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( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2
Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)
Filtration and Dust Cake Experiment by Ceramic Candle Filter in High Temperature Conditions
Chung, Jin-Do,Hwang, Tae-Won,Park, So-Jin 한국화학공학회 2003 Korean Journal of Chemical Engineering Vol.20 No.6
Particulate collection at high temperature and high pressure (HTHP) is important in an advanced coal power genemion system not only to improve the thermal efficiency of the system, but also to prevent the gas turbine from erosion and to meet the emission limit? of the effluent gas. The specifications for particulate collection in those systems such as Integrated Gasification Combined Cycle (IGCC) and Pressmized Fluidized Bed Combustion (PFBC) require absolutely high collection efficiency and reliability. Advanced cyclone, granular bed fdter, elechostatic precipitator, and ceramic filter have been developed for particulate collection in the advanced coal power generation system. However, rigid ceramic filters and granular bed filters among them show the best potential. The problems experienced of these systems on performance, materials, and mechanical design were investigated. Ceramic candle filters have the best potential for IGCC at this moment because they have nearly the highest efficiency compared with other filtering systems and have accumulated many reliable design data from many field experiences. The purpose of this study was to investigate the efficiency of ceramic filters and stability of material against high temperature and long-term operation condition by applying fly ash on the surface of the filter and relation of pressure drop and dust cake thickness. Experimental conditions were 50 hours at 450 ℃, 650 ℃ and 850 ℃.
Transcriptome analysis of the endangered freshwater pearl bivalve Cristaria plicata
Tae Hun Wang,Bharat Bhusan Patnaik,Se Won Kang,Hee Ju Hwang,So Young Park,Eun Bi Park,Jong Min Chung,Dae Kwon Song,Changmu Kim,Soonok Kim,Jun Sang Lee,Yeon Soo Han,Hong Seog Park,Yong Seok Lee 한국수산해양기술학회(구 한국어업기술학회) 2015 한국수산해양기술학회 학술발표대회 Vol.2015 No.10
Tae Kyung Kim,Yoon Jae Kim,Jun Won Chung,Yun Soo Kim,김주현,Woon Kee Lee,함기백 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.4
Interleukin 1β gene (IL-1β) polymorphism has been reported to be associated with gastric cancer(GC) or chronic atrophic gastritis (CAG), which are known to be mostly influenced by inflammatoryresponse of Helicobacter pylori (H. pylori). However, there have been striking differences in implicationof IL-1β polymorphisms as predictor for gastric cancer between Western and Asian countries, as forwhich plausible reason for discrepancy could be that the most association studies were done regardingassociation between normal control and GCs. Therefore, in the current study, we investigated anassociation of the genotype of IL-1β gene polymorphisms between CAG, high risk group of GC, andGC patients. A total of 365 Korean patients (CAG:257, GC:108) were studied. The polymorphismsin IL-1β gene promoter -31 or -511 were assessed by single base primer extension assay. In the univariateanalysis, IL-1β-511 T allele carriers were identified in 183 of 257 in the CAG compared to 64 of 108in GC group (76.57% vs. 64%; p=0.037) and in multivariate analysis, IL-1β-31 C/C vs. C/T vs. T/Tgenotype could significantly predict the risk for GC among CAG. When we repeated analysis of datacomparing IL-1β haplotype (ht) among the different groups, the IL-1β ht1/ht1 vs. ht1/ht2 vs. ht2/ht2genotype influenced GC development among patients with CAG, especially compounded with H. pyloriinfection and alcohol drinking. IL-1β-31 or -511 genetic polymorphisms were significantly associatedwith GC risk in Korean patients with high risk group of CAG, especially compounded with H. pyloriinfection and alcohol drinker.
Dextran-based block copolymer for pH-responsive delievry of doxorubicin
Tae-Won Kwak,Young-IL Jeong,Do-Hyung Kim,Hye-Myung Lee,Cy-Hyun Kim,Chung-Wook Chung,Dae Hwan Kang 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Nanoparticles or polymeric micelles based on stimuli-responsive drug release have been extensively investigated in recent decades [1,2]. Especially, pH-sensitive drug targeting using pH-sensitive polymers against solid tumor has attracted remarkably since solid tumor has acidic environment [3]. Tumor targeting based on pH-responsive polymeric nanoparticles or micelles is known to have superior antitumor activity against various solid tumors. In this study, we prepared block copolymers composed of poly(L-histidine) (PHS) and dextran (DexPHS) to make pH-responsive polymeric micelles for pH-based tumor targeting. Doxorubicin (DOX) incorporated pH-resposive polymeric micelles of DexPHS block copolymer was prepared by dialysis method. DOX- incorporated polymeric micelles showed that particle size was changed by changes of solution pH, i.e. size of polymeric micelles were increased at acidic pH while they showed reduced particle size at basic pH. Furthermore, drug release was faster at acidic pH than basic pH. These results indicated that DexPHS polymeric micelles have pH-sensitive properties and then drug release was also controlled by pH. Antitumor activity of DOX-incorporated DexPHS polymeric micelles were studied using HCT116 human colon cancer cells. Results indicated that cell viability with polymeric micelle treatment was decreased at acidic pH while DOX treatment did not show significant changes against pH variation. In colculsion, our results indicated that DexPHS polymeric micelles are promising candidates for antitumor drug targeting.
Polymorphisms of GSTM1,GSTT1,GSTP1,NATII and CYP1A1 and the Susceptibility to Asthma
Chung, Hai Won,Ahn, Tai Hui,Kim, Su Young,Kim, Tae Yon,Paek, Domyung 한국유전학회 2002 Genes & Genomics Vol.24 No.3
The associations of asthma with genetic polymorphisms remains unclear. The purpose of this study is to find the association of NA72, GSTM1, GS7T1, GS7P1 and CYP1A1 polymorphism with asthma in Koreans. The genetic polymorphisms of GS7M1, GS7T1, GS7P1, NA7II and CYP1A1 genes among 33 asthma patients and 66 controls were investigated to find the association of the polymorphism with the risk of asthma. The frequency of the GS7Tl null genotype was slightly higher in asthma patients than that in controls, but this difference was not statistically significant. No difference in the frequencies of GS7T1 and GS7Pl was found between patients and controls. Excess risk for the combined GS7T1 and GS7M1 null genotype was found (O.R = 7.62, 95% CI: 1.13-51.46). There was no association with asthma risk by NA72 genotypes. The presence of the homozygous variant type (M/M of CYP1A1 led to the increased risk (O.R = 4.40, 95% CI:1.01-19.29) for asthma compared to wild type (WT) and heterozygous variant type (W/M). An increased risk of asthma for the combined GS7T1 null genotype (MM and CYP1A1 homozygous variant genotype (M/M) was also found (O.R. = 11.61, 95% CI: 1.14 - 118.43). The CYP1AI genotype, combined GS7M1 and GS7T1 genotypes as well as the combination of CYP1A1 and GS7T1 genotypes may be used as susceptible markers for asthma.
Chung, Tae Nyoung,Kim, Jin Hee,Choi, Bo Young,Chung, Sung Phil,Kwon, Sung Won,Suh, Sang Won unknown 2015 Stem cells translational medicine Vol.4 No.2
<P>Global cerebral ischemia (GCI) is the leading cause of a poor prognosis even after successful resuscitation from cardiac arrest. Therapeutic induction of hypothermia (TH) is the only proven therapy-and current standard care-for GCI after cardiac arrest; however, its application has been significantly limited owing to technical difficulties. Mesenchymal stem cells (MSCs) are known to suppress neuronal death after cerebral ischemia. The prevention of blood-brain barrier (BBB) disruption has not been suggested as a mechanism of MSC treatment but has for TH. We evaluated the therapeutic effect of MSC administration on BBB disruption and neutrophil infiltration after GCI. To evaluate the therapeutic effects of MSC treatment, rats were subjected to 7 minutes of transient GCI and treated with MSCs immediately after reperfusion. Hippocampal neuronal death was evaluated at 7 days after ischemia using Fluoro-Jade B (FJB). BBB disruption, endothelial damage, and neutrophil infiltration were evaluated at 7 days after ischemia by immunostaining for IgG leakage, Rat endothelial antigen-1, and myeloperoxidase (MPO). Rats treated with MSCs showed a significantly reduced FJB+ neuron count compared with the control group. They also showed reduced IgG leakage, endothelial damage, and MPO+ cell counts. The present study demonstrated that administration of MSCs after transient GCI provides a dramatic protective effect against hippocampal neuronal death. We hypothesized that the neuroprotective effects of MSC treatment might be associated with the prevention of BBB disruption and endothelial damage and a decrease in neutrophil infiltration.</P>
Chung, Chin Youb,Sung, Ki Hyuk,Lee, Kyoung Min,Lee, Seung Yeol,Choi, In Ho,Cho, Tae-Joon,Yoo, Won Joon,Park, Moon Seok Wolters Kluwer Health, Inc. All rights reserved. 2015 Journal of pediatric orthopedics Vol.35 No.4
BACKGROUND:: Recurrence of equinus deformity after surgery is common in patients with cerebral palsy. This retrospective study was undertaken to estimate the recurrence rate of the equinus deformity after tendo-Achilles lengthening (TAL) in patients with cerebral palsy and to investigate the risk factors associated with the recurrence. METHODS:: Two-hundred forty three ambulatory patients with cerebral palsy, who underwent TAL for equinus foot deformity since 1995, and had undergone a preoperative and postoperative 3-dimensional gait analysis, were included. Cox proportional hazards model was used to determine the significant contributing factor for the recurrence of equinus foot deformity. RESULTS:: The mean patient age at surgery was 7.8±2.7 years and the mean follow-up duration was 8.1±3.4 years. Equinus deformity recurred in 22 of the 243 patients (9.1%) and the Kaplan-Meier survival estimate was shown to be 89.4% at 10 years not needing repeat surgery. According to the multivariate analysis using the Cox proportional hazard model, preoperative ankle dorsiflexion at initial contact (P=0.016) was the only significant factor for recurrence of equinus deformity after surgery. Age at surgery and the type of limb involvement were not associated with the recurrence (P=0.433 and 0.269). The cutoff values of preoperative gait kinematics between the nonrecurrence and recurrence groups were −19 degrees of ankle dorsiflexion at initial contact (P=0.018). CONCLUSIONS:: This study showed that the severity of preoperative equinus deformity was a risk factor associated with recurrence after TAL in patients with cerebral palsy. Therefore, surgeons should consider the recurrence and later revision surgery for the patients with severe equinus foot deformity. LEVEL OF EVIDENCE:: Therapeutic level III.