건강질단 질병 유소견자들의 순천향구미병원 외래이용에 영향을 미치는 요인

김진석,우극현,함정오,유재영,최태성,하봉구,윤성용 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background ; The purpose of routine health screening of employee is not only to detect worker's disease at early stage but also to provide early appropriate health service. But, majority of patients who diagnosed by routine health screening haven't underwent health service utilization. Soonchunhyang Kumi Hospital had been provide total occupational health service in kumi industrial estate including health screening, worker interview at workplace by occupational nurses and doctors. Object ; We want to know how much proportion of patient who are diagnosed by routine health screening had visited Soonchunhyang Kumi hospital out-patient clinic and factors influencing such health care service utilization. Method ; Initial study subject were 189 workers who had proved to have hypertension, diabetes mellitus, hyperlipidemia in routine health screening which performed during year of 2000. Among those, 160 workers who had finished questionnaire were selected for final study subject. We investigate whether they had visited health services or not, if they had, what kind of health care facility they visited, and other factors which influencing their health service utilization. Result ; Among 160 workers, 59(36.9%) had visited Soonchunhyang Kumi hospital, 47(29.4%) had visited other health care facility, and 54(33.8%) had not went to any health care facility. Factors which influencing Soonchunhyang Kumi hospital utilization is sex, job, staff's support to hospital visit during worktime, history of medical consultation about health screening result.

한국산 배의 Polyphenol 화합물군이 쥐의 면역기능에 미치는 영향

최희진,한호석,박정혜,배종호,우희섭,안봉전,배만종,김현구,최청 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.4

This study was conducted to investigate immunofunctional activity of the polyphenol fractions isolated from Korean pear. In the experimental of Rosette forming cell, the results showed that all the polyphenol fractions enhance the cell count compared with the control group. Especially polyphenol fraction II and III showed highly significant effect on Rosette forming cell, and allergy inhibition. After antigen challenge, histamine content of blood of the polyphenol groups was lowered to near the normal group.

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

위암의 위벽침윤정도의 평가 : 나선형전산화단층촬영과 복부초음파의 비교 Comparison of Spiral CT and Transabdominal Ultrasound

최종철,남경진,구봉식 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

담즙정체성 간염의 임상적 양상

최선택,은종렬,임상우,김봉준,이헌주,구미진,최준혁 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: Cholestatic hepatitis is failure of bile to reach the duodenum with hepatocellular damage and no demonstrable obstruction of the major bile ducts. The prognosis is usually good with recovery in less than 4 weeks after withdrawal of the offending drug. However, a prolonged course lasting over 3 months is possible and, in rare cases, progression to ductopenia with development of a vanishing bile duct syndrome occurs. A differential diagnosis with other causes of Chronic liver disease is needed. Materials and Methods: From January 1991 through Jaunary 2000, 14 patients diagnosed as cholestatic hepatitis by liver biopsy were inclouded. The possible causative drug, clinical features, laboatory findings, and progression of cholestatic hepatitis were evaluated. The semiquantitative study of liver lesions was performed by two independent observers. Results: Causes of cholestatic hepatitis are 5 cases of oriental medicine, 3 cases of anti-tuberculosis medication, 1 case of ticlopidine and antibiotics and 4 cases of unknown causes. The clinical features of cholestatic hepatitis were jaundice, itching, urine color change, and general weakness. During 6 to 30 months, LFT of 5 patients showed prolonged elevation. Elevated total cholesterol ≥250 mg/dL in 6 patients, pheripheral blood eosinophilia in 5 patients, auto-antibody positive in 6 patients were observed respectively. The biopsies showed intralobular bilirubinostasis with a mixed portal inflammatory infiltration. Conclusion: In cholestatic hepatitis. durations of abnormal LFT are variable regardless of causative drugs. If cholestatic hepatitis progresses toward chronic course, viral hepatitis, primary biliary cirrhosis, and autoimmune hepatitis should be differentially diagnosed and sequential liver biopsies are needed.

중소기업형 CIM시스템 구축을 위한 생산계획수립 및 실적파악 모듈

최후곤,신완선,장중순,서준성,여명구,안동근,김진봉 成均館大學校 科學技術硏究所 1996 論文集 Vol.47 No.2

This study Focuses on developing several modules involved in an integrated production information system for medium- or small-sized industries. The modules of order management, quality control, production scheduling, and shop management are executed for an example case industry. The potential values of this research includes that the major information modules to collect, analysis, and display production data and shop data for constructing the computer integrated manufacturing system(CIMS) are programmed with various features of medium- or small-sized industries

유근피로부터 분리한 hederagenin 3-O-b-D-glucopyranosyl(1→3)-a-L-rhamnopyranosyl(1→2)-a-L-arabinopyranoside (HDL)의 항산화 효과

Jin-Gu Bong(봉진구),Yoon-yub Park(박윤엽) 한국생명과학회 2010 생명과학회지 Vol.20 No.2

본 연구는 유근피(root bark of Ulmus davidiana)에서 분리한 화합물인 hederagenin 3-O-b-D-glucopyranosyl(1→3)-a-L-rhamnopyranosyl(1→2)-a-L-arabinopyranoside (HDL)을 이용하여 CoCl₂에 의해 생성된 ROS에 대한 항산화 기전을 밝히기 위하여, ROS 생성과 관련된 산화 효소 및 항산화 효소에 대한 저해효과를 조사하였다. 또한 HDL이 CoCl₂에 의해 생성된 ROS의 조절을 통해 산화적 스트레스와 관련된 단백질 발현 및 세포주기에 미치는 영향을 조사하였다. 그 결과 HDL은 CoCl₂에 의해 유발된 xanthine oxidase와 H₂O₂ 생성 증가를 억제하였고, 산화와 관련된 SOD, CAT의 활성을 증가시켜 H₂O₂의 가수분해를 촉진하였다. 그리고 HDL은 CoCl₂에 의해 유발된 ferritin의 손상과 ferritin iron의 방출을 억제하였으며, 지질과산화의 증가를 억제하였다. 뿐만 아니라 HDL은 CoCl₂에 의해 증가된 G1 phase의 세포를 감소시켰으며, 세포주기와 관련된 p53 및 p21<SUP>CIP1/WAF1</SUP>의 발현을 감소시켰다. 이러한 연구결과들은 HDL이 천연물로부터 유래한 독성이 없는 항산화제로서의 가능성을 제시한다. We investigated the antioxidant effects of hederagenin 3-O-b-D-glucopyranosyl(1→3)-a-L-rhamnopyranosyl(1→2)-a-L-arabinopyranoside (HDL) isolated from root bark of Ulmus davidiana on the activity of enzymes related to reactive oxygen species (ROS) in human osteosarcoma U2OS cells. Cobalt chloride (CoCl₂), a transition metal, was used as an inducer of oxidative stress, generating hydrogen peroxide (H₂O₂) via increasing xanthine oxidase (XO) activity. The increased levels of H₂O₂, XO, ferritin, and ferritin iron by CoCl₂ were diminished effectively by co-treatment with HDL in U2OS cells. Furthermore, decreased levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) by CoCl2 were highly increased by co-treatment with HDL in U2OS cells; however, the levels of glutathione peroxidase (GPx) did not change. The increased contents of TBARS related to lipid peroxidation were significantly reduced by HDL in U2OS cells. The concentration of GSH changed in a pattern that went against regulated TBARS by CoCl₂ and HDL. We examined the expression of p53, p21<SUP>CIP1/WAF1</SUP>, and p27<SUP>KIP1</SUP> proteins related to oxidative stress and cell cycle regulation. As a result, the expression of p27KIP1 modulated by CoCl₂ was not changed by HDL. However, the expression of p53 and p21<SUP>CIP1/WAF</SUP> increased by CoCl₂ was reduced by HDL in U2OS cells. Together with alteration of p53 and p21<SUP>CIP1/WAF1</SUP> proteins, the accumulated cells at G1 phase by CoCl₂ was decreased by HDL in U2OS cells. Our data suggests that HDL inhibits CoCl₂-generated ROS in U2OS cells, providing potentially new antioxidant compounds that are isolated from natural products.

Expression of growth hormone/insulin-like growth factor axis genes in olive flounder (Paralichthys olivaceus) fed a diet with partial replacement of dietary fish meal

Jin-Sung Moon,Dae Han Oh,Su-Jin Park,Jin-Song Seo,Dong-Uk Kim,Seong-Hwan Moon,Hung Sik Park,Sang-Gu Lim,Kang-Woong Kim,Bong-Joo Lee,Sang-Woo Hur,Hyeong-Jun Lee,Taek Jeong Nam,Youn Hee Choi 한국수산과학회 양식분과 2019 한국수산과학회 양식분과 학술대회 Vol.2019 No.5

Activated Macrophage-Targeted Photoactivatable Theranostic Nanoagents for Photodynamic Therapy

Bong Gu Yi,Myeong Seon Jeong,Seung Hae Kwon,Seongsoo Lee,Sungwoo Ryoo,Jin Won Kim,Won-Jin Moon,Kyeongsoon Park 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

각종 종양표지자를 이용한 위암의 병기진단

봉진구(Jin Gu Bong),유완식(Wan Sik Yu),황일우(Il Woo Whang) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.6

N/A The serum concentrations of AFP, CEA, CA19 9 and CA125 were measured in sera of 401 patients with histologically proven gastric cancer, who were managed at the Department of Surgery, Kyungpook National University Hospital from January 1991 to July 1993 to evaluate the clinical significance of these tumor markers in diagnosis and staging of gastric cancer. The percentages of patients whose serum samples were positive for AFP, CEA, CA19 9, and CA125 were 13.7%, 31.8%, 21.6%, and 13.6%, respectively. Positive rates of tumor markers were significantly increased with the depth of tumor invasion(CEA and CA19 9), the tumor size or ulcer size(CA19 9), the lymph node metastasis(CEA and CA19 9), and the TNM stage (AFP, CEA, CA19 9, CA125). The specificity of AFP, CEA, CA19 9, and CA125 in detecting nodal metastasis was 90.5%, 76.9%, 89.5%, and 84.6%, in detecting hepatic me- tastasis was 86.6%, 69.3%, 78.6%, and 86.9%, in detecting peritoneal seeding was 87.3%, 69.6%, 81.1%, and 89.2%, and in detecting distant metastasis was 87.6%, 71.7%, 82.1%, and 88.3%, respectively. The combined analysis of these tumor markers was more sensitive than single analysis. The combined analysis of CEA and CA19 9 revealed higher positive rate than other combinations, and the positive rate of this combination and combined analysis of four markers were signifi- cantly increased with the depth of tumor invasion, the tumor size, the nodal involvement, the distant metastasis, and the TNM stage. Because of the low sensitivity, measurement of these tumor markers in patients serum cannot provide information for diagnosis of gastric cancer. But because of significant correlation of high serum concentration of these tumor markers and distant metastasis of gastric cancer, this can provide information about the operability and the prognosis of the patients with gastric cancer.(Korean J Gastroenterol 1994; 26: 899-906)