공공기관의 성과관리, PMS의 이용방식, 조직학습 및조직성과간의 관계

박경원(Park, Kyong-Won),반혜정(Ban, Hye-Jung) 글로벌경영학회 2012 글로벌경영학회지 Vol.9 No.4

본 연구는 공공기관의 성과관리 제도와 BSC에 기반을 둔 PMS에 주목하여 목적적합한 이용방식의 역할과 효과를 검증하는데 그 목적이 있다. 공공기관을 대상으로 성과관리의 도입이 조직성과의 개선에 미치는 영향, 성과관리가 경영자의 PMS의 이용방식에 미치는 영향 및 조직학습이 조직성과의 개선에 미치는 영향 등을 분석하도록 한다. 지금까지 공공기관을 대상으로 성과관리와 PMS의 이용방식의 역할과 효과에 대한 연구가 거의 이루어지지 않았다. 본 연구의 결과를 요약하면 다음과 같다. 공공기관의 성과관리는 수준이 높을수록 조직성과는 개선되는 것으로 나타났다. 성과관리가 관리자에게 목표와 운영의 초점을 제공하고, 성과증진에 대한 동기를 부여하여 조직성과를 개선시키는 것으로 해석할 수 있다. 둘째, 공공기관의 성과관리는 PMS의 진단적 이용방식과 상호작용적 이용방식의 활용을 증가시켰다. 성과정보의 진단적 이용은 통제 및 평가도구로 적절하며, 상호작용적 이용은 새로운 정책접근을 위한 탐색을 용이하게 하기 때문인 것으로 판단된다. 셋째, PMS의 이용방식은 조직성과의 개선에 기여하는 것으로 나타났다. PMS의 적극적인 이용은 조직 성과에 긍정적인 영향을 주는 것으로 판단된다. 넷째, PMS의 이용방식 중 상호작용적 이용방식은 조직 학습에 영향을 미치는 것으로 나타났다. 마지막으로 조직학습은 조직성과의 개선에 기여하는 것으로 나타났다. 본 연구결과를 종합해 보면, 공공기관은 조직성과를 향상시키기 위해서는 성과관리를 효율적으로 운영해야 한다는 것을 강조하고 있으며, 성과정보의 진단적 이용과 상호작용적 이용이 적절히 선택될 수있어야 하며, 조직학습을 잘 활용해야 한다는 것을 강조하고 있다. This study is one of empirical studies to provide evidence on the roles and effects of the performance management and use of performance measurement systems in public sector organizations. At a very generic level, this study investigates that the performance management is associated with the use of performance measurement systems and organizational performance. The aim of this study is to examine consequences of various different ways in which performance information can be used, and whether the difference in a way of use affects causality of our research model and performance. There were few studies performed on public sector organizations. Findings of this study could be summarized as follows;Firstly, we observe a positive and significant direct effect of performance management on performance. Secondly, we find a positive and significant relationship between the performance management and use of PMS. Thirdly, we find that using the PMS for diagnostic and interactive purposes has direct effect on performance. Fourthly, it was found out that while the diagnostic use of PMS did not have any significant effect on organizational learning, the interactive use of PMS had a significant effect on organizational learning. And it was shown that organizational learning contributed to improvement of organizational performance In total, these results suggests that manager of public sector organizations need to manage performance management efficiently. It also have implications for the importance of managers’ proper choice for use of PMS and needs to utilize organizational learning well in order to improve organizational performance.

Whole-genome resequencing analysis of 20 Micro-pigs

Da‑Hye Son,Nam‑Hyun Hwang,Won‑Hyong Chung,Ha‑Seung Seong,Hyungbum Lim,Eun‑Seok Cho,Jung‑Woo Choi,Kyung‑Soo Kang,Yong‑Min Kim 한국유전학회 2020 Genes & Genomics Vol.42 No.3

Background Miniature pigs have been increasingly used as mammalian model animals for biomedical research because of their similarity to human beings in terms of their metabolic features and proportional organ sizes. However, despite their importance, there is a severe lack of genome-wide studies on miniature pigs. Objective In this study, we performed whole-genome sequencing analysis of 20 Micro-pigs obtained from Medi Kinetics to elucidate their genomic characteristics. Results Approximately 595 gigabase pairs (Gb) of sequence reads were generated to be mapped to the swine reference genome assembly (Sus scrofa 10.2); on average, the sequence reads covered 99.15% of the reference genome at an average of 9.6-fold coverage. We detected a total of 19,518,548 SNPs, of which 8.7% were found to be novel. With further annotation of all of the SNPs, we retrieved 144,507 nonsynonymous SNPs (nsSNPs); of these, 5968 were found in all 20 individuals used in this study. SIFT prediction for these SNPs identified that 812 nsSNPs in 402 genes were deleterious. Among these 402 genes, we identified some genes that could potentially affect traits of interest in Micro-pigs, such as RHEB and FRAS1. Furthermore, we performed runs of homozygosity analysis to locate potential selection signatures in the genome, detecting several loci that might be involved in phenotypic characteristics in Micro-pigs, such as MSTN, GDF5, and GDF11. Conclusion In this study, we identified numerous nsSNPs that could be used as candidate genetic markers with involvement in traits of interest. Furthermore, we detected putative selection footprints that might be associated with recent selection applied to miniature pigs.

신촌 연세로 대중교통전용지구는 어떻게 성공적으로 도입되었는가?

김혜원(Kim, Hye Won),이정욱(Lee, Jung Wook) 한국지방정부학회 2018 지방정부연구 Vol.21 No.4

대중교통전용지구는 교통수요관리와 상권 활성화를 통해 도시의 지속가능성을 제고할 수 있으나 승용차 통행을 제한해 사업을 추진하려는 정부당국과 지역주민 간 갈등이 첨예하여 시행이 어려운 사업이다. 그러나 신촌 연세로 대중 교통전용지구의 경우 사업추진과정과 효과 모두 성공적이라고 평가된다. 그렇다면 연세로 대중교통전용지구의 성공적 도입은 어떻게 설명할 수 있는가? 이와 관련하여 본 연구는 Kingdon(2011)의 다중흐름모형과 Moore(1995)의 정치적 관리를 결합한 분석틀을 활용하였다. 다중흐름모형은 정책이 채택되는 환경적 맥락을, 정치적 관리 전략은 이러한 맥락 속에서 정책을 성공적으로 추진하기 위한 구체적인 실천전략을 제시한다. 분석 결과 연세로의 교통정체와 상권 침체를 해결하기 위해 ‘차 없는 거리’ 등의 대안이 존재했으나 박원순 서울시장이 당선되면서 정책의 창이 열리 고대중교통전용지구라는 정책대안에 대한 논의가 본격화되었다. 서대문구는 개방적 의사결정, 논리적인 협상, 공적 숙의, 공공부문 마케팅 등의 정치적 관리 전략을 통해 지역상인과 유관기관으로부터 정책에 대한 정당성과 지지를 확보하였다. 본 연구는 갈등적인 지역사업을 성공적으로 추진하기 위한 관리적 함의를 제공한다. Transit malls are a means to ensure the sustainability and revitalization of local commercial districts by allowing only public transport and pedestrians to use the roads. Efforts by localities to introduce a transit mall often meet with intense opposition from conflicting interests, which makes it very challenging to put this policy idea successfully into action. The case of Sinchon Yonsei Road, however, is considered an exception: the process in which it was officially designated as a transit mall, as well as the positive outcomes such a decision brought about, makes the case clearly distinguished from other similar attempts. What explains the successful introduction of the Yonsei Road transit mall? To answer this question, the present study took an analytical approach that integrated Kingdon’s(2011) multiple streams framework and Moore’s(1995) political management perspective: the former is instrumental in understanding the context in which policies come to be adopted, while the latter allows assessing the effectiveness of the strategies policy entrepreneurs employ in that process. The analysis shows that the election of Park Won-sun as the Mayor of Seoul opened up the policy window where the idea of converting Yonsei Road into a transit mall began to gain serious attention as a viable policy alternative; it also reveals that Seodaemun-gu - the policy entrepreneur in this case - effectively engaged in a series of policy management strategies, which collectively helped to reach a consensus in a relatively short time span. This successful policy adoption case provides managerial implications for local initiatives that involve a complex array of conflicting interests.

Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score

( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2

Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)

우리나라 노인여성의 골다공증성 척추골절로 인한 경제적 부담 추계

강혜영,강대룡,장영화,박성은,최원정,문성환,양규현,Kang, Hye-Young,Kang, Dae-Ryong,Jang, Young-Hwa,Park, Sung-Eun,Choi, Won-Jung,Moon, Seong-Hwan,Yang, Kyu-Hyun 대한예방의학회 2008 예방의학회지 Vol.41 No.5

Objectives : To estimate the economic burden of osteoporotic vertebral fracture (VF) from a societal perspective. Methods : From 2002 to 2004, we identified all National Health Insurance claims records for women ${\geq}50$ years old with a diagnosis of VF. The first 6-months was defined as a "clearance period," such that patients were considered as incident cases if their first claim of fracture was recorded after June 30, 2002. We only included patients with ${\geq}$ one claim of a diagnosis of, or prescription for, osteoporosis over 3 years. For each patient, we cumulated the claims amount for the first visit and for the follow-up treatments for 1 year. The hospital charge data from 4 hospitals were investigated to measure the proportion of the non-covered services. Face-to-face interviews were conducted with 106 patients from the 4 study sites to measure the out-of-pocket spending outside of hospitals. Results : During 2.5 years, 131,453 VF patients were identified. The patients had an average of 3.38 visits, 0.40 admissions and 6.36 inpatient days. The per capita cost was 1,909,690 Won: 71.5% for direct medical costs, 20.6% for direct non-medical costs and 7.9% for indirect costs. The per capita cost increased with increasing age: 1,848,078 Won for those aged 50-64, 2,084,846 Won for 65-74, 2,129,530 Won for 75-84and 2,121,492 Won for those above 84. Conclusions : Exploring the economic burden of osteoporotic VF is expected to motivate to adopt effective treatment options for osteoporosis in order to prevent the incidence of fracture and the consequent costs.

Insulin resistance mediates high-fat diet-induced pulmonary fibrosis and airway hyperresponsiveness through the TGF-β1 pathway

Park, Yoon Hee,Oh, Eun Yi,Han, Heejae,Yang, Misuk,Park, Hye Jung,Park, Kyung Hee,Lee, Jae-Hyun,Park, Jung-Won Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.5

<▼1><P>Prior studies have reported the presence of lung fibrosis and enhanced airway hyperresponsiveness (AHR) in mice with high-fat-diet (HFD)-induced obesity. This study evaluated the role of TGF-β1 in HFD-induced AHR and lung fibrosis in a murine model. We generated HFD-induced obesity mice and performed glucose and insulin tolerance tests. HFD mice with or without ovalbumin sensitization and challenge were also treated with an anti-TGF-β1 neutralizing antibody. AHR to methacholine, inflammatory cells in the bronchoalveolar lavage fluid (BALF), and histological features were evaluated. Insulin was intranasally administered to normal diet (ND) mice, and in vitro insulin stimulation of BEAS-2b cells was performed. HFD-induced obesity mice had increased insulin resistance, enhanced AHR, peribronchial and perivascular fibrosis, and increased numbers of macrophages in the BALF. However, they did not have meaningful eosinophilic or neutrophilic inflammation in the lungs compared with ND mice. The HFD enhanced TGF-β1 expression in the bronchial epithelium, but we found no differences in the expression of interleukin (IL)−4 or IL-5 in lung homogenates. Administration of the anti-TGF-β1 antibody attenuated HFD-induced AHR and lung fibrosis. It also attenuated goblet cell hyperplasia, but did not affect the AHR and inflammatory cell infiltration induced by OVA challenge. The intranasal administration of insulin enhanced TGF-β1 expression in the bronchial epithelium and lung fibrosis. Stimulating BEAS-2b cells with insulin also increased TGF-β1 production by 24 h. We concluded that HFD-induced obesity-associated insulin resistance enhances TGF-β1 expression in the bronchial epithelium, which may play an important role in the development of lung fibrosis and AHR in obesity.</P></▼1><▼2><P><B>Obesity: A trigger for asthma onset</B></P><P>Insulin resistance may be an important causative factor underlying the increased risk of asthma and other respiratory issues in obese individuals. Obesity doubles the likelihood of developing asthma, with symptoms that are more difficult to control than in non-obese patients. The connection between these conditions is poorly understood, but researchers led by Jung-Won Park, Yonsei University College of Medicine, Seoul, South Korea, have identified a potential mechanism. They demonstrated that a signaling molecule called TGF-β1 contributes to airway sensitivity and tissue scarring in a mouse model of diet-induced obesity. Subsequent experiments showed that treatment with insulin also gives rise to increased TGF-β1 production in the mouse lung. Since insulin resistance is a common feature of obesity, resulting in abnormally high levels of circulating insulin, this could also account for the increased risk of respiratory problems.</P></▼2>

Regional disparities in major cancer incidence in Korea, 1999-2018

Eun Hye Park(Eun Hye Park),Mee Joo Kang(Mee Joo Kang),Kyu-Won Jung(Kyu-Won Jung),Eun Hye Park(Eun Hye Park),E Hwa Yun(E Hwa Yun),Hye-Jin Kim(Hye-Jin Kim),Hyun-Joo Kong(Hyun-Joo Kong),Chang Kyun Choi(C 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: This study investigated regional disparities in the incidence of 8 major cancers at the municipal level in Korea during 1999-2018 and evaluated the presence or absence of hot spots of cancer clusters during 2014-2018. METHODS: The Korea National Cancer Incidence Database was used. Age-standardized incidence rates were calculated by gender and region at the municipal level for 4 periods of 5 years and 8 cancer types. Regional disparities were calculated as both absolute and relative measures. The possibility of clusters was examined using global Moran’s I with a spatial weight matrix based on adjacency or distance. RESULTS: Regional disparities varied depending on cancer type and gender during the 20-year study period. For men, the regional disparities of stomach, colon and rectum, lung, and liver cancer declined, and those of thyroid and prostate cancer recently decreased, despite an overall increasing incidence. For women, regional disparities in stomach, colon and rectum, lung, liver, and cervical cancer declined, that of thyroid cancer recently decreased, despite an overall increasing incidence, and that of breast cancer steadily increased. In 2014-2018, breast cancer (I, 0.61; 95% confidence interval [CI], 0.53 to 0.70) showed a high probability of cancer clusters in women, and liver cancer (I, 0.48; 95% CI, 0.40 to 0.56) showed a high probability of cancer clusters in men. CONCLUSIONS: Disparities in cancer incidence that were not seen at the national level were discovered at the municipal level. These results could provide important directions for planning and implementing local cancer policies.

Development of simultaneous analytical method for determination of imidacloprid and its metabolites in chicken and egg using LC-MS/MS

Jung Ah Do,Shin-Min Park,Seung-Hee Lim,Won-Min Pak,Ji Hye Yoon,Hye-Sun Shin,Hyung-Wook Chung,Gyu-Seek Rhee 한국분석과학회 2017 학술대회논문집 Vol.2017 No.11

Development of the analytical method for determination of antibiotic streptomycin residues in agricultural products using LC-MS/MS

Jung-Ah Do,Ji Hye Yoon,Seung-Hee Lim,Shin-Min Park,Won-Min Pak,Hye-Sun Shin,Hyung-Wook Chung,Gyu-Seek Rhee 한국분석과학회 2017 학술대회논문집 Vol.2017 No.11

Predicting Mortality in Patients with Tuberculous Destroyed Lung Receiving Mechanical Ventilation

( Won-young Kim ),( Mi-hyun Kim ),( Eun-jung Jo ),( Jung Seop Eom ),( Jeongha Mok ),( Ki Uk Kim ),( Hye-kyung Park ),( Min Ki Lee ),( Kwangha Lee ) 대한결핵 및 호흡기학회 2018 Tuberculosis and Respiratory Diseases Vol.81 No.3

Background: Patients with acute respiratory failure secondary to tuberculous destroyed lung (TDL) have a poor prognosis. The aim of the present retrospective study was to develop a mortality prediction model for TDL patients who require mechanical ventilation. Methods: Data from consecutive TDL patients who had received mechanical ventilation at a single university-affiliated tertiary care hospital in Korea were reviewed. Binary logistic regression was used to identify factors predicting intensive care unit (ICU) mortality. A TDL on mechanical Ventilation (TDL-Vent) score was calculated by assigning points to variables according to β coefficient values. Results: Data from 125 patients were reviewed. A total of 36 patients (29%) died during ICU admission. On the basis of multivariate analysis, the following factors were included in the TDL-Vent score: age ≥65 years, vasopressor use, and arterial partial pressure of oxygen/fraction of inspired oxygen ratio <180. In a second regression model, a modified score was then calculated by adding brain natriuretic peptide. For TDL-Vent scores 0 to 3, the 60-day mortality rates were 11%, 27%, 30%, and 77%, respectively (p<0.001). For modified TDL-Vent scores 0 to ≥3, the 60-day mortality rates were 0%, 21%, 33%, and 57%, respectively (p=0.001). For both the TDL-Vent score and the modified TDL-Vent score, the areas under the receiver operating characteristic curve were larger than that of other illness severity scores. Conclusion: The TDL-Vent model identifies TDL patients on mechanical ventilation with a high risk of mortality. Prospective validation studies in larger cohorts are now warranted.