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유산양 유방염에 대한 Chitosan 약침의 치료 효과
황수현,서진석,김덕환,김명철,신상태,전무형,南三郞,김영찬,이우근,표수일 충남대학교 수의과대학 동물의과학연구소 1999 動物醫科學硏究誌 Vol.7 No.-
To improve the therapeutic method for mastitis, treatment effect of chitosan pharmacopuncture was examined in three milking goats(A,B and C). Mastitis was artificially induced in two milking goats(A and B) and one goat(C) was naturally infected case with mastitis. The acupoint used was Yang-Ming and chitosan suspensions(provided from Tottory University, Japan: 30㎎ of chitosan/㎖)were injected to the acupoint with 5㎖/time for 3 days, respectively. As for the change of somatic cells in milk along with chitosan pharmacopuncture, they showed a decreasing tendency after increase on the 3rd day in all udders of B. In addition, as for the change of total leukocyte counts of peripheral blood with chitosan pharmacopuncture, they showed a decreasing tendency after increase on the 3rd day in B and C except A which showed a increasing tendency until on the 7th day. In the change of neutrophil/lymphocyte(N/L) ratio, increasing tendency was seen in A and C but increasing tendency after slight decrease was observed in B. Further, in the change of serum total protein and A/G ratio, serum total protein content was decreased after slightly increase on the 3rd day in A, and they were decreased after increase until on the 7th day in B and C, respectively. As for the change of A/G ratio, different pattern increasing tendency was shown in A, B and C.
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
열성화상으로 인한 상후두부 통증에서 상후두신경차단의 진통효과 : 증례보고
임경준,이재황,고우석 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.3
Thermal bum of pharynx and larynx can cause dysphagia and dyspnea which can be life threatening. Pain of larynx due to thermal bum does not subside sufficiently to drug therapy, Physiologic therapy. Here a case of acute epiglottitis with severe pain, which was successfully treated with superior laryngeal nerve block, is reported.
석세일,김진혁,김원중,이상민,이지호,김우일,황훈,진건형 대한척추외과학회 1999 대한척추외과학회지 Vol.6 No.3
서론 : 이중 흉추 만곡을 갖는 특발성 척추측만증에서 상부 흉추 만곡에 대한 유합술의 적응증은 아직까지 명백하지 않으며, 상부 흉추 만곡을 간과할 경우 술후 대상 부전 또는 어깨 높이의 차이가 악화되는 결과를 초래할 수 있다. 연구목적 : 본 논문은 후향적 연구로, 특발성 척추측만증에서 상부 흉추 만곡의 유합술에 대한 적응증을 알아보고자 하였다. 대상 및 방법 : 분절 척추경 나사 고정술 및 반회전술(derotation)로 치료한 특발성 척추측만증 환자 중 하부 흉추 만곡 40도이상, 상부 흉추 25도 이상인 환자 40명을 대상으로 하였다. 환자중 18명은 상,하부 흉추 만곡 모두 유합하였으며(제 1군), 22명은 하부 흉추 만곡의 각도 및 교정도와 양측 어깨높이의 차이를 측정하였다. 결과 : 제 1군에서는 상부 흉추 만곡은 술전 45±9도에서 술후 21±11도로 55.2±17.7%교정되었으며, 하부 흉추 만곡은 술전 55±10도에서 술후 20±10도로 교정되었다. 어깨높이 차이는 술전 -6±12㎜에서 술후 1±9㎜로 개선되었다. 제 2군에서는 상부 흉추 만곡은 술전 32.5도에서 술후 도로 18±6%교정되었으며, 하부 흉추 만곡은 술전 58±10도에서 술후 18±6도로 교정되었다. 어깨 높이의 차이는 제 1군에서는 술전 어깨높이 차이x0.6+12㎜이었다. 결론 : 상부 흉추 만곡이 25도 이상인 특발성 흉추 척추만증에서 술전 좌측 어깨높이가 우측보다 비슷하거나 높을 경우 상하부 만곡 모두 유합하여야 술후 어깨높이의 악화를 방지할 수 있을 것으로 사료된다. Study design : A retrospective study. Objectives : To determine the indications of fusing the proximal thoracic curve when treating an idiopathic thoracic scoliosis with segmental instrumentation. Summary of background data : Failure to recognize a significant proximal thoracic curve often results in postoperative shoulder asymmetry due to relative overcorrection of the lower thoracic curve. With segmental instrumentation that enhances the correction of the instrumented curve, the double thoracic curve pattern that needs fusion of both the proximal and the distal thoracic curves needs to be redefined. Materials and methods : Forty thoracic AIS patients with a right lower thoracic curve >40 and a left proximal thoracic curve >25 treated by segmental pedicle screw instrumentation were analyzed after a minimum follow up of 2 years. Results : Of the 40 patients. 18 were treated by fusion of both the proximal and the distal curves while 22 were treated by fusion of the distal curve only. The postoperative shoulder height difference(SHD.㎜) was 0.9 x preoperative SHD(㎜) + 5.3 for the both curve fusion and 0.6 x preoperative SHD(㎜) + 12 for the distal curve fusion(linear regression), showing that proximal thoracic curve fusion improved the SHD when the left shoulder was level with or higher than the right. Conclusions : An idiopathic thoracic scoliosis with a proximal thoracic curve>25 and level or elevated left shoulder should be considered a double thoracic curve pattern and treated by both the proximal and the distal curve fusion when using a segmental instrumentation.
소화성 궤양 출혈에서 내시경적 클립 시술의 기술적 완성도 결정인자
황순오,이석호,김종화,김수지,서성우,이용관,전웅,조영신,최문한,최재혁 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2
Background/Aims: Although endoscopic hemoclip therapy for bleeding peptic ulcer has widely been used, there are few reports that assess its technical completeness. We retrospectively evaluated the related factors for the completeness of endoscopic hemoclip placement with bleeding peptic ulcer. Methods: 50 patients were enrolled. They received emergency endoscopy and received hemoclip application for bleeding peptic ulcer, then follow up endosconv was performed after 48 hours. We analyzed endoscopic feature, clinical factors and operator's experience retrospectively. Results: Initial hemostasis was achieved in 100%. The rebleeding rate was 10%. In cases larger and peripherally located vessel on the ulcer, difficult site of ulcer to access and insufficiently experienced endoscopist, the rate of completeness of endoscopic hemoclip placement were significantly lower with statistical difference(p<0.05). Conclusions: Endoscopic hemoclip application provides effective hemostasis in the treatment of bleeding peptic ulcer. But in difficult cases, we have to attend various technical re-adjustment or may consider other hemostatic procedures instead of doing hemoclip therapy.
Oh, Suck Hoon,Hwang, Yong Pil,Choi, Jae Ho,Jin, Sun Woo,Lee, Gi Ho,Han, Eun Hee,Chung, Young Ho,Chung, Young Chul,Jeong, Hye Gwang Elsevier 2018 Food and chemical toxicology Vol.121 No.-
<P><B>Abstract</B></P> <P>Kahweol is a coffee-specific diterpene found in the beans of <I>Coffea arabica</I> and has been reported to demonstrate various biological activities, including anti-inflammatory, antioxidant, and apoptotic properties. In the present study, we examined the molecular mechanism of kahweol in human epidermal growth factor receptor-2 (HER2)-overexpressing breast cancer cells. Kahweol preferentially inhibited cell proliferation and induced cell death through the induction of a caspase 3-dependent pathway in HER2-overexpression breast cancer cell lines. Kahweol treatment substantially reduced the levels of HER2 protein, mRNA, and transcriptional activity in SKBR3 cells. Kahweol exerts its potent anticancer efficacy by the upregulation of polyomavirus enhancer activator 3 (PEA3) and downregulation of activator protein 2 (AP-2) to inhibit aberrantly activated HER2 signaling. Fatty acid synthase (FASN) expression and sterol regulatory element-binding protein-1c (SREBP-1c) activity were downregulated by kahweol. In addition, kahweol lowered the levels of phosphorylated Akt and its downstream targets mammalian target of rapamycin (mTOR) and cyclin D1. Furthermore, we found that blocking Akt signaling through kahweol treatment significantly reduced FASN expression and subsequently suppressed cell proliferation in HER2-overexpressing cancer cells. Overall, this study suggests that kahweol could be a useful adjuvant therapeutic agent in the treatment of HER2-overexpressing breast cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Kahweol, a coffee-specific diterpene, exhibits anti-tumor effect in HER2-overexpressing cancer cells. </LI> <LI> Kahweol inhibits proliferation and induces apoptosis <I>through the</I> downregulation of FASN and HER2 expression. </LI> <LI> Kahweol inhibits HER2 expression and activity through the regulation of PEA3 and AP-2. </LI> <LI> Kahweol inhibits the phosphorylation of Akt, mTOR, and GSK3β. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>