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Lim, Seung-Oe,Park, Sung-Gyoo,Yoo, Jun-Hi,Park, Young-Min,Kim, Hie-Joon,Jang, Kee-Taek,Cho, Jae-Won,Yoo, Byung-Chul,Jung, Gu-Hung,Park, Cheol-Keun WJG Press 2005 World journal of gastroenterology Vol.11 No.14
<P>Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)-related HCC.</P>
Lim, Sang-Gu,Baeck, Jae Min,Kim, Chul Won,Kim, Young Soo 한국발생생물학회 2014 발생과 생식 Vol.18 No.3
Rearing experiments were conducted using several regimes combined with different photoperiods and water temperatures to investigate the role of temperature and photoperiod as environmental cues regulating reproduction in red marbled rockfish, Sebastiscus tertius. The initial gonadosomatic index (GSI) was 1.62±0.32% and that in the 15˚C control was 7.01±0.46% at the end of the experiment. The highest GSI was 9.10±0.35% in the 12L:12D photoperiod-treated fish. The highest GSI at 19˚C was 15.03±0.86% in the 12L:12D photoperiod treatment. The initial hepatosomatic index (HSI) was 3.09±0.72% and that in the 15˚C control was 3.88±0.45%. The highest HSI was 4.00±0.56% in the 15L:9D treated fish. The highest HSI at 19˚C was 4.05±0.63% in the 12L:12D treated fish.
Aggressive surgical resection for concomitant liver and lung metastasis in colorectal cancer
Sung Hwan Lee,Sung Hyun Kim,Jin Hong Lim,Sung Hoon Kim,Jin Gu Lee,Dae Joon Kim,Gi Hong Choi,Jin Sub Choi,Kyung Sik Kim 한국간담췌외과학회 2016 한국간담췌외과학회지 Vol.20 No.3
Backgrounds/Aims: Aggressive surgical resection for hepatic metastasis is validated, however, concomitant liver and lung metastasis in colorectal cancer patients is equivocal. Methods: Clinicopathologic data from January 2008 through December 2012 were retrospectively reviewed in 234 patients with colorectal cancer with concomitant liver and lung metastasis. Clinicopathologic factors and survival data were analyzed. Results: Of the 234 patients, 129 (55.1%) had synchronous concomitant liver and lung metastasis from colorectal cancer and 36 (15.4%) had metachronous metastasis. Surgical resection was performed in 33 patients (25.6%) with synchronous and 6 (16.7%) with metachronous metastasis. Surgical resection showed better overall survival in both groups (synchronous, p=0.001; metachronous, p=0.028). In the synchronous metastatic group, complete resection of both liver and lung metastatic lesions had better survival outcomes than incomplete resection of two metastatic lesions (p=0.037). The primary site of colorectal cancer and complete resection were significant prognostic factors (p=0.06 and p=0.003, respectively). Conclusions: Surgical resection for hepatic and pulmonary metastasis in colorectal cancer can improve complete remission and survival rate in resectable cases. Colorectal cancer with concomitant liver and lung metastasis is not a poor prognostic factor or a contraindication for surgical treatments, hence, an aggressive surgical approach may be recommended in well-selected resectable cases.