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홍남두,김종우,송일병,원도희,김남재,김진성 한국약제학회 1985 Journal of Pharmaceutical Investigation Vol.15 No.2
Analgesic, anticonvulsive, sedative and antipyretic actions of Yangkyuksanwha tang which is composed of nine crude drugs including Rehmanniae Radix, and its effects on isolated ileum and blood vessel were investigated. The results of the studies were summerized as follows; 1. Analgesic and antipyretic effects were observed. 2. Suppressive actions were not shown on the convulsion induced by strychnine, but significant effects were noted on the convulsion induced by picrotoxin. 3. A prolongation of anesthetic time induced by pentobarbital sodium was significantly observed. 4. Relaxing actions were noted on the ileum of mice, and also, same effects were recognized on the contraction of the ileum due to acetylcholine chloride and barium chloride. 5. The expansion of blood vessels by relaxation of smooth muscle and hypotensive effects were noted.
생약 복합제제의 품질평가에 관한 연구(제2보) : 생맥산의 품질평가 방법에 관하여
홍남두,김종우,원도희,강윤상,김남재,주수만 한국약제학회 1987 Journal of Pharmaceutical Investigation Vol.17 No.1
Evaluation method of crude drug preparations was studied in Saengmaek-san. Zig-zag TLC scanning profiles and high performance liquid chromatograms were obtained from Saengmaek-san and its each crude drug. A method using TLC densitometry and high performance liquid chromatography was established for the precise determination of ginsenoside Rb₁ in Saengmaek-san containing Ginseng Radix. Consequently, ginsenoside Rb₁ content was 0.45-0.48 ㎎ per g of Saengmaek-san. This method was found to be useful for the quality evaluation of oriental medicinal preparations.
산지별 녹용류의 성분분석 연구(I) - 미량금속의 정량 및 Gangliosides의 TLC Pattern 분석
홍남두,원도희,김남재,장승엽,윤황금,김혜수,Hong Nam Doo,Won Do Hee,Kim Nam Jae,Chang Seung Youb,Youn Whang-Geum,Kim Hae-Soo 한국양록협회 1991 양록회보 Vol.14 No.-
Several experiments were carried for the purpose of establishing the basis for the quality evaluation of deer horn. Deer horn originated from China, New Zealand, Soviet and Alaska were used as objectives and some constituents involved in deer horn were as
홍남두,노영수,조영환,설수용,김신규 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.1
Anemarrhenae Rhizoma has been clinically used as a sedative drug in oriental medicine. We observed the sedative action and effect on the movement of isolated-ileum with each water extract of Anemarrhenae Rhizoma (F-I), saline solution treated preparation (F-II) and 25% ethanol treated preparation (F-III). The results obtained were summerized as follows; 1) Sedative actions were recognized with F-I, F-II and F-III. 2) Prolonged effect of sleeping time was recognized significantly with F-I, F-II and F-III. 3) Each fraction of Anemarrhenae Rhizoma showed the released action on the isolated-ileum of the mouse, rat, rabbit and guinea pig, and antagonic action against contraction induced by acetylcholine, barium chloride and histamine. Thus the mechanism in the released action of the smooth muscle was partly considered as the direct dependence of the smooth muscle.
홍남두,김종우,김남재,김진식,Hong, Nam-Doo,Kim, Jong-Woo,Kim, Nam-Jae,Kim, Jin-Sik 한국생약학회 1992 생약학회지 Vol.23 No.2
The water extract of Gamidaebo-Tang depressed the lethal toxicity of cis-platin$(45{\mu}M/kg,\;s.c.)$, and mitomycin C (6mg/kg, s.c.). Significant depression of renal toxicity(indicated by an increased blood urea nitrogen value and creatinine value) of cis-platin $(35{\mu}M/kg)\;s.c.)$, was observed in mice treated with Gamidaebo-Tang. In rats treated with mitomycin C and Gamidaebo-Tang, the increased LDH activity and reduced total protein and albumin contents by mitomycin C were significantly depressed. The number of WBC was significantly increased in rats treated with mitomycin C but in the rats treated with mitomycin C and Gamidaebo-Tang, the number of WBC was increased and the hematocrit value and the number of RBC and Hgb were significantly increased in the dose-dependent manner. Therefore, bone marrow toxicity of mitomycin C in the rats treated with Gamidaebo-Tang was depressed. In the end, alleviative effects of the side actions of cis-platin and mitomycin C were acknowledged by combined usage of Gamidaebo-Tang and these anti-neoplastic drugs.