정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

A rare case of abdominal adenoid basal cell carcinoma in a patient with a history of radiation therapy

Kim, Ji Hun,Kim, Sun Eung,Cheon, Young Woo Korean Society of Plastic and Reconstructive Surge 2020 Archives of Plastic Surgery Vol.47 No.1

Basal cell carcinoma (BCC) is the most common skin cancer and its incidence is steadily increasing. Prior radiation therapy is one of the most important risk factors for BCC. Although the mechanism remains undefined, long-term studies have shown that people exposed to radiation have an increased risk of BCC. Despite the fact that BCC occurs most frequently in sun-exposed areas of the body, patients with a history of radiation therapy have an increased risk of BCC in areas previously exposed to radiation. Here, we report a case of adenoid BCC on the abdomen in a 67-year-old woman after radiation therapy post-hysterectomy.

단기교육으로 시행가능한 심실기능평가법

김원,임경수,오병연,홍은석,김영식,김선만,이부수,현석천,김영득 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The initial history, physical examination, and ECG assessment should focus on identification of potentially serious noncardiac or cardiac disorders, including coronary artery disease, congestive heart failure, and electrical instability at the emergency room. additionally, it is essential to define disease severity, stability and need for emergency therapy. echocardiography is a useful tool for this purpose. especially Doppler echocardiography may be more sensitive and time-saving diagnostic tool for the evaluation of patients presenting with cardiogenic symptoms. So we evaluate the feasibility of the echocardiographic measurement by emergency physicain after short-term course. Method and Results: Twenty volunteers(10 male, 38.8±9.3 years) were included in the study for measurement of myocardial performance index and established parameters of ventricular function using conventional echo-Doppler methods. Myocardial performance index: (ICT+IRT)/ET, was obtained by subtracting ejection time(ET) from the interval between cessation and onset of the mitral inflow velocity to give the sum of isovolumic contraction time(ICT) and isovolumic relaxation time(IRT). The most of mean values of echocardiogrphic parameters were not significantly different between those of cardiologist and those of emergency physicians(p<0.01). The duration for measuring myocardial performance index was shortest among echocardiographic parameters. the validity of echocardiographic parameters measured by emergency physicians was proved relatively good. Conclusion: It is proved to be feasible for emergency physician to perform echocardiographic evaluation of ventricular function after short-term course

全南地方 傳統住居建築 壁面의 比例特性에 관한 硏究

천득염,이영미,김선영 대한건축학회 2004 대한건축학회논문집 Vol.20 No.6

This thesis try to search the proportion character existing in the wall surfaces by examining the proportion relations appearing in the windows and doors of the traditional residence architecture, that is the opening, with numerical data. And the results of the analysis on this study are as follows. 1) The Shaping Principles by the Make-up Elements ① Shaping Principles by Embellishment Materials : The types of the make-up elements are varied according to the functions of the respective rooms. ② Shaping Principles by the Walls and Doors : In the case of the facade, visual features seems to have been considered much, whereas the rear side has the feature of being relatively free compared to the facade. 2) The Shaping Principles by the proportion relations of the Walls ① One-dimensional proportion : In both horizontal and vertical proportions, the proportion relation between Woman's quaters bedroom to the Hall the kitchen to the Hall have respectively different system, and it is thought to be the shaping principle following a hierarchy ② Two-dimensional proportion : The shape of 1 and √2 grid is found between the walls and the opening. In the elevation of the building, there seems to be the proportion relation that our ancestors preferred. And such kind of proportion relation is different from the existing western proportion relations like root·golden·rectangular proportion, it can be thought to be the very Korean proportion system existing as the formative standard in our traditional architecture.

升麻葛根湯 및 升麻葛根湯合四物湯의 抗 Histamine 效果에 關한 硏究

金賢兒,鄭智天,朴宣東 동국대학교 한의학연구소 1994 東國韓醫學硏究所論文集 Vol.3 No.-

In order to find out the effect of Anti-Histamine of the Sungmagalkuntang and Sungmagalkuntang-plus-samultang I've investigated the effect of the time to death, the peripheral vascular Peaneability, the amount of secretion of Gastric Juice, the total Acidity of Gastric Juice, the contraction of Intestine Tube by Histarnine and the effect of the Skin-Reaction by the decrease of DNCB. These results are following 1. The effect of Mice s rime to death by Histamine was that the injection group of sungmagalkuiigtang and the injection group of sungmagalkungtang-plus-samultang both have had the effect of the extention uf the time lo death, which indicated a statistical significance in comparison with comparative group. 2. The effect of the increased vascular permeability by Histamine was that the injection group of sungmagalkuntang and the injection group of sungmagalkuntang-plus-samultang both have had the effect of the restraint of the increased vascular permeability, which indicated a statistical significance in comparison with comparative group. 3. The effect of the the amount of the secretion of Gastric Juice by Histamine stimulus was tirat the injection group of sungmagalkuntang-plus-samultang only has had the effect of restraint of the increased of the secretion of Gastric Juice, which indicated a statistical significance in comparison with comparative group. 4. The effect of the chan,ge of total Acidity of Gastric Juice by Histamine's stimulus was that the injection group of sungmagalkuntang-plus-samultang only has had the effect of the restraint of the increase of tolal Acidity of Gastric Juice,, which indicated a statistical significance in comparison with comparative group. 5. The effect of the contraction of Intestine Tube by Histamine was that sungmagalkuntang and sungmagalkuntang-plus-samultang both have had the effect of the contraction and the restraint According to the increase of the density, the effect of the restraint was more clear. But the difference of the effects between two substances had little. 6. The effect of the reaction of skin by the decrease of DNCB was that the injection group of sungmagalkuntang and the injection group of sungmagalkuntang-plus-samultang have had the decreased effect of the Skin-Reaction in comparison with comparative group. sungmagalkun-tang-plus-samultang aws more effective. In these results shown above, both sungmagalkuntang and sungmagalkuntang-plus-samultang was shown as more effective one

Overlay 기반의 WiBro와 WLAN 이종망 연동을 위한 Vertical 핸드오버 구현 및 성능 측정에 관한 연구

이재호,류형근,강선무,이재용,김승천 한국정보사회진흥원 2007 정보화정책 Vol.14 No.3

유비쿼터스 사회를 위한 미래 네트워크는 다양한 이종 무선망이 혼합된 형태가 될 것으로 예상되고 있다. 본 논문에서는 개별 무선망의 특징을 최대한 활용하여 1,270,000㎡ 면적의 KAIST(Korea Advanced Institute of Science and Technology) 대학교 캠퍼스에 IEEE 802.16e/WiBro와 IEEE 802.11/WLAN 를 복합적으로 설치하여 건물외부에서는 WiBro, 건물내부에서는 WLAN으로 자동 스위칭 되는 Vertical 핸드오버 System을 구축하고 이동 성능을 분석하였다. 이종망 통합 과정에서 제조사 및 통신사업자의 사정으로 인하여 Mobile IP를 지원하지 않는 라우터들이 존재하였고, 특히 현재 WiBro에 사용되는 ACR(Access Control Router)은 Mobile IP를 지원하지 않기 때문에 이를 해결하기 위하여 Overlay 기반의 Mobility 기법을 적용하였다. 본 연구에서는 실제로 대규모 통신망을 구현하고, 이에 대한 성능시험을 시행한 후 handover delay 시간 분석을 통한 현장 적용 가능성 및 개선 필요사항을 도출하였다. 그 결과 이종망간 핸드오버 시간은 평균 2.58초로써 일반 데이터 서비스는 이종망간 연속성이 보장됨을 확인하였고, 음성∙영상과 같은 실시간 서비스는 중간에 지연시간이 발생하나 응용서비스 세션 자체는 유지됨을 확인하였다. The future network is forecast with the fact that the form where the various heterogeneous wireless networks. In this paper we build both IEEE 802.16e/WiBro and IEEE 802.11/WLAN network on the KAIST(Korea Advanced Institute of Science and Technology) campus(1,270,000m2) as well as established the vertical handover system which supported WLAN in the building and WiBro outside the building. A Mobile IP is considered for the efficient vertical mobility function in IEEE 802.16/WiBro and IEEE 802.11/WLAN environment. However, during the deployment of WiBro, only some of the ACRs(Access Control Router) can support the Mobile IP function. Therefore, WiBro network can not support the mobility function for the mobile node. In this paper, we implement an overlay-based Mobile IP function and measure the performance through a field trial. Moreover, we evaluate the possibility of commercial deployment and suggest areas that need to be improved. The average handover time between WiBro and WLAN was 2.58 seconds. As a result, the user application session maintained but real time applications were delayed during the handover time.

장간막 림프절염으로 발현된 Kikuchi-Fujimoto병 1예

최원섭,이승순,권진우,이영석,김선영,전선영,김민정,정두련 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

Kikuchi-Fujimoto 병은 주로 경부 림프절을 침범하는 질환이지만, 드물게 회맹부 장간막 림프절을 침범하여, 발열을 동반한 우하복부 통증과 반발압통을 나타내는 장간막 림프절염을 일으킬 수 있다. 급성 충수돌기염과 유사한 양상의 급성 복증을 호소하는 젊은 성인의 경우, 장간막 림프절염 여부를 확인하여야하며, 그럴 경우 Kikuchi-Fujimoto 병을 감별 진단에 포함시켜야 한다. 저자 등이 경험한 장간막 림프절염으로 발현된 성인의 KikuchiFujimoto 병 1예는 국내에서는 최초로 발견된 것이기에 문헌 고찰과 함께 보고하는 바이다. Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a benign, rare, self limitimg disease presenting with mainly cervical lymphadenopathy and fever unresponsive to antibiotics or medical treatment. A 28-year old man presented with fever and right lower quadrant abdominal pain. Physical examination showed abdominal tenderness and rebound tenderness mimicking acute appendicitis. Imaging studies showed normal appendix and other abdominal organs except enlarged multiple mesenteric lymph nodes. Symptoms persisted despite antimicrobial therapy. Multiple tender lymph nodes were palpable on bilateral cervical area at the 7th hospital day. The biopsy of the neck node showed large areas of patchy, irregular necrosis with prominent nuclear debris surrounded by T lymphocytes, histiocytes without neutrophils and granuloma, so he was diagnosed as Kikuchi- Fujimoto disease. With conservative management, clinical improvement was observed. We suggest that Kikuchi-Fujimoto disease with mesenteric lymphadenitis should be added to the differential diagnosis of acute abdomen mimicking acute appendicitis in young adults.

심정지환자에서 epinephrine투여시 혈중 catecholamine의 변화

임경수,황성오,이부수,이강현,이진웅,임종천,김영식,김선만,김 현 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Background : Cardiac arrest is a potent stimulus for the release of endogenous catecholamine and high plasma catecholamine concentration has been reported during cardiopulmonary resuscitation(CPR). Few data were present about the clinical effect of high plasma catecholamine and endogenous catecholamine response to exogenous epinephrine administration during CPR. Purpose : This study was designed to evaluate endogenous catecholamine response to cardiac arrest and exogenously administered epinephrine during CPR. Method : In 21 cardiac arrest victims, blood sample for epinephrine and norepinephrine was drawn before and 1 minute after each epinephrine administration during CPR. 1mg of epinephrine was administered immediately after intravenous access and 3 minute interval during CPR. Plasma catecholamines were quantitated by high-performance liquid chromatography. Result : Baseline plasma epinephrine concentraqtion was higher in patients with cardiac arrest than normal controls (985±1627 vs 194±173 pg/ml, p<0.05). Baseline plasma norepinephrine concentration was also elevated in patients with cardiac arrest than normal controls, although statistically insignificnat(1965±4915 vs 360±250 pg/ml). Plasma epinephrine concentration in cardiac arrest patients was significantly elevated after exogenous administration of epinephrine, but its response was blunted after the third does of epinephrine. Plasma norepinephrine concentration in cardiac arrest patients was also elevated, but its response was observed only after the first epinephrine administration. Plasma epinephrine concentration was persistently higher in patients with return of spontaneous circulation (ROSC) than patients without ROSC. there was no significant difference of plasma norepinephrine concentration whether spontaneous circulation was restored or not. Endogenous epinephrine response to exogenous epinephrine was not observed in patients having prolonged arrest time over 20 minutes. Conclusion : Results of this study suggests that significant amount of catecholamine is released by exogenous epinephrine administration in spite of high plasma catecholamine concentration, and degree of endogenous catecholamine response influences resuscitation outcome.

최근 국내 유입 Vibrio cholerae균 및 1995년도 국내 집단 발생 콜레라의 역학적 양상

김호훈,신영학,강연호,유천권,박미선,김동술,유재연,전정훈,이복권,박기덕,김동진,정태화,이종구,박기동,김상순,이동모,김문식,조병륜 대한감염학회 1996 감염 Vol.28 No.6

목적 : 1992년 이후 국내에 유입, 확인되는 V. cholerae 균은 현격한 증가 추세를 보이고 있으며, 1995년도 국내 집단 발생 콜레라의 역학적 양상이 종래의 경우와 상이한 바 있어 최근의 콜레라균 유입상황과 국내 역학적 특성을 정리하여 향후의 방역 대책에 참고로 하기 위하여 본 연구를 시행하였다. 방법 : 국내 유입 V. cholerae 균은 세균학적 방법에 의해 1986-1995년 사이에 확인된 균주를 대상으로 분석하였고, 국내 집단발생 콜레라는 1995년도에 내국인 거주자에게서 진성 콜레라 환자로 구명된 환자를 대상으로 역학적 양상을 살펴보았다. 결과 : 국내 유입 V. cholerae균은 1992년 이후 1995년 사이에 계절과 무관하게 뚜렷한 증가 추세를 보였다. 1995년도 콜레라 국내 집단 발생의 역학적 양상은 초발 환자가 인지되면서 단기간 사이에 지역적 연고가 없는 다양한 지역에서 콜레라 환자 발생이 확인되었다. 환자 발생 지역 내에서는 비교적 소규모 환자 발생에 그쳤고 진성 콜레라 환자로 확인된 환자 중 사망자는 없었으며 남성에서 여성보다 발병율이 높았다. 결론 : V.cholerae O1균의 국내 유입이 최근 현격히 증가되었고, 1994년에는 V. cholerae O139균의 국내유입이 처음으로 확인되었다. 콜레라 환자의 국내 집단 발생 위험은 1992년 이후 증가되었으며 1995년도의 집단 환자 발생은 지역적 연고가 없는 다양한 지역에서 비교적 단기간에 사망자 없이 소규모의 환자 발생양상을 보였다. Background: Imported Vibrio cholerae strains have increasingly been found since 1992 and the pattern of recent cholera epidemic outbreak in Korea showed a little difference from that of former epidemic outbreak. Methods: We had collected suspected V. cholerae isolates from Quarantine Stations or Public Health Laboratories, which were identified as V. cholerae O1 or O139. Epide miological analysis was made on the base of field surveys. Results: During the period from 1986 through 1995, 138 V. cholerae strains were imported. Nearly 85.5% of the strains (118 strains) were imported within recent 4 years from 1992 to 1995. One hundred and twenty-eight strains were E1 Tor-Ogawa type V. cholerae O1, 6 strains were V. cholerae O139 and 4 strains were E1 Tor-Inaba type V. cholerae O1. Of 138 strains, 71 strains were isolated from the airplane toilet swab and 67 strains from the passengers who entered into Korea after international travel. From 1993 to 1995, 101 strains were imported from the Southeast Asian countries; including Thailand(65), Indonesia(17), Philippines(10), Hongkong(6) Singapore(2) and Vietnam(1). During the cholera epidemic in 1995, 68 patients with V. cholerae O1 (E1 Tor-Ogawa) were found. Oneset of the index-case occurred on August 26th and the last on September 13th. Geographically it occurred in Incheon city(25), Chungcheongnam do(25), Kangwon do(6), Kyungsangbuck do(5), Kyunggi do(4), Daejeon city(2) and Pusan city(1). Of total 68 cases, 39 were male. Cases were found in all age groups, but it was more common in elderly groups. During the epidemic, E1 Tor-Ogawa type V. cholerae O1 strains were also isolated from the coastal sea water of Kanghwa kun where the epidemic outbreak occurred. Conclusions: In Korea, the imported V. cholerae O1 and V. cholerae O139 strains have increasingly been found without seasonal variation since 1992. Cholera epidemic outbreak in 1995, occurred simultaneously at many different local areas within a short period without mortality.

Suppressive Effect of Solanum Iyratum Aqueous Extract Via Down-regulation of $TNF-{\alpha}$ and $IFN-{\gamma}$ Production on Collagen-induced Arthritis in Mice

Kim, Seung-Hyung,Seo, Chang-Woo,Kim, Chang-Min,Kim, Yang-Jin,Lee, Boo-Kyun,Choi, Yong-Sun,Oh, Hwang,Yoon, Ho-Sok,Lee, Seon-Goo,Lee, Jang-Cheon,Lee, Young-Cheal The Physiological Society of Korean Medicine and T 2007 동의생리병리학회지 Vol.21 No.5

Solanum Iyratum Thunb (Solanaceae) has multiple applications in korean traditional medicine because of its cytotoxic, immunological and anti-inflammatory activities. However, no study on the anti-arthritic activity of Solanum Iyratum Thunb has been reported in vivo. Rheumatoid arthritis (RA) is a systemic autoimmune disease with chronic inflammation characterized by hyperplasia of synovial cells in affected joints, which ultimately leads to the destruction of cartilage and bone. Cytokine production were assessed during CIA(collagen-induced arthritis) model mice in lymph node (LN), in knee joint and spleen, using ELISA. DBA/1j mice were immunized with bovine type II collagen. After a second collagen immunization, mice were treated with Solanum Iyratum Thunb (SLT) orally at 400, 200 mg/kg once a day for 4 weeks. The severity of arthritis within the knee joints was evaluated by histological assessment of cartilage destruction and pannus formation. SLT significantly suppressed the progression of CIA and inhibited the production of TNF-alpha and IFN-gamma in serum and spleen cell culture supernatant. The erosion of cartilage was dramatically reduced in mouse knees after treatment with SLT. In conclusion, our results demonstrates that SLT significantly suppressed the progression of CIA. This action was characterized by suppression of arthritis index, cartilage erosion and synovial cell infiltration and the decreased production of $TNF-{\alpha}$, $IFN-{\gamma}$, CD4+, CD19+, CD3+/CD69+ cells (in lymph node), CD11b+/Gr-1 + (in knee joint).