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      • KCI등재

        Study on an emulsion-type blockage removal agent for heavy oil recovery enhanced by polymer

        Tongyu Zhu,Hongbin Yang,Haizhuang Jiang,Xin Kang,Menglan Li,Min Zhang,Wanli Kang,Bauyrzhan Sarsenbekuly,Saule Aidarova,Maratbek Gabdullin 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-

        In polymerflooding process, the poor solubility of polymer and the wrap of incompletely dissolvedpolymer particles with heavy oil lead to the generation of complicated blockage, which seriously affectsthe normal production of wells. Therefore, how to fabricate an effective blockage removal agent isparticularly important. Based on the blockage from Bohai Offshore Oilfield in China, a blockage removalagent composed of (0.5 wt% potassium persulfate + kerosene (the ratio of kerosene: blockage is 3:5)+0.3 wt% OP-10, the oil-water ratio is 1:9) was developed. The removal effect and mechanism werecharacterized by weight loss method and core test. Moreover, the emulsification property of the removalagent was also evaluated by microscopic appearance. The results showed that the blockage removal agentcan be formulated as an O/W emulsion and had good stability for more than 72 h. Core test showed thatthe permeability had a significant improvement after injection of removal agent. The emulsion-typeremoval agent can demulsify after contact with the blockage, then the oil-soluble detergent as internalphase in emulsion can be released which contributes to the wash off of heavy oil. Accompanied with thepolymer degradation by the oxidant, this agent realized the effective dissolution and removal of blockage.

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        RAR-Related Orphan Receptor: An Accelerated Preeclampsia Progression by Activating the JAK/STAT3 Pathway

        Ying Yu,Tongyu Zhu 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.6

        Purpose: To investigate the effect and underlying mechanism of RAR related orphan receptor A (RORA) on preeclampsia (PE). Materials and Methods: Differentially expressed genes (DEGs) in four datasets were obtained by using the Venn diagram method. RORA mRNA and protein expressions were detected by qRT-PCR, western blot, and immunohistochemistry. HTR-8/SVneocell viability, proliferation, invasion, migration, and angiogenesis were detected by CCK-8 assay, EdU assay, Transwell, woundhealing assay, and tube formation assay, respectively. The concentration of Ang-1 in cells was assessed using available ELISA kit. Epithelial-mesenchymal transition, proliferation, and angiogenesis-related proteins were detected by western blot. GSEA analysiswere performed for common DEGs, and the expression of enriched pathway-related proteins was also detected. Results: The expression of RORA was increased in PE tissue and HTR-8/SVneo cells. Silencing RORA could promote the migration,invasion, epithelial-mesenchymal transition, proliferation, and angiogenesis of hypoxia-treated HTR-8/SVneo cells. Mechanistically,RORA contributed to the deterioration of PE by activating the JAK2/STAT3 signaling pathway to promote cell proliferation,migration, invasion, and angiogenesis. Conclusion: RORA was up-regulated in PE and affected HTR-8/SVneo cell proliferation, invasion, migration, apoptosis, and angiogenesisvia the JAK2/STAT3 signaling pathway. This provided a novel strategy for the prevention and treatment of PE.

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        Shear resistance performance of low elastic polymer microspheres used for conformance control treatment

        Hongbin Yang,Shuo Shao,Tongyu Zhu,Chaocheng Zhao,Shuren Liu,Bobo Zhou,Xiaoyu Hou,Yang Zhang,Wanli Kang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.79 No.-

        Low elastic polymer microsphere (L-EPM) has been proposed as a functional polymer microsphere theseyears. L-EMP has the excellent deformation ability in the porous medium due to the low storage modulus. Herein, one kind of L-EPM with storage modulus (G0) of 23.6 Pa was prepared by inverse suspensionpolymerization. The shear resistance of L-EPM was researched by using coreflooding experiment andhigh shear rate emulsifier. The conformance control behavior of L-EPM was investigated by using doubleparallel sandpackflooding experiment. The results showed that L-EPM was a kind of swollen particle gelwith three-dimensional net structure and contained amide, carboxyl, and sulfonate groups. Themechanism of water swelling property was mainly due to the formation of hydrogen bonds, hydrolysis ofhydrophilic groups and the diffusion caused by osmotic pressure difference. Compared with high elasticpolymer microspheres (H-EPM) and low elastic preformed particle gel (L-PPG), L-EPM had better shearresistance in the porous medium and the well casing perforation. In addition, the critical shear points ofL-EPM was proposed in this work. Due to the better shear resistance and deformation ability, theconformance control behavior of L-EPM showed that L-EPM was a promising conformance control agentin the heterogeneous reservoirs.

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        Coalescence behavior of aqueous drops in water-in-oil emulsions under high-frequency pulsed AC fields

        Wanli Kang,Menglan Li,Hongbin Yang,Xin Kang,Fang Wang,Haizhuang Jiang,Min Zhang,Tongyu Zhu,Bauyrzhan Sarsenbekuly 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-

        High-frequency pulsed alternating currentfield (HFPACF) has attracted attentions owing to its excellentperformances of eliminating short circuit, saving energy and reducing environmental pollution. To studythe coalescence mechanism of aqueous drops in water-in-oil (W/O) emulsions under HFPACF, micro-behavior of dispersed drops for W/O emulsion was monitored by using a self-designed micro-visualmodel and coalescence mechanism was analyzed by discussing effects of pulse amplitude, pulsefrequency, pulse width ratio, demulsifier concentration, aqueous mass ratio of emulsion, and differentmodel oil emulsions. The results show that the dispersed drops coalesce under the action of electricfield,and the particle size of dispersed drops increases with the increase of pulse frequency and amplitude. When the pulse frequency or amplitude reach to a critical value, aqueous drops are driven to form waterstring or water channel between two electrodes which hinders further drops coalescence in other areas. However, with the increase of pulse width ratio, the size of dispersed drops increases slowly. Theoptimum pulse frequency and pulse amplitude are obtained at 3.9 kV and 4.21 kHz, respectively, theoptimal pulse width range is 54.9%-84.4%. When the concentration of demulsifier is 60 mg/L, thesynergistic demulsification effect achieves the highest performance. When the aqueous mass ratio ofemulsion reaches a high level (over 30%), which means the drops in emulsion have big size, thecoalescence performance under the same electricfield strength is great. Also, it is discovered that thedispersed drops in Yongping model oil emulsion have difficulty in forming water chains, since there aremuch asphaltenes and resins in the water-oil interface leading to high strength offilm. For Shuanghe oilemulsion drops are prevented from coalescing, because it contains a mass of paraffin, which can stabilizeemulsion at low temperature.

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