急性間歇性 Porphyria의 5例報告

白漢基,金成七,金光一,宣汪周,申舜鉉,金敎命 한림대학교의료원 1977 人間科學 Vol.1 No.3

적응 슬라이딩 모드 제어를 이용한 차량 속도 제어에 관한 연구

장광수,백창현 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.1

An adaptive sliding mode controller with loads estimation is designed for AICC. The developed discrete time adaptation law differs from that of conventional sliding mode control, and aims at adaptation on a large disturbance or unmodeled dynamics. The closed loop stability is checked in the discrete time domain, and the exponential decay of the adaptation error can be guaranteed by a proper placement of the discrete time closed loop poles. The results of numerical simulation show better adaptation and tracking performance over the conventional adaptation scheme. The new adaptive scheme is shown to be especially effective under rapid changes of commanded speed.

주요 인체 프로바이오틱 생균 제품의 내산성 및 내담즙산성

이광호,백현동 경남대학교 환경문제연구소 1999 환경연구 Vol.22 No.-

Probiotics is defined as live microorganisms, e.g. as freeze-dried cells or in a fermented product to improve the health status of man or animals, to have its effect in the mouse or gastrointestinal tract, the upper respiratory tract or in the urogenital tract. So far, human probiotics have been appropriately used for the treatment of long-term intestinal disorder, since microorganism can successfully reach the target intestine. The purpose of this study was to evaluate human probiotic products in reaching the target intestines. Probiotics were then found suitable as a probiotics based on its ability to survive in artificial gastric juice at pH 3.0 and in the presence of 0.3% bile. When Lactobacillus products were fed to gastric juice and bile acid, the organism was survived number in almost 62-90% against gastric acid and 4.5-33% against bile acid. On the other hand, when Bacillus products were fed to gastric juice and bile acid, the organism was survived high number in approximately 94-97% against gastric acid and 93-100% against bile acid. Viability by combined tolerance of gastric acid and bile acid on probiotic products seems to be lower that of gastric acid or bile acid. Thus, Bacillus probiotic products would be better in and bile tolerance when compared to lactic acid bacteria probiotic products.

유산소 운동과 복합 운동 프로그램이 비만 중년 여성의 건강 관련 체력에 미치는 영향

권기욱,백광현 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

In this research fourteen obese middle-aged women were divided into two groups of Aerobic & Combined Training. After twelve weeks of training, the effects on the body composition, plasma lipids, and strength conditioning of the subjects were evaluated. The results of this study were as follows: 1. While the group of aerobic exercise showed the tendency to decrease in the areas of weight, fat weight and lean body mass, the other group showed the tendency to increase in all the areas. 2. Whereas there wasn't any significant change for the group of aerobic exercise in the fitness factors such as power(sargent jump), muscular endurance(push-ups, sit-ups), agility (side-step, reflex movement), balance(stork stand), flexibility (bend over reach, back- stretch), the group of combined exercise showed significant increase in all the areas. 3. In an isokinetic strength test, the group of aerobic exercise showed the tendency to increase in quadriceps, but tended to decrease in hamstrings. However, the group of combined exercise significantly increased in quadriceps and tended to increase in hamstrings. 4. For the density of plasma lipids, both groups showed the tendency to increase in TC(total cholesterol), to decrease in TG(triglyceride) and both significantly increased in HDL-C(high density lipoprotein cholesterol). The group of aerobic exercise tended to increase in LDL-C(low density lipoprotein cholesterol) but the group of combined exercise tended to decrease. With regards to the changes of the body composition, fitness factors, muscular strength, plasma lipids that have occurred in the obese middle-aged women in this research, a conclusion can be reached that combined training, rather than only an aerobic exercise, is a more effective way of improving fitness factors and muscular strengthas well as losing weight and reducing the risk of coronary disorder.

결핵균 30 kDa 항원과 Triton X-100 Solubilized Protein 항원에 의한 대장암 주변 림프절 단핵구의 활성화

박정규,김광호,조은경,임재현,민들레,송영자,김화중,백태현 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Tumor-draining lymph node mononuclear (TDLMN) cells are specifically sensitized to the growing tumor but such cells are deficient for mediating an antitumor response. In this study, we examined the feasibility of using mycobacterial 30 kDa or Triton X-100 solubilized protein (TSP) antigen to stimulate mononuclear cells of colon cancer-draining lymph node for the generation of cell mediated immune effector cells. The proliferative response of TDLMN cells stimulated with mycobacterial 30 kDa or TSP antigen was determined by ^(3)H-thymidine incorporation assay. The proliferation of TDLMN cells to mycobacterial 30 kDa or TSP antigen was significantly increased in PPD (+) patients, but a poor response to the 30 kDa or TSP antigen was observed in PPD (-). The expression on γδ T cells to mycobacterial 30 kDa or TSP antigen was assessed by flow cytometry. The γδ T cells from PPD ( + ) patient responded only to 30 kDa antigen but to TSP antigen. An investigation of cytokine mRNA expression was undertaken using reverse transcription-polymerase chain reaction (RT-PCR) to follow TDLMN cells stimulated with the 30 kDa or TSP antigens for 5 days. The IFN-γ and TNF-α mRNA expression was only induced in TDLMN cells of PPD ( + ) patient in response to the 30 kDa or TSP antigen. The IL-2 mRNA expression was induced in both PPD (+) and PPD (-) in response to the 30 kDa or TSP antigen. But the IL-4 mRNA expression was not induced in response to the 30 kDa or TSP antigen. These results suggest that the 30 kDa and TSP antigens may serve as biologic response modifier for the generation of cell mediated immune effector cells.

圓光醫大 附屬 第2病院 神經精神科 患者에 對한 統計的 考察(Ⅱ)

박민철,장광철,김상원,김한주,유미경,김훈,유용진,김현정,박남진,오상우,이귀행,노승호,백영석 圓光大學校 醫科大學 神經精神科學敎室 1992 圓光精神醫學 Vol.8 No.1

본 연구는 1986년 7월 11일부터 1991년 7월 10일까지 원광의대 부속 제2병원 신경정신과에서 의래 및 입원치료를 받았던 6,072명의 환자를 대상으로 병원 역학조사를 실시하고 그 결과를 1차조사 (박민철 등1986)와 비교했다. 1.전체 환자 중 남자가 54.4%로 여자보다 많았고, 이리와 이리 인접지역이 84.0%로 대부분의 지역을 나타났다. 의료보장상태는 보험환자가 57.1%, 의료보호환자21.8%, 일반환자 21.1%였으며 연령별로는 20대 24.6%, 30대 22.8%로 20대 30대가 절반정도를 차지했다. 2.외래환자에서는 신경중성장애가 46.0%로 가장 많고 정동장애, 경련성장애 순이며, 입원환자에서는 정신분열증이 30.5%로 가장 많고 기질성정신장애, 정동장애의 순이었다. 3.남자는 신경증성쟝애(23.4%), 정신분열증, 기질성정신장애 순이고 여자는 신경증성장애(39.9%), 정동장애, 정신분열증의 순이었다. 남자가 여자보다 많은 진단은 알코올정신장애(94.6%), 기질성정신장애, 소아정신장애 순이고, 여자가 남자보다 많은 진단은 정동장애(64.5%), 신경증성장애였다. 4.진단별 연령분포에서 신경증성장에는 30대(25.3%), 20대, 40대 순이고, 정신분열증은 20대(40.5%), 30대, 40대 순이며, 정동장애는 20대, 30대, 50대 순이나 비교적 비슷한 융이었다. 5.진단별 발병연령에서 신경증성장에는 20대, 30대가 절반이고,정신분열증은 20대(51.3%), 10대, 30대 순이며 정동장애는 20대(30.7%), 30대, 50대 순이었다. 진단별 평균 발병연령은 신경증성장애 32.7세, 정동장애 36.1세, 정신분열증 23.6세였다. 6.진단별 이병기간은 2년이상이 신경증성장에 28.3%, 정신분열증 68.5% 정동장애 43.9%인데 전체적으로 41.0%였다. 진단별 평균 이병기간은 정신분열증 73.2개월, 정동장애 45.5개월, 신경증성장애 29.5개월이었다. We examined epidemiologic study of 6,072 patients who visited Wonkwang Neuropsychiatric hospital since July 11 of 1986 until July 10 of 1991 and compared this results with previous study(Park et al 1986). The study revealed as follows:1. Of total patients males visited this hosptial more than females as 57.1%, Most of them(84.0%) resided Iri and neighbouring Iri. In the point of insurance, insured patients, medicaid patients and uninsured patients were 57.1%, 21.8% and 21.1% respectively. On the distribution of age, the twenties, the thirties were 24.6%, 22.8% respectively and twenties and thirties were about half of total patients. 2. Of outpatients neurotic disorder was the most as 46.0%, secondly mood disorder and thirdly convulsive disorder, but of inpatients schizophrenia was the most as 30.5%, secondly organic mental disorder and thirdly mood disorder. 3. Of males neurotic disorder was the most as 23.4%, secondly schizophrenia, and thirdly organic mental disorder, but of females neurotic disorder was the most as 39.9%, secondly mood disorder and thirdly schizophrenia. alcoholic mental disorder(94.6%), organic mental disorder, child mental disorder were mostly found in males,but mood disorder(64.5%) and neurotic disorder were mostly found in females. 4. On the distribution of age neurotic disorder was found the most in the thirties(25.3%), next in the twenties and in the forties, and schizophrenia was found the most in the twenties(40.5%), next in the thirties and in the forties, but mood disorder was found the most in the twenties, next in the thirties and in the forties but revealed similar rates relatively. 5. On the distribution of age of onset neurotic disorder developed nearly half during the twrnties and the thirties, schizophrenia developed mostly during the twenties (51.3%), secondly the teens and thirdly the thirties, but mood disorder developed firstly the twenties(30.7%), secondly the thirties and thirdly the fifties. on the average age of onset of illness neurotic disorder, mood disorder and schizophrenia were 32.7 years, 36.1 years and 23.6 years respectively. 6. On the duration of illness more than two years was 28.3% in neurotic disorder, 68.5% in schizophrenia and 3.9% in mood disorder and on the average duration of illness schizophrenia, mood disorder and neurotic disorder were 73.2 months, 45.5 months and 29.5 months respectively.

교수 학습 순서에 따른 화학 변화 관련 개념 획득 정도의 비교 연구

李惠爛,柳五鉉,林光秀,白盛惠,朴國泰 한국교원대학교 과학교육연구소 1999 청람과학교육연구논총 Vol.9 No.1

중학교 2학년 과학 교과서 물질의 구성 단원의 주요 개념인 화학 변화 관련 개념을 학습함에 있어 논리적 위계에 따라 제시된 과학 교과서의 교수 학습순서인 화학 변화→원자→분자→분자 운동과, 분자와 원자를 화학 변화의 선행 조직자로 하여 새롭게 배열한 분자→분자 운동→원자→화학 변화의 교수 학습 순서 중, 어떠한 교수 학습 순서가 화학 변화 관련 개념을 이해하는데 효과적인가를 알아보았다. 이를 위하여 서울에 위치한 1개 중학교에서 남, 여 학생 각각 2개 반 씩 168명을 표집하여 실험반과 통제반으로 나누어 연구를 실시하였다. 연구 결과, 과학 교과서에서 제시하고 있는 교수 학습 순서 보다 본 연구에서 새롭게 배열한 교수 학습 순서가 학생들의 화학 변화 관련 개념 이해에 효과적이었음을 나타내었다. 그러나 학생들은 수업 처치가 효과가 있었음에도 불구하고 혼란스러웠다는 문제점을 제기하였으므로, 학생들에게 혼란스러움을 주지 않으면서도 효과적인 개념 학습을 위해서는 모든 과학 교과서의 획일적인 교수 학습 순서를 지양하고 교과서마다 특색 있고, 다양한 교수 학습 순서를 제시하는 것이 필요할 것으로 생각된다. This study was to investigate the effective order of instruction for students learning the concepts of chemical change. Chemical change was considered as the important area in 8th grade chemistry part. The study consisted of 168 8th grade students, two classes of boys and girls each, from a middle school in Seoul. They were divided into two groups, the experimental group and the control group. The control group was taught in the order, which was presented in the science textbook; chemical change, atom, and molecule(CAM). For the experimental group, the order was molecule, atom, and chemical change(MAC). From the results of the study, there was a statistically significant difference between the control group and the experimental group. But the interviews indicated that the students were confused with the MAC method in spite of the effective learning. Therefore, for more effective concepts learning without a confusion, we need to provide our students with various learning sequences of science textbooks rather than fixed learning sequences.

위암세포에 의한 종양침윤 림프구의 면역반응 억제기전에 관한 연구

박정규,송규상,서광선,최정목,배진선,장일성,윤완희,노승무,조은경,백태현 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3

Tumor-infiltrating lymphocytes ('1°ILs) interact most closely with tumor cells and thus are more likely to reflect tumor host interactions accurately. But it is unknown whether such T cells are nonspecific inflammatory cells or a subset of specific host immune responses. In this study, there was no clear correlation between the infiltration of T lymphocytes in stomach cancer and the overexpression of c-ErbB-2 or increasing class I MHC expression on tumor cells. A positive correlation was seen between the presence of TILs in the tumor and tumors with diploidy by flow cytometric DNA analysis. The proliferative responses of Ills stimulated with IL-2, anti-CD3 mAb, or both were examined. When compared to normal mucosal-associated lymphoid tissue lymphocytes, the proliferative response of TILs to high dose IL-2 was minimal. A similarly poor response to anti-CD3 mAb plus IL-2 was also observed. The freshly isolated TILs exhibit reduced ability to proliferate in response to IL-2, anti-CD3 mAb or both. The microenvironment of the tumor suppresses the proliferative capacity of the TILs. The mechanism of this suppression remains unknown. It could be mediated by suppressor cells, by soluble substances within the tumor, or both. To examine this question, supernatants of stomach cancer cells (SNSNU-1) were tested for the presence of immunosuppressive factors. Human peripheral blood T-cells and tumor-draining lymph node lymphocytes (TDLNL) were incubated for 3 days with SNSNU-1 and then assessed for proliferative responses to PMA, anti-CD28 mAb, or both and for the inducibility to express IFN- r or IL-4 mRNA to PMA. Peripheral blood T-cells pretreated with SNSNU-1 were unable to proliferate in response to PMA, anti-CD28 mAb or both. SNSNU-1 also produces inhibitory activities of TDLNL proliferative response to PMA or anti-CD28 mAb and PMA (49%, 52%, respectively). In contrast, culture supernatants obtained from HEp-2, K562 or Daudi showed normal proliferative responsiveness of peripheral blood T-cells and TDLNL by PMA, anti-CD28 mAb or both.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

Multiple Hepatocellular Carcinoma within the Milan Criteria: When to Consider Surgical Resection?

( Joo Hyun Oh ),( Dong Hyun Sinn ),( Gyu-seong Choi ),( Jong Man Kim ),( Jae-won Joh ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Although surgical resection is usually considered for single tumor, several reports suggested that resection can be considered for multiple tumor and may provide better outcome. We analyzed whether resection can provide better long-term outcome for patients with multiple hepatocellular carcinoma (HCC) within the Milan criteria, and looked for factors that may guide treatment selection. Methods: A total of 314 consecutive patients with multiple HCCs within Milan criteria and had preserved liver function, defined by Child-Pugh class A, who underwent resection (n=49), radiofrequency ablation (RFA) (n=97) or transarterial chemoembolization (TACE) (n=168), as an initial treatment, between January 2009 and December 2013 were analyzed. Results: The 5-year overall survival rates were 91.3%, 69.1%, and 61.0%, for patients received resection, RFA and TACE, respectively (P=0.003). Patients who received resection were younger and had more preserved liver function assessed by albumin-bilirubin (ALBI) grade, showed different tumor characteristics (more frequently two tumors and had higher PIVKA-II levels) compared to those received RFA or TACE. Resection was rarely performed for those with ALBI grade 2 (n=2). In multivariable analysis, initial treatment modality was independent factor associated with overall survival, along with ALBI grade and PIVKA-II levels. When stratified according to ALBI grade and PIVKA-II levels, long-term outcome was significantly different (5-years survival rates: 90.7%, 72.6% and 45.7% for resection, RFA and TACE, respectively, P=0.004) by initial treatment modality for those with ALBI grade 1 and high PIVKA-II levels (>40 mAU/ml). For other subgroups, there was no significant different of overall survival by initial treatment modalities. Conclusions: Our findings suggest that resection can provide better long-term outcome than RFA or TACE in selected multiple HCC patients within the Milan criteria. ALBI grade and PIVKA-II levels were factors that can be used to guide initial treatment modalities in this situation, which warrants prospective validation.