Infliximab으로 호전된 장관 증상없이 발생한 구강-안면 크론병

정보용 ( Bo Yong Jung ),이석호 ( Suck Ho Lee ),정승규 ( Seung Kyu Chung ),이창균 ( Chang Kyun Lee1 ),이태훈 ( Tae Hoon Lee ),정일권 ( Il Kwun Chung ),김선주 ( Sun Joo Kim ),조현득 ( Hyun Deuk Cho ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6

Crohn`s disease is a chronic inflammatory bowel disease that can involve the whole gastrointestinal tract. The orofacial manifestation of Crohn`s disease, which is rare, can develop irrespective of intestinal involvement. These orofacial lesions are often misdiagnosed as simple oral ulcers. Corticosteroids are the mainstay of therapy for orofacial Crohn`s disease. However, infliximab, the chimeric monoclonal antibody to tumor necrosis factor-α, is now considered as a primary treatment because of the disease`s relatively high rate of steroid resistance. We present a case of deep oral ulcer and periorbital swelling in a 65-year-old woman. She was diagnosed with intestinal Crohn`s disease 7 years ago, which was in remission after treatment with an immunosuppressive agent (azathioprine). The patient was given the diagnosed with orofacial Crohn`s disease and successfully treated with infliximab. (Korean J Gastroenterol 2012;59:437-440)

전자우편 기반의 인터넷 EDI를 위한 수신 부인방지 및 메시지 반환 기능 설계 연구

이보경,김명주 서울여자대학교 자연과학연구소 1999 자연과학연구논문집 Vol.11 No.-

Although S/MIME and OpenPGP are representative protocols used in transferring messages securely on internet environment, they have defects in the internet electronic data interchange (IEDI). In case of S/MIME, the implementation is most difficult due to the restricted usage of public key encryption library. And OpenPGP does not provide receiver non-repudiation and has weak extensibility under public key ring architecture for the authentication. In this paper, we propose a secure message transfer protocol by combining the protocols above in order that it may guarantee us receiver non-repudiation and return-of-content, which are necessary in E-mail based Internet EDI. By using this protocol, we can prevent the message-incurred resource waste in IEDI.

특발성 과호산구 증후군 환자의 치료 도중 발생한 간혈종 1례

이영태,김동기,박지훈,김윤정,김기향,박보민,권민정,김애란,이원식,주영돈,손창학 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Idiopathic hypereosinophilic syndrome is characterized by marked elevation of eosinophil count ( >1,500/㎣) in peripheral blood without explaining etiology. It shows tissue involvement in many organs such as liver, G-I tract, myocar dium, lung, skin, kidney and nerve. Some case of hypereosinophilic syndrome with hepatic involvement have been reported, but not much. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 40 year old man who presented with RUQ pain. By abdominal CT, ill- defined subcapsular hematoma was detected. Liver biopsy showed eosinophilic infiltration within the portal tract and sinusoid. Drain procedure and corticosteroid adminiiatbrought marked improvement of clinical manifestation, hematologic abnormality and radiologic abnormality.

산국의 수량과 유효성분에 대한 NPK의 효과

이경동,양민석,정연규,손보균,조주식,이성태,김필주 한국농화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.2

본 연구는 3요소(N-PO_2O_5-K_2O)처리가 산국(Chysanthemum boreale M.)의 수량과 유효성분에 미치는 효과를 조사하여 효과적인 재배시스템을 개발하고자하였다. 처리구는 무처리, NPK(250-160-160), NK(250-0-160), PK(0-160-160kg/ha)의 5처리로 설정하여 산국을 재배한 결과, 건물수량은 NPK처리구가 PK처리구에 비하여 4.0배의 증수가 있었으며, 다른 처리구보다 무기이온의 흡수율, 생육 및 수량에서 NPK처리구가 가장 우수하였다. 식용으로 많이 쓰이는 꽃의 주요 아미노산은 proline, glutamic acid과 aspartic acid이였고, 다른 처리구들에 비하여 NPK처리구가 높은 함량을 보였다. 혈압강하효과가 우수한 cumambrin A는 PK처리구에 비하여 NPK처리구가 6.2배의 증수효과가 있었다. NK처리구는 NP처리구보다 cumambrin A의함량을 높이기 위해서는 인산의 시용보다 칼리의 시용이 더 요구되며, 야외포장에서의 인산과 칼리의 적정 시비량의 설정이 필요하다고 판단된다. To establish the fertilization condition to increase the productivity of Chrysanthemum boreale M. with high quality, the effects of three nutrients (N, P, K) on the yields and the effective components were investigated in the pot scale. NPK was applied by chemical fertilizers with N-P_2O_5-K_2O = 250-160-160 kg/ha as a main treatment, and NP (N-P_2O_5 = 250-160 kg/ha), NK (N-KO = 250-160 kg/ha), and PK (PO_2-KO_5 = 160-160 kg/ha) treatments were settled as comparison. Dry yields of C. boreale M. was increased significantly to 4 fold higher by nitrogen. Nitrogen increased apparently plant growth and inorganic nutrient uptake. In the flower, which is most useful and edible part as a herbal medicine, main amino acids were glutamic acid and aspartic acids, and the total content was increased significantly by three elements of application. In addition, the content of cumambrin A, which is known to have the effect of blood-pressure reduction, was increased source to 6.2 times by nitrogen higher than that in PK treatment. Potassium was more effective in biosyndiesis of cumatnbrin A than phosphorus, but the biological pathway was not clear, still.

젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구

이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.

工業敎育大學 化學工學敎育科 敎育改善에 關한 硏究

李輔成,李來然,周赫鍾 충남대학교 공업교육연구소 1981 論文集 Vol.4 No.1

In Korea the structure and activity in chemical industry(in accordance with the rapid development of chemical technology) is rapidly promoted day by day. Therefore the education in College of Industrial Education must be up to date and up to the grade in teaching because the graduates from this college should teach the future technical engineers and introduce new technology into teaching. Through the consideration of this idea we have reached to results as following; 1) The improvement of Chemical Engineering Education must be continued. 2) The curricula should be renewed in accordance with the current circumstances of technology. 3) The Department of Chemical Engineering in the College of Industrial Education must play the role of improving the curricula of technical high school. 4) Future engineers and today technicians must be trained in the college and the technical high schools, respectively. 5) Since the education through the audio-visual aids, especially the experiment is of great effect, such a method must be widely applied. 6) Students in doing graduation tasks must be grouped and every group must be oriented by each professor for the student to be oriented in the future research. 7) Options should be guided in conformity with the student's aptitude.

중국 광동성 한국전통정원 조성사업 기본계획

서주환,이준근,심성보,전영임 경희대학교 디자인연구원 2004 예술· 디자인학연구 Vol.7 No.1

The cultural interchanges have been dramatically increased between Korea and China since the diplomatic agreement on the 24th of August, 1992, Among the several discussions between the two countries, particularly building up Korea traditional garden will take concrete shape in Kwan-dong in China. These followings are the basic plans. First, the project approaches the garden as a place for the interchange and the cooperation between the counties, and where people can experience Korea traditional garden. Secondly, it is plotted to express the distinct character and originality of Korea traditional garden. Third, it applies the same materials, subject matters and the same construction method of Korea traditional garden. We can use the most similar materials if it is not possible. Fourth, the project is plotted to make the efficient use of the land form to decrease the damage of natural environment.

GIS를 이용한 농촌용수구역 정보 검색시스템 개발

고보성,김선주,이광야 한국농업정보과학회 2003 농업정보과학 Vol.4 No.1

The main issues on the demand and supply of water in rural areas are optimization of the water resources development, provision of infrastructure in agriculture by appropriate utilization and conservation, and conservation of rural environment. However, the characteristics in using rural water was not properly considered in the management of rural water, since rural water has not been managed by the watershed unit but by the administrative unit due to the convenience. The purpose of this study is to delineate rural water districts to reflect property of rural water and to build spatial database for analysis of using rural water, to develop a prototype GIS system for query and to evaluate the applicability of the system with applying it to a tested site. This system also aims to provide various analyses based on a standardized common watershed map, which was generated and harmonized by different ministries of the government.

조기 후두암의 Docetaxel-Cisplatin 유도 화학요법에 대한 임상연구

정주섭,권보란,최영진,왕수건,이병주,조군제 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

정상교합자의 Ⅲ급 부정교합자의 저작근 근전도에 관한 연구

박영국,이기수,주보훈 대한치과교정학회 1991 대한치과교정학회지 Vol.21 No.1

The purpose of the present study was to investigate the differences of EMG activity of the masticatory muscles between normal occlusion and Class Ⅲ malocclusion during various jaw functions. 46 subjects of 18.4-25.7 years were employed in this study: 26 subjects were normal occlusions, and 20 subjects were Class Ⅲ malocclusions. The EMG data from the anterior and posterior temporal, anterior and posterior masseter muscles in both sides as mandibular elevators and supra-hyoid muscle group(close to the anterior belly of digastric muscle in right side) as mandibular depressor were recorded with the Medelec MS 25 electromyographic machine. The EMG recordings were analyzed during mandibular rest position, maximal biting, mastication with chewing gum, and swallowing of peanuts. All data were recorded and statistically processed. 1.The maximal mean amplitude of the anterior temporal muscle was stronger significantly in Class Ⅲ malocclusion than in normal occlusion, and then the posterior temporal was weaker during mandibular rest position. 2.The maximal mean amplitudes in the anterior and posterior temporal muscles and the anterior masseter muscle of Class Ⅲ malocclusion was weaker significantly than that of normal occlusion during maximal biting. 3.During mastication of the chewing gum, the maximal mean amplitudes of Class Ⅲ malocclusion was weaker significantly than normal occlusion in the anterior and posterior temporal muscles of the working side, and the duration of Class Ⅲ malocclusion was longer in the anterior temporal muscles of both sides and the posterior temporal and the anterior masseter muscle of the balancing side. There were significant increasings of the latency in balancing anterior temporal, working posterior temporal muscles and supra-hyoid muscle group of Class Ⅲ malocclusion. The silent period durations was 16.36 ms in Class Ⅲ malocclusion while 10.76 ms in normal occlusion, which was statistically different(P<0.05). 4.At swallowing of peanuts, the maximal mean amplitude of Class malocclusion was weaker significantly in the posterior temporal muscle than that of normal occlusion. There was no significant difference of duration between normal occlusion and Class Ⅲ malocclusion. 5.The muscle activities of Class Ⅲ malocclusion had a tendency of decrease less than normal occlusion. And then the muscle activities of the anterior temporal and anterior masseter muscles in Class Ⅲ malocclusion showed the tendency of the increase more than other muscles of Class Ⅲ malocclusion.