셀레나이트로 유도되는 백내장에서 선삼 성분에 따른 백내장 억제효과의 비교 분석

이상목,정문선,정진호,김미금,위원량,박정일,이진학,Sang Mok Lee,MD,Jung Moon Sun,MD,Jin Ho Jeong,MD,Mee Kum Kim,MD,Won Ryang Wee,MD,Jeong Hill Park,PhD,Jin Hak Lee,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.5

Purpose: To compare the protective effects of saponin and non-saponin Sun-ginseng extract fractions in a selenite-induced rat cataract model. Methods: A total of 101 Sprague-Dawley rat pups were divided into four groups by treatment: Sun-ginseng, saponin fraction, non-saponin fraction, and control. For induction of cataracts, sodium selenite 15 nmol/g was injected subcutaneously in 13 day-old rat pups. Sun-ginseng extract 100 μg/g (Group I, Ginseng Science, Seoul, Korea), saponin fraction 100 μg/g (Group II), non-saponin fraction 100 μg/g (Group III), and phosphate buffered saline (Control group) were injected intraperitoneally every two days for a total of seven injections. The rats were sacrified and their lenses were dissected and photographed at day 7 and 14, and the cataracts were graded according to the ratio of the cataract area to the total lens area. The blind method was used for the evaluation of the cataract area. Results: At day 14, cataract formation rates (CFR) were 33.3% in group I, 76.4% in group II, 41.2% in group III, and 77.7% in the control group. The mean cataract area (MCA) was 13.4±20.8% in group I, 14.4±11.7% in group II, 5.7±7.7% in group III, and 15.8±12.1% in the control group. Group III showed statistically significant results compared with those of control group (CFR p=0.001, MCA p=0.001). We observed significantly lower incidence and smaller mean cataract area in Group I and Group III at day 7 compared with the control group (Group I, CFR p=0.018; Group III, CFR p=0.032, MCA p=0.005). Conclusions: The protective effects of Sun-ginseng extract are caused by the components in the non-saponin fraction, not by those in the saponin fraction, in a selenite-induced cataract rat model. J Korean Ophthalmol Soc 2010;51(5):733-739

Fluoroquinolone계 항생제의 경구투여에 따른 양식넙치 및 조피볼락의 체내 잔류량의 변화

조미라,김진우,박미선,김풍호,김동수 경성대학교 공학기술연구소 2008 공학기술연구지 Vol.15 No.-

The residue depletions of fluoroquinolones were investigated in the olive flounder (Paralichthys olivaceus) and black rockfish (Sebastes schlegeli) after 840 hours treatment with medicated feed at a dose 20 mg/kg·bw/day The bloods of samples were taken at 5, 10, 24, 48, 72, 120, 168, 216, 312, 480, 720, 840 and 960 hour after treatment. Fluoroquinolones concentrations were detected by high performance liquid chromatography equipped with UV detector. The recovery rates of fluoroquinolones in fish samples ranged 91.95~99.69%, 93.43~97.54% and 92.99~97.87% for the concentration of 0.1, 0.5, 1.0 ㎍/g, respectively In the blood of olive flounder, the concentrations of ciprofloxacin, enrofloxacin, norfloxacin and sarafloxacin detected at 10, 10, 24 and 24 hour after treatment were 6.433 ㎍/g, 6.065 ㎍/g, 11.8334 ㎍/g and 10.3168 ㎍/g as maximum level, respectively In the black rockfish, ciprofloxacin, enrofloxacin, norfloxacin and sarafloxacin at 24, 24, 24 and 10 hour after treatment were 8.2634㎍/g, 8.0276㎍/g, 7.2888㎍/g and 9.3787㎍/g as maximum level, respectively On the other hand, ciprofloxacin enrofloxacin, norfloxacin and sarafloxacin were not detected at 840, 480, 720 and 720 hours after treatment in the olive flounder, and at 720, 480, 720 and 480 hours after treatment in the black rockfish, respectiveley.

Original Article : Geographic difference of epidemiological features of HCV infection in Korea

( Kyung Ah Kim ),( Sook Hyang Jeong ),( Eun Sun Jang ),( Young Seok Kim3 ),( Youn Jae Lee ),( Eun Uk Jung ),( In Hee Kim ),( Sung Bum Cho ),( Mee Kyung Kee ),( Chun Kang ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4

Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection. (Clin Mol Hepatol 2014;20:361-367)

혈관외피종 -1증례 보고-

강유미,지미경,양기화,강석진,김병기,김선무,정수일 대한병리학회 1990 Journal of Pathology and Translational Medicine Vol.25 No.5

청소년 자녀와 어머니의 갈등과 해결방식에 관한 연구

김명자,이정우,계선자,박미석,박수선 숙명여자대학교 출판부 2002 生活科學硏究誌 Vol.17 No.-

This examines the overall traditional cultural aspect of the parent-child conflict, reciprocal action involved and copying of the conflict to understand how the parent and child each perceives these actions in an analytical perspective. The subject of this study was eight pairs of first or second year high school students and their mothers. At least three interviews were conducted on each student and mother pair using the qualitative study method. The results of this research can be summarized as follows. First, the different types of conflicts between mothers and their adolescent children can be classified as conflicts in academic achievement, territory of personal life, discrimination based on gender, and relationships with friends. Second, most adolescent children used avoidance to cope with conflict situations with their mothers. Others made deals to get what they wanted, or resolved conflicts through dialog, letters, and e-mail. Third, when faced dith a conflict with their adolescent children, most mothers used persuasion as or made the children to give up something in return for letting them have something they want. In other cases the father intervened. Though few in numbers, some mothers used letters or e-mail to resolve conflicts.

폐결핵치료 중인 환자에서 Rifampicin에 의해 유발된 위막성 대장염 2예

김봉진,권균홍,임창섭,김자영,홍정범,옥미선,배용목,김지연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Pseudomembranous colitis (PMC) is a disease caused by Clostridium difficile proliferation. The causative drugs are clindamycin, third-generation cephalosporins, flouroquinolone and so on. Rifampicin has been reported as a cause of PMC in the 1980s, and the frequency of PMC is increasing because rifampicin is a first line drug for anti-tuberculosis therapy. Two patients were recently admitted to our hospital due to watery diarrhea for 1 month and they were diagnosed with PMC by sigmoidoscopy. Their onset age were 74, 72 years old and latent period of symptoms were 60, 129 days, respectively. In one case, the patient displayed coexisting hypertension and diabetes. The clinical symptoms improved after discontinuing the rifampicin and then administering oral metronidazole. We report here on two cases presumed to be rifampicin-induced PMC.

일 전문대학 간호과 학생들이 인지하는 강의평가 기준에 대한 조사연구

김정애,이애경,주미경,정안순,장은정,김정수,강정희,이정애 경복대학 2004 京福論叢 Vol.8 No.-

일개 전문대학 간호과 학생들을 대상으로 강의평가 기준을 파악하고자 하였다. 개방형 질문지를 이용하였으며 7개의 교수관련 강의평가 문항 각각에 대해 좋은 점수 및 나쁜 점수를 부여하는 기준을 조사하였다. 각 문항별로 다양한 기준이 확인되었으며, 간호과 학생들의 강의 만족도를 높일 수 있는 교수설계를 위한 기초 자료로 활용할 수 있을 것이다. We aimed to set standards for the student evaluation of instruction for college students of Nursing. We used an open questionaire and surveyed the standards for how students judge the instruction good of bad by using seven questions related to the instructor. Various standards set from each question could be used as basic materials to meet the students' needs in the classroom when the instructors try to find out new instructional design.

전문대학 간호과 통합교과과정 개발에 관한 연구

김영희,김정수,김정애,방숙명,배경진,이애경,장은정,정안순,주미경,최나영 경복대학 1998 京福論叢 Vol.2 No.-

교과과정의 조직은 체계적이고 뜻이 있는 순서로 학생들을 가르치기 위해 지식을 어떻게 조직화할 것인지와, 과목들 사이에서 공통된 내용은 통합시켜 중첩되는 일이 없도록 조정할 필요가 있다. 이에 현재 본 대학 간호과에서 운영되었던 97학년도의 17개 전공과목들의 교과과정의 내용을 비교, 분석하여 중복을 줄이며 순차적 지식의 습득을 도모하는 새로운 통합교과과정의 틀을 개발, 제시함으로써 보다 나은 전문직 간호교육이 이루어지도록 하고자 하였다. Most curricula are considered how to teach the student in systematic and meaningful orders. And it is necessary to coordinate the duplicate contents in major subjects in nursing. So this study was designed to set up a new comprehensive curriculum through comparing and ananlyzing each seventeen major subjects in Nursing Department of Kyung-Bok College. Therefore, the purpose of this study is to present the new comprehensive curricula for promoting the efficiency and effectiveness in diploma degree course of nursing education.

1930년대 '신식'화장담론이 구성한 소비주체로서 신여성 : 여성잡지 『신여성』, 『신가정』, 『여성』을 중심으로 'New style' cosmetics Discourse and Construction of The New Woman in Colonial Korea

김미선 이화여자대학교 한국여성연구원 2005 여성학논집 Vol.22 No.2

본 연구는 식민지 조선의 소비문화가 새로운 여성 주체인 신여성을 구성하는 데 어떤 영향을 미쳤는지를 밝히는 데 목적이 있다. 이를 위해 1930년대 발간된 여성잡지『신여성』,『신가정』,『여성』에 실린 화장품 광고와 여성미 및 화장에 관한 미용사와 지식인의 글을 중심으로 하여 '신식'화장담론을 분석하였다. 그 결과, 1930년대 화장문화의 산업화와 전문화 과정 속에서 부상한 '신식'화장담론이 구성한 새로운 여성주체는 화장품과 같은 상품 소비를 통해 화장과 같은 외모관리를 실천하는 소비주체로서의 신여성이다. 그리고 이러한 담론은 식민지 조선사회에서 여성성 규범의 일환으로써 외모관리가 부상하도록 영향을 미치는 등 ‘새로운’ 젠더장치로 부상 및 작동하였다. This research examines the characteristics of women subjects constructed by the 'New style' cosmetics discourses in the 1930s. It analyzes articles and advertisements related to cosmetics that appeared in three major women magazines in the 1930s - Sinyosung, Singajung and Yosung. My findings are as follows. First, male intellectuals in the colony invented a new concept of women's beauty as a discourse, as its standards came from the western world. Modern women were expected to have a modern look, one identical to the western look in this discourse. Second, cosmetics became commercialized, industrialized, and professionalized in order to make the practice mundane. Consumption was central to the construction of modern female subjects, and cosmetics became a necessity. Third, the New Women, as modern female subjects that were constructed by the 'New style' cosmetics discourse, consumed cosmetics in modern public spheres such as department stores, cosmetic shops and women magazines. Through such activities, these female subjects became individualized consuming subjects. This shows that the New Woman was an important actor in the modern consumption culture. This research demonstrates that the consumer culture in the colonial period was a central factor in the making of 'New Woman' subjects under colonization

조기위함에서 침윤, 유형 및 분화도에 따른 p53, bcl-2의 발현

권오선,조현득,오미혜,김의한,양승하 순천향대학교 의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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