methods] The subjects of our study aged between 18 and 70 were selected through stratified sampling nationwide and interviewed by trained interviewers using structured questionnaire to collect information on general characteristics, use of plastics, dietary habits related with potential exposure to phthalates. Total 1,874 urine samples were collected and stored at -20℃ until measurement for 10 selected metabolites of phthalates using HPLC (high performance liquid chromatography). Out of 10 metabolites, six ones were selected for further statistical analyses based on proportion of samples over LOQ (limit of quantification), i.e, MnBP, MiBP, MbZP, MeHP, MeOHP, and MeHHP. For each urinary levels (ug per gram creatinine), geometric mean and 50th, 75th, 90th, 95th were represented. Given the distribution of response variable deviates from normal distribution, log transformation was performed, and then tested for its statistical significance. Differences by selected variables were analyzed for statistical significance by ANCOVA (analysis of covariance) adjusted for age, sex, income, and body mass index. [Results] Common phthalate metabolites included MnBP (GM=41.7, GSE=1.9), MeHHP (38.1, 1.9), MeOHP (17.5, 1.9), MiBP (17.0, 2.2), and MBzP (15.8, 2.8), whereas the proportion of data above LOQ was less than 20 for MCHP, MnOP, MiNP, and MiDP. The levels for the six metabolites tended to be higher compared to those from the national survey in US (NHANES), and lower compared to those from the national survey in Germany (GerES4). Significant correlations between the six urinary metabolites were observed. Urinary level of phthalates were observed to be higher among subjects with older age, females, subjects with higher body mass index (BMI), and lower income.