소아 류마치스열

남성지,안두홍 慶北大學校 醫科大學 1983 慶北醫大誌 Vol.24 No.2

A clinical observation was done on 30 children with rheumatic fever, who had been admitted to the Pediatric Department of Kyungpook National University Hospital from March 1978 to May 1983, and following results were obtained. Age distribution showed 43.6% in the age group of 6-10 years and 56.4%, 11-15 years. Male to female ratio was 1 2.9, and 18 patients (46.2%) experienced relapse more than one time. The common presenting symptoms were dyspnea on exertion in 79.5%, malaise in 69.2%, fever in 61.5%, arthralgia in 61.5%. palpitation in 53.6%, abdominal pain in 41.0%, and epistaxis in 10.3%. Physical examination showed cardiac murmur of mitral insufficiency in 100.O%, and hepatomegaly in 66.7%. frequency of major manifestations were carditis 100.0%, polyarthritis 15.4%, erythema marginatum 7.7%, subcutaneous nodules 5.1%, and chorea 5.l%. Laboratory findings showed leukocytosis in 48.7%, anemia in 43.6%, elevated erythrocyte sedimentation rate in 82.1%, antistreptolysin 0 titer over 300 units in 52.8%, and positive Creactive protein in 69.2%. Generalized cardiomegaly on chest radiogram was observed in 87.2%, left atrial enlargement on right anterior oblique view in 92.3%, and left ventricular hypertrophy in 84.6%. Electrocardiogram showed PR prolongation in 38.5%, QTc prolongation in 79.5%, ST and T wave change in 59.0%, left atrial enlargement in 56.4%, and left ventricular hypertrophy in 35.9%. In the majority of patients, clinical symptoms such as fever and resting dyspnea improved within 3 days of therapy with prednisolone and digitalis. However, elevation of peripheral venous pressure, increased ESR, and positive C-reactive protein returned gradually toward normal values requiring more than 10 days of treatment.

웹 기반 공동작업 지원시스템의 개발

문남두,안건태,김진홍,박양수,이명준 울산대학교 2001 공학연구논문집 Vol.32 No.1

최근 웹의 확산과 더불어 제품개발을 위하여 공동작업 구성원들 사이의 정보 공유와 재사용을 지원하는 웹 기반의 공동작업 지원 시스템 개발에 대한 관심이 고조되고 있다. 기업 및 공공기관의 공동작업은 광범위하게 분산되어 있는 경우가 많으며, 여러 작업그룹 내의 구성원은 이러한 환경에서 효과적으로 서로의 정보를 교환하고 공유할 수 있는 작업공간을 필요로 한다 또한 공동작업의 결과로서 생성된 기술문서의 체계적인 관리 기능과 실시간 의사전달의 기능 등이 함께 제공되는 것이 바람직하다. 본 논문에서는 웹 기반의 공동작업 지원 시스템인 CoWare의 설계와 구현에 대하여 설명한다. CoWare는 통합시스템으로서 CoSpace, CoDocs, CoMail로 명명된 세 개의 관련된 시스템으로 구성된다. CoSpace는 자료의 저장과 공유를 위하여 개인 및 작업그룹을 위한 작업공간을 제공하고, CoDocs는 전자문서의 체계적인 관리를 지원하며, CoMail은 실시간 의사전달의 기능을 제공한다. CoSpace, CoDocs, 그리고 CoMail은 기본적으로 사용자 정보, 사용자 그룹정보, 작업그룹정보의 공유를 통하여 상호 연계되어, 보다 자연스럽고 효율적으로 공동작업을 지원할 수 있다. With rapid growth of World-Wide Web(WWW or Web), much interest has shifted to develop a Web-based collaborative work system which supports information sharing and reusing. Most of collaborative works in a company or a public corporation are widely distributed. In such an environment, members of work groups require workspaces for exchanging and sharing information. In addition to those workspaces, it is desirable to support real-time messaging facility and systematic management of technical documents produced during collaborative works. In this paper, we describe the design and implementation of a Web-based groupware, named CoWare, which supports effective collaboration. The CoWare system is an integrated system including three related systems : CoSpace, CoDocs and CoMail. The CoSpace system provides personal workspace and shared workspace for storing and sharing informations. The CoDocs system manages electronic documents systematically, while the CoMail system supports real-time messaging facility. Basically, the user information, the user group information, and the work group information are shared among CoSpace, CoDocs, and CoMail. Thereby, the CoWare system supports more natural and effective collaboration.

Taxol합성에 관한 연구. Ⅱ : 3-(2-Hydroxyethyl)-2, 2, 4-trimethyl-3-cyclohexenone SEM ether의 합성

임남수,신동수,정윤성,김정주,박두천,주우홍 昌原大學校 基礎科學硏究所 1995 基礎科學硏究所論文集 Vol.7 No.-

3-(2-Hydroxyethyl)-2,2,4-trimethyl-3-cyclohexenone SEM ether ??, an intermediate in the synthesis of taxol was provided in eight steps. The keto ketal ?? was obtained in three steps from 1,3-cyclohexanedione. Reaction of the potassium enolate of ?? with N-phenyltrifluoromethanesulfonimide provided triflate ?? in 84% yield. Thus palladium-mediated cross-coupling reaction of enol triflate ?? with vinyltributylstannane afforded diene ?? in a 89% yield. 3-(2-Hydroxyethyl)-2,2,4-trimethyl-3-Cyclohexenone SEM ether was prepared from diene ?? by sequential hydroboration [9-BBN, THF, 89%], deprotection[pTsOH ·H₂O, THF-H₂O,~100%], and silyation [SEMC], iPr₂NEt, nBu₄NI, CH₂Cl₂, 94%]

[Gln]1.4,[Phe]11 - Neurotensin 의 합성

박두천,홍남주,박영택 國立 昌原大學校 産業技術硏究所 1989 産技硏論文集 Vol.3 No.-

1980年度 痢疾樣 大便을 가진 患兒들에 對한 臨床的 細菌學的 觀察

趙龍勳,南聖枝,具滋薰,安斗洪,薛盛用 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.2

1980年 1月부터 1980年 8月까지 滿 8個月間 痢疾樣 大便을 主訴로 本 小兒科에서 入院및 來院한 患兒 75名을 對象으로 臨床的, 細菌學的 觀察을 하여 다음과 같은 咸績을 얻었다. 年齡別 分布는 1歲에서 5歲 사이가 35例(47%)로 가장 높았으며 이들中 Shigella는 23例(30%), Entameba histolytica는 13例(17%)였고 Vibrio parahaemolyticus는 한 例도 檢出되지 않았다. 檢出된 Shigella 23菌株는 모두 Shigella flexneri 였다. 月別分布는 6月 16例(20%), 7月 30例(40%)로서 最多數를 占하였으나 細菌性 痢疾의 경우 月別에 관계없이 均等하게 分布하고 있었다. 臨床症狀및 理學的 所見으로는 細菌性痢疾의 경우 38℃ 以上의 發熱 19例(83%), 嘔吐 6例(26%), 腹痛 8例(35%), 痙攣 5例(22%)였으며, 아메바性 痢疾에서는 發熱 4例(31%), 痙攣 1例(8%)로서 細菌性 痢疾에서 아메바性 痢疾보다 發熱과 痙攣이 빈번히 나타났다. 泄瀉의 性狀에서는 細菌性 痢疾 23例中 血粘液性이 19例(83%)였는데 비해 아메바性 痢疾 13例에서는 粘液性이 8例(62%)였다. 泄瀉의 回數에서도 細菌性 痢疾에서는 대부분이 11回以上이었는데 比해 아메바性 痢疾에서는 대부분이 10回未滿이었다. 末梢血液에서의 白血球數는 全例의 35%에서 白血球 增多症을 보였다. 分離된 Shigella 23菌株에 對한 抗生劑 感受性 檢査를 平板混合포稀釋法에 依해 調査해 본 結果 kanamycin, gentamicin, amikacin, cephaloridine, rifampin이 100%의 感受性을 나타내어 가장 높았고, nalidixic acid에서도 87%의 感愛性을 나타냈으며, sulfonamide, chloramphenicol, streptomycin, tetracycline, ampicillin, bactrim 에서는 한 菌株를 제외한 모든 菌株에서 耐性을 나타냈다. 그리고 이들 Shigella 23菌株中 1菌株를 제외한 나머지 모든 菌株에서 6種 以上의 抗生物質에 對해 多抗生物質耐性을 보여 주었다. A clinical and laboratory study was conducted on 75 children with dysentery-like stool, who were admitted or visited to our pediatric department during 8 months period from January to August 1980. The following results were obtained: One to five years of age group was affected most frequently (47%). Shigella flexneri was identified by stool culture in 23 cases (30%) and Entameba hitolytica in 13 cases (17%). In bacillary dysentery group, fever was the most common symptom occuring in 83%, followed by abdominal pain in 35%, vomiting in 26% and convulsion in 22%. In amoebic dysentery group, fever was noted in 31% and convulsion in 8%, showing some contrast to the frequency of fever and CNS manifestation. About the character of diarrheal stools, 83% of bacillary dysentery group showed bloody, mucoid stool and 62% of amoebic dysentery group mucoid ones. Frequency of diarrhea was 11 times per day or more in 73% of bacillary dysentery patients, and 10 times per day or less in 92% of amoebic dysentery patients. The result of sensitivity test of isolated Shigella to various antibiotics were as follow: 100% sensitive to kanamicin, gentamicin, amikacin, cephaloridine and rifampin. 87% to nalidixic acid, and 4.3% to sulfonamide, chloramphenicol, streptomycin, tetracyclin, ampicillin and bactrim. And 22 out of 23 isolated Shigella strains revealed multiplydrug-resistance patterns to 6 or more antibiotics.

견비통의 한·양방 진료 및 협진의 경제성 평가

장혜정,홍상민,박유선,남동우,이두익,이재동,이윤호,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Objectives : The purpose of this study was to evaluate and compare the cost-effectiveness of Eastern, Western and collaborative treatments and suggest a cost-effective approach for patients with frozen shoulder pain. Methods : Using the data of fifty-two patients, treatment effectiveness was measured by CSA, SPADI, and ROM scales and changes from the baseline score were evaluated. Data source for cost estimation was based on the national health insurance (NHI) payment system. Because the price in NHI was differentiated by health care institutions, five collaborative types were considered in assessing costs. Cost-effective ratios were computed tor economic evaluation. Results : Compared with Eastem treatinent, collaborative and Westerm treatments showed better effects on CSA scale after 4 weeks' treatment. The collaborative approach was also the most effective treatment on SPADI and ROM scales The direct cost per patient receiving Eastern treatment was less than other treatments. In general, collaborative treatment dominated Eastern and Western treatments in cost-effectiveness analysis However, the cost-effectiveness ratio of Eastern treatment resulted in \9,0OO compared to W29,OOO of collaborative treatment on SPADI Four different indicators of ROM scales resulted in different approaches as the cost-effective treatment. Conclusiuns : Considering cost-effectiveness ratios, collaborative treatment was the best treatment on CSA and SPADl scales after 4 weeks' treatment As for ROM scales, the recommended altematives were Eastern treatment for patients with abduction and adduction disabilities, Western treatment for those with flexion disability, and collab-orative approach for those with extension disability.

漢方藥劑의 品質評價와 藥效에 關한 硏究(第6報) : 元柴胡및 竹柴胡 水性엑스의 中樞抑制作用에 對하여 Central Depressive Action of Bupleurum Falcatum and Bupleurum Longiradiotum

徐成勳,洪南斗,權昌鎬,金壽億 慶熙大學校 1988 論文集 Vol.17 No.-

The effects of the aqueous extracts of Bupleurun falcatum and Bupleurum longiradiotum on the central nervous depressive action were studied by the behaviroral pharmacological method. The roots of Bupleuri radix was extracted with distilled water for 8 hours. Effect of extracts were tested by spontaneous movement activity using photoelectric method, openfield method, sloped plate method, rotarrod method and extension of hypnosis time induced with sodium phenobarbital and pentobarbital sodium, and defense against convulsive action induced with strychnine, picrotoxine and electric shock seizure in mice and rats. Extracts was found to pharmacologically expect above various action similar to these of diazepam but action of samples weaker than that of diazepame. Extracts of Bupleurum longiradiotum was definitely superior to the Bupleurum extracts in the central nervousderpressive action.

漢方藥의 成分 및 藥效에 관한 硏究(제3보) : 退黃散이 肝臟代謝 및 利膽에 미치는 影響

權昌鎬,洪南斗 慶熙大學校 1985 論文集 Vol.14 No.-

In order to investigate pharmacological action of the combined preparation of crude drugs "Toiwhang-San" were studied. These studies were conducted in an attempt to investigate the effect of "Toiwhang-San" on activities of the liver enzyme, contents of cholesterol, bilirubin, glucose, triglyceride and the excretory action of bile juice in the serum of CCl_4 and galactosamine intoxicated rate. The result of this investigate were summerized as follows; GOT, GPT activities in the serum of rats damaged by CCl_4 were shown to the remarkable decrease in the administration of the sample. GOT, GPT activities in the serum of rate damaged by galactosamins were shown to the remarkable decrease in the administration of the sample. ALP, LDH activities in the serum of rats damaged by galactosamine were shown to the remarkable decease in the administration of the sample. Contents of cholesterol, bilirubin, glucose, triglyceride in the serum of rats damaged by galactosamine were shown to the remarkable decrease in the administration of the sample. Excretory action of bile juice in rate were shown to the remarkable increase in the administration of the sample.

정신과 환자들의 의료서비스 이용에 관한 연구 : 경기도 연천 지역에서 In Yonchon Area of Kyunggi Province

황성혜,홍진표,권준수,우종인,김중술,조두영,이부영,조맹제,양병국,배재남 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

본 연구는 농촌지역 정신과 환자들의 의료서비스 이용 형태를 알아보고자 하여 행하여졌다. 경기도 연천군 주민중 1993년 1년간 지역 의료보험과 의료보호자료에서 정신과적 진단을 받은 사람들 1295명 중 209명을 대상으로 하였다. 연구자들이 제작한 반구조화된 면담도구를 사용하여 13명의 훈련된 면담자에 의해 증상을 처음 느낀 후 이용한 의료서비스를 차례대로 조사하였다. 결과는 다음과 같다. 정신증적 장애 환자들은 정신과 치료만을 받은 경우가 28.8%이며 처음 방문한 의료서비스는 정신과 45%, 일반의 28%, 약국 6%, 한방치료 5%, 요양원 6%, 기타 10%였다. 비정신증적 장애 환자들은 정신과를 한번이라도 이용한 경우는 32.1%였고 처음 방문한 의료서비스는 정신과 15%, 일반의59%,약국 17%, 한방치료8%, 기타1%였다. 진단에 따라서는, 정신분열병의 경우 64.5%가 처음에 정신과를 방문하였고 정동형 정신병의 경우는 20.8%에 불과했고 64.1%가 일반이나 약국을 처음에 방문하였다. 신경증적 장애(ICD-9 300)는 40.0%가 일반의만을 방문했다. 이상의 결과로 정신분열병 환자들은 대다수가 정신과 치료를 받는 것으로 나타났으나 정동형 정신병과 신경증적 장애는 다수가 일반의를 이용하는 것으로 나타났다. 지역사회 정신보건에서 일반의의 역할이 매우 중요하며 일반의에 대한 정신과 교육이 절실하고, 보다 전문적인 치료환경과 기술을 요하는 경우에는 정신과와의 연계 체계의 필요성도 요구된다. The purpose of this study was to investigate the pathways of health care seeking by the psychiatric patients at a well - defined rural area in Korea. Among 1,295 patients diagnosed to have mental disorders by ICD-9 in a year, all the psychotic patients(184 in number) and randomly selected 15% of nonpsychotic patients(162 in number) were selected as subjects of this study. Thirteen well - trained interviewers collected the data using semi-structurd inter-view instrument developed by the authors. Two hundred nine patients(60.4%) fully responded to the interviews. As for psychotic patients, 28.8% used only psychiatric services, and the first visits for help were psychiatrists, general practitioners, pharmacists, asylums and oriental herb medicine in the order of decreasing frequency. Only 32.1% of nonpsychotic patients used mental health specialties during the course of their illness, and their most common first visits for care were general practitioners(59%) followed by pharmacists(17%) and psychiatrists(15%). Majority(64%) of schizophrenic patient visited psychiatrist first, while 64.1% of affective psychosis patients visited general practitioners and pharmacists first. The forty percent of neurotic patients(ICD-9 300) visited general practitioners only for their health care.

생약복합제제의 병용투여에 관한 연구 (제1보) : 가미청심연자탕과 항고혈압약물과의 병용투여 Combined usage of Kamichungsimyunja-Tang and Anti-hypertensive Drugs

이석주,김남재,김종우,홍남두 한국병원약사회 1993 병원약사회지 Vol.10 No.4

Effects of Combined usage of combined preparation of crude drugs(Kamichungsimyunja-Tang) and anti-hypertensive drugs were examined in anti-hypertensive effects in rats and diuretic effects in mice. Kamichungsimyunja-Tang is an added and subtracted prescription of Chungsimyunja-Tang which it has become one of the favorate prescriptions at the Oriental Medical Hospital, Kyung-Hee University. Kamichungsimyunja-Tang has been used widely in cardiovascular disorder in Oriental medicines. Kamichungsimyunja-Tang was orally given and anti-hypertensive drugs such as hydralazine, verapamil and atenolol were intravenously given to rats. Effects of combined usage of Kamichungsimyunja-Tang and antihypertensive drugs for the anti-hypertensive actions significantly increased the anti-hypertensive effect of anti-hypertensive drugs. Kamichungsimyunja-Tang and diuretic drugs such as furosemide and hydrochlorothiazide was orally given to mice. Effects of combined usage of Kamichungsimyunja-Tang and diuretic drugs for the diuretic effects significantly increased the effect of diuretic drugs. These result suggested that combined usage of Kamichungsimyunja-Tang and anti-hypertensive drugs and diuretic drugs for the anti-hypertensive and diuretic actions significantly increased the effect of anti-hypertensive and diuretic drugs.