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김일규,박형준,최진호,장금수,김왕식 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1
Hemangiomas are benign tumors in blood vessels that occur by traumatic or congenital origin. Lesions are appeared early in life, with 73% present at birth and 85% developing by the end of the first year. Head & neck hamangiomas represent about 25%∼33% of all hemangiomas. Kaban & Mulliken divided vascular birthmarks into two major categories : hemangioma and vascular malformation. Case 1 was diagnosed as cavernous hemangioma and the mass was excised completely and defected space was reconstructed with fat tissue. Case 2 was diagnosed definitely as traumatic A-V malformation by post-op histopathological examination and the mass was excised completely. This report describes two cases that were successfully treated by complete surgical excision for hemangioma in maxillofacial region.
악골에 발생한 중심성 골종(Central Osteoma)의 치험례
김일규,김효정,최진호,장금수,오남식 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1
Two cases are described of Endosteal Osteoma which developed in the Jaw bone and were painful. The tumors were radiographically characterized by dense radiopaque lesion. The surface was smooth and overlying mucosa was normal in color. Tentative diagnosis was OSteoma. The tumors were treated surgically. Postoperatively the patients made uneventful recovery and the wound healed satisfactory. Postoperative radiograph showed that radiopaque mass had been completely removed. Histologically, biopsy was reported as Central Osteoma. Subsequent follow-up examinations show no recurrence of the lesion or the pain.
구강악안면 영역의 수술 시 악하 기관 삽관술의 유용성에 대한 임상적 고찰
김일규,장금수,최진호,오남식,류승현,김재우,정종권 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2
It is hardto make a decision of what route we will select for endotracheal intubation at open reduction of oral and maxillofacial trauma. In the patients with fractures of multiple facial bones combined with fracture of crainal basal bone, intermaxillary fixtion makes oro-endotracheal intubation impossible. And the possibility of injury to the fracture site of crainal basal bone and the impossibility of reconstruction of naso-orbito-ethmoidal(NOE) complex fractures also make the naso-endotracheal intubation difficult. But it is not easy to select the tracheostomy because of its several complications and abhorrences. For above reson, Altermir introduced submental route for endotracheal intubation as new technique in 1986 and Green etc. modified this technique in 1996. The purpose of this article is to evaluate the efficiency of submental route for endotracheal intubation after experience of 10-clinical cases for variable reasons with review of articles.
VBNC Campylobacter jejuni의 회복특성
장금일,손진영,이희봉,김광엽 忠北大學校 農業科學硏究所 2003 農業科學硏究 Vol.20 No.-
We studied the characteristics of the recovery process where the coccoid (Viable but non-culturable, VBNC) form Campylobacter jejuni which was inactivated under aerobic condition with lower temperature (4 and 25 C jejuni ATCC 43429 strain did not recovered from VBNC form to active spiral form at 4 and 25, whereas C jejuni ATCC 33291 strain recoveredfro VBNC form at 25 Morphology and the fatty acid pattern of cell membrane of VBNC C. jejuni ATCC 33291 and ATCC 43429 were analyzed. The morphological differences between two C jejuni strains were verified using flow cytometry. C16 0(palmiticacid) and C19 0(cyclic fatty acid) showed decrease in the fatty acid composition of C. jejuni ATCC 33291 On the other hand, C19 0 in the fatty acid composition of C jejuni ATCC 43429 was increased and C14:1(myristoleic acid) was found only in C jejuni ATCC 43429 The differences in the fatty acid composition of C jejuni could be possibly related with the recovery of VBNC form C jejuni
Monoamine Oxidase 의 활성 변화에 의한 기미론 연구
黃今熙,마진열,金仁洛 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1
To explain the theory of KIMI which is the theory of therapeutics in oriental medicine, the monoamine oxidase(MAO) activities were determined in the brain and liver of mouse which was orally adminstered cold and hot drugs, and forced swimming in cold and hot water. The MAO plays a central role in the metabolism of many amines including the neurotransmetter monoamines. MAO is a flavoprotein found exclusively in the mitochondrial outer membrane, occuring in the MAO-A and MAO-B subtypes. MAO-A deaminates serotonin and noradrenaline, whereas MAO-B prefers penylethylamine and benzylamine as substrates. Serotonin is important neurotransmetter for the control of body temperature. Coptis japonica Makino was selected as the cold drug, and Radix Aconiti lateralis preparata was as the hot drug. Coptis japonica Makino elevated the MAO-A activity which was increased by cold stress, whereas it inhibited the MAO-B activity which was increased by cold stress. Coptis japonica Makino elevated the MAO-A activity which was decreased by heat stress, whereas it inhibited the MAO-B activity which was increased by heat stress. Radix Aconiti lateralis preparata inhibited the MAO-A activity which was increased by cold stress, whereas it inhibited the MAO-B activity which was increased by heat stress.
일부 시판세치제의 비교치아마모도 및 경과시간에 따른 유효불소농도변화에 관한 연구
장덕수,이병진,배광학,방금석,이원재,노정,백대일,김종배 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.3
The purpose of this study was to assess relative tooth abrasivity and to measure effective fluoride concentration of dentifrices selling in Korea for help consumer's selection of suitable dentifrice. Assessment of the abrasion on tooth produced by different dentifrices were carried out on bovine teeth in the laboratory and tested by radioactive dentin abrasion method. And total soluble fluoride concentrations within the dentifrices was determined using fluoride ion selective electrode with standard curve obtained from standard solutions of known fluoride concentration. 10 dentifrice samples were stored at 49t for 15 weeks and the measurements were made for each dentifrice in 1 week, 2 weeks, 3 weeks, 13 weeks and 15 weeks and 11 dentifrice samples were stored at 40.6C for 3 weeks and the measurements were made for each dentifrice in 1 week and 3 weeks. Tooth abrasivity of selling dentifrices is suitable for toothbrushing but dentifrice which recommended for patient who have tooth abrasion or erosion was somewhat high abrasivity level. Effective fluoride concentrations of selling dentifrices were maintained generally optimal level. But some dentifrices contaning CaCO_(3), as abrasive were decreased as time elapsed. It was suggested that relative tooth abrasivity must be marked on package and fluoride level should be maintained acceptable level in dentifrices for consumer's selection of suitable dentifrice.
Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구
장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.
( Dong Jin Kim ),( Hyun Seok Kang ),( Hyuk Soon Choi ),( Hye Jin Cho ),( Eun Sun Kim ),( Bo Ra Keum ),( Hyong Gin An ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Yong Sik Kim ),( Hyung Joon Yim ),( Yoon Tae 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.2
Background/Aims: Several studies suggested that serum cystatin C (CysC) is more useful than serum creatinine (Cr) for the assessment of renal function in patients with liver cirrhosis. This study evaluated the clinical significance of CysC in patients with cirrhotic ascites and normal Cr level. Methods: We enrolled patients with cirrhotic ascites and a normal serum Cr level (<1.2 mg/dL). GFR was measured by 99mTc-DTPA renal scan. Serum Cr, CysC, and Cr clearance (CCr) were measured on the same day. Significant renal impairment and severe renal impairment were defined as GFR <60 mL/min and GFR <30 mL/min, respectively. Results: Eighty-nine patients with cirrhotic ascites were enrolled in the study (63 men and 26 women; age, 55±11 years). Forty-seven (52.8%) and 42 (47.2%) patients were in Child-Pugh grade B and C, respectively. Serum Cr and CysC levels and GFR were 0.8±0.2 mg/dL, 1.1±0.3 mg/L, and 73.4±25.5 mL/min, respectively. Significant and severe renal impairment were noted in 28 (31.5%) and 2 (2.2%) patients, respectively. GFR was well correlated with serum Cr, CysC, and e-GFRMDRD, while it was not correlated with e-GFRC&G. In multivariate analysis, only CysC was significantly correlated with GFR (β, 45.620; 95% CI, 23.042-68.198; P<0.001). Serum CysC level was the only independent predictor for significant renal impairment. Conclusions: Significant renal dysfunction was not rare in patients with cirrhotic ascites, even their serum Cr level is normal. Serum CysC is a useful marker for detecting significant renal dysfunction in these patients.