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      • KCI등재

        Energy-Efficient Base Station Sleep Scheduling in Relay-Assisted Cellular Networks

        ( Hongbin Chen ),( Qiong Zhang ),( Feng Zhao ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.3

        We Relay-assisted cellular network architecture has been developed to cover cell-edge users and to improve capacity. However, the deployment of relay stations (RSs) in cellular networks may increase the total energy consumption. Though energy efficiency has become a major concern in cellular networks, little work has studied the energy efficiency of relay-assisted cellular networks by sleep scheduling. In this paper, a distributed base stations (BSs) sleep scheduling scheme in relay-assisted cellular networks is proposed. The goal is to maximize the energy efficiency under the spectral efficiency constraint. Firstly, whether the BSs should be sleeping or active is determined by the traffic profile. Then, the transmission powers of the active BSs are optimized within the game-theoretic framework, by using an interior-point method, so as to maximize the energy efficiency. Simulation results demonstrate that the effectiveness of the proposed scheme is superior to that turning on all the BSs without sleep scheduling.

      • KCI등재

        Shear resistance performance of low elastic polymer microspheres used for conformance control treatment

        Hongbin Yang,Shuo Shao,Tongyu Zhu,Chaocheng Zhao,Shuren Liu,Bobo Zhou,Xiaoyu Hou,Yang Zhang,Wanli Kang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.79 No.-

        Low elastic polymer microsphere (L-EPM) has been proposed as a functional polymer microsphere theseyears. L-EMP has the excellent deformation ability in the porous medium due to the low storage modulus. Herein, one kind of L-EPM with storage modulus (G0) of 23.6 Pa was prepared by inverse suspensionpolymerization. The shear resistance of L-EPM was researched by using coreflooding experiment andhigh shear rate emulsifier. The conformance control behavior of L-EPM was investigated by using doubleparallel sandpackflooding experiment. The results showed that L-EPM was a kind of swollen particle gelwith three-dimensional net structure and contained amide, carboxyl, and sulfonate groups. Themechanism of water swelling property was mainly due to the formation of hydrogen bonds, hydrolysis ofhydrophilic groups and the diffusion caused by osmotic pressure difference. Compared with high elasticpolymer microspheres (H-EPM) and low elastic preformed particle gel (L-PPG), L-EPM had better shearresistance in the porous medium and the well casing perforation. In addition, the critical shear points ofL-EPM was proposed in this work. Due to the better shear resistance and deformation ability, theconformance control behavior of L-EPM showed that L-EPM was a promising conformance control agentin the heterogeneous reservoirs.

      • KCI등재후보

        Joint Beamforming and Power Allocation for Multiple Primary Users and Secondary Users in Cognitive MIMO Systems via Game Theory

        ( Feng Zhao ),( Jiayi Zhang ),( Hongbin Chen ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.6

        We consider a system where a licensed radio spectrum is shared by multiple primary users (PUs) and secondary users (SUs). As the spectrum of interest is licensed to primary network, power and channel allocation must be carried out within the cognitive radio network so that no excessive interference is caused to PUs. For this system, we study the joint beamforming and power allocation problem via game theory in this paper. The problem is formulated as a non-cooperative beamforming and power allocation game, subject to the interference constraintsof PUs as well as the peak transmission power constraintsof SUs. We design a joint beamforming and powerallocation algorithm for maximizing the total throughput of SUs, which is implemented by alternating iteration of minimum mean square error based decision feedback beamforming and a best response based iterative power allocation algorithm. Simulation results show that the algorithm has better performance than an existing algorithm and can converge to a locally optimal sum utility.

      • KCI등재

        Rapid visual detection of Mycobacterium avium subsp. paratuberculosis by recombinase polymerase amplification combined with a lateral flow dipstick

        Guimin Zhao,Hongmei Wang,Peili Hou,Chengqiang He,Hongbin He 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.2

        Paratuberculosis (Johne’s disease) is a chronic debilitating disease of domestic and wild ruminants. However, widespread point-of-care testingis infrequent due to the lack of a robust method. The isothermal recombinase polymerase amplification (RPA) technique has applied for rapiddiagnosis. Herein, RPA combined with a lateral flow dipstick (LFD) assay was developed to estimate DNA from Mycobacterium avium subsp. paratuberculosis. First, analytical specificity and sensitivity of the RPA-nfo primer and probe sets were assessed. The assay successfullydetected M. paratuberculosis DNA in 30 min at 39oC with a detection limit of up to eight copies per reaction, which was equivalent to thatof the real-time quantitative polymerase chain reaction (qPCR) assay. The assay was specific, as it did not amplify genomes from five otherMycobacterium spp. or five pathogenic enteric bacteria. Six hundred-twelve clinical samples (320 fecal and 292 serum) were assessed byRPA-LFD, qPCR, and enzyme-linked immunosorbent assay, respectively. The RPA-LFD assay yielded 100% sensitivity, 97.63% specificity,and 98.44% concordance rate with the qPCR results. This is the first report utilizing an RPA-LFD assay to visualize and rapidly detect M. paratuberculosis. Our results show this assay should be a useful method for the diagnosis of paratuberculosis in resource-constrained settings.

      • KCI등재

        Enhancement of Gastric Ulcer Healing and Angiogenesis by Hepatocyte Growth Factor Gene Mediated by Attenuated Salmonella in Rats

        Xiaoqin Ha,Junhua Peng,Hongbin Zhao,Zhiyun Deng,Juzi Dong,Hongyan Fan,Yong Zhao,Bing Li,Qiangsheng Feng,Zhihua Yang 대한의학회 2017 Journal of Korean medical science Vol.32 No.2

        The present study developed an oral hepatocyte growth factor (HGF) gene therapy strategy for gastric ulcers treatment. An attenuated Salmonella typhimurium that stably expressed high HGF (named as TPH) was constructed, and the antiulcerogenic effect of TPH was evaluated in a rat model of gastric ulcers that created by acetic acid subserosal injection. From day 5 after injection, TPH (1 × 109 cfu), vehicle (TP, 1 × 109 cfu), or sodium bicarbonate (model control) was administered orally every alternate day for three times. Then ulcer size was measured at day 21 after ulcer induction. The ulcer area in TPH-treated group was 10.56 ± 3.30 mm2, which was smaller when compared with those in the TP-treated and model control groups (43.47 ± 4.18 and 56.25 ± 6.38 mm2, respectively). A higher level of reepithelialization was found in TPH-treated group and the crawling length of gastric epithelial cells was significantly longer than in the other two groups (P < 0.05). The microvessel density in the ulcer granulation tissues of the TPH-treated rats was 39.9 vessels/mm2, which was greater than in the TP-treated and model control rats, with a significant statistical difference. These results suggest that TPH treatment significantly accelerates the healing of gastric ulcers via stimulating proliferation of gastric epithelial cells and enhancing

      • KCI등재

        Catalytic transfer hydrogenation of 7-ketolithocholic acid to ursodeoxycholic acid with Raney nickel

        He Tian,Xuejun Cao,Hongbin Zhao 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.2

        Ursodeoxycholic acid was produced by the stereoselective reduction of 7-ketolithocholic acid. This hydrogenation reaction was catalyzed by the T-1 Raney nickel and potassium borohydride was used as hydrogen donor instead of inflammable hydrogen gas. Potassium tert-butoxide was introduced to improve yield of ursodeoxycholic acid from about 70% to a maximum of 94% by inducing the stereoselectivity on hydroxyl group at 40 8C and atmospheric pressure. Reduction reaction conditions such as amount of reactants, temperature and stirring speed were optimized. The whole process is safe and low-cost. Eventually, the product, ursodeoxycholic acid was characterized by IR, 1H NMR and 13C NMR spectra.

      • KCI등재

        A Novel Unsteady Fractal Derivative Creep Model for Soft Interlayerswith Varying Water Contents

        Wenmin Yao,Bin Hu,Hongbin Zhan,Chong Ma,Nenghao Zhao 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.12

        Creep properties of soft interlayers are key factors associated with the long-term stability of geological bodies. An experimental and theoretical study on the ring shear creep properties of soft interlayers collected from Esheng, Sichuan province, China are performed in this study. Ring shear creep tests of soft interlayers, which are remolded into over-consolidated samples having various water contents and the same initial dry density, are performed in laboratory, to analyze the creep deformation characteristics of samples in detail. The calculated long-term shear strength of samples is close to residual strength. By substituting the dashpot with a new unsteady fractal dashpot, a novel unsteady fractal derivative creep (UFDC) model, which can be defined in series with an improved Maxwell model and an improved viscoplastic model, is proposed based on theory of fractal derivative. The new model can efficiently explain the soft interlayers creep deformation. The results indicate that most model parameters are sensitive to the shear stress. However, at the accelerated creep stage, the fractional order of the second dashpot in the UFDC model has little effect on the fitting of experimental data.

      • KCI등재

        Development of a multiplex qRT-PCR assay for detection of African swine fever virus, classical swine fever virus and porcine reproductive and respiratory syndrome virus

        Yating Chen,Kaichuang Shi,Huixin Liu,Yanwen Yin,Jing Zhao,Feng Long,Wenjun Lu,Hongbin Si 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.6

        Background: African swine fever virus (ASFV), classical swine fever virus (CSFV), and porcine reproductive and respiratory syndrome virus (PRRSV) are still prevalent in many regions of China. Co-infections make it difficult to distinguish their clinical symptoms and pathological changes. Therefore, a rapid and specific method is needed for the differential detection of these pathogens. Objectives: The aim of this study was to develop a multiplex real-time quantitative reverse transcription polymerase chain reaction (multiplex qRT-PCR) for the simultaneous differential detection of ASFV, CSFV, and PRRSV. Methods: Three pairs of primers and TaqMan probes targeting the ASFV p72 gene, CSFV 5′ untranslated region, and PRRSV ORF7 gene were designed. After optimizing the reaction conditions, including the annealing temperature, primer concentration, and probe concentration, multiplex qRT-PCR for simultaneous and differential detection of ASFV, CSFV, and PRRSV was developed. Subsequently, 1,143 clinical samples were detected to verify the practicality of the assay. Results: The multiplex qRT-PCR assay could specifically and simultaneously detect the ASFV, CSFV, and PRRSV with a detection limit of 1.78 × 100 copies for the ASFV, CSFV, and PRRSV, but could not amplify the other major porcine viruses, such as pseudorabies virus, porcine circovirus type 1 (PCV1), PCV2, PCV3, foot-and-mouth disease virus, porcine parvovirus, atypical porcine pestivirus, and Senecavirus A. The assay had good repeatability with coefficients of variation of intra- and inter-assay of less than 1.2%. Finally, the assay was used to detect 1,143 clinical samples to evaluate its practicality in the field. The positive rates of ASFV, CSFV, and PRRSV were 25.63%, 9.36%, and 17.50%, respectively. The co-infection rates of ASFV+CSFV, ASFV+PRRSV, CSFV+PRRSV, and ASFV+CSFV+PRRSV were 2.45%, 2.36%, 1.57%, and 0.17%, respectively. Conclusions: The multiplex qRT-PCR developed in this study could provide a rapid, sensitive, specific diagnostic tool for the simultaneous and differential detection of ASFV, CSFV, and PRRSV.

      • SCIESCOPUSKCI등재

        Comparison of cecal microbiota composition in hybrid pigs from two separate three-way crosses

        Yang, Yuting,Shen, Liyan,Gao, Huan,Ran, Jinming,Li, Xian,Jiang, Hengxin,Li, Xueyan,Cao, Zhenhui,Huang, Ying,Zhao, Sumei,Song, Chunlian,Pan, Hongbin Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.7

        Objective: The intestinal microbiota plays an important role in host physiology, metabolism, immunity, and behavior. And host genetics could influence the gut microbiota of hybrid animals. The three-way cross model is commonly utilized in commercial pig production; however, the use of this model to analyse the gut microbial composition is rarely reported. Methods: Two three-way hybrid pigs were selected, with Saba pigs as the starting maternal pig: Duroc× (Berkshire×Saba) (DBS) pig, Berkshire×(Duroc×Saba) (BDS) pig. One hundred pigs of each model were reared from 35 days (d) to 210 d. The body weight or feed consumption of all pigs were recorded and their feed/gain (F/G) ratio was calculated. On day 210, 10 pigs from each three-way cross were selected for slaughter, and cecal chyme samples were collected for 16S rRNA gene sequencing. Results: The final body weight (FBW) and average daily gain (ADG) of DBS pigs were significantly higher than those of BDS pigs (p<0.05), while the F/G ratios of DBS pigs were significantly lower than those of BDS pigs (p<0.05). The dominant phyla in DBS and BDS pigs were Bacteroidetes (55.23% vs 59%, respectively) and Firmicutes (36.65% vs 34.86%, respectively) (p>0.05). At the genus level, the abundance of Prevotella, Roseburia, and Anaerovibrio in DBS pigs was significantly lower than in BDS pigs (p<0.01). The abundance of Eubacterium, Clostridium XI, Bacteroides, Methanomassiliicoccus, and Parabacteroides in DBS pigs was significantly higher than in BDS pigs (p<0.05). The FBWs and ADGs were positively correlated with Bacteroides, ClostridiumXI, and Parabacteroides but negatively correlated with the Prevotella, Prevotella/Bacteroides (P/B) ratio, Roseburia, and Anaerovibrio. Conclusion: These results indicated that host genetics affect the cecal microbiota composition and the porcine gut microbiota is associated with growth performance, thereby suggesting that gut microbiota composition may be a useful biomarker in porcine genetics and breeding.

      • SCIESCOPUSKCI등재

        Correlation analysis of muscle amino acid deposition and gut microbiota profile of broilers reared at different ambient temperatures

        Yang, Yuting,Gao, Huan,Li, Xing,Cao, Zhenhui,Li, Meiquan,Liu, Jianping,Qiao, Yingying,Ma, Li,Zhao, Zhiyong,Pan, Hongbin Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.1

        Objective: Temperature could influence protein and amino acid deposition as well as gut microbiota profile and composition. However, the specific effects of ambient temperature on amino acids deposition and gut microbiota composition remain insufficiently understood. Methods: A total of 300 one-day-old Avian broilers were randomly divided into three groups and reared at high, medium, and low temperature (HT, MT, and LT), respectively. Breast muscle and fecal samples were collected for amino acid composition analysis and 16S rRNA gene sequence analysis. Results: Our data showed that compared to the MT group, there was a decrease of muscle leucine and tyrosine (p<0.05), as well as an increase of methionine in the HT group (p<0.05) and a decrease of serine in the LT group. Examination of microbiota shift revealed that at genus level, the relative abundance of Turicibacter and Parabacteroides was increased in the HT group (p<0.05) and that the relative abundances of Pandoraea, Achromobacter, Prevotella, Brevundimonas, and Stenotrophomonas in the LT group were higher than those in the MT group (p<0.05). In addition, there were substantial correlations between microbes and amino acids. In the HT group. Turicibacter was negatively correlated with aspartic acid and tyrosine, whereas Parabacteroides was positively correlated with methionine (p<0.05). In the LT group, there were multiple positive correlations between Achromobacter and arginine, isoleucine or tyrosine; between Prevotella and cysteine or phenylalanine; between Brevundimonas and cysteine; and between Stenotrophomonas and cysteine as well as a negative correlation between Stenotrophomonas and serine. Conclusion: Our findings demonstrated that amino acid content of breast muscle and intestinal microbiota profile was affected by different ambient temperatures. Under heat exposure, augmented abundance of Parabacteroides was correlated with elevated methionine. Low temperature treatment may affect muscle tyrosine content through the regulation of Achromobacter.

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