2.9% 과산화수소를 함유한 부착형 미백제의 임상적 효능과 안정성에 관한 연구

박은숙,성소래,홍성태,김지은,이소영,황수연,이신재,진보형,손호현,조병훈 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.4

2.9%의 과산화수소를 함유한 시험용 부착형 미백제(Medison dental whitening strip, Samsung medical Co.,Anyang,Korea)를 실험군 피험자 23명, 시험용 미백제에서 과산화수소를 제외한 동일한 제재를 대조약으로 대조군 피험자 24명에게 매일 1시간 30분씩, 2주간 적용하여 임상적 효능과 안전성을 평가하였다. 미백 효과는 Shade Vision, Chroma Mete 및 Vitapan classical shade guide를 이용하여 색변화를 측정하여 다음과 같은 결론을 얻었다. 1. 실험군에서의 전체 치아의 색변화량(ΔE^(*))은 세 가지 측정법에서 모두 대조군에 비해 통계적으로 유의한 차이를 보였고 (p < 0.05). 쉽게 인지할 수 있는 정도였다. 2. 색변화는 색좌표 상에서 명도의 증가와 녹색조 및 청색조로의 변화에 의해 얻어졌다. 3. 치아별로는 어두운 견치의 색변화량이 가장 컸고, 측절치, 중절치 순으로 감소하였다. 4. 47명의 피험자 중 5명이 경도의 과민증을 경험하였으나 곧 완화되었다, 치은염증지수와 전기치수검사 결과 시험 전후에 차이가 없어 안전성을 확인하였다. This study evaluated the effectiveness and safety of an experimental bleaching strip (Medison dental whitening strip, Samsung medical Co., Anyang, Korea) containing 2.9% hydrogen peroxide. Twenty-three volunteers used the bleaching strips for one and a half hour daily for 2 weeks. As control group, the same strips in which hydrogen peroxide was not included were used by 24 volunteers with the same protocol. The shade chang (ΔE^(*), color differnce) of twelve anterior teeth was measured using Shade Vision (X-Rite Inc., S. W. Grandville, MI, USA), Chroma Meter (Minota Co., Ltd. Osaka, Japan) and Vitapan classical shade guide (Vita Zahnfabrik, Germany). The shade change of overall teeth in the experimental group was significantly greater than that in the control group (p < 0.05) and was easily perceivable. The change resulted from the increase of lightness (CIE L^(*) value) and the decrease of redness (CIE a^(*) value) and yellowness (CIE b^(*) value). The shade change of individual tooth was greatest in canine, can smallest in central incisor. The safety of the bleaching strip was also confirmed. 〔J Kor Acad Cons Dent 31(4):269-281, 2006〕

FORREST II 궤양 출혈의 적절한 치료 유용성 : 전향적 무작위 연구

김성은,이선영,신정은,주미순,전정현,이경은 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Objectives : This study is to compare the clinical and cost effectiveness of various pharmacologic therapies with of without endoscopic procedure in the Forrest II ulcer. Methods : Between May 2001 and June 2002, total of 58 Forrest II bleeding activity patients (37 cases of NBVV, 6 adherent blood clots, 9 flat red spot, and 6 flat black spot) with gastric ulcer(32 cases) and duodenal ulcer(26 cases) were analyzed. UGI endoscopy was performed within 12 hours of the first bleeding episodes, and underwent repetitive endoscopy after 48h. All the patients were randomly assigned to receive somatostatin(group I), PPI(omeparzole : group II), only H2 blocker (famotidine, group III), or endoscopic injection therapy followed by famotidine (group IV). We compared with rebleeding rates, changes of ulcer size, and modified estimated costs for 3 day-hospital in four groups respectively. Results : 1) Twelve patients experienced rebleeding(20.7%). 2) The rates of rebleeding were 16.6% (2/12) in group I, 28.6%(4/14) in group II, 5.9%(1/17) in group III, 26.7% in group IV. There was no significant difference in rebleeding rate among the groups, but there was low rebleeding tendency in group III, compared with group II(p=0.087).3)Type of stigmata including non-bleeding visible vessels and adherent clots were associated with an increased rate of recurrent bleeding(p=0.01).4) When modified estimated costs were calculated, group III could be treated at the lowest cost(p<0.05). Conclusion : In Forrest II bleeding ulcer, medical therapy, especially famotidine could be suggested prudently as a proper treatment modality for this lesion, considering the cost-effecti-veness. 목적: 위십이지장의 궤양성 출혈은 대부분 특별한 치료없이 보존적인 치료만으로 지혈된다. 그러나 활동성 출혈이 있는 Forrest II 궤양의 경우는 흔히 내시경적인 치료를 하게 되는데 최근 여러 연구에서 약물치료와 비교 연구가 있었으나 다양한 약물들과 내시경 치료의 효과 및 비용-효용성의 비교는 이루어지지 않았다. 방법: 2001년 5월부터 2002년 6월가지 Forrest II 궤양출혈 환자 68명을 전향적으로 포함시켰고 이중 위암으로 진단된 경우와 내시경의 추적 검사를 거부한 경우 또는 다른 중증의 내과적 질환이 동반된 경우를 제외시켜 58명의 환자를 대상으로 하였다. 대상 환자 58명은 위궤양이 32명이고 십이지장 궤양이 26명으로 비출혈성노출 혈관 37명, 신선 부착 혈괴 6명, 적색반 9명, 그리고 흑색반 6명이었다. 초기 상부 위장관 내시경은 내원 후 12시간 이내에 이루어졌고 추적 검사는 48시간 이후에 시행되었다. 치료는 네 개의 군으로 나누어 무작위로 소마토스타틴 투여군(1군), 프로톤펌프 억제제 투여군 (2군), H₂수용체 차단제 투여군(3군), 그리고 내시경적 지혈제 주사군(4군)으로 치료하였고 각 군의 재출혈 여부, 혈압, 수혈, 궤양의 크기, 급성 출혈 흔적 등을 비교 관찰하였고 입원 3일간의 입원치료비용을 계산하였다. 결과: 1) 재출혈은 12명(20.7%) 에서 발생하였다. 2) 각군에서의 재출혈은 제1군이 16.6%(2/12), 제2군에서 28.6%(4/14), 제3군이 5.9%(1/17), 제4군이 26.7%(4/15)로 각 군의 재출혈 빈도는 차이가 없었으나 제3군에서 제2군에 비해 재출혈이 낮은 경향을 보였다.(p=0.087).3) 재출혈에 영향을 미치는 인자는 노출 현환과 신선 혈괴였다(p=0.01). 4)평균 입원치료 비용은 제3군이 가장 적어 높은 치료 비용-효과를 보였다.(p<0.05).

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

만성 간질환에 대한 DDB(Biphenyl Dimethyl Dicaboxylate)의 임상적 효과

이헌영,임의혁,김성걸,김진희,육은주,성자원,김병호,정형용,강대영,김영건 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To investigate the effects of short-term administration of DDB(Biphenyl Dimethyl Dicarboxylate) for decreasing elevated serum aminotransferase levels in chronic liver diseases, authors applied 3 capsules of DDB per day at each meal time for 35 patients and compared with 35 patients treated with other conservative management. The following results were obtained. 1. Serum alanine aminotransferase (ALT) levels significantly decreased from 247.1± 180.0 IU/L of pretreatment level to 96.6±126.0 IU/L, 61.1±62.7 IU/L and 38.0±26.8 IU/L after 1, 3 and 6 months of treatment(p<0.05) and effective rates were observed in 60.0%, 71.4% and 88.6% of patients after 1, 3 and 6 months of treatment. 2. Serum aspartate aminotransferase (AST) levels decreased also significantly from 167.8±96.9 IU/L of pretreatment levels to 124.4±155.0 IU/L, 77.9±49.6 IU/L, 60.6± 46.9 IU/L after 1, 3 and 6 months of treatment(p<0.05), but decreasing pattern of serum AST was less significant than that of serum ALT. 3. No significant difference were observed in the serum ALT and AST changes according to the cause and duration of hepatitis. 4. No significant adverse effects were observed in whole patients treated with DDB. It is suggested that small dose administration of DDB is effective for decreasing serum aminotrans ferase levels in chronic liver disease in which other conservative management was not effective.

운동신경원성 질환을 동반한 전측두엽 치매 1례

최성혜,나덕렬,김병준,이정일,서연림,김상은 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

DHA의 lipoxygenation에 의한 17-H(P)DHA 의 제조 및 LC/MS/MS를 이용한 구조분석

이은실,이은주,강종성 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-

Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are essential fatty acids and necessary for the development of brain, nerve system and retina. Recently, novel hydroxy compounds generated from DHA and EPA showing various biological activities were reported. In this study, hydroperoxy compound of DHA was prepared by incubating 15-lipoxygenase (15-LOX) and DHA, and was purified and analyzed by HPLC. The purified compound (MW 360) with the absorption maximum of 238 nm was identified as 17-hydroperoxy DHA (17-HPDHA). 17-HPDHA was reduced to a hydroxy compound by sodium borohydride and identified as 17-hydroxy DHA (HDHA) by LC/MS/MS. This method could afford to gain the commercially unavailable precursor of biologically active mediator.

요양병원 환자분류체계 개발

이지윤,윤주영,김정회,송성희,주지수,김은경 대한간호학회 간호행정학회 2008 간호행정학회지 Vol.14 No.3

Purpose: To develop the patient classification system based on the resource utilization for reimbursement of long-term care hospitals in Korea. Method: Health Insurance Review & Assessment Service (HIRA) conducted a survey in July 2006 that included 2,899 patients from 35 long-term care hospitals. To calculate resource utilization, we measured care time of direct care staff (physicians, nursing personnel, physical and occupational therapists, social workers). The survey of patient characteristics included ADL, cognitive and behavioral status, diseases and treatments. Major category criteria was developed by modified delphi method from 9 experts. Each category was divided into 2-3 groups by ADL using tree regression. Relative resource use was expressed as a case mix index (CMI) calculated as a proportion of mean resource use. Result: This patient classification system composed of 6 major categories (ultra high medical care, high medical care, medium medical care, behavioral problem, impaired cognition and reduced physical function) and 11 subgroups by ADL score. The differences of CMI between groups were statistically significant (p<.0001). Homogeneity of groups was examined by total coefficient of variation (CV) of CMI. The range of CV was 29.68-40.77%. Conclusions: This patient classification system is feasible for reimbursement of long-term care hospitals.

Silver Nitrate가 雄兎의 精巢에 미치는 影響

李殷奉,趙聖均 順天大學校 1983 論文集 Vol.2 No.1

Silver Nitrate 稀釋液(1%, 5%)을 白色 日本系 雄兎를 使用하여(生後 4∼5個月令) 9區로 各 4마리씩 配置하여 總 36마리에 1%, 5% Group에 0.5㎖씩 精巢內에 注入한 結果 다음과 같은 結果를 얻었다. 1. 各 Group間에 體重의 增減의 有差差가 없는 것으로 成長과 增體에는 支障이 없는 것 같다. 2. 外的인 精巢의 變化를 보면 1%, 5% Group 共히 注入後 2日에 膨脹(23.6×10.2mm→34.7×18.1mm)되었다가 다시 收縮되었으며 5% Group은 20日 後에 精巢組織의 壞死로 因하여 消失을 가져와 測定할 수가 없다. 3. 內的인 精巢의 變化를 보면 局部的 또는 全體的 組織의 壞死를 가져와 移動的이 아니라는 것을 알 수 있으며 暗褐黑靑色을 띠었다. 4. 白血球의 數는 S.N의 注入으로 7,000∼11,000(正常値)에서 13,575로 急增加 하였으나 時日이 經過함에 따라 正常으로 復歸가 되었다.(13,575→9,500) 5. 完全去勢보다 部分去勢가 增體에 效果的이라는 것에 一致된 것 같다. To investigate the effect of Silver Nitrate solution on the testis and the body weight in male rabbit, this experiment was carried out and used thirty six White-Japeness Rabbits, which were 4to5 months old, as experimental animal. Those animals were assigned into 9 groups of 4 rabbits, and these groups consited of three control groups and three groups with 1%, three groups with 5% silver nitrate solution which injected 0.5ml into the testis tissue of these male rabbits. The results obtained summarized were as follows; 1. The growth and the body weight gain showed no significant effect in all the groups. 2. In the changes of the external testes, showed expending testes in 2 days after injection and then constructing in all the groups with the exception of control groups. In groups with 5% S.N.solution, however, most of testes were disappeared in 20 days after injection because of necrosis of internal testis tissue. 3. It seemed that the internal testis tissue restored in the groups with 1% S.N.solution as time goes by, but appeared the necrosis of the internal testis tissue in the groups with 5% S.N.solution. 4. Nos. of leucocyte were increased after injection of S.N.solution and then restored with the passage of time. *S.N:Silver Nitrate.

標本클럭 合成 計數方式의 디지틀 周波數 合成器 具現 및 性能改善에 關한 硏究

李成洙,金元厚,張殷永 한국항공대학교 1990 論文集 Vol.28 No.-

기존의 디지틀 주파수 합성기는 위상을 누적하여 출력파형을 직접 합성하는 방식으로서, 합성파형상에 위사왜곡이 수반되어 불규칙적인 불요잡음이 크게 나타나는 단점이 있다. 본 논문에서는 이러한 단점을 개선하기 위해 위상 누적 방식에 관한 이론을 고찰한 후, 새로운 방식의 파형 이론식을 유도하고 이에 적합한 시스템을 구성하였다. 이 방식은 표본클릭의 합성초기치를 계속 누적하여 표본 클럭을 합성하고, 이 클럭을 사용하여 생성하려는 주파수에 해당되는 정현파형의 한주기당 일정한 표본갯수를 계수하므로써 위상왜곡을 제거하게 된다. 또한 표본클럭합성 과정에서 PN 부호를 사용하여 순시적인 주파수 도약상태를 확인하였다. In conventional digital frequency synthesizer, a output wave is directly constructed by the phase accumulating method, which has a periodic phase distortion in frequency spectrum. In order to improve this defect, the method is reconsidered in the side of the output wave formula expresssion, and a new mechanism which are constructed by a most suitable logic elements is proposed. In this new form the sample numbers per the period of sinusoidal output wave are fixed and the sampling clock synthesized by the initial clock value adding is counting the number. So there is eliminated the periodic phase distorition and obtained the only uniform quantization noise. Addtionally, we confrim the coherence frequency hopping state with the pseudorandom code sequence which makes the instantaneous inital clock value.