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Layout Optimization of Stiffeners in Heavy-Duty Thin-Plate Box Grider
Hao Zhang,Yixiao Qin,Jinpeng Gu,Haibiao Gao,Qianqian Jiao,Feng Wang,Zhenshan Guo,Yangyang Zhang,Chenghong Mi 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.8
The optimization of layout and sizes of the stiffeners in heavy-duty box girder could make this kind of the structure more compact and reasonable, which has certain engineering values. In this study, on the basis of the establishment of parametric finite element model, the function approaching method and gradient search method are combined to form a high-precision optimization algorithm, which makes structural analysis be integrated into the optimization process. The optimization takes the type and location of longitudinal stiffening ribs and the thickness and hole position of transverse diaphragms as design variables, the box girder structural behaviors as constraint conditions, and the total volume as objective function. Finally, the weight is reduced by nearly 7%. More importantly, the new asymmetrical layout of the stiffeners is obtained, the distance between the longitudinal stiffening ribs on the main web and the neutral layer is longer than the distance between the longitudinal stiffening ribs on the secondary web and the neutral layer, and the hole position of transverse diaphragms is close to the secondary web. Compared with the current production of symmetrical layout structure, this layout provides a new idea for the design of stiffeners in the bias-rail box girder.
Li Qin Zhang,Xiao Peng Zhang,Yu Ying Hao,Bao Li Zhang,Xin Dong Guo 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.88 No.-
When overexposed to ultraviolet B (UVB) irradiation, skin can cause a series of abnormal reactions, suchas excessive pigmentation and solar elastosis. In order to better treat the skin after overexposed to UVB,we designed a dissolving microneedles (MNs) loading hydrophilic ascorbic acid and hydrophobic vitaminA palmitate to achieve codelivery. Here, we confirmed that MNs had enough mechanical strength toinsert the skin and two drugs were delivered subcutaneously in sequence in vitro. In white guinea pigs,surface observation and histological observation results confirmed that two drugs by MNs transdermaldelivery were better than topical administration in the treatment of UVB-damaged skin. The MNs providea method of loading different drugs into the needles and advance the development of transdermal drugdelivery.
Qin, Hao,Yang, Qixia,Zhuang, Qiang,Long, Jianwu,Yang, Fan,Zhang, Hongqi The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.5
Objective : To investigate the morphological and hemodynamic parameters associated with middle cerebral artery (MCA) bifurcation aneurysm rupture. Methods : A retrospective study of 67 consecutive patients was carried out based on 3D digital subtraction angiography data. Morphological and hemodynamic parameters including aneurysm size parameters (dome width, height, and perpendicular height), longest dimension from the aneurysm neck to the dome tip, neck width, aneurysm area, aspect ratio, Longest dimension from the aneurysm neck to the dome tip (Dmax) to dome width, and height-width, Bottleneck factor, as well as wall shear stress (WSS), low WSS area (LSA), percentage of LSA (LSA%) and energy loss (EL) were estimated. Parameters between ruptured and un-ruptured groups were analyzed. Receiver operating characteristics were generated to check prediction performance of all significant variables. Results : Sixty-seven patients with MCA bifurcation aneurysm were included (31 unruptured, 36 ruptured). Dmax (p=0.008) was greater in ruptured group than that in un-ruptured group. D/W (p<0.001) and the percentage of the low WSS area ($0.09{\pm}0.13$ vs. $0.01{\pm}0.03$, p<0.001) were also greater in the ruptured group. Moreover, the EL in ruptured group was higher than that in unruptured group ($6.39{\pm}5.04$ vs. $1.53{\pm}0.86$, p<0.001). Multivariate regression analysis suggested D/W and EL were significant predictors of rupture of MCA bifurcation aneurysms. Correlation analyses revealed the D/W value was positively associated with the EL (R=0.442, p<0.01). Conclusion : D/W and EL might be the most two favorable factors to predict rupture risk of MCA bifurcation aneurysms.
Zhang WenXin,Li Hao,Cong Haofei,Zhou Ruifu,Qin Yuanbin,Xu Peilong,Liu Xuhai,Wang Fengyun 한국물리학회 2023 Current Applied Physics Vol.48 No.-
One-dimensional wide band-gap metal oxide semiconductors demonstrate enormous potential in high-performance ultraviolet photodetectors. Here, via tuned zinc oxide (ZnO) concentration ratio and heterojunction structure as well as decent VTH value, we electrospun tin zinc oxide (SnZnOX) nanowires for photoelectronic conversion function. The constructed optimized photodetectors based on Sn8Zn2OX nanowires can exhibit a remarkable detectivity of 1.77 × 1016 Jones, excellent responsivity of 2.23 × 103 A/W and relative high sensitivity over 104. In addition to the excellent photodetection performance, Sn8Zn2OX nanowire devices exhibit nonvolatile memory effect, which can maintain the light-induced low resistance state at 5 V without light. Moreover, a voltage of 30 V was applied to Sn8Zn2OX nanowires devices to realize light-writing state switching to bias-erasing state, and the device could come back to their initial high resistance state. These results indicate SnZnOX nanowires devices possess a tremendous potential in the circuit design of the artificial visual system.
Qin Huang,Hao Zhang,Dan Xue 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.4
Puerariae radix (PR) is a traditional Chinesefood and medicine. In this study, the chemical profile andbioactivities of PR fermented with Aspergillus niger (PFA)were investigated. Based on HPLC analysis, PFA chemicalprofile changed and total phenols increased by 12.5% relativeto PR. Consequently, the in vitro antioxidant activitysignificantly improved. According to the blood lipid analysisin mice, PFA showed a better ability to inhibit theincreased blood lipid levels induced by Triton WR-1339than PR. In a quantitative real-time PCR (qRT-PCR) study,PFA up-regulated cholesterol 7-alpha hydroxylase(CYP7A1) and low-density lipoprotein receptor mRNAexpression, which were 50% and 44.8% higher than thelevels induced by high-dose PR. Conversely, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCoAR) mRNAexpression was down-regulated to 46.8% lower than thelevels induced by high-dose PR. The qRT-PCR resultssuggested that PFA displayed better hypolipidemic activitythan PR, due to its superior ability to regulate mRNAexpression.
Hao Dong,Hao-Qin Zhang,Gang Liang,Bing-Xing Ren,Xiao-Long Zhao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.4
Twin rotors concentric face-gear power-split transmission system (TRCFGPSTS) is a new and more advanced main reducer configuration of the high-speed helicopter. Its loadsharing performance between different branches has a great impact on the service life performance. Its load distribution is complex, and the research on the influence law of error on loadsharing performance is not clear. Therefore, to study the influence of system error and pinions floating on the mechanical properties of the system, the static load-sharing mathematical model of the system was established. The load-sharing model comprehensively considers the factors of manufacturing error (ME) and installation error (IE), meshing stiffness, torsional stiffness, support stiffness and member floating. The coordination conditions of torsional angle elastic deformation of the system with central displacement offset and the mechanical balance conditions under the action of elastic support and floating support are derived, which reflects the change law of load distribution from the perspective of the system as a whole. The load-sharing model is solved by the least square method. The load-sharing coefficient (LSC) of the system is obtained. The influence of ME, IE and floating pinions on load-sharing performance is analyzed. The results show that the LSC shows irregular periodic fluctuation under the combined action of error, and the LSC is 1.212. Under the single influence of ME, the LSC also shows irregular periodic fluctuation, and the LSC is 1.610. Under the single influence of IE, the LSC presents a constant influence law, and the LSC is 1.326. The error of each gear in the III-stage has the most obvious influence on the load-sharing characteristics. The LSC of I-stage and II-stage floating pinion under the single influence are 1.113 and 1.120, respectively. The floating gear can significantly improve the load-sharing performance, and meet the load-sharing at the ±5 % service requirement.
Zhang, Yumiao,Hong, Hao,Sun, Boyang,Carter, Kevin,Qin, Yiru,Wei,Wang, Depeng,Jeon, Mansik,Geng, Jumin,Nickles, Robert J.,Chen, Guanying,Prasad, Paras N.,Kim, Chulhong,Xia, Jun,Cai, Weibo,Lovell, Jonat The Royal Society of Chemistry 2017 Nanoscale Vol.9 No.10
<P>Surfactant-stripped, nanoformulated naphthalocyanines (nanonaps) can be formed with Pluronic F127 and low temperature membrane processing, resulting in dispersed frozen micelles with extreme contrast in the near infrared region. Here, we demonstrate that nanonaps can be used for multifunctional cancer theranostics. This includes lymphatic mapping and whole tumor photoacoustic imaging following intradermal or intravenous injection in rodents. Without further modification, pre-formed nanonaps were used for positron emission tomography and passively accumulated in subcutaneous murine tumors. Because the nanonaps used absorb light beyond the visible range, a topical upconversion skin cream was developed for anti-tumor photothermal therapy with laser placement that can be guided by the naked eye.</P>
Zhang Li,Zhu Yu-Qin,Yan Xin-Xin,Wu Hao,Li Kun 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.6
In this paper, an optimized mixture kernels independent component analysis and echo state network fl ame image recognition model is proposed. Firstly, in order to describe the fl ame image feature information in detail, 19 feature vectors of the three types of color, shape and texture feature are comprehensively extracted; a mixture kernels independent component analysis method is proposed to perform nonlinear transformation and reduce the correlation of them. The mixture kernels function among them is a combination of linear kernel function, Matérn kernel function and Gaussian radial basis kernel function. Then, the feature vector after nonlinear transformation isused as the input vector, and the echo state network model is trained as the recognition model. At the same time, a normal cloud-black hole optimization algorithm (NCGBH) combining black hole algorithm with cloud model is proposed, which can optimize several adjustable parameters of the model. Four benchmark functions are fi rstly used for simulation experiments to prove advancement of the proposed NCGBH algorithm; and then, several fl ame images are used to verify performance of the proposed recognition model. From the comparison and analysis, it is verifi ed that the proposed method has good results in recognition performance, generalization ability, and computational time.