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${\varepsilon}$-Caprolactam 이용성(利用性) 세균(細菌)의 분리(分離) 및 그 성질(性質)
최선택,이인구,Choi, Sun Taek,Rhee, In Koo 경북대학교 농업과학기술연구소 1985 慶北大農學誌 Vol.3 No.-
대구(大邱) 신천(新川) 하상(河床) 오니(汚泥)로부터 ${\varepsilon}$-caprolactam이용성(利用性)이 우수한 균(菌)을 분리(分離)하여 Arthrobacter globiformis N-2-1로 동정(同定)했다. Arthrobacter globiformis N-2-1의 배양(培養)을 위한 최적배지(最適培地)의 조성(組成)은 ${\varepsilon}$-caprolactam 0.4%, $K_2HPO_4$ 0.2%, $KH_2PO_4$ 0.05%, $MgSO_4{\cdot}7H_2O$ 0.02%, $F3Cl_3{\cdot}6H_2O$ 0.01%, yeast extract 0.05%이었다. 이 균(菌)의 생육(生育)을 위한 최적(最適) pH는 7.0, 온도(溫度)는 $30^{\circ}C$ 부근(附近)이었다. 본(本) 균(菌)은 무기염 배지(培地)에서 yeast extract를 가(加)하지 않고서도 ${\varepsilon}$-caprolactam을 잘 분해(分解)하여 증식(增殖)할 수 있었으나, yeast extract를 가(加)하면 생육(生育)이 더욱 촉진되었다. 또한 본(本) 균(菌)은 대부분의 당(糖)을 잘 이용(利用)할 수 있었고 유기산(有機酸)으로는 ${\alpha}$-ketoglutarate, adipate, p-hydroxybenzoate는 잘 이용(利用)하였으나 gluconate는 잘 이용(利用)할 수 없었다. 그리고 amino acid는 대부분 잘 이용(利用)하는 것으로 나타났다. 0.4%의 ${\varepsilon}$-caprolactam을 함유한 배지(培地)에서 60시간(時間) 배양(培養)으로 ${\varepsilon}$-caprolactam을 완전히 분해(分解)할 수 있었다. 분리균(分離菌) N-2-1에 의한 ${\varepsilon}$-caprolactam의 분해(分解) 생성물(生成物)은 ${\varepsilon}$-aminocaproic acid로 확인되었다. A bacterium which utilizes ${\varepsilon}$-caprolactam as a sole source of carbon and nitrogen was isolated from sludge of Shinchun river in Taegu and identified as Arthrobacter globiformis N-2-l. The growth medium for the optimum culture condition was composed of 0.4% ${\varepsilon}$-caprolactam, 0.02% $K_2HPO_4$, 0.05% $KH_2PO_4$, 0.02% $MgSO_4{\cdot}7H_2O$, 0.01% $FeCl_3{\cdot}6H_2O$ and 0.05% yeast extract. The optimum pH and temperature for growth were 7.0 and $30^{\circ}C$ respectively. The bacterial growth on the ${\varepsilon}$-caprolactam medium did not require any other organic nitrogen source such as yeast extract, although it was remarkably stimulated by the yeast extract. The bacteria utilized wide range of sugars and organic acids such as ${\alpha}$-ketoglutarate, adipate and P-hydroxybenzoate. The bacteria could use all kind of amino acids, ${\varepsilon}$-Caprolactam in the medium was consumed completely in the timecourse culture at $30^{\circ}C$ for 60 hr on the shaker by the bacteria. Decomposition product of ${\varepsilon}$-caprolactam by Arthrobacter globiformis N-2-1 was ${\varepsilon}$-aminocaproic acid.
최선택,은종렬,이정훈,박윤선,최재원,김국현,장병익,김태년,이헌주 대한소화기내시경학회 2006 Clinical Endoscopy Vol.33 No.6
Gastrogastric fistula is an extremely rare complication of benign gastric ulcer. We report a case of gastrogastric fistula in a 67-year-old male who presented with symptoms of dyspnea on exertion, pretibial pitting edema, and dyspepsia. He suffered from a peptic ulcer 9 years ago and from a gastric outlet obstruction 5 years ago. A gastrogastric fistula was observed by endoscopy, and the biopsy forceps were passed through the fistulous tract. The patient was treated with proton pump inhibitors, and H. pylori was eradicated. Gastrogastric fistula, unlike other types of gastric fistulas, can be cured using non-surgical therapy as long as complications such as peritonitis, gastric outlet obstruction, and bleeding do not occur. (Korean J Gastrointest Endosc 2006;33:364 367)
최선택,은종렬,임상우,김봉준,이헌주,구미진,최준혁 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1
Background: Cholestatic hepatitis is failure of bile to reach the duodenum with hepatocellular damage and no demonstrable obstruction of the major bile ducts. The prognosis is usually good with recovery in less than 4 weeks after withdrawal of the offending drug. However, a prolonged course lasting over 3 months is possible and, in rare cases, progression to ductopenia with development of a vanishing bile duct syndrome occurs. A differential diagnosis with other causes of Chronic liver disease is needed. Materials and Methods: From January 1991 through Jaunary 2000, 14 patients diagnosed as cholestatic hepatitis by liver biopsy were inclouded. The possible causative drug, clinical features, laboatory findings, and progression of cholestatic hepatitis were evaluated. The semiquantitative study of liver lesions was performed by two independent observers. Results: Causes of cholestatic hepatitis are 5 cases of oriental medicine, 3 cases of anti-tuberculosis medication, 1 case of ticlopidine and antibiotics and 4 cases of unknown causes. The clinical features of cholestatic hepatitis were jaundice, itching, urine color change, and general weakness. During 6 to 30 months, LFT of 5 patients showed prolonged elevation. Elevated total cholesterol ≥250 mg/dL in 6 patients, pheripheral blood eosinophilia in 5 patients, auto-antibody positive in 6 patients were observed respectively. The biopsies showed intralobular bilirubinostasis with a mixed portal inflammatory infiltration. Conclusion: In cholestatic hepatitis. durations of abnormal LFT are variable regardless of causative drugs. If cholestatic hepatitis progresses toward chronic course, viral hepatitis, primary biliary cirrhosis, and autoimmune hepatitis should be differentially diagnosed and sequential liver biopsies are needed.
대구 지방 C형 간염 환자의 바이러스 유전자형과 인터페론 치료의 단기 효과
최선택,이헌주,최진수,은종렬,권순욱,송영두 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.1
Background/Aims : It has been reported that the difference in the hepatitis C virus (HCV) genotype due to genetic heterogeneity of HCV influence the clinical features, prognosis of HCV associated liver disease and response to interferon therapy. Prevalence of different genotypes of HCV may also vary between geographic areas. The aim of this study was to examine the relationship between the response to interferon alpha (IFN-α) therapy and HCV genotypes in patients with chronic HCV infection in Taegu and its environs. Methods : One hundred seventy six patients known to be HCV antibody and HCV-RNA positive were evaluated for HCV genotypes by restriction fragment length polymorphism. Among patients who had elevated ALT levels, 67 patients have been investigated for the role of the HCV genotype on disease outcome and the response of IFN-α therapy. Results : Genotype 1b were found in 59.0% of patients (103/176), genotype 2a in 37.5% (66/176). The mode of transmission of HCV infection was guessed as transfusion inenotype 1b, but as parenteral infection in genotype 2a. According to their response to IFN-α therapy, 73 patients were divided into three groups, complete response, 18 (60%) of 30 patients with genotype 2a and 21 (48.8%) of 43 patients with genotype 1b: partial response, 5 (16.7%) of 30 patients with genotype 2a and 7 (16.2%) of 43 patients with genotype 1b: no response, 7 (23.3%) of 30 patients with genotype 2a and 15 (34.9%) of 43 patients with genotype 1b. Good response to IFN-α therapy was observed among patients group showing normal platelet count in patients with genotype 1b and normal GGT in patients with genotype 2a. Conclusions: The most frequently identified genotype was genotype 1b in Taegu and its environs, followed by genotype 2a. The HCV genotype was not a reliable predictor of response to IFN-α therapy. When a standardized regimen of IFN-α was administered, pretreatment serum platelet counts and GGT level seem to be useful predictor of IFN-α therapy in HCV infection. Further investigationsrequired in order to establish a correlation between viral factors and therapeutic responses. (Korean J Hepatol 1999;5:22-32)