급성백혈병의 화학요법에서 조혈간세포 보충요법

이규보,배선근,손상균,이재태,이건수,이경혜,서장수 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

1. 목적 급성백혈병의 화학요법에 있어서 관해유도 요법시에 보다 더 강력한 항암화학요법을 시행하고 골수억제의 회복을 위하여 말초혈액에서 채취한 조혈모세포의 투여로 그 효과를 증대시키고자 시도하였다. 2. 방법 관해유도 화학요법후에 골수억제시기로부터 회복단계로서 백혈구감소증이 호전도면서 단핵세포가 증가될 때에 말초혈액에서 조혈간세포(stem cell)로 인정되고 있는 CD34+세포의 함유량이 1% 이상되는 시기를 찾아내고 그 때부터 평균 4차례의 단핵구를 분리채집을 하여 -74。C에 냉동보관하였다가 제2차 화학요법후에 해동시켜서 정맥주입하였다. 3. 결과 대상 급성백혈병환자는 6명에 23회의 조혈간세포를 함유한 단핵구 채집을 시행하였고 유효한 단핵구의 채집은 4례에서 가능하였고 2례에서는 유효한 채집이 못되었다. 채집효율은 39.0-74.5%로서 평균 49.8%였다. 채집 후에 혈액학적 변화는 혈색소의 약간 감소 (평균 1.34g/dl)와 혈소판의 감소 (평균20.25%)를 나타내었다. 해동 단핵구를 투여할시에 일과성인 불쾌감, 기침, 흉부압박감, 호흡곤란 등이 있었다. 4. 결론 자가골수이식에서 자기말초혈액조혈간세포이식으로 관심이 이행되는 현시점에 자가조혈간세포를 채집하여 수혈하는 기술이 확립되는 기초를 이루었다고 본다. 이번 대상들은 재발된 금성백혈병들에 시행하였으나, 향후에는 초발시에 제일차 관해유도 화학요법 과정에 시도해야할 것으로 생각한다. Object: Peripheral blood stem cells(PBSC) were collected after remission induction chemotherapy and reinfused after intensified chemotherapy in order to increase the chemotherapeutic efficacy. Method: Collection of mononuclear cells (MNC) was started when CD34+ cells above 1% and WBC above 1,000/ul with mononuclear cell percentage above 30%, the collection procedures were done 2-6 time in each patient of total 6 cases. The collected MNCs were stored in - 750C and reinfused after thawing in the water bath at 370C Results: Twenty three collection procedures from the 6 cases of acute leukemia had made effective MNC collection in 4 cases and mean collection efficiency was 49.8%(from 39.0% to 74.5%). Hematological changes after the procedure were mean reduction of hemoglobin 1.34g/dl and mean 20.25% of decreased platelet count. There were noticed transient symptoms of discomfort, coughing, chest tightness and dyspnea in association with the infusion of stored cells. Conclusion: The basic process for the peripheral blood stem cell transplantation (PBSCT) was accomplished with this supportive care for the consolidation chemotherapy of acute leukemia. Effective PBSCT would be warrented with more qualified process and high does chemotherapy. (Korean J Blood Transfus 6(2) : 41~47,1995)

Infliximab으로 호전된 장관 증상없이 발생한 구강-안면 크론병

정보용 ( Bo Yong Jung ),이석호 ( Suck Ho Lee ),정승규 ( Seung Kyu Chung ),이창균 ( Chang Kyun Lee1 ),이태훈 ( Tae Hoon Lee ),정일권 ( Il Kwun Chung ),김선주 ( Sun Joo Kim ),조현득 ( Hyun Deuk Cho ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6

Crohn`s disease is a chronic inflammatory bowel disease that can involve the whole gastrointestinal tract. The orofacial manifestation of Crohn`s disease, which is rare, can develop irrespective of intestinal involvement. These orofacial lesions are often misdiagnosed as simple oral ulcers. Corticosteroids are the mainstay of therapy for orofacial Crohn`s disease. However, infliximab, the chimeric monoclonal antibody to tumor necrosis factor-α, is now considered as a primary treatment because of the disease`s relatively high rate of steroid resistance. We present a case of deep oral ulcer and periorbital swelling in a 65-year-old woman. She was diagnosed with intestinal Crohn`s disease 7 years ago, which was in remission after treatment with an immunosuppressive agent (azathioprine). The patient was given the diagnosed with orofacial Crohn`s disease and successfully treated with infliximab. (Korean J Gastroenterol 2012;59:437-440)

연취급 근로자들의 사회 심리적 스트레스와 연노출 지표들간의 관련성

김용배,안현철,황보영,리갑수,황규윤,이성수,안규동,이병국 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목 적 : 연취급 근로자를 대상으로 사회 심리적 스트레스 수준을 알아보고 이를 기초자료로 활용하며 사회 심리적 스트레스와 연노출 지표들간의 관련성을 알아보고자 시도하였다. 방 법 ' 1차 연제련업종의 근로자 234명을 대상으로 일반적 특성, 사회 심리적 스트레스, 직업적 특성과 사회적 지지를 문진과 설문지를 통해 확인했으며 연노출 수준을 알기 위해 혈중 ZPP 농도, 혈중연농도, 요중 δ-ALA 배설량, 혈색소, 혈구용적치등을 측정했다. 결 과 : 단일변량 분석결과 혈중 연농도 수준과 직업적 특성에 따른 사회 심리적 스트레스는 유의한 차이가 있었으며 혈중 연농도가 증가함에 따라 스트레스 수준도 증가되는 경향을 나타냈다. 사회 심리적 스트레스와 연노출 지표 및 다른 변수들간의 관련성을 파악하기 위하여 상관분석을 실시한 결과 혈중 연농도만이 사회 심리적 스트레스와 양의 상관관계를 나타냈으며 유의했다. 결 론 : 고농도 연노출의 가능성이 있는 직종인 경우 기존의 연관련 자각증상에 대한 설문조사와 함께 사회 심리적 스트레스 측정도 병행하여 실시하는 것이 연에 의한 건강장해를 조기에 발견하고 예방하는데 필요하다. Objectives : This study was carried out to assess psychosocial distress of lead workers and to examine the relationship between lead exposure indices and psychosocial distress. Methods The study design was cross-sectional and research subjects were 234 lead workers in primary smelting industry. General characteristics, job characteristics and social support were obtained by self-administered questionnaire and history taking. Psychosocial distress was measured using PWI(Psychosocial Well-being Index), a 45-item self-administered instrument. Blood lead(PbB), zinc protoporphyrin(ZPP), δ-aminolevulinic acid in urine (ALAU) were selected as indicators of lead exposure. Results : There was significant difference in PWI according to lead exposure level and job characteristics. The results of correlation analysis showed that PWI was significantly correlated with PbB (r=0.203, p=0.002). Conclusions : Our results supported the association between lead exposure and psy-chosocial distress. The inclusion of psychosoclal distress measurement as a special health examination for lead workers was highly recommended for the effective health manage-ment.

림프종 환자에서의 갈륨, TI-201 그리고 Tc-99m MIBI 섭취의 비교

천경아,조인호,원규장,이경희,이형우,현명수,이재태,이규보 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.2

Purpose; Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. Materials and Methods: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. Results: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. Conclusion: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.

한글대장경 검색 시스템

이금석,이용규,홍영식,한태식 동국대학교 전자불전연구소 2002 전자불전 Vol.4 No.-

한글대장경의 전산화 및 검색 시스템 개발은 세계에 우리 문화의 우수성을 널리 알리고, 우리 문화유산에 대한 국민적 관심을 높이며 해당 분야에 대한 효과적인 연구를 지원하기 위해 반드시 필요하다. 한글대장경은 고려대장경의 번역본으로 주로 한글로 기록되어 있지만, 원문의 이해를 돕기 위해서 다양한 한자가 사용되고 있다. 이러한 한자들은 본자(本字)와 뜻은 같지만 모양이 틀린 이체자(異體字)및 오자(誤字)나 탈자(脫字)로 간주되는 파자(破字) 등을 포함하고 있으므로 입력이나 저장 뿐 아니라 검색 관점에서도 여러 가지 문제점을 갖는다. 또한 인터넷이 널리 보급되면서 인터넷을 통한 문헌 검색이 증가하였지만 기존의 문헌 검색 시스템은 용어 검색, 색인 검색 등과 같은 단순한 검색만을 지원하기 때문에 사용자의 다양한 검색 요구를 충족시키기가 어려웠다. 본 연구에서는 한글대장경의 효과적인 입력과 저장을 위해 유니코드(unicode)를 사용하였고, 효율적인 검색을 위해 문서 구조를 XML로 정의하였으며, 결과내 검색과 히스토리 검색 등과 같은 다양한 검색 방법을 지원하는 웹 기반 한글 대장경 검색 시스템을 개발하였다.

쌍정 경계가 고온 초전도체 Y₁Ba₂Cu₃O단결정의 자기적특성에 미치는 영향

이보화,박정수,김채옥,김의훈,정규채 漢陽大學校 自然科學硏究所 1997 自然科學論文集 Vol.16 No.-

일반적으로 쌍정 경계(twin boundary)는 고온초전도체Y₁Ba₂Cu₃O??? 단결정 내에서 핀 고정점(pinning center)로 작용하여 단결정 시료의 자화에 영향을 미칠 것으로 알려져 왔다. 그러나 이에 대한 체계적인 실험적 연구가 수행되지 않고 있다. 본 실험에서는 Y₁Ba₂Cu₃O??? 단결정 시료를 성장시킨 후, 재 후열처리 과정 중에 단축 가압 방법(uniaxial stress method)을 이용하여 단결정 시료를 detwinning 하였다. 편광효과가 관측된 micro-Raman spectra와 X-ray 회절 패턴으로부터 관측된 (001)면의 주 피크의 2Θ 값을 통해서 단결정이 잘 성장되었음을 확인하였다. 그리고, 반자성 차폐 효과, 마이스너 효과 및 자기이력 측정 결과로부터 detwinning시간이 길어져서 쌍정 경계의 비율이 감소할수록 자화폭이 감소함을 관측하였다. 이로부터 자속 고정(flux pinning)이 줄어듦을 알 수 있었다. 그러므로 쌍정 경계가 고온초전도체 Y₁Ba₂Cu₃O??? 단결정의 핀 고정점으로 작용한다는 것을 알 수 있었다. Generally it is suggested that twin boundaries play the major role of the pinning center in high-Tc superconductor Y₁Ba₂Cu₃???? single crystal and influences the magnetization. However, any systematic experiment related with this expectation has not been performed yet. In this experiment, after growing Y₁Ba₂Cu₃??? single crystals, we detwinned them in oxygen atmosphere using uniaxial stress method while annealing them again. It was verified that single crystals had been grown well from micro-Raman spectra that showed the polarization effect and 2Θ values of (001) plain peaks in X-ray diffraction pattern. We observed that values of magnetization of samples decreased from antimagnetic shield effects, Meissner effect and magnetic hysteresis as detwinning time was increased and this result means that flux pinning decreases. As a result we confirmed that twin boundaries act as a pinning center in high-Tc superconductor Y₁Ba₂Cu₃??? single crystal.

산국의 수량과 유효성분에 대한 NPK의 효과

이경동,양민석,정연규,손보균,조주식,이성태,김필주 한국농화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.2

본 연구는 3요소(N-PO_2O_5-K_2O)처리가 산국(Chysanthemum boreale M.)의 수량과 유효성분에 미치는 효과를 조사하여 효과적인 재배시스템을 개발하고자하였다. 처리구는 무처리, NPK(250-160-160), NK(250-0-160), PK(0-160-160kg/ha)의 5처리로 설정하여 산국을 재배한 결과, 건물수량은 NPK처리구가 PK처리구에 비하여 4.0배의 증수가 있었으며, 다른 처리구보다 무기이온의 흡수율, 생육 및 수량에서 NPK처리구가 가장 우수하였다. 식용으로 많이 쓰이는 꽃의 주요 아미노산은 proline, glutamic acid과 aspartic acid이였고, 다른 처리구들에 비하여 NPK처리구가 높은 함량을 보였다. 혈압강하효과가 우수한 cumambrin A는 PK처리구에 비하여 NPK처리구가 6.2배의 증수효과가 있었다. NK처리구는 NP처리구보다 cumambrin A의함량을 높이기 위해서는 인산의 시용보다 칼리의 시용이 더 요구되며, 야외포장에서의 인산과 칼리의 적정 시비량의 설정이 필요하다고 판단된다. To establish the fertilization condition to increase the productivity of Chrysanthemum boreale M. with high quality, the effects of three nutrients (N, P, K) on the yields and the effective components were investigated in the pot scale. NPK was applied by chemical fertilizers with N-P_2O_5-K_2O = 250-160-160 kg/ha as a main treatment, and NP (N-P_2O_5 = 250-160 kg/ha), NK (N-KO = 250-160 kg/ha), and PK (PO_2-KO_5 = 160-160 kg/ha) treatments were settled as comparison. Dry yields of C. boreale M. was increased significantly to 4 fold higher by nitrogen. Nitrogen increased apparently plant growth and inorganic nutrient uptake. In the flower, which is most useful and edible part as a herbal medicine, main amino acids were glutamic acid and aspartic acids, and the total content was increased significantly by three elements of application. In addition, the content of cumambrin A, which is known to have the effect of blood-pressure reduction, was increased source to 6.2 times by nitrogen higher than that in PK treatment. Potassium was more effective in biosyndiesis of cumatnbrin A than phosphorus, but the biological pathway was not clear, still.

各級 學敎 學生들의 國家意識에 關한 硏究

李珪範,金均保,河在煥 釜山敎育大學 1973 부산교육대학 논문집 Vol.9 No.1

Educating the students so as to have a strong, racial and national consciousness is one of the essential aims of Korean education. The purpose of this study is to analyze, compare, and evaluate the degree how far the abovementioned aim has been achieved at the schools of various level, in order to get some useful materials an and certain directions for the educational planning. In this study, the national consciousness has been defined as the individual's cognitive and affective intention toward his own nation. Especially it has been regarded as a characteristic of actions having an emotional colour, the essence of which is the collective feeling. In terms of the fore-going conception, the writer has examined the internal structure of the national consciousness and, having devised the necessary tools, has measured the national consciousness of the students at the schools of various level. The samples for the investigation have been collected from the schools of each level in the various part of th nation. The results of this investigation can be summarized as follows. (1) The students of schools of lower grade have been found to have relatively higher national consciousness than those of schools of higher grade have. (2) As a whole, the national consciousness of female students is higher than that of male students. (3) The students of humanity and social science fields have higher national consciousness than those of science and technology fields have. (4) Generally the students of lower grade have shown the more affirmative and optimistic attitude toward their nation than those of schools of higher grade have shown. The national consciousness of the students is relatively decreasing in its degree as they advance to the schools of upper grade, which means that some serious problems are hidden in the the education of this aspect. And this means that while the racial and national consciousness has been continuously emphasized as a fundamental ideology in our national education, it has failed to grow to become a part of the students' inner life as they advance in their grade. And it can be said that we must analyze the above mentioned phenomena to discover the underlying meanings and reasons of those problems and must find out the most adequate educationl programs and methods to meet those problems.

甲狀腺製劑 投與中의 甲狀腺機能動態

李圭寶,孫惠卿,黃基錫 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

1982年 1月부터 1982年 8月사이에 慶北醫大附屬病院 核醫學科에서 甲狀腺製劑(Comthyroid)를 投與받고 있는 患者中 3∼6個月사이에 甲狀腺機能檢査를 比較觀察할 수 있었던 35例를 檢査한 結果 다음과 같은 所見을 얻었다. RAIU檢査는 甲狀腺製劑 投與前에 比하여 6時間値나 24時間値가 모두 有意하게 正常以下로 低下되었으나, 血中 T_3와 T_4 値는 少數例에서 上昇되어있었으나 全體的으로 別 有意한 上昇은 없었다. 臨床的으로 腺腫의 約半數例에서 縮小效果가 있었으며 藥濟服用으로 因한 副作用은 없었다. 甲狀腺腫의 抑制法으로 投與하는 甲狀腺製劑의 效果는 臨床的으로 甲狀腺 hormone의 生體에 對한 影響이나 副作用은 없이 뇌하수체-甲狀腺軸에만 作用하여 甲狀腺機能抑制 또는 腺腫縮小를 招來할 수 있다고 思料된다. In order to evaluate the effects of thyroid hormone preparation upon the thyroid function, authors investigated comparative thyroid function tests including of RAIU, serum T_3, and T_4 before and after Comthyroid therapy from January to August 1982 in 35 cases of nontoxic goiter. RAIU both in 6 hrs and 24 hrs were significantly decreased during medication, whereas serum T_4 and T_3 showed no appreciable change. There was no case of side reaction from the regimen, however size of goiter seemed regressed more or less in more than half of the cases.

심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8