발달장애유아의 언어행동발달 연구

김춘희,변찬석,서경희,유은정,이효신,전헌선,최성규 大邱大學校 特殊敎育·再活科學硏究所 2000 特殊敎育硏究 Vol.23 No.1

본 논문은 발달장애유아 언어행동발달 컨텐츠 개발에 요구되는 기초연구로써 연구의 이론적 바탕을 확립하고자 하였다. 연구에 사용된 방법은 문헌조사 방법 및 현장 인터뷰기법을 병행하였다. 본 연구의 주된 목적은 크게 3가지로 구분된다. 첫째, 발달장애유아의 가정 내 교육 욕구를 분석하고자 하였다. 둘째, 발달장애유아의 언어발달 양상을 검토하고자 하였다. 세 번째 목적은 유아의 언어행동발달 컨텐츠 구성의 주요 지침을 설정하고자 하였다. 이상의 연구목적에 따른 연구결과를 요약하면 다음 몇 가지로 제시된다. 1.가정 내 부모-유아간 관계형성이 우선 고려 되어야하고, 이에 따른 상호작용은 발달적 애착형성이 가능한 방향으로 정립되어야한다. 2.발달장애유아의 언어행동발달양상을 검토한 결과에 따르면, Piaget는 언어행동발달에 있어 감각운동기적 환경탐색 기능을 강조하고 있고, 이는 현재까지 중요한 유아 발달의 기저로 정착되었다. 따라서, 발달장애유아의 언어행동발달을 위한 컨텐츠 개발 내용에 있어서도 이러한 기저에 충실함이 합리적이다. 3.발달장애유아들에게는 언어행동 양상의 갈래가 크게 운동장애 및 감각결함으로 나누어질 수 있으므로, 이 두 가지 갈래의 각기 다른 특성이 컨텐츠 구성에서 충분히 고려되어야한다. 4.자폐성과 같은 중증 전반적 발달장애 유아를 위한 언어행동발달 컨텐츠 구성에서 특히 고려해야 할 두 가지 요소는 모방행동기능과 반복단순훈련기능 향상으로 결론지을 수 있다. This article planed to establish the theoretical foundations of the research as a basic study needed for developing the contents of verbal(language) behavior development for the infants with developmental disabilities. The methods used in the study was previous literature researches and interviews with subjects. The purposes of the study were divided into three parts. First, it was to analyze the educational needs of the infants with developmental disabilities in home settings. Second, it was to review and discover the language patterns of the infants with developmental disabilities. The third purpose was to devise the major guidelines of their language development's contents. The results of the study were described as the followings. 1.The relationships between the infants with developmental disabilities and their parents and their interactions should move to build the developmental attachments between them. 2.According to the literature findings of their language development patterns, Piaget concentrated on the functions of sensory motor environmental exploring in the language behavior development. The functions have been settled down into the important foundation for the infants' development. Thus, it was resonable that the content's development of the language behaviors for the infants with developmental disabilities should based on the function addressed by Piaget. 3.The language behaviors' patterns of the infants with developmental disabilities generally were classified into motor disabilities and sensory defect(deficiency). Therefore, the two factors should be considered for the constructions of the contents. 4.Constructing the contents of the language behavior developments for the infants with severely pervasive developmental disabilities such as autism, the improvements of two functions, imitative behavior and repetitive simple training should be considered.

무릎관절 각도가 발목 근육의 근전도 활동에 미치는 영향

유경석,김택연 대한정형도수치료학회 2006 대한정형도수물리치료학회지 Vol.12 No.1

The purpose of this study was to investigate the influence of the various knee angles and ground state on the muscular activities and fatigue of the ankle muscles by integrated electromyograms (iEMG) and median frequency of tibialis anterior (TA), peroneus longus (PL), flexor digitorum longus (FDL) and gastrocnemius (GC). Ten healthy male subjects were participated into stable and balance ball sessions at four angles of knee joint. The surface electromyograms (sEMG) were recorded from the TA, PL, FDL and GC on stable and balance ball with full weight bearing at four knee angles of 0˚, 15˚, 30˚ and 45˚. The time serial data of the surface electromyographic signals were transformed into integrated and frequency serial data by fast fourier transformation. On the stable ground, the iEMG signals of the TA, PL, FDL and GC were significantly higher at 45˚ and 30˚ of knee angles than 0˚ and 15˚ of knee flexion (p<0.05). On the balance ball, the iEMG of the TA, PL, FDL and GC were significantly higher at 45˚ and 30˚ of knee angles than 0˚ and 15˚of knee flexion (p<0.05). The median frequency of the TA, PL, FDL and GC were significantly lower at 45˚ and 30˚ of knee angles than 0˚ and 15˚ of knee on the stable ground (p<0.05). On the balance ball, also the median frequency of the TA, PL, FDL and GC were significantly lower at 45˚ and 30˚ of knee angles than 0˚ and 15˚ of knee flexion (p<0.05). The iEMG of the TA, PL, FDL and GC were significantly higher on the balance ball at 0˚, 15˚, 30˚ and 45˚ of knee angles compared with stable ground. The median frequency of the TA, PL, FDL and GC were significantly lower on the balance ball at 0˚, 15˚, 30˚ and 45˚ of knee angles compared with stable ground. These results indicate that the ground conditions and angles of the knee joint involved to muscular activities and fatigue of ankles muscles, may performed at first on stable ground and then balance ball in order to 0˚, 15˚, 30˚ and 45˚ of knee flexion.

마우스 대장암 모델 구축 및 항암제 활성 평가를 위한 예비 연구

김예솔,강봉석,이상은,이은주,이경록,정상헌,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract – Aberrant crypt foci (ACF) are early imorphological changes observed in rodents after administration of colon-specific carcinogen such as azoxymethane (AOM). ACF are considered to be putative preneoplastic lesions and are widely used as a surrogate biomarker to rapidly evaluate chemopreventive potential of compounds. The size of colorectal cancer was evaluated after administration of three anticancer drugs, 1 parent drug and 2 prodrugs. The body weights of mice were measured daily and considered as a surrogate for evaluation of general wellbeing. Colons were removed, cut along the longitudinal axis and flushed with phosphate-buffered saline. Each colon was cut into three equal lengths and fixed flat between filter papers. The fixed colon sections were stained with methylene blue. The number of ACF per colon, the number of aberrant crypts observed in each focus and the location of each focus were recorded. After single administration of AOM and multiple doses of anticancer drugs, no significant changes in the body weights of the mice was observed which was recorded for 52 days. However, an expected ACF was not observed in any treated groups. These findings suggest the induction of ACF in mice requires the promotion by dextran sulfate sodium as well as the initiation by AOM.

감자를 첨가한 기능성 크림수프의 품질 특성

한경필,한재숙,소기신행,김동석,박미란,이갑랑 한국조리과학회 2005 한국식품조리과학회지 Vol.21 No.1

The purpose of this study was to investigate the quality characteristics of potato added functional cream soup. The highest crude protein (p<.01) and crude lipid (p<.001) were for the potato soup with added potato peel (S₃). The highest pH of 5.95 was for the potato soup with added potato peel (S₄). The highest lightness of 69.46(1, value) was for the potato soup with added potato peel (S₃) (p<.01). The redneess(a value) and yellowness(b value) were increased by the adding of potato peel to the potato soup(p<.01). Viscosity was increased by potato content, and was the highest for the potato soup (S₂) (p<.001). The glycoalkaloid content of the potato soup with added potato peel was 175 mg and 2.20 mg, for Si and S4 respectively. In sensory evaluation. the highest sensory scores for flavor and taste (p<.05) of mean 3.55 and 3.45, respectively, were obtained from the potato soup with added potato peel (S₄). The highest overall acceptability of mean 3.00 was for the potato soup with added potato peel (S₃) (p<.01).

습동면유 겸용 수용성 금속가공유제의 제조 및 특성 연구

윤을용,노정석,김해원,김선덕,진경록,김재권 한국공업화학회 2004 응용화학 Vol.8 No.2

At processing of a metal process, much problems are happening by mixing between slide-way fluid and water-solubility metal-working fluid(MWF). In this study, measure physical & chemical properties and biodegradable properties of base stock and additives that is used to lubricant, and developed water-soluble metal working fluid by slide-way fluid combined use. Biodegradability of developed combined use fluid for 28 days is displayed lower than 10 ppm, and more superior performance than similar fluids in lubrication special quality test.

감자껍질을 첨가한 기능성 쿠키의 품질 특성

한재숙,김정애,한경필,김동석,소기신행,이갑랑 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.6

The purpose of this study was to investigate the quality characteristics of functional cookies made with potato peels (cortex layer) containing high amounts of glycoalkaloid. Cookies were processed by mixing ratios of 10, 15 and 20% potato peel relatively to flour. The spread ratio of the cookies was increased with increasing potato peel addition. Texture measurement for the cookies on substituting 10% of flour for potato peel showed a decreased hardness, but the cohesiveness and springiness were increased compared to the control and other ratios. The glycoalkaloid contents of the cookies on substituting 10, 15 and 20% of the flour forpotato peel were 6.27, 9.40 and 12.54mg, respectively, which according to the USAD guidelines are safe amounts for the human body, and also enough for making functional cookies. In the sensory evaluations, the cookies with 10% of the flour substituted for potato peel had the highest scores in flavor, taste, appearance and texture.

건강인에서 결핵균 30-kDa항원이 말초혈액 임파구증식에 미치는 영향

최대경,고석신,김화중,조은경,백태현,신철식 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

T lymphocytes are thought to play a central role in cell mediated immune response. To Study the T lymphocyte proliferative response to 30-kDa antigen purified from Mycobacterium tuberculosis H37Rv, peripheral blood lymphocytes isolated from healthy subjects were stimulated with the 30kDa antigen, crude antigen or PHA. Healthy subjects were divided into three groups so that PPD(+), PPD(±) and PPD(-). The proliferations of lymphocytes were measured by the incroporation of ^3H-thyrnidine. The results were summarized as follows: 1. For the PPD(+) person, at concentration of < 1 ㎍/ml, the proliferative response to 30-kDa antigen resulted in a mild reduction but crude antigen showed relatively rapid reduction. For the PPD(-) person, decreasing the concentration of the both antigens showed rapid reduction of proliferation 2. The lymphocytes proliferations to 30-kDa antigen and crude antigen were significantly increased in PPD(+) group when compared to those in PPD(-) group, but PHA response was no significant difference. 3. The sensitivity and specificity of lymphocyte proliferation assay to 30-kDa antigen and crude antigen when compared with skin test results were 92.3%, 100% and 76.9%, 50%, respectively.

Dysfunction Syndrome을 가진 만성 요통환자의 요천골도수교정에 의한 자세의 변화 : 증례 보고 2

전차선,유경석,김택연 대한정형물리치료학회 2003 대한정형도수물리치료학회지 Vol.9 No.2

본 case study는 척추 관절에 변화를 일으켜 근육의 변화와 통증에 변화가 있는 지를 알아보기 위하여 dysfunction syndrome을 가진 5명의 만성 여성 요통환자의 single group에 Geenman의 impulse technique(glade5)을 1회 적용 후 Pain Scale와 IBS -2000를 사용하여 검사 하였다. - Pain Scale는 0 ~ 100 단계로 나누어 환자에게 직접 아픈 정도를 기입하게 하고 치료 후 재검사와 통증의 변화 정도를 기입하게 하였다. -lBS-2000는 체형 진단기로써 레이저를 이용하여 인체 근육의 경사도를 등고선으로 나타내는 측정기로서 주로 근 Balance와 체형의 균형을 알아보는 기구이다. 측정 방법은 후두-견봉의 각도, C7-견봉의 각도, L4 -S2의 각도, 전 후만의 비, 척추의 기울기를 측정하였다. 자료 분석은 Pained T - test을 하였다. 이 측정치의 결과로 Dysfunction syndrome을 가진 요통환자의 척추 및 근 평형성의 다음과 같은 결과를 얻었다. 1. 주관적인 통증 변화는 교정 전 407.07 였고, 교정 후 309.24로 p<0.05를 보여 유의한 차이가 있었다. 2. 객관적인 측정으로써 후두 -견봉의 각도 변화는 교정 전 왼쪽 362.60, 오른쪽 373.16 였다. 교정 후 왼쪽 33.704.31, 오른쪽 353.05로 p>0.05를 보여 각도의 변화는 보이나 유의한 차이를 보이지 못 하였다. 3. C7 -견봉 각도의 변화는 교정 전 왼쪽 173.73, 오른쪽 175.30 였다. 교정 후 왼쪽 162.55, 오른쪽 172.07로 p>0.05를 보여 각도의 변화는 보이나 유의한 차이를 보이지 못 하였다. 4. 요추 골반의 각도 변화는 왼쪽 19.58 2.75, 오른쪽 20.13 2.75 였다. 교정 후 왼쪽 19.793.33, 오른쪽 21.094.51로 p >0.05를 보여 각도의 변화는 보이나 유의한 차이를 보이지 못하였다. 5. 척추의 전·후만 깊이의 변화는 교정 전 TTD는 2.20 1.44cm , TLD는 2.070.53cm 였고 교정 후 TTD는 2.19 0.49cm , TLD는 1.880.11cm 로 수치의 변화를 보이나 p>0.05로 유의한 차이는 없었다. 6. 척추의 전·후만 비의 변화는 교정 전 TTDR은 0.560.20, TTDR은 0.430.02 였고 교정 후 TTDR은 0.630.02, TLDR은 0.350.02로 변화를 보이나 유의한 차이는 없었다. 7. 척추의 기울기의 변화는 교정전 XD/YD는1.720.77, 교정 후 0.900.41로 수치의 변화는 보이나 유의한 차이를 보이지 못하였다. 전체적인 평형성의 수치를 보이나 유의한 차이는 보이지 못 하였다.

MS-1020 is a novel small molecule that selectively inhibits JAK3 activity

Kim, Byung-Hak,Oh, Sei-Ryang,Yin, Chang-Hong,Lee, Sangku,Kim, Eun-Ah,Kim, Min-Seok,Sandoval, Claudio,Jayabose, Somasundaram,Bach, Erika A.,Lee, Hyeong-Kyu,Baeg, Gyeong-Hun Blackwell Publishing Ltd 2010 British journal of haematology Vol.148 No.1

<P>Summary</P><P>In order to identify Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling inhibitors, a cell-based high throughput screening was performed using a plant extract library that identified <I>N</I>b-(&agr;-hydroxynaphthoyl)serotonin called MS-1020 as a novel JAK3 inhibitor. MS-1020 potently inhibited persistently-active STAT3 in a cell type-specific manner. Further examination showed that MS-1020 selectively blocked constitutively-active JAK3 and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling but not prolactin-induced JAK2/STAT5 signalling. Furthermore, MS-1020 affected cell viability only in cancer cells harbouring persistently-active JAK3/STATs, and <I>in vitro</I> kinase assays showed MS-1020 binds directly with JAK3, blocking its catalytic activity. Therefore, the present study suggested that this reagent selectively inhibits JAK3 and subsequently leads to a block in STAT signalling. Finally, MS-1020 decreased cell survival by inducing apoptosis via down-regulation of anti-apoptotic gene expression. These results suggest that MS-1020 may have therapeutic potential in the treatment of cancers harbouring aberrant JAK3 signalling.</P>

<i>ABCG2</i>Q141K polymorphism is associated with chemotherapy-induced diarrhea in patients with diffuse large B-cell lymphoma who received frontline rituximab plus cyclophosphamide/doxorubicin/ vincristine/prednisone chemotherapy

Kim, In-Suk,Kim, Hoon-Gu,Kim, Dong Chul,Eom, Hyeon-Seok,Kong, Sun-Young,Shin, Ho-Jin,Hwang, Sang-Hyun,Lee, Eun-Yup,Lee, Gyeong-Won Wiley (Blackwell Publishing) 2008 CANCER SCIENCE Vol.99 No.12

<P>ATP-binding cassette transporter G2 (ABCG2) is the most recently described transporter of the multidrug-resistance pump and it promotes resistance to anticancer drugs such as doxorubicin, mitoxantrone, topotecan, and SN-38. Of the ABCG2 polymorphisms, V12M and Q141K alter the functional activity of the ABCG2 transporter and influence the drug response and various toxicities to chemotherapeutic agents. We therefore evaluated the impact of the ABCG2 V12M and Q141K polymorphisms on the therapeutic outcomes and toxicities of primary rituximab plus cyclophosphamide/doxorubicin/vincristine/prednisone (R-CHOP) therapy in 145 Korean patients with diffuse large B-cell lymphoma (DLBCL). ABCG2 V12M and Q141K genotyping was carried out by pyrosequencing of polymerase chain reaction products. The clinical characteristics, treatment outcomes, toxicities of the patients, and the predictive value of the polymorphisms on response, survival, and adverse events to R-CHOP for 145 patients were analyzed according to the ABCG2 V12M and Q141K polymorphisms. No differences were observed according to ABCG2 Q141K and V12M genotype in patient characteristics, disease characteristics, response, survival, or hematology toxicity profiles in patients with DLBCL who received frontline R-CHOP chemotherapy. On multivariate analysis, grade I-IV diarrhea was statistically significant according to ABCG2 Q141K polymorphism (the QQ genotype vs the QK or KK genotypes; hazard ratio 2.835; 95% confidence interval 1.432-5.613; P = 0.003). This study demonstrates that the ABCG2 Q141K polymorphism may correlate with chemotherapy-induced diarrhea in patients with DLBCL who have received frontline R-CHOP chemotherapy, and this has implications for optimizing treatment with such agents.</P>