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金壽億,權昌鎬,洪南斗 慶熙大學校 1987 論文集 Vol.16 No.-
In order to investigate the pharmacological effects of the combined preparation of oriental crude drung, Taeeuminyuldahanso-Tang. It has been widely used for emesis, vomiting, diarrhea etc. Here we studied on the anticonvulsion, analgesic, antipyretic, isolated ileum and diuretic effect in mice, rats, guinea-pigs and rabbits. Following results were obtained; Anticonvulsive effect was noted on the convulsion induced by strychnine and picrotoxin. In acetic acid method analgesic action was noted. Antipyretic effect on the fever induced by typhoid vaccine was significantly recognized. Spontaneous mortility of the isolated ileum was suppressed and its contraction caused by Ach, Ba, Histamine was remarkablely nhibited. Diuretic action was significantly noted. According to the above results, effects based on oriental medical references approximate to the actual experimental results.
김창덕(Chang-Dug Kim),서성훈(Sung-Hoon Seo),김수억(Soo-Uck Kim) 한국생약학회 1981 생약학회지 Vol.12 No.1
정신신경안정제의 투여는 날로 증가되어가고 있으나, 이들의 부작용, 독성 등 안전성문제가 크게 대두됨에 따라, 안정성이 우수한 한방제제로써, 불면, 노이로제, 신경쇠약 등에 널리 사용되는 온담탕의 중추억제작용을 실험적으로 평가한다는 것은 큰 의의가 있다고 사려되어, 이것의 수성엑기스를 조제하여 마우스를 사용하고 이것의 일반행동 ·자발운동량 및 수면 효과에 미치는 영향을 실험한바 다음과 같았다. 온담탕 수성엑기스는 mouse의 체위·보행상태 등 일반행동에 있어 중추억제작용을 나타냈으며 mouse의 자발운동을 억제하는 작용도 있었다. 또한, Peutobarbital-Na, Amobarbital-Na의 mouse 수면지속시간을 연장시켰다.
썰린댁/β-싸이클로 덱스트린 包接化合物 및 썰린댁/폴리 비니르피로리돈 共沈物에 관한 硏究
金壽億 慶熙大學校 1987 論文集 Vol.16 No.-
To increase the solubility of Sulindac which is used widely as a non-steroidal anti-inflammatory drug, its inclusion complex and coprecipitate were prepared and studied in this paper. Inclusion complex of sulindac with β-cyclodextrin were prepared by the four different methods; neutralization method, freezedrying method, kneading method and solvent evaporation method. Also copreciptates of sulindac with polyvinylpyrrolidone K30 and T40 were preparcd by solvent method. Inclusion complex formation of sulindac with β-cyclodextrin and coprecipitate formation of sulindac with polyvinylpyrrolidone K30 and T40 were ascertained by X-ray diffractometry, differential scanning calorimetry and IR spectroscopy. It was found that he inclusion complex formation prepared by freeze-drying method, ?? evaporation method and neutralization method were similar, Freeze-drying method seemed to suitable for preparation of complex with most higher dissolution rate but kneeding method seemed not to be suiable for complex formation. Coprecpitate formation of sulindac prepared with polyvinylpyrrolidone K30 and T40 were similar. Dissoluton behaviors of the inclusion complex and the coprecipitate were examined. As a result, the release of sulindac from the inclusion complex and the coprecipitate was significantly improved than that of infact sulindac. The dissolution rate of coprecipitate was found to be no different between sulindac-polyvinyl pyrrolidone K30 system and sulindac-polyvinylpyrrolidone T40 system.
金在植,金壽億,徐成勳 慶熙大學校 1984 論文集 Vol.13 No.-
This experiment was conducted to investigate the release pattern of allantion from six kind of ointment bases. Release rate(K) of PEG ointment was 3.68 which was the most value in experimented ointment base, nest order was cold cream (K=1.42). In the case of additives, urea enhanced the release of allantion from six kind of ointment , PVP enhanced the release of allantoin from only Hydrophobic ointment bases. Addition of DMS retarded the release of allantion from six kind of ointments, the more concentration of DMS was increasing, the greater retarding effect became. But, in the case of PVP and urea, the greater concentration of additives became, the more release rate was increasing
김수억,서성훈,윤형중,백운봉 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.3
To increase the solubility of fentiazac which is used widely as a non-steroidal antiinflammatory drug, its inclusion complex and suppositories were prepared and studied. Inclusion complexes of fentiazac with β-cyclodextrin (β-CyD) were prepared by four diffrent methods; coprecipitation method, kneading method, solvent evaporation method, freeze drying method. Suppositories of fentiazac/β-CyD with PEG 1500 and Witepsol H-15 were prepared by solvent evaporation method and freeze drying method. Inclusion complex formation of fentiazac with β-CyD was ascertained by powder X-ray diffractometry, differential scanning calorimetry and IR spectroscopy. The dissolution rate of fentiazac from the inclusion complex increased in distilled water and KP 2nd disintegration test fluids (pH 6.8) but extemly decreased in KP 1st disintegration test fluid (pH 1.2). Inclusion complexes prepared by freeze drying method and solvent evaporation method were similar. Freeze drying method seemed to be suitable for preparation of complex with most higher dissolution rate but coprecipitation method seemed not to be suitable. The dissolution rate of fentiazac increased markedly by β-CyD complexation. The release rates of suppositories increased in the following order. Complex prepared by freeze dying method in PEG 1500>complex prepared by solvent evaporation method in PEG 1500>fentiazac in PEG 1500 > complex prepared by freeze dying method in Witepsol H-15 > complex prepared by solvent evaporation method in Witepsol H-15>fentiazac in Witepsol H-15.