소화기 Behcet병: 13예의 임상분석

정희원,유빈,문희범,이인철,김병식,박건춘,김진천 대한대장항문학회 1995 Annals of Coloproctolgy Vol.11 No.1

개에서 피지선 과형성의 진단 및 치료 증례

박희서,손화영,정성목,송근호,조종기,이영원,신상태,김명철,김덕환,박성준 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

An eleven year old castrated male Maltese was presented to the Veterinary Medical Teaching Hospital of Chungnam National University. In physical examination, approximately 0.5 cm round mass was observed on tail base. This small elevated mass has also shown alopecic and firm configuration. It was differentially diagnosed as sebaceous adenoma and hyperplasia by fine needle aspiration. After surgical removal, the sample was diagnosed as sebaceous hyperplasia by histopathological examination. It has not yet shown any signs of recurrence and prognosis has teen good.

물곰팡이 Allomyces macrogynus의 홀씨와 팡이실에 존재하는 칼슘이온결합 단백질의 검색

박현숙,이수웅,오근희,박영식 인제대학교 1994 仁濟論叢 Vol.10 No.1

45Ca overlay를 이용한 방법으로 Allomyces macrogynus의 생장과정에서 형성되는 암수배우자 홀씨, 반수체 홀씨, 그리고 이배체 홀씨등의 세가지 홀씨와 팡이실에 존재하는 칼슘이온결합단백질들을 검색하였다. 세가지의 홀씨 각각에서는 모두 5가지 종류의 칼슘이온결합단백질들이 동일하게 관찰되었다. 팡이실에서는 적어도 6개 이상의 칼슘이온결합단백질들이 관찰되었으며, 이중에 3가지는 홀씨에서 관찰된 것과 동일한 것으로 판단된다. Ca2+-dependent phenyl-sepharose를 이용하여 팡이실에서 SDS-PAGE 겔 상에서 19kDa의 분자량을 가지는 칼슘이온결합단백질을 분리하였다. 이 단백질은 등전점이나 열에 대한 안정성, 칼슘이온에 의한 전기영동상에서의 움직임의 변화 등으로 판단하건 데 calmodulin으로 추정된다. 따라서 Allomyces macrogynus의 홀씨와 팡이실에는 calmodulin을 비롯하여 다수의 칼슘이온결합단백질들이 존재하며, 이들 중에는 홀씨, 또는 팡이실에서만 관찰되는 것들도 있었다. Calcium binding proteins(CaBPs) present in 3 different types of zoospores and in mycelium of Allomyces macrogynus were screened by using 45Ca overlay method. Five different kinds of CaBPs were equally observed in gametes, haploid spores, and diploid spores, respectively. Six kinds of CaBPs were observed in fractions of DEAE-cellulose chromatography of mycelial extract. Among them 3 CaBPs were shown to be identical with those detected in zoospore extract. 19-kDa CaBP was isolated from mycelial extract by Ca2+-dependent phenyl-sepharose chromatography. The 19-kDa mCaBP showed calmodulin-like properties as determined by molecular weight, isoelectric point, and Ca2+-dependent mobility shift on SDS-PAGE. It is shown that a variety of CaBPs including calmodulin-like protein are present in zoospores and mycelium of Allomyces macrogynus and some are confined to either.

된장의 항돌연변이 효과 : 된장찌개 및 된장국의 Aflatoxin B₁에 대한 돌연변이유발 억제효과 Inhibitory Effect of Doenjang Stew and Soup on the Mutagenicity Induced by Aflatoxin B₁

박건영,문숙희,이숙희 A.R. Liss 1994 ENVIRONMENTAL MUTAGENS AND CARCINOGENS Vol.14 No.2

Salmonella Assay System에서 고염도 김치의 보(補)돌연변이 유발성

박건영,김소희,서명자 부산대학교 가정대학 1990 家政大學硏究報告 Vol.16 No.-

고염도 김치의 추출물에서 돌연변이 및 보돌연변이 유발성을 Ames mutagenicity test를 이용하여 연구하였다. 잘 읽은 고염도 김치(10˚C에서 2주간 발효)를 solvent로 추출하여 3분획으로 나누고 이들의 돌연변이 유발성을 검토해 보았다. 긴치 자체로는 돌연변이 유발성이 없었다. 그러나 direct한 mutagen인 MNNG나 4-NQO를 김치 추출물과 혼합하여 반응시켰을 때 대조군에 비해 각 김치 시료의 첫 번째 분획은 이들 mutagen의 돌연변이성을 도와주는 보돌연변이 유발효과가 있는 것으로 나타났다. 그러나 모든 김치 추출분획들은 indirect한 mutagen인 aflatoxin B1과 함께 혼합하여 반응시켰을 때는 보돌연변이 효과가 전혀 없었다. 이와 같은 MNNG와 4-NQO에 대한 보돌연변이 효과는 이들 김치계의 고농도의 소금때문이었으리라고 추정되었다. The mutagenic and comutagenic effects of high salted Kimchi were studied by using Ames mutagenicity test. All solvent extracts (3 fractions) from the Kimchi showed no mutagenicity in the test system. However, first fractions of the Kimchi samples exhibited some comutagenic activities toward direct mutagens of N-methyl-N'-nitrosoguanidine (MNNG) and 4-nitroquinoline-1-oxide(4-NQO), while the fractions showed no comutagenic effect to a indirect mutagen of aflatoxin B₁. It was suggested that high levels of NaCl in the Kimchi systems might cause this comutagenic effect toward MNNG and 4-NQO.

개에서 발생한 신우신염 증례

유건우,이선희,임수정,박형진,김태신,송은식,송근호 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 6 years old Schunauzer dog (7.2kg, intact female) with history of hematuria for two days was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Complete blood cell count showed no significant abnormalities and serum chemistry profile showed increased phosphate profile. On urinanalysis, there was evidence of bacterial infection. On ultrasonographic evaluation, irregular renal contour and increased echogenecity, pelvic and uretral dilation, and thickening of urinary bladder wall were observed. Based on these finding, the dog was diagnosed as pyelonephritis. The dog was treated with antibiotics based on antimicrobial susceptibility test results, then successfully resolved after 8 weeks of treatment.

Olfactory neuroblastoma 증례보고

박익수,이정근,노양호,김동우,김우형,이희철 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

Olfactory neuroblastoma is an uncommon malignant tumor(just over 300 cases have been reported in the medical literature by 1996)arising within the nasal cavity. This tumor has a neuroectodermal cell origin and is believed to specifically arise from the olfactory epithelium. The tumor was ftrst decribed in the French medical literayure by Berger and associates in 1924 by the name esthesioneuropitheliome olfactif. The english version of this term is esthesioneuroblastoma, and current medical literture uses this name interchangeably with olfactory neuroblastoma. We experienced a case of olfactory neuroblastoma in the mxillary sinus. We treated this patient with tumor resection, chmotherapy and radiotherapy. And now, the patient has been following up for 2years 6month, but olfactory neuroblastoma is very rare. SO we report this case with a review of literature.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

소아의 하악 과두 골절의 비외과적 치료 : 증례보고 CASES REPORTS

이정근,박익수,노양호,김동우,김우형,이희철 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1

Of all facial fractures in children, condylar fractures have the greatest propensity to produce a growth disturbance. The pediatric condylar fracture occurs very frequently in the mandible, but this injury is occasionally ignored due to difficulty of diagnosis and no cooperation of patient. The adequate initial diagnosis and active treatment must be performed because delayed and improper treatment lead to possible severe complications such as facial asymmetry, TMJ pain, limiation of motion and deflection, midline deviation of the dental arch. So, the goal of managing condyle fractures in the growing patient is to restore mandibular symmetry, occlusion, function without interfering with future growth. Commonly, fracture teatment aims at restoring function through repositioning and rigid fixation of the bony fragments. However, the generally preferred management of condylar fractures in growing children is nonsurgical. So, we present the clinical and radiographic follow-up results of 4 condylar fractures in pediatric patients whom we managed in conservative and functional method. We can summarize our protocol in management of pediatric condylar fracture as the following: The IMF using acrylic resin splint with circumferential wiring was performed for 1 or 2 weeks. After releasing IMF, the active physical therapy was done with guiding elastic band. Opening deviation was controlled by mannual pressure of surgeon or parents for 2 weeks. When unstable occlusion or functional problem remained, functional appliance after construction bite registration was used for several months.

전산화단층촬영에 있어서 X-선 흡수계수의 신뢰도에 관한 실험적 연구

이희우,김건상,박수성 중앙대학교 의과대학 의과학연구소 1985 中央醫大誌 Vol.10 No.4

For evaluation of reliability of CT numbers, one ovoid and three round phantoms, which were filled with pure water and different in their diameters, were scanned under various conditions with five whole body and four head CT scanners. The results were as follows: 1. The ovoid phantom similar to human body in size and shape scanned with whole body scanners revealed stable and relatively correct CT numbers throughout entire of phantom. 2. CT numbers were generally higher in phantoms of round and smaller types. 3. There was definite tendency to show higher CT numbers at peripheral zone of phantoms. 4. With increase of kVp, CT numbers were decreased. 5. By the change in mA and slice thickness, some CT scanners were influenced, but the others were not. 6. CT numbers were not influenced by scan time. 7. CT numbers were not influenced by position of phantom in the aperture of gantry of CT scanner. 8. The bone density had no influence upon CT numbers at the region distant more than 1㎝. In two CT scanners, CT numbers were significantly increased within 1㎝ to bone density higher than 455 Hounsfield Unit. 9. CT scanners from different manufacturers showed different results, but those of same model from same manufacturer revealed similar results.