18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

고령자 급성 췌장염의 임상적 고찰

백용한,서정훈,송건훈,이진헌,송시영,정재복,강진경,박인서,이수진 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

고령자 급성 췌장염의 임상적 고찰

이진헌,강진경,박인서,송건훈,정재복,백용한,송시영,서정훈 대한소화기학회 1998 대한소화기학회지 Vol.32 No.3

Background/Aims: Inflammatory diseasas of the pancreas are not uncommon. The advanced age is one of the significant factors in assessing the severity of acute pancreatitis. It has been shown that the biliary tract disease is a more frequent cause of acute pancreatitis in the elderly than in the young. With the increased life span, the elderly are comprising a large proportion of the population. As a result, physicians are more often being faced with acute pancreatitis in the elderly. The purpose af this study was to evaluate clinical features of acute panereatitis in the elderly. Methods: A total of 188 patients with acute pancreatitis were reviewed. We investigated the differences of clinical characteristics between the elderly patients aged over 60 and the young patients aged under 60. Results: The sex distribution showed male preponderance in the young patients (M:F=2.4:1), but was nearly equal in the elderly patients (M:F=1.1:1). The most common cause of acute pancreatitis in the elderly was biliary tract disease (52.5%), while alcohol abuse was the most common cause in the young patients (38.8%), Local complications of acute pancreatitis, such as psuedocyst, necrosis, abscesses were not differently shown between the elderly (16.9%) and the young (20.2%) patients. Systemic complications including acute puhnonary failure occurred more frequently in the elderly patients than the young patients. The mortality rate of the elderly patients (5.1%) was not significantly different from that of the young patients (3.1%). Conclusions: To detect correctable underlying bihary tract diseases the elderly patients with acute pancreatitis should be completely investigated using endoscopic retrograde cholangiopancreatography (ERCP). In addition, the patient should be closely monitored for the development of the systemic complications during the disease process.

식물생장조절제 Seaweed extracts(GA14)의 수도 품종간 생육 및 수량에 미치는 효과

송재영,김용일,박보영,정재영,최현구,정종태,이희봉 충남대학교 농업과학연구소 2004 농업과학연구 Vol.31 No.1

This study was carried out to identify the effects of seaweed extracts(GA14) on growth of two rice cultivars, Junambyo and Donganbyo. Seedling qualities of two cultivars were better in all items including heading dates at early stage treated at seedling plus 2-3 leaf stages than at single treatment of seedling. Ripening ratio of Junambyo in paddy field was increased 0.3% by seaweed extracts(GA14) treatment, but that of Donganbyo decreased 0.5%. 1,000 grain weight of Junambyo and Donanbyo by seaweed extracts(GA14) treatment was two to four grams higher and the yield of two cultivars was also higher by three to four percent. Appearance characters of two rice cultivars was high in head, while damaged, chalky and crack rate were low at seaweed extracts(GA14) treatment. Protein, moisture and amylose characteristics related to table quality of Junambyo were not different by seaweed extracts treatment, but table values was high in only treatment. Donganbyo was also similar to Junambyo, but table quality was slightly high at non-treatment.

한국인 인슐린 비의존형 당뇨병 및 이차성 당뇨병 환자에서 글루코키나제 유전자 변이

남재현(Jae Hyun Nam),이현철(Hyun Chul Lee),김연의(Youn Euy Kim),권석호(Suk Ho Kwon),윤용석(Yong Suk Yoon),박석원(Suk Won Park),원영준(Young Jun Won),차봉수(Bong Su Cha),송영득(Young Duk Song),이은직(Eun Jig Lee),임승길(Sung Kil Lim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6

N/A Objectives: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this gene to the development of non insulin dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM) and post-renal transplantation diabetes mellitus (PTDM). Method: Identification of GCK mutation was attempted on 39 NIDDM patients, 2 GDM patients and 58 selected renal allograft recipients with PTDM and 45 normal controls. The exons in the GCK gene were examined by polymerase chain reaction (PCR), followed by analysis of single-stranded DNA conformational polymorphism (SSCP). The abnormal bands were also confirmed by DNA sequencing analysis. The exons of affected family members were also investigated for mutations of the GCK gene. Results: Two of the 58 PTDM patients (3.4%) were found to have CKK mutations. One had the mutation on exon 5 and the other on intron 7. One control subject had the mutation on intmn 9. The mutation of exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has not ever reported before. The family members of the PFDM patient with mutation of exon 5 were analyzed by PCR followed by SSCP, and two of them revealed the same mutation. The abnormal band on the SSCP analysis of exon 7 was identified as the insertion of base C/T at the 39th nucleotide in intron 7. Two family members of this patients also had same band on SSCP. The one mutation of 45 normal controls was CT located at the 8th nucleotide in intron 9, which was a common polymorphism. Conclusion: We found GCK mutations in subjects with PTDM and we speculate that these mutations may be one of the contributing cause of PTDM.

급성 심근허혈에 의해 윤발된 승모판 폐쇄부전의 기전에 관한 실험적 연구

강덕현,송현,송재관,김현숙,이재환,임희영,이재원,박성욱,박승정,송명근 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.8

기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

지역사회획득 폐렴의 치료지침 권고안

송재훈,정기석,강문원,김도진,배현주,서지영,심태선,안중현,안철민,우준희,이남용,이동건,이미숙,이상무,이영선,이혁민,정두련,지역사회획득 폐렴 치료지침 제정위원회 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

A successful therapy of community-acquired pneumonia requires appropriate empirical antimicrobial therapy. Etiology and antimicrobial susceptibility of major pathogens of pneumonia can differ by country. Therefore, an ideal treatment guideline of community-acquired pneumonia should be based on the studies performed in each country. We developed a treatment guideline for community-acquired pneumonia in immunocompetent adults in Korea. This guideline was developed by the joint committee of the Korean Society for Chemotherapy, the Korean Society of Infectious Diseases, and the Korean Academy of Tuberculosis and Respiratory diseases.

햄스터에서 camostat mesilate와 proglumide가 담즙구성 성분에 미치는 영양

송영진,김성열,이상전,윤효영,장이찬,최재운 충북대학교 의과대학 충북대학교 의학연구소 1995 忠北醫大學術誌 Vol.5 No.1

콜레스테롤 담석 생성 기전을 보면 콜레스테롤이 담즙산이나 인지질에 비해 과포화되어 담석이 형성되는 것으로 알려져 있다. 색소성 담석도 CCK의 분비저하와 연관이 있는 것으로 생각되고 있으나 담즙 구성 성분의 농축과 연관이 있는 지는 알려져 있지는 않다. Kim등의 실험에서 콜레시스토기닌이 항진되어 담즙 구성 성분이 희석되었다. 만약 콜레시스토키닌 분비를 감소시킨다면 담즙 구성 성분이 농축될지는 알려져 있지 않다. 콜레시스토키닌 분비의 증감에 따라 담즙 구성 성분이 희석, 농축된다면 콜레시스토키닌과 담즙 구성 성분은 유기적으로 작용한다고 생각되어 질 수 있다 이에 저자들은 콜레시스토키닌 분비를 억제하고, 항진시키면 담즙의 구성 성분이 농축되고, 희석될 것이라는 가설을 설정하였고, 콜레시스토키닌 분비 길항제로 알려진 proglumide와 콜레시스토키닌 항진제인 camostat mesilate를 햄스터에서 투여하여 담즙구성 성분의 변화를 살펴보고자 하였다. 햄스터 80마리를 크게 4군으로 나누어 비슷한 체중을 보이는 햄스터를 짝을 지어 쥐장 1개에 4마리씩 넣어 키웠다. I군(n=20)에서는 고탄수화물식을 Ⅱ군(n=20)은 1% proglumide를 함유한 고탄수화물식이를 Ⅲ군(n=20)은 0.2% camost mesilate를 함유한 고탄수화물식이를 Ⅳ군(n=20)은 1% proglumide와 0.2% camostat mesilate를 함유한 고탄수화물식이를 2주간 투여하였다. 실험시작 2주후 24시간 금식을 시킨후 동물을 희생시켰다. 담당에서 담즙을 채취하여 구성성분을 분석하였다. 사료소모량과 체중 증가는 Ⅱ군에서 가장 높았고 Ⅲ군에서 가장 낮았다(p value=0.003). 담즙 구성 성분중 총빌리루빈, 인지질은 Ⅱ군에서 가장 높았고 Ⅲ군에서 가장 낮았다(p value=0.02, 0.03). 콜레스테롤은 Ⅱ군에서 가장 높았고 Ⅲ군에서 가장 낮았지만 통계적 유의성은 없었다(p value=0.1). 담즙산은 대조군에서 가장 높았고, Ⅲ군에서 가장 낮았다(p value=0.06). 콜레시스토키닌분비 항진제와 길항제의 투여에 따라 담즙구성 성분중 총빌리루빈치와 인지질, 콜레스테롤은 희석되고 농축되었다. 이는 콜레시스토키닌의 분비 증감에 기인하는 것으로 추정되며 처음에 설정된 가설이 일부분 증명된 것이라고 생각된다. 담즙산이 proglumide를 투여한 군에서 대조군에 비해 낮은 것은 이 약제의 용량이 적었기 때문인 것으로 추정된다. Comostat mesilate를 투여한 Ⅲ군에서 사료소모량이 감소한 것은 콜레시스토키닌의 혈중농도가 상승했기 때문인 것으로 생각된다. It has been suggested that pigment stone formation is associated with decreased secretion of cholecystokinin. It has not defined yet for decreased secretion of cholecystokinin to concentrate bile composition will be diluted if cholecystokinin increase by camostat mesilate and if bile composition will be concentrated if cholecystokinin decrease by proglumide. The present study was undertaken to define the effect in dile composition after ingestion of proglumide and camostat mesilate in hamsters. Eighty hamsters were divided into 4 groups : Group I Fed high carbohydrate diet and libitum, Group Ⅱ fed high carbohydrate diet and 1% proglumide. Group Ⅲ fed high carbohydrate and 0.2% camostat mesilate diet for 2 weeks. Hamsters was sacrificed at 3rd week. GB bile was aspirated and gallbladdder bile was analysed by kits. The level of total bilirubin and phospholipid was highest in group Ⅱ and lowest in group Ⅲ(P value=0.02, 0.003). The level of cholesterol has similar trend but it was not statistically significant(p value=0.1). The level of bile acid was lower in Group Ⅱ, Ⅲ, Ⅳ than I, but not statistically significant(p value=0.06) In conclusion, Increased secretion of CCK by camostat mesilate dilute and decreased secretion of CCK by proglumide concentrated some bile composition, this effect may be derived from gallbladder contractility and bile flow. The reason why bile acid was not in similar pattern may come from inadequate dosage of drugs.

N個 프로세스에 의하여 竝行遂行하는 R/W에 관한 硏究

송영재,최범재 慶熙大學校 1986 論文集 Vol.15 No.-

In this paper, the algorithm for N-asynchronous processes reading and writing shared data while data are being modified by another process is proposed. The classical concurrent reading and writing problem is solved by using mutual exclusion. Though mutual exclusion solved concurrent R/W problem, it involved waiting. For the purpose of reducing waiting time by mutual access of shared data, copying of shared data is permitted. This algorithm takes advantage of ability is make copies of the shared data. Consequently, copying of shared data can be reduced and even eliminated However, one of the most notable deficiencies of this algorithm is that the writer, during a single pass, may nave to make n copies for the reader. In the future, it should be studied about reducting copying buffer numbers of shared data and using original nature of shared data.